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11 results on '"Manickchund, Nithendra"'

1. Clearance of persistent SARS-CoV-2 associates with increased neutralizing antibodies in advanced HIV disease post-ART initiation

Author

Karim, Farina, Riou, Catherine, Bernstein, Mallory, Jule, Zesuliwe, Lustig, Gila, van Graan, Strauss, Keeton, Roanne S., Upton, Janine-Lee, Ganga, Yashica, Khan, Khadija, Reedoy, Kajal, Mazibuko, Matilda, Govender, Katya, Thambu, Kershnee, Ngcobo, Nokuthula, Venter, Elizabeth, Makhado, Zanele, Hanekom, Willem, von Gottberg, Anne, Hoque, Monjurul, Karim, Quarraisha Abdool, Abdool Karim, Salim S., Manickchund, Nithendra, Magula, Nombulelo, Gosnell, Bernadett I., Lessells, Richard J., Moore, Penny L., Burgers, Wendy A., de Oliveira, Tulio, Moosa, Mahomed-Yunus S., and Sigal, Alex

Published
2024
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2. Evolution and neutralization escape of the SARS-CoV-2 BA.2.86 subvariant

Author

Khan, Khadija, Lustig, Gila, Römer, Cornelius, Reedoy, Kajal, Jule, Zesuliwe, Karim, Farina, Ganga, Yashica, Bernstein, Mallory, Baig, Zainab, Jackson, Laurelle, Mahlangu, Boitshoko, Mnguni, Anele, Nzimande, Ayanda, Stock, Nadine, Kekana, Dikeledi, Ntozini, Buhle, van Deventer, Cindy, Marshall, Terry, Manickchund, Nithendra, Gosnell, Bernadett I., Lessells, Richard J., Karim, Quarraisha Abdool, Abdool Karim, Salim S., Moosa, Mahomed-Yunus S., de Oliveira, Tulio, von Gottberg, Anne, Wolter, Nicole, Neher, Richard A., and Sigal, Alex

Published
2023
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3. Omicron infection enhances Delta antibody immunity in vaccinated persons

Author

Khan, Khadija, Karim, Farina, Cele, Sandile, Reedoy, Kajal, San, James Emmanuel, Lustig, Gila, Tegally, Houriiyah, Rosenberg, Yuval, Bernstein, Mallory, Jule, Zesuliwe, Ganga, Yashica, Ngcobo, Nokuthula, Mazibuko, Matilda, Mthabela, Ntombifuthi, Mhlane, Zoey, Mbatha, Nikiwe, Miya, Yoliswa, Giandhari, Jennifer, Ramphal, Yajna, Naidoo, Taryn, Sivro, Aida, Samsunder, Natasha, Kharsany, Ayesha B. M., Amoako, Daniel, Bhiman, Jinal N., Manickchund, Nithendra, Abdool Karim, Quarraisha, Magula, Nombulelo, Abdool Karim, Salim S., Gray, Glenda, Hanekom, Willem, von Gottberg, Anne, Milo, Ron, Gosnell, Bernadett I., Lessells, Richard J., Moore, Penny L., de Oliveira, Tulio, Moosa, Mahomed-Yunus S., and Sigal, Alex

Published
2022
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4. Omicron BA.4/BA.5 escape neutralizing immunity elicited by BA.1 infection

Author

Khan, Khadija, Karim, Farina, Ganga, Yashica, Bernstein, Mallory, Jule, Zesuliwe, Reedoy, Kajal, Cele, Sandile, Lustig, Gila, Amoako, Daniel, Wolter, Nicole, Samsunder, Natasha, Sivro, Aida, San, James Emmanuel, Giandhari, Jennifer, Tegally, Houriiyah, Pillay, Sureshnee, Naidoo, Yeshnee, Mazibuko, Matilda, Miya, Yoliswa, Ngcobo, Nokuthula, Manickchund, Nithendra, Magula, Nombulelo, Karim, Quarraisha Abdool, von Gottberg, Anne, Abdool Karim, Salim S., Hanekom, Willem, Gosnell, Bernadett I., Lessells, Richard J., de Oliveira, Tulio, Moosa, Mahomed-Yunus S., and Sigal, Alex

Published
2022
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5. Author Correction: Omicron BA.4/BA.5 escape neutralizing immunity elicited by BA.1 infection

Author

Khan, Khadija, Karim, Farina, Ganga, Yashica, Bernstein, Mallory, Jule, Zesuliwe, Reedoy, Kajal, Cele, Sandile, Lustig, Gila, Amoako, Daniel, Wolter, Nicole, Samsunder, Natasha, Sivro, Aida, San, James Emmanuel, Giandhari, Jennifer, Tegally, Houriiyah, Pillay, Sureshnee, Naidoo, Yeshnee, Mazibuko, Matilda, Miya, Yoliswa, Ngcobo, Nokuthula, Manickchund, Nithendra, Magula, Nombulelo, Karim, Quarraisha Abdool, von Gottberg, Anne, Abdool Karim, Salim S., Hanekom, Willem, Gosnell, Bernadett I., Lessells, Richard J., de Oliveira, Tulio, Moosa, Mahomed-Yunus S., and Sigal, Alex

Published
2022
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6. Hen egg white bovine colostrum supplement reduces symptoms of mild/moderate COVID-19: a randomized control trial

Author

Mann, Jaclyn Kelly, primary, Reddy, Tarylee, additional, der Stok, Mary van, additional, Ngubane, Ayanda, additional, Mulaudzi, Takalani, additional, Mchunu, Nobuhle, additional, Nevhungoni, Portia, additional, Manickchund, Nithendra, additional, Manickchund, Pariva, additional, Louise Cairns, Chelline Helena, additional, Govender, Vaneshree, additional, Ndung'u, Thumbi, additional, Suleman Moosa, Mahomed Yunus, additional, and Gosnell, Bernadett Isabel, additional

Published
2023
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7. Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization

Author

Cele, Sandile, Jackson, Laurelle, Khoury, David S., Khan, Khadija, Moyo-Gwete, Thandeka, Tegally, Houriiyah, San, James Emmanuel, Cromer, Deborah, Scheepers, Cathrine, Amoako, Daniel G., Karim, Farina, Bernstein, Mallory, Lustig, Gila, Archary, Derseree, Smith, Muneerah, Ganga, Yashica, Jule, Zesuliwe, Reedoy, Kajal, Hwa, Shi Hsia, Giandhari, Jennifer, Blackburn, Jonathan M., Gosnell, Bernadett I., Abdool Karim, Salim S., Hanekom, Willem, Davies, Mary Ann, Hsiao, Marvin, Martin, Darren, Mlisana, Koleka, Wibmer, Constantinos Kurt, Williamson, Carolyn, York, Denis, Harrichandparsad, Rohen, Herbst, Kobus, Jeena, Prakash, Khoza, Thandeka, Kløverpris, Henrik, Leslie, Alasdair, Madansein, Rajhmun, Magula, Nombulelo, Manickchund, Nithendra, Marakalala, Mohlopheni, Mazibuko, Matilda, Moshabela, Mosa, Mthabela, Ntombifuthi, Naidoo, Kogie, Ndhlovu, Zaza, Ndung’u, Thumbi, Ngcobo, Nokuthula, Nyamande, Kennedy, and Patel, Vinod

Subjects
Multidisciplinary
Abstract

The emergence of the SARS-CoV-2 variant of concern Omicron (Pango lineage B.1.1.529), first identified in Botswana and South Africa, may compromise vaccine effectiveness and lead to re-infections1. Here we investigated Omicron escape from neutralization by antibodies from South African individuals vaccinated with Pfizer BNT162b2. We used blood samples taken soon after vaccination from individuals who were vaccinated and previously infected with SARS-CoV-2 or vaccinated with no evidence of previous infection. We isolated and sequence-confirmed live Omicron virus from an infected person and observed that Omicron requires the angiotensin-converting enzyme 2 (ACE2) receptor to infect cells. We compared plasma neutralization of Omicron relative to an ancestral SARS-CoV-2 strain and found that neutralization of ancestral virus was much higher in infected and vaccinated individuals compared with the vaccinated-only participants. However, both groups showed a 22-fold reduction in vaccine-elicited neutralization by the Omicron variant. Participants who were vaccinated and had previously been infected exhibited residual neutralization of Omicron similar to the level of neutralization of the ancestral virus observed in the vaccination-only group. These data support the notion that reasonable protection against Omicron may be maintained using vaccination approaches.

Published
2021

8. Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization

Author

Cele, Sandile, Jackson, Laurelle, Khoury, David S., Khan, Khadija, Moyo-Gwete, Thandeka, Tegally, Houriiyah, San, James Emmanuel, Cromer, Deborah, Scheepers, Cathrine, Amoako, Daniel G., Karim, Farina, Bernstein, Mallory, Lustig, Gila, Archary, Derseree, Smith, Muneerah, Ganga, Yashica, Jule, Zesuliwe, Reedoy, Kajal, Hwa, Shi Hsia, Giandhari, Jennifer, Blackburn, Jonathan M., Gosnell, Bernadett I., Abdool Karim, Salim S., Hanekom, Willem, Davies, Mary Ann, Hsiao, Marvin, Martin, Darren, Mlisana, Koleka, Wibmer, Constantinos Kurt, Williamson, Carolyn, York, Denis, Harrichandparsad, Rohen, Herbst, Kobus, Jeena, Prakash, Khoza, Thandeka, Kløverpris, Henrik, Leslie, Alasdair, Madansein, Rajhmun, Magula, Nombulelo, Manickchund, Nithendra, Marakalala, Mohlopheni, Mazibuko, Matilda, Moshabela, Mosa, Mthabela, Ntombifuthi, Naidoo, Kogie, Ndhlovu, Zaza, Ndung’u, Thumbi, Ngcobo, Nokuthula, Nyamande, Kennedy, Patel, Vinod, Cele, Sandile, Jackson, Laurelle, Khoury, David S., Khan, Khadija, Moyo-Gwete, Thandeka, Tegally, Houriiyah, San, James Emmanuel, Cromer, Deborah, Scheepers, Cathrine, Amoako, Daniel G., Karim, Farina, Bernstein, Mallory, Lustig, Gila, Archary, Derseree, Smith, Muneerah, Ganga, Yashica, Jule, Zesuliwe, Reedoy, Kajal, Hwa, Shi Hsia, Giandhari, Jennifer, Blackburn, Jonathan M., Gosnell, Bernadett I., Abdool Karim, Salim S., Hanekom, Willem, Davies, Mary Ann, Hsiao, Marvin, Martin, Darren, Mlisana, Koleka, Wibmer, Constantinos Kurt, Williamson, Carolyn, York, Denis, Harrichandparsad, Rohen, Herbst, Kobus, Jeena, Prakash, Khoza, Thandeka, Kløverpris, Henrik, Leslie, Alasdair, Madansein, Rajhmun, Magula, Nombulelo, Manickchund, Nithendra, Marakalala, Mohlopheni, Mazibuko, Matilda, Moshabela, Mosa, Mthabela, Ntombifuthi, Naidoo, Kogie, Ndhlovu, Zaza, Ndung’u, Thumbi, Ngcobo, Nokuthula, Nyamande, Kennedy, and Patel, Vinod

Abstract

The emergence of the SARS-CoV-2 variant of concern Omicron (Pango lineage B.1.1.529), first identified in Botswana and South Africa, may compromise vaccine effectiveness and lead to re-infections1. Here we investigated Omicron escape from neutralization by antibodies from South African individuals vaccinated with Pfizer BNT162b2. We used blood samples taken soon after vaccination from individuals who were vaccinated and previously infected with SARS-CoV-2 or vaccinated with no evidence of previous infection. We isolated and sequence-confirmed live Omicron virus from an infected person and observed that Omicron requires the angiotensin-converting enzyme 2 (ACE2) receptor to infect cells. We compared plasma neutralization of Omicron relative to an ancestral SARS-CoV-2 strain and found that neutralization of ancestral virus was much higher in infected and vaccinated individuals compared with the vaccinated-only participants. However, both groups showed a 22-fold reduction in vaccine-elicited neutralization by the Omicron variant. Participants who were vaccinated and had previously been infected exhibited residual neutralization of Omicron similar to the level of neutralization of the ancestral virus observed in the vaccination-only group. These data support the notion that reasonable protection against Omicron may be maintained using vaccination approaches.

Published
2022

9. Persistent SARS-CoV-2 infection and intra-host evolution in association with advanced HIV infection

Author

Jennifer Giandhari, Khadija Khan, Mallory Bernstein, Houriiyah Tegally, Richard J Lessells, Tulio de Oliveira, Eduan Wilkinson, Nithendra Manickchund Nithendra, Bernadett I Gosnell, Sureshnee Pillay, Lavanya Singh, Nokukhanya Msomi, Cele Sandile, Alex Sigal, Koleka Mlisana, Emmanuel James San, Farina Karim, Upasana Ramphal, Mohamed Ys Moosa, and Willem A. Hanekom

Subjects
Whole genome sequencing, Immune system, Host (biology), Mechanism (biology), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), biology.protein, Human immunodeficiency virus (HIV), medicine, Antiretroviral treatment, Biology, Antibody, medicine.disease_cause, Virology
Abstract

SummaryWhile most people effectively clear SARS-CoV-2, there are several reports of prolonged infection in immunosuppressed individuals. Here we present a case of prolonged infection of greater than 6 months with shedding of high titter SARS-CoV-2 in an individual with advanced HIV and antiretroviral treatment failure. Through whole genome sequencing at multiple time-points, we demonstrate the early emergence of the E484K substitution associated with escape from neutralizing antibodies, followed by other escape mutations and the N501Y substitution found in most variants of concern. This provides support to the hypothesis of intra-host evolution as one mechanism for the emergence of SARS-CoV-2 variants with immune evasion properties.

Published
2021

11. Emtricitabine-induced pure red cell aplasia

Author

Manickchund, Nithendra, primary, Du Plessis, Camille, additional, John, Melanie-Anne A., additional, Manzini, Thandekile C., additional, Gosnell, Bernadett I., additional, Lessells, Richard J., additional, and Moosa, Yunus S., additional

Published
2019
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