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Dissertação de Mestrado Integrado em Medicina Veterinária, área científica de Produção Animal e Segurança Alimentar Dried salted cod is a traditional food product with a long history of consumption. Each year in Portugal, nearly 70 thousand tons are consumed, which accounts for approximately 7kg per person. Nevertheless, dried salted cod can present several quality and safety related non-conformities. To mitigate these issues, food business operators must adopt preventive measures and strict control procedures in the production, storage, and distribution of dried salted cod. The aim of this work was to assess dried salted cod and related products non conformities detected at the reception step of a logistic operator, and to design a practical visual guide to further enhance control procedures at the incoming raw materials section. Thus, quality and safety control records, as well as temperature monitoring records, and analytical control reports of dried salted cod from 2017 to 2022 were assessed. Additionally, to develop the incoming raw materials visual guide, Codex Alimentarius Commission texts were explored and a photographic record of dried salted cod and related products was performed from October 2021 to February 2022. Most of the detected non-conformities were related to net weight defects (71.40%), but rouge (0.25%) and dun (0.37%) were also reported. Considering dried salted cod and related products temperature measurements performed at the reception step, 79.80% were non compliant, while 69% presented non-conforming humidity measurements. The incoming raw materials visual guide included appropriate sampling plans for the reception step of dried salted cod and related products, together with illustrative pictures of conforming and non conforming products and a references list of related publications for further delving were also included. Taken together, results revealed a high rate of non-conformities related to temperature and humidity of incoming dried salted cod and related products at the logistic operator. The visual guide will further assist the quality and safety control procedures and activities, as well as the decision-making process related to dried salted cod and related products at the reception step of the logistic operator RESUMO - Avaliação da qualidade e segurança de bacalhau salgado seco num operador logístico: desenvolvimento de um guia visual prático para melhorar procedimentos à receção. - Bacalhau salgado seco é um produto tradicional com uma longa história de consumo. Todos os anos em Portugal cerca de 70 mil toneladas são consumidas, correspondente a aproximadamente 7kg por pessoa. No entanto, pode apresentar várias não conformidades relacionadas com a sua segurança e qualidade. De modo a mitigar estes problemas, os operadores do setor alimentar devem adotar medidas de prevenção e controlo na sua produção, armazenamento e distribuição. O objetivo deste trabalho foi o de avaliar não conformidades em bacalhau salgado seco e produtos afins detetadas à receção num operador logístico, e de desenhar um guia visual prático para melhorar procedimentos de controlo de qualidade na secção de receção de matéria-prima. Foram, então, avaliados os registos de atividades de controlo à receção, assim como os de medição da temperatura e de controlo analítico da humidade de 2017 a 2022. Adicionalmente, de modo a desenvolver o guia prático e visual, textos do Codex Alimentarius Commission foram analisados e foi realizado um registo fotográfico do bacalhau seco salgado e produtos afins de outubro de 2021 a fevereiro de 2022. A maior proporção de não conformidades detetada está relacionada com defeitos de peso líquido (71,40%), mas também foram detetados rouge (0,25%) e empoado (0,37%). Considerando as medições de temperatura de bacalhau seco salgado e produtos afins efetuadas na fase de receção, 79,80% não estavam em conformidade, enquanto 69% apresentavam medições de humidade não conformes. O guia prático inclui um plano de amostragem, juntamente com imagens ilustrativas de produtos conformes e possíveis não conformidades, e uma lista de referências também incluída. Os resultados revelaram uma elevada taxa de não-conformidades relacionadas com a temperatura e humidade do bacalhau salgado seco e produtos afins no operador logístico. O guia prático e visual ajudará os procedimentos e atividades de controlo de qualidade e segurança e o processo de tomada de decisões relacionadas com o bacalhau seco salgado e produtos afins na fase de receção do operador logístico N/A

BACKGROUND: Recent studies demonstrated the positive impact of neoadjuvant treatment in locally advanced gastric cancer. OBJECTIVE: To assess the accuracy of endoscopic ultrasound (EUS) in the selection of patients with gastric adenocarcinoma for neoadjuvant therapy (T ≥ 2 and/or N+). METHODS: Retrospective analysis of patients with an anatomopathological diagnosis of gastric adenocarcinoma between January 2011 and June 2017, who had EUS for staging and underwent surgery as a first therapeutic attempt. The concordance (k) and accuracy (area under the curve (AUC)) of EUS for T ≥ 2 and/or N+ were assessed using the anatomopathological staging of the resected surgical specimen as the gold standard. RESULTS: The final sample included 152 patients (66.4% male, 67.1 ± 12.2 years). The concordance, accuracy, sensitivity and specificity of the EUS for T ≥ 2 and/or N+ were 0.72, 0.86 ± 0.03, 88.5% and 83.1%, respectively. The results were higher in proximal (k = 0.93, AUC = 0.96 ± 0.05, sensitivity (S) = 99.0% and specificity (E) = 90.9%) compared with distal lesions (k = 0.67, AUC = 0.84 ± 0.04, S = 85.7% and E = 81.5%), and in intestinal subtype (k = 0.77, AUC = 0.88 ± 0.04, S = 92.6% and E = 84.1%) compared with diffuse (k = 0.58, AUC = 0.79 ± 0.10, S = 85.0% and E = 72.7%) or mixed-subtype tumours (k = 0.65, AUC = 0.84 ± 0.10, S = 76.9% and E = 90.0%). CONCLUSION: In one of the largest series of patients, we showed that EUS has overall high agreement and accuracy in the selection of patients with gastric adenocarcinoma for neoadjuvant therapy, although the agreement and accuracy are greater for proximal and intestinal lesions.

Gonadal dysgenesis (GD) is a disorder of sexual development (DSD) characterized by defective or incomplete formation of the gonads (ovary or testis) due to either structural or numerical modifications of the sex chromosomes or due to mutations in the genes responsible for gonadal development. Two cases of unrelated phenotypically female patients are presented, a complete GD and a partial GD. Both cases were diagnosed with premalignant lesions at a prepubertal age. Even at very young ages there is a high tumor risk, which reiterates the importance of early diagnosis of suspected cases, in order to better characterize and guide this patients. To prevent the development of malignancy, a gonadectomy is recommended, as close as possible to the diagnosis., Portuguese Journal of Pediatrics, Vol. 51 No. 3 (2020)

A 12-year-old Caucasian girl was referenced to a paediatric endocrinology consultation for extensive acanthosis nigricans (AN), hirsutism and severe obesity (Body Mass Index (BMI): 37.5 kg/m2, z-score 3.57). She had a normal psychomotor development. Her mother and her maternal grandfather had

Submitted by Ana Costa (apcosta@porto.ucp.pt) on 2020-03-12T12:04:02Z No. of bitstreams: 1 TESE FINAL.pdf: 887529 bytes, checksum: 8fc5fa3ef2607788064d16638510b3cd (MD5) Approved for entry into archive by Maria Helena Ribeiro (helena.ribeiro@lisboa.ucp.pt) on 2020-03-18T11:31:20Z (GMT) No. of bitstreams: 1 TESE FINAL.pdf: 887529 bytes, checksum: 8fc5fa3ef2607788064d16638510b3cd (MD5) Made available in DSpace on 2020-03-18T11:31:20Z (GMT). No. of bitstreams: 1 TESE FINAL.pdf: 887529 bytes, checksum: 8fc5fa3ef2607788064d16638510b3cd (MD5) Previous issue date: 2019-02-06

A 3-year-old female child with personal history of atopic dermatitis presented with confluent vesicular and shallow ulcers pruritic rash surrounded by an erythematous base located to both hands and wrists, with 1-week evolution. She had no fever or other symptoms. There was no personal or family history of herpetic infections. Topical antibiotic, topical corticosteroid and oral antihistaminic were tried with no improvement. Physical examination was unremarkable except for generalised dry skin and lesions in figure 1. On suspicion of superinfected viral rash or bullous impetigo she was treated with oral …

Primary cutaneous lymphomas (PCL) are rare in pediatrics. Mycosis fungoides (MF) is the most frequent PCL diagnosed in childhood. There are various clinical variants of MF, including the hypopigmented MF (HMF). We present a 5-year-old boy with an 18-month history of progressive, generalized, nonpruritic hypopigmented lesions with central lacy erythema. He had no improvement with emollients. Skin biopsy showed typical features of HMF. He was treated with topical corticosteroids and tacrolimus and narrow-band ultraviolet B (NBUVB) phototherapy, with good response. HMF may mimic multiple skin disorders. Unusual hypopigmented skin lesions should be biopsied. Though phototherapy is effective, recurrence is common.

A three-year-old male child presented with erythematous maculopapular nonpruritic generalized rash, poor feeding, vomiting, and cramping generalized abdominal pain. He was previously healthy and there was no family history of immunologic or other diseases. On examination he was afebrile, hemodynamically stable, with painful palpation of the right upper quadrant and positive Murphy's sign. Laboratory tests revealed elevated inflammatory markers, elevated aminotransferase activity, and features of cholestasis. Abdominal ultrasound showed gallbladder wall thickening of 8 mm with a positive sonographic Murphy's sign, without gallstones or pericholecystic fluid. Acute Alithiasic Cholecystitis (AAC) was diagnosed. Tests for underlying infectious causes were negative except positive blood specimen for Human Herpes Virus Type-6 (HHV-6) by polymerase chain reaction. With supportive therapy the child became progressively less symptomatic with gradual improvement. The child was discharged on the sixth day, asymptomatic and with improved analytic values. Two months later he had IgM negative and IgG positive antibodies (1/160) for HHV-6, which confirmed the diagnosis of previous infection. In a six-month follow-up period he remains asymptomatic. To the best of our knowledge, this represents the first case of AAC associated with HHV-6 infection., info:eu-repo/semantics/publishedVersion

Lactente do sexo masculino com seis meses. Antecedentes pessoais: gestação de termo, vigiada e sem intercorrências, somatometria ao nascimento adequada, índice de Apgar 10/10 no 1º e 5º minuto e período neonatal sem intercorrências. os 4 meses apresentou episódio de bronquiolite aguda com resolução em ambulatório. Antecedentes familiares: história de atopia na mãe.

Tese de mestrado. Biologia (Biologia Evolutiva e do Desenvolvimento). Universidade de Lisboa, Faculdade de Ciências, 2011 Submitted by Lurdes Saramago (lurdes.saramago@fc.ul.pt) on 2011-11-21T18:57:01Z No. of bitstreams: 1 ulfc090918_Maria_Fernandes.pdf: 2814011 bytes, checksum: 7586b6652eb961c4dbd80022cb95b92c (MD5) Made available in DSpace on 2011-11-21T18:57:30Z (GMT). No. of bitstreams: 1 ulfc090918_Maria_Fernandes.pdf: 2814011 bytes, checksum: 7586b6652eb961c4dbd80022cb95b92c (MD5) Previous issue date: 2011