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8 results on '"Mastrella, Giorgia"'

1. APLN / APLNR-targeting improves anti-angiogenic efficiency and blunts pro-invasive side effects of VEGF-A / VEGFR2-blockade in GBM

Author

Kälin, Roland, Stöcklein, Veit, Mastrella, Giorgia, Hou, Mengzhuo, Zdouc, Nina, Li, Min, Tonn, Jörg-Christian, and Glass, Rainer

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Objective: Anti-angiogenic therapy of glioblastoma (GBM) blocking vascular endothelial growth factor-A (VEGFA) often resulted in accelerated tumor-cell invasion and upregulation of alternative angiogenic pathways. Here, we studied the role of the proangiogenic receptor APLNR and its cognate ligand apelin[for full text, please go to the a.m. URL], 69. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Mexikanischen und Kolumbianischen Gesellschaft für Neurochirurgie

Published
2018

2. ANGI-03. PHARMACOLOGICAL TARGETING OF APELIN/APLNR SIGNALING BLUNTS THERAPY RESISTANCE TO VEGFA/VEGFR2 ANTI-ANGIOGENIC TREATMENT IN GLIOBLASTOMA

Author

Kälin, Roland, primary, Mastrella, Giorgia, additional, Hou, Mengzhuo, additional, Li, Min, additional, Stoecklein, Veit, additional, Zdouc, Nina, additional, Volmar, Marie, additional, Miletic, Hrvoje, additional, Reinhard, Sören, additional, Herold-Mende, Christel, additional, Kleber, Susanne, additional, Eisenhut, Katharina, additional, Gargiulo, Gaetano, additional, Synowitz, Michael, additional, Vescovi, Angelo, additional, Harter, Patrick, additional, Penninger, Josef, additional, Wagner, Ernst, additional, Mittelbronn, Michel, additional, Bjerkvig, Rolf, additional, Hambardzumyan, Dolores, additional, Schüller, Ulrich, additional, Tonn, Joerg-Christian, additional, Radke, Josefine, additional, and Glass, Rainer, additional

Published
2019
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3. Targeting APLN/APLNR Improves Antiangiogenic Efficiency and Blunts Proinvasive Side Effects of VEGFA/VEGFR2 Blockade in Glioblastoma

Author

Mastrella, Giorgia, primary, Hou, Mengzhuo, additional, Li, Min, additional, Stoecklein, Veit M., additional, Zdouc, Nina, additional, Volmar, Marie N.M., additional, Miletic, Hrvoje, additional, Reinhard, Sören, additional, Herold-Mende, Christel C., additional, Kleber, Susanne, additional, Eisenhut, Katharina, additional, Gargiulo, Gaetano, additional, Synowitz, Michael, additional, Vescovi, Angelo L., additional, Harter, Patrick N., additional, Penninger, Josef M., additional, Wagner, Ernst, additional, Mittelbronn, Michel, additional, Bjerkvig, Rolf, additional, Hambardzumyan, Dolores, additional, Schüller, Ulrich, additional, Tonn, Jörg-Christian, additional, Radke, Josefine, additional, Glass, Rainer, additional, and Kälin, Roland E., additional

Published
2019
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4. ANGI-02. INHIBITION OF APLN-APLNR SIGNALLING BLOCKS TUMOUR ANGIOGENESIS AND ATTENUATES INVASIVE GLIOBLASTOMA GROWTH

Author

Glass, Rainer, primary, Mastrella, Giorgia, additional, Hou, Mengzhuo, additional, Stöcklein, Veit, additional, Miletic, Hrvoje, additional, Herold-Mende, Christel, additional, Synowitz, Michael, additional, Vescovi, Angelo, additional, Bjerkvig, Rolf, additional, Schüller, Ulrich, additional, Tonn, Joerg-Christian, additional, and Kaelin, Roland, additional

Published
2017
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5. Decreased demand for olfactory periglomerular cells impacts on neural precursor cell viability in the rostral migratory stream

Author

Langenfurth, Anika, primary, Gu, Song, additional, Bautze, Verena, additional, Zhang, Caiyi, additional, Neumann, Julia E., additional, Schüller, Ulrich, additional, Stock, Kristin, additional, Wolf, Susanne A., additional, Maier, Anna-Maria, additional, Mastrella, Giorgia, additional, Pak, Andrew, additional, Cheng, Hongwei, additional, Kälin, Roland E., additional, Holmbeck, Kenn, additional, Strotmann, Jörg, additional, Kettenmann, Helmut, additional, and Glass, Rainer, additional

Published
2016
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6. Monitoring of Tumor Growth with [18F]-FET PET in a Mouse Model of Glioblastoma: SUV Measurements and Volumetric Approaches

Author

Holzgreve, Adrien, primary, Brendel, Matthias, additional, Gu, Song, additional, Carlsen, Janette, additional, Mille, Erik, additional, Böning, Guido, additional, Mastrella, Giorgia, additional, Unterrainer, Marcus, additional, Gildehaus, Franz J., additional, Rominger, Axel, additional, Bartenstein, Peter, additional, Kälin, Roland E., additional, Glass, Rainer, additional, and Albert, Nathalie L., additional

Published
2016
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8. Monitoring of Tumor Growth with [sup.18]F]-FET PET in a Mouse Model of Glioblastoma: SUV Measurements and Volumetric Approaches.

Author

Holzgreve, Adrien, Brendel, Matthias, Song Gu, Carlsen, Janette, Mille, Erik, Böning, Guido, Mastrella, Giorgia, Unterrainer, Marcus, Gildehaus, Franz J., Rominger, Axel, Bartenstein, Peter, Kälin, Roland E., Glass, Rainer, and Albert, Nathalie L.

Subjects
TUMOR growth, GLIOBLASTOMA multiforme, POSITRON emission tomography, DIAGNOSIS
Abstract

Noninvasive tumor growth monitoring is of particular interest for the evaluation of experimental glioma therapies. This study investigates the potential of positron emission tomography (PET) using O-(2-[18F-fluoroethyl)-L-tyrosine ([18F]-FET) to determine tumor growth in a murine glioblastoma (GBM) model--including estimation of the biological tumor volume (BTV), which has hitherto not been investigated in the pre-clinical context. Fifteen GBM-bearingmice (GL261) and six controlmice (shams) were investigated during 5 weeks by PET followed by autoradiographic and histological assessments. [18F]-FET PET was quantitated by calculation of maximum and mean standardized uptake values within a universal volume-of-interest (VOI) corrected for healthy background (SUVmax/BG, SUVmean/BG). A partial volume effect correction (PVEC) was applied in comparison to ex vivo autoradiography. BTVs obtained by predefined thresholds for VOI definition (SUV/BG: ≥1.4; ≥1.6; ≥1.8; ≥2.0) were compared to the histologically assessed tumor volume (n = 8). Finally, individual "optimal" thresholds for BTV definition best reflecting the histology were determined. In GBM mice SUVmax/BG and SUVmean/BG clearly increased with time, however at high inter-animal variability. No relevant [18F]-FET uptake was observed in shams. PVEC recovered signal loss of SUVmean/BG assessment in relation to autoradiography. BTV as estimated by predefined thresholds strongly differed from the histology volume. Strikingly, the individual "optimal" thresholds for BTV assessment correlated highly with SUVmax/BG (ρ = 0.97, p < 0.001), allowing SUVmax/BG-based calculation of individual thresholds. The method was verified by a subsequent validation study (n = 15, ρ = 0.88, p < 0.01) leading to extensively higher agreement of BTV estimations when compared to histology in contrast to predefined thresholds. [18F]-FET PET with standard SUV measurements is feasible for glioma imaging in the GBM mouse model. PVEC is beneficial to improve accuracy of [18 F]-FET PET SUV quantification. Although SUVmax/BG and SUVmean/BG increase during the disease course, these parameters do not correlate with the respective tumor size. For the first time, we propose a histology-verified method allowing appropriate individual BTV estimation for volumetric in vivo monitoring of tumor growth with [18]-FET PET and show that standardized thresholds from routine clinical practice seem to be inappropriate for BTV estimation in the GBM mouse model. [ABSTRACT FROM AUTHOR]

Published
2016
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