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1. Treatment of a full-thickness skin lesion in a prematurely born infant. Integra® Bilayer for bridging to skin grafting until epidermal maturation allows safe harvesting. A rare case

Author

Michel Mueller-Eggenberger, Claudia Kanduth, Matthias Rab, Christian Breschan, and Maximilian Neuwirth

Subjects
Neonatal skin development, Skin grafting in premature neonates, Dermal substitute in premature infants, Skin harvesting in neonates, Dermatology, RL1-803, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract

We report a case of a highly premature born infant in the 24th week of gestation that suffered from an extravasation injury. A central venous catheter caused a large full-thickness defect at the chest. Coverage was necessary and provided by using a split skin graft; however, at this age dermal maturation is not completed and the skin is much thinner and less functional in terms of mechanical strength and epidermal layering. When harvesting skin, this may result in secondary defects. The authors describe the successful and novel use of a dermal substitute with a superficial silicon layer (Integra® Bilayer) to bridge the time until neonatal skin development allows safe skin harvesting. A positive side effect is that the use of this dermal substitute also improved the scar quality in the premature infant.

Published
2021
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3. Treatment of a full-thickness skin lesion in a prematurely born infant. Integra® Bilayer for bridging to skin grafting until epidermal maturation allows safe harvesting. A rare case

Author

Matthias Rab, Maximilian Neuwirth, Claudia Kanduth, Michel Mueller-Eggenberger, and Christian Breschan

Subjects
medicine.medical_specialty, integumentary system, Side effect, Skin grafting in premature neonates, RC86-88.9, business.industry, Bilayer, medicine.medical_treatment, Neonatal skin development, Skin harvesting in neonates, Dermal substitute in premature infants, Medical emergencies. Critical care. Intensive care. First aid, Dermatology, General Medicine, Surgery, Lesion, RL1-803, Rare case, Full thickness skin, Medicine, Skin grafting, medicine.symptom, business, Neonatal skin, Central venous catheter
Abstract

We report a case of a highly premature born infant in the 24th week of gestation that suffered from an extravasation injury. A central venous catheter caused a large full-thickness defect at the chest. Coverage was necessary and provided by using a split skin graft; however, at this age dermal maturation is not completed and the skin is much thinner and less functional in terms of mechanical strength and epidermal layering. When harvesting skin, this may result in secondary defects. The authors describe the successful and novel use of a dermal substitute with a superficial silicon layer (Integra® Bilayer) to bridge the time until neonatal skin development allows safe skin harvesting. A positive side effect is that the use of this dermal substitute also improved the scar quality in the premature infant.

Published
2021

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