Search

Your search keyword '"Massardier-Pilonchéry A"' showing total 14 results
Start Over Author "Massardier-Pilonchéry A" Search Limiters Full Text
14 results on '"Massardier-Pilonchéry A"'

1. Assessment of serological techniques for screening patients for COVID-19 (COVID-SER): a prospective, multicentric study

Author

Sophie Trouillet-Assant, Amélie Massardier-Pilonchery, Barbara Charbotel, Nicolas Guibert, Jean-Baptiste Fassier, Muriel Rabilloud, Chloe Albert Vega, Antonin Bal, Julie Anne Nazare, Pascal Fascia, Adèle Paul, Constance d Aubarede, Virginie Pitiot, Matthieu Lahousse, André Boibieux, Djamila Makhloufi, Chantal Simon, Mary Anne Trabaud, François Gueyffier, Jérôme Adnot, Dulce Alfaiate, Alain Bergeret, Florent Bonnet, Gaëlle Bourgeois, Florence Brunel-Dalmas, Eurydice Caire, Pierre Chiarello, Laurent Cotte, Constance d'Aubarede, François Durupt, Escuret Vanessa, Fascia Pascal, Fassier Jean-Baptiste, Fontaine Juliette, Gaillot-Durand Lucie, Gaymard Alexandre, Gillet Myriam, Godinot Matthieu, Gueyffier François, Guibert Nicolas, Josset Laurence, Lahousse Matthieu, Lina Bruno, Lozano Hélène, Makhloufi Djamila, Massardier-Pilonchéry Amélie, Milon Marie-Paule, Moll Frédéric, Morfin Florence, Narbey David, Nazare Julie-Anne, Oria Fatima, Paul Adèle, Perry Marielle, Pitiot Virginie, Prudent Mélanie, Rabilloud Muriel, Samperiz Audrey, Schlienger Isabelle, Simon Chantal, Trabaud Mary-Anne, and Trouillet-Assant Sophie

Subjects
Medicine
Abstract

Introduction The COVID-19 pandemic caused by SARS-CoV-2 threatens global public health, and there is an urgent public health need to assess acquired immunity to SARS-CoV-2. Serological tests might provide results that can be complementary to or confirm suspected COVID-19 cases and reveal previous infection. The performance of serological assays (sensitivity and specificity) has to be evaluated before their use in the general population. The neutralisation capacity of the produced antibodies also has to be evaluated.Methods and analysis We set up a prospective, multicentric clinical study to evaluate the performance of serological kits among a population of healthcare workers presenting mild symptoms suggestive of SARS-CoV-2 infection. Four hundred symptomatic healthcare workers will be included in the COVID-SER study. The values obtained from a control cohort included during the prepandemic time will be used as reference. A workflow was set up to study serological response to SARS-CoV-2 infection and to evaluate antibody neutralisation capacity in patients with a confirmed SARS-CoV-2 infection. The sensitivity and specificity of the tests will be assessed using molecular detection of the virus as a reference. The measurement of IgM and IgG antibodies will be performed once per week for 6 consecutive weeks and then at 6, 12, 18, 24 and 36 months after the diagnosis. The kinetics of IgM and IgG will determine the optimal period to perform serological testing. The proportion of false negative PCR tests in symptomatic subjects will be determined on the basis of subsequent seroconversions.Ethics and dissemination Ethical approval has been obtained from the national review board for biomedical research in April 2020 (Comité de Protection des Personnes Sud Méditerranée I, Marseille, France) (ID RCB 2020-A00932-37). Results will be disseminated through presentations at scientific meetings and publications in peer-reviewed journals.Trial registration number NCT04341142.

Published
2020
Full Text
View/download PDF

2. Immunogenicity and efficacy of          heterologous ChAdOx1–BNT162b2 vaccination

Author

Pozzetto, Bruno, Legros, Vincent, Djebali, Sophia, Barateau, Véronique, Guibert, Nicolas, Villard, Marine, Peyrot, Loïc, Allatif, Omran, Fassier, Jean-Baptiste, Massardier-Pilonchéry, Amélie, Brengel-Pesce, Karen, Yaugel-Novoa, Melyssa, Denolly, Solène, Boson, Bertrand, Bourlet, Thomas, Bal, Antonin, Valette, Martine, Andrieu, Thibault, Lina, Bruno, Cosset, François-Loïc, Paul, Stéphane, Defrance, Thierry, Marvel, Jacqueline, Walzer, Thierry, and Trouillet-Assant, Sophie

Published
2021
Full Text
View/download PDF

3. Exposure to loud noise and risk of vestibular schwannoma : results from the INTERPHONE international case–control study

Author

INTERPHONE Study Group, Deltour, Isabelle, Schlehofer, Brigitte, Massardier-Pilonchéry, Amélie, Schlaefer, Klaus, Armstrong, Bruce, Giles, Graham G, Siemiatycki, Jack, Parent, Marie-Elise, Krewski, Daniel, McBride, Mary, Johansen, Christoffer, Auvinen, Anssi, Salminen, Tiina, Hours, Martine, Montestrucq, Lucile, Blettner, Maria, Berg-Beckhoff, Gabriele, Sadetzki, Siegal, Chetrit, Angela, Lagorio, Susanna, Iavarone, Ivano, Yamaguchi, Naohito, Takebayashi, Toru, Woodward, Alistair, Cook, Angus, Tynes, Tore, Klaeboe, Lars, Feychting, Maria, Lönn, Stefan, Fleming, Sarah, Swerdlow, Anthony J, Schoemaker, Minouk J, Moissonnier, Monika, Kesminiene, Ausrele, Cardis, Elisabeth, and Schüz, Joachim

Published
2019

4. Six-month antibody response to SARS-CoV-2 in healthcare workers assessed by virus neutralization and commercial assays

Author

Jérôme, Adnot, Dulce, Alfaiate, Antonin, Bal, Alain, Bergeret, André, Boibieux, Florent, Bonnet, Gaëlle, Bourgeois, Florence, Brunel-Dalmas, Eurydice, Caire, Barbara, Charbotel, Pierre, Chiarello, Laurent, Cotte, d'Aubarede, Constance, François, Durupt, Vanessa, Escuret, Pascal, Fascia, Jean-Baptiste, Fassier, Juliette, Fontaine, Lucie, Gaillot-Durand, Alexandre, Gaymard, Myriam, Gillet, Matthieu, Godinot, François, Gueyffier, Nicolas, Guibert, Laurence, Josset, Matthieu, Lahousse, Bruno, Lina, Hélène, Lozano, Djamila, Makhloufi, Amélie, Massardier-Pilonchéry, Marie-Paule, Milon, Frédéric, Moll, Florence, Morfin, David, Narbey, Julie-Anne, Nazare, Fatima, Oria, Adèle, Paul, Marielle, Perry, Virginie, Pitiot, Mélanie, Prudent, Muriel, Rabilloud, Audrey, Samperiz, Isabelle, Schlienger, Chantal, Simon, Mary-Anne, Trabaud, Sophie, Trouillet-Assant, Martine, Valette, Bal, Antonin, Trabaud, Mary-Anne, Fassier, Jean-Baptiste, Rabilloud, Muriel, Saker, Kahina, Langlois-Jacques, Carole, Guibert, Nicolas, Paul, Adèle, Alfaiate, Dulce, Massardier-Pilonchery, Amélie, Pitiot, Virginie, Morfin-Sherpa, Florence, Lina, Bruno, Pozzetto, Bruno, and Trouillet-Assant, Sophie

Published
2021
Full Text
View/download PDF

6. Evaluation of commercial Anti-SARS-CoV-2 neutralizing antibody assays in seropositive subjects

Author

Kahina Saker, Bruno Pozzetto, Vanessa Escuret, Virginie Pitiot, Amélie Massardier-Pilonchéry, Bouchra Mokdad, Carole Langlois-Jacques, Muriel Rabilloud, Dulce Alfaiate, Nicolas Guibert, Jean-Baptiste Fassier, Antonin Bal, Sophie Trouillet-Assant, Mary-Anne Trabaud, Hospices Civils de Lyon (HCL), Commission Spécialisée Maladies infectieuses et maladies émergentes (CSMime), Haut Conseil de la Santé Publique (HCSP), Virpath-Grippe, de l'émergence au contrôle -- Virpath-Influenza, from emergence to control (Virpath), Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Unité Mixte de Recherche Epidémiologique et de Surveillance Transport Travail Environnement (UMRESTTE UMR_T9405), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Gustave Eiffel, Département biostatistiques et modélisation pour la santé et l'environnement [LBBE], Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Institut des Agents Infectieux [Lyon] (IAI), ASTREDHOR Sud-Ouest, Association nationale des structures d'expérimentation et de démonstration en ... et de démonstration en horticulture ornementale (ASTREDHOR), Hôpital de la Croix-Rousse [CHU - HCL], and Virology and human respiratory Pathologies - Virology and human respiratory Pathologies (VirPath)

Subjects
Competitive anti-RBD immunoassays, History, Polymers and Plastics, SARS-CoV-2, Surrogate markers of protection, [SDV]Life Sciences [q-bio], COVID-19, Antibodies, Viral, Neutralizing antibodies, Antibodies, Neutralizing, Industrial and Manufacturing Engineering, Commercial tests, Infectious Diseases, Neutralization Tests, Virology, Humans, Business and International Management
Abstract

The virus neutralization test (VNT) is the reference for the assessment of the functional ability of neutralizing antibodies (NAb) to block SARS-CoV-2 entry into cells. New competitive immunoassays measuring antibodies preventing interaction between the spike protein and its cellular receptor are proposed as surrogate VNT (sVNT). We tested three commercial sVNT (a qualitative immunochromatographic test and two quantitative immunoassays named YHLO and TECO) together with a conventional anti-spike IgG assay (bioMérieux) in comparison with an in-house plaque reduction neutralization test (PRNT50) using the original 19A strain and different variants of concern (VOC), on a panel of 306 sera from naturally-infected or vaccinated patients. The qualitative test was rapidly discarded because of poor sensitivity and specificity. Areas under the curve of YHLO and TECO assays were, respectively, 85.83 and 84.07 (p-value >0.05) using a positivity threshold of 20 for PRNT50, and 95.63 and 90.35 (p-value =0.02) using a threshold of 80. However, the performances of YHLO and bioMérieux were very close for both thresholds, demonstrating the absence of added value of sVNT compared to a conventional assay for the evaluation of the presence of NAb in seropositive subjects. In addition, the PRNT50 assay showed a reduction of NAb titers towards different VOC in comparison to the 19A strain that could not be appreciated by the commercial tests. Despite the good correlation between the anti-spike antibody titer and the titer of NAb by PRNT50, our results highlight the difficulty to distinguish true NAb among the anti-RBD antibodies with commercial user-friendly immunoassays.

Published
2022
Full Text
View/download PDF

7. Evaluation of Commercial Anti-SARS-CoV-2 Antibody Assays and Comparison of Standardized Titers in Vaccinated Health Care Workers

Author

Saker, Kahina, primary, Escuret, Vanessa, additional, Pitiot, Virginie, additional, Massardier-Pilonchéry, Amélie, additional, Paul, Stéphane, additional, Mokdad, Bouchra, additional, Langlois-Jacques, Carole, additional, Rabilloud, Muriel, additional, Goncalves, David, additional, Fabien, Nicole, additional, Guibert, Nicolas, additional, Fassier, Jean-Baptiste, additional, Bal, Antonin, additional, Trouillet-Assant, Sophie, additional, and Trabaud, Mary-Anne, additional

Published
2022
Full Text
View/download PDF

8. Six-month antibody response to SARS-CoV-2 in healthcare workers assessed by virus neutralization and commercial assays

Author

Bal, Antonin, primary, Trabaud, Mary-Anne, additional, Fassier, Jean-Baptiste, additional, Rabilloud, Muriel, additional, Saker, Kahina, additional, Langlois-Jacques, Carole, additional, Guibert, Nicolas, additional, Paul, Adèle, additional, Alfaiate, Dulce, additional, Massardier-Pilonchery, Amélie, additional, Pitiot, Virginie, additional, Morfin-Sherpa, Florence, additional, Lina, Bruno, additional, Pozzetto, Bruno, additional, Trouillet-Assant, Sophie, additional, Jérôme, Adnot, additional, Dulce, Alfaiate, additional, Antonin, Bal, additional, Alain, Bergeret, additional, André, Boibieux, additional, Florent, Bonnet, additional, Gaëlle, Bourgeois, additional, Florence, Brunel-Dalmas, additional, Eurydice, Caire, additional, Barbara, Charbotel, additional, Pierre, Chiarello, additional, Laurent, Cotte, additional, d'Aubarede, Constance, additional, François, Durupt, additional, Vanessa, Escuret, additional, Pascal, Fascia, additional, Jean-Baptiste, Fassier, additional, Juliette, Fontaine, additional, Lucie, Gaillot-Durand, additional, Alexandre, Gaymard, additional, Myriam, Gillet, additional, Matthieu, Godinot, additional, François, Gueyffier, additional, Nicolas, Guibert, additional, Laurence, Josset, additional, Matthieu, Lahousse, additional, Bruno, Lina, additional, Hélène, Lozano, additional, Djamila, Makhloufi, additional, Amélie, Massardier-Pilonchéry, additional, Marie-Paule, Milon, additional, Frédéric, Moll, additional, Florence, Morfin, additional, David, Narbey, additional, Julie-Anne, Nazare, additional, Fatima, Oria, additional, Adèle, Paul, additional, Marielle, Perry, additional, Virginie, Pitiot, additional, Mélanie, Prudent, additional, Muriel, Rabilloud, additional, Audrey, Samperiz, additional, Isabelle, Schlienger, additional, Chantal, Simon, additional, Mary-Anne, Trabaud, additional, Sophie, Trouillet-Assant, additional, and Martine, Valette, additional

Published
2021
Full Text
View/download PDF

9. Exposure to loud noise and risk of vestibular schwannoma : results from the INTERPHONE international case‒control study

Author

Deltour, Isabelle, Schlehofer, Brigitte, Massardier-Pilonchéry, Amélie, Auvinen, Anssi, Salminen, Tiina, et al, Lääketieteen ja terveysteknologian tiedekunta - Faculty of Medicine and Health Technology, Yhteiskuntatieteiden tiedekunta - Faculty of Social Sciences, and Tampere University

Subjects
noise, acoustic neuroma, vestibular schwannoma, exposure, noise exposure, Kansanterveystiede, ympäristö ja työterveys - Public health care science, environmental and occupational health, international, Syöpätaudit - Cancers, INTERPHONE, Terveystiede - Health care science, epidemiology, case‒control study, loud noise
Published
2019

11. Evaluation de la nuisance acoustique professionnelle par analyse collective du déficit auditif

Author

Normand, Jean-Claude, Duclos, Jean-Claude, Massardier-Pilonchéry, Amélie, Thiéry, Léon, Leclere, Quentin, and Société Française d'Acoustique - SFA

Subjects
[SPI.ACOU] Engineering Sciences [physics]/Acoustics [physics.class-ph], [PHYS.MECA.ACOU] Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph]
Abstract

Le déficit auditif induit par l'exposition au bruit professionnel reste préoccupant. Pour prévenir ce risque, deux approches sont utilisables : le mesurage des niveaux d'exposition au bruit et le suivi audiométrique des travailleurs exposés. Ces approches ont cependant des limites. Compte tenu des parcours professionnels, il n'est souvent pas possible d'extrapoler à la totalité d'une carrière le résultat de mesures d'exposition au bruit effectuées dans des circonstances spécifiques. Quant à l'interprétation des pertes auditives des travailleurs, elle reste toujours difficile, et les effets attribuables à l'âge ou à des facteurs extraprofessionnels s'opposent à une interprétation collective aisée des résultats. Pour remédier à ces difficultés, des méthodes d'analyse de données audiométriques ont été élaborées pour évaluer le risque collectif, par usine et par atelier : - dénombrement du pourcentage constaté des atteintes auditives excédant un seuil spécifié, - analyse sous contrôle de l'effet de l'âge, par classement en zones de « perte auditive moyenne standard » et en stades de « pertes auditives significatives » liées au bruit professionnel. Le logiciel AudioGT® permet de mettre en œuvre ces différentes approches de l'analyse collective du déficit auditif et de caractériser la nocivité sonore des ateliers. Ces méthodes ont été appliquées à plusieurs groupes de travailleurs et les résultats sont discutés en vue de montrer en quoi ce type d'analyse de données médicales peut inciter à la prévention collective du risque lié au bruit professionnel.

Published
2010

12. Exposure to loud noise and risk of vestibular schwannoma: results from the INTERPHONE international case‒control study

Author

Isabelle Deltour, Brigitte Schlehofer, Amélie Massardier-Pilonchéry, Klaus Schlaefer, Bruce Armstrong, Graham G Giles, Jack Siemiatycki, Marie-Elise Parent, Daniel Krewski, Mary McBride, Christoffer Johansen, Anssi Auvinen, Tiina Salminen, Martine Hours, Lucile Montestrucq, Maria Blettner, Gabriele Berg-Beckhoff, Siegal Sadetzki, Angela Chetrit, Susanna Lagorio, Ivano Iavarone, Naohito Yamaguchi, Toru Takebayashi, Alistair Woodward, Angus Cook, Tore Tynes, Lars Klaeboe, Maria Feychting, Stefan Lönn, Sarah Fleming, Anthony J Swerdlow, Minouk J Schoemaker, Monika Moissonnier, Ausrele Kesminiene, Elisabeth Cardis, Joachim Schüz, and INTERPHONE Study Group

Subjects
vestibular schwannoma, interphone, case‒control study, acoustic neuroma, epidemiology, exposure, noise, noise exposure, international, loud noise, Public aspects of medicine, RA1-1270
Abstract

OBJECTIVE: Studies of loud noise exposure and vestibular schwannomas (VS) have shown conflicting results. The population-based INTERPHONE case‒control study was conducted in 13 countries during 2000–2004. In this paper, we report the results of analyses on the association between VS and self-reported loud noise exposure. METHODS: Self-reported noise exposure was analyzed in 1024 VS cases and 1984 matched controls. Life-long noise exposure was estimated through detailed questions. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using adjusted conditional logistic regression for matched sets. RESULTS: The OR for total work and leisure noise exposure was 1.6 (95% CI 1.4–1.9). OR were 1.5 (95% CI 1.3–1.9) for only occupational noise, 1.9 (95% CI 1.4–2.6) for only leisure noise and 1.7 (95% CI 1.2–2.2) for exposure in both contexts. OR increased slightly with increasing lag-time. For occupational exposures, duration, time since exposure start and a metric combining lifetime duration and weekly exposure showed significant trends of increasing risk with increasing exposure. OR did not differ markedly by source or other characteristics of noise. CONCLUSION: The consistent associations seen are likely to reflect either recall bias or a causal association, or potentially indicate a mixture of both.

Published
2019
Full Text
View/download PDF

13. Assessment of serological techniques for screening patients for COVID-19 (COVID-SER): a prospective, multicentric study

Author

Trouillet-Assant, Sophie, Albert Vega, Chloe, Bal, Antonin, Nazare, Julie Anne, Fascia, Pascal, Paul, Adèle, Massardier-Pilonchery, Amélie, d Aubarede, Constance, Guibert, Nicolas, Pitiot, Virginie, Lahousse, Matthieu, Boibieux, André, Makhloufi, Djamila, Simon, Chantal, Rabilloud, Muriel, Trabaud, Mary Anne, Gueyffier, François, Fassier, Jean-Baptiste, Centre International de Recherche en Infectiologie - UMR (CIRI), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hospices Civils de Lyon (HCL), Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), HCL Groupement Hospitalier Nord [Lyon], Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL), Hôpital Henry Gabrielle [CHU - HCL], Unité Mixte de Recherche Epidémiologique et de Surveillance Transport Travail Environnement (UMRESTTE UMR_T9405), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Gustave Eiffel, Hôpital Edouard Herriot [CHU - HCL], Université de Lyon, Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Hospices Civils de LyonFondation des Hospices Civils de Lyon, COVID-SER study group: Jérôme Adnot, Dulce Alfaiate, Antonin Bal, Alain Bergeret, André Boibieux, Florent Bonnet, Gaëlle Bourgeois, Florence Brunel-Dalmas, Eurydice Caire, Barbara Charbotel, Pierre Chiarello, Laurent Cotte, Constance d'Aubarede, François Durupt, Escuret Vanessa, Fascia Pascal, Fassier Jean-Baptiste, Fontaine Juliette, Gaillot-Durand Lucie, Gaymard Alexandre, Gillet Myriam, Godinot Matthieu, Gueyffier François, Guibert Nicolas, Josset Laurence, Lahousse Matthieu, Lina Bruno, Lozano Hélène, Makhloufi Djamila, Massardier-Pilonchéry Amélie, Milon Marie-Paule, Moll Frédéric, Morfin Florence, Narbey David, Nazare Julie-Anne, Oria Fatima, Paul Adèle, Perry Marielle, Pitiot Virginie, Prudent Mélanie, Rabilloud Muriel, Samperiz Audrey, Schlienger Isabelle, Simon Chantal, Trabaud Mary-Anne, Trouillet-Assant Sophie, Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and CarMeN, laboratoire

Subjects
Male, SARS-CoV-2, public health, [SDV]Life Sciences [q-bio], COVID-19, General Medicine, Antibodies, Viral, diagnostic microbiology, [SDV] Life Sciences [q-bio], molecular diagnostics, Humans, Mass Screening, Female, Serologic Tests, Public Health, Prospective Studies, Pandemics
Abstract

International audience; INTRODUCTION: The COVID-19 pandemic caused by SARS-CoV-2 threatens global public health, and there is an urgent public health need to assess acquired immunity to SARS-CoV-2. Serological tests might provide results that can be complementary to or confirm suspected COVID-19 cases and reveal previous infection. The performance of serological assays (sensitivity and specificity) has to be evaluated before their use in the general population. The neutralisation capacity of the produced antibodies also has to be evaluated. METHODS AND ANALYSIS: We set up a prospective, multicentric clinical study to evaluate the performance of serological kits among a population of healthcare workers presenting mild symptoms suggestive of SARS-CoV-2 infection. Four hundred symptomatic healthcare workers will be included in the COVID-SER study. The values obtained from a control cohort included during the prepandemic time will be used as reference. A workflow was set up to study serological response to SARS-CoV-2 infection and to evaluate antibody neutralisation capacity in patients with a confirmed SARS-CoV-2 infection. The sensitivity and specificity of the tests will be assessed using molecular detection of the virus as a reference. The measurement of IgM and IgG antibodies will be performed once per week for 6 consecutive weeks and then at 6, 12, 18, 24 and 36 months after the diagnosis. The kinetics of IgM and IgG will determine the optimal period to perform serological testing. The proportion of false negative PCR tests in symptomatic subjects will be determined on the basis of subsequent seroconversions. ETHICS AND DISSEMINATION: Ethical approval has been obtained from the national review board for biomedical research in April 2020 (Comité de Protection des Personnes Sud Méditerranée I, Marseille, France) (ID RCB 2020-A00932-37). Results will be disseminated through presentations at scientific meetings and publications in peer-reviewed journals. TRIAL REGISTRATION NUMBER: NCT04341142.

Published
2020
Full Text
View/download PDF

14. Outcome of the Compensation Process Initiated by an Occupational and Environmental Diseases Center.

Author

Scherer M, Lamouroux C, Fiquemont A, Fassier JB, Gautheron L, Massardier-Pilonchéry A, and Charbotel B

Subjects
Humans, Male, Occupational Diseases epidemiology, Occupational Diseases etiology, Physicians
Abstract

Background: Regional Centers for Occupational and Environmental Pathologies (CRPPE) are responsible for identifying possible occupational etiologies of pathologies. When an occupational origin is determined, an Initial Medical Certificate (IMC) is given to the patient to allow him to initiate a procedure for recognition as an occupational disease (OD) by his health insurance organization., Objectives: The main aim of this study was to investigate the outcome of occupational disease claims in patients who received an IMC delivered by the CRPPE of Lyon., Methods: A telephone interview was systematically conducted with patients who consulted the CRPPE for a claim for occupational disease recognition between 07/2020 and 06/2021, about six months after the consultation. It was conducted by a physician using a standardized questionnaire., Results: Out of 128 patients eligible for this study, 98 were included. Diseases of the respiratory system (34.7%) and cancers (28.6%) were the most common pathologies in our population. A process of OD compensation was initiated by 86 patients (87.8%). At the time of the study, the outcome was favorable for 63 patients (73.3%). Moreover, 18 patients (18.4%) wished for additional help from the CRPPE to carry out the procedures. Nine patients requested a new consultation, including five who still needed to complete the process., Conclusion: This study shows the benefit of a consultation by occupational disease consultants. However, difficulties still need to be solved in these procedures. Thus, the systematic follow-up of patients shows its advantages. The provision of support to carry out the process seems necessary.

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results