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4. Pharmacological Properties of Bergapten: Mechanistic and Therapeutic Aspects

Author

Quetglas-Llabrés, Maria Magdalena, primary, Quispe, Cristina, additional, Herrera-Bravo, Jesús, additional, Catarino, Marcelo D., additional, Pereira, Olívia R., additional, Cardoso, Susana M., additional, Dua, Kamal, additional, Chellappan, Dinesh Kumar, additional, Pabreja, Kavita, additional, Satija, Saurabh, additional, Mehta, Meenu, additional, Sureda, Antoni, additional, Martorell, Miquel, additional, Satmbekova, Dinara, additional, Yeskaliyeva, Balakyz, additional, Sharifi-Rad, Javad, additional, Rasool, Naeem, additional, Butnariu, Monica, additional, Bagiu, Iulia Cristina, additional, Bagiu, Radu Vasile, additional, Calina, Daniela, additional, and Cho, William C., additional

Published
2022
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5. Concepts of advanced therapeutic delivery systems for the management of remodeling and inflammation in airway diseases

Author

Dhanjal, Daljeet Singh, primary, Sharma, Parvarish, additional, Mehta, Meenu, additional, Tambuwala, Murtaza M, additional, Prasher, Parteek, additional, Paudel, Keshav R, additional, Liu, Gang, additional, Shukla, Shakti D, additional, Hansbro, Philip M, additional, Chellappan, Dinesh Kumar, additional, Dua, Kamal, additional, and Satija, Saurabh, additional

Published
2022
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6. Protein and peptide delivery to lungs by using advanced targeted drug delivery

Author

Chellappan, Dinesh Kumar, primary, Prasher, Parteek, additional, Saravanan, Vilashini, additional, Vern Yee, Vanessa See, additional, Wen Chi, Wendy Chai, additional, Wong, Jia Wei, additional, Wong, Joon Kang, additional, Wong, Jing Tong, additional, Wan, Wai, additional, Chellian, Jestin, additional, Molugulu, Nagashekhara, additional, Prabu, Sakthivel Lakshmana, additional, Ibrahim, Rania, additional, Darmarajan, Thiviya, additional, Candasamy, Mayuren, additional, Singh, Pankaj Kumar, additional, Mishra, Vijay, additional, Shastri, Madhur D., additional, Zacconi, Flavia C., additional, Chakraborty, Amlan, additional, Mehta, Meenu, additional, Gupta, Piyush Kumar, additional, Dureja, Harish, additional, Gulati, Monica, additional, Singh, Sachin Kumar, additional, Gupta, Gaurav, additional, Jha, Niraj Kumar, additional, George Oliver, Brian Gregory, additional, and Dua, Kamal, additional

Published
2022
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7. Nanotechnology based advanced therapeutic strategies for targeting interleukins in chronic respiratory diseases

Author

Hussain, Md Sadique, primary, Sharma, Parvarish, additional, Dhanjal, Daljeet Singh, additional, Khurana, Navneet, additional, Vyas, Manish, additional, Sharma, Neha, additional, Mehta, Meenu, additional, Tambuwala, Murtaza M., additional, Satija, Saurabh, additional, Sohal, Sukhwinder Singh, additional, Oliver, Brian.G.G., additional, and Sharma, Hari S., additional

Published
2021
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8. Versatility of liquid crystalline nanoparticles in inflammatory lung diseases

Author

Chan, Yinghan, primary, Mehta, Meenu, additional, Paudel, Keshav Raj, additional, Madheswaran, Thiagarajan, additional, Panneerselvam, Jithendra, additional, Gupta, Gaurav, additional, Su, Qian Peter, additional, Hansbro, Philip Michael, additional, MacLoughlin, Ronan, additional, Dua, Kamal, additional, and Chellappan, Dinesh Kumar, additional

Published
2021
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9. Interferon therapy for preventing COPD exacerbations

Author

Mehta, Meenu, Paudel, Keshav R., Shukla, Shakti D., Shastri, Madhur D., Singh, Sachin K., Gulati, Monica, Dureja, Harish, Gupta, Gaurav, Satija, Saurabh, Hansbro, Philip M., Chellappan, Dinesh K., and Dua, Kamal

Subjects
Cigarette smoking, Viral infection, COPD, Interferons, Toxicology, Letter to the Editor, Airway inflammation
Abstract

EXCLI Journal; 19:Doc1477; ISSN 1611-2156

Published
2020

11. Rutin-loaded liquid crystalline nanoparticles attenuate oxidative stress in bronchial epithelial cells: a PCR validation

Author

Mehta, Meenu, primary, Paudel, Keshav Raj, additional, Shukla, Shakti D, additional, Shastri, Madhur D, additional, Satija, Saurabh, additional, Singh, Sachin Kumar, additional, Gulati, Monica, additional, Dureja, Harish, additional, Zacconi, Flavia C, additional, Hansbro, Philip M, additional, Chellappan, Dinesh Kumar, additional, and Dua, Kamal, additional

Published
2021
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12. An overview of vaccine development for COVID-19

Author

Shahcheraghi, Seyed H, primary, Ayatollahi, Jamshid, additional, Aljabali, Alaa AA, additional, Shastri, Madhur D, additional, Shukla, Shakti D, additional, Chellappan, Dinesh K, additional, Jha, Niraj K, additional, Anand, Krishnan, additional, Katari, Naresh K, additional, Mehta, Meenu, additional, Satija, Saurabh, additional, Dureja, Harish, additional, Mishra, Vijay, additional, Almutary, Abdulmajeed G, additional, Alnuqaydan, Abdullah M, additional, Charbe, Nitin, additional, Prasher, Parteek, additional, Gupta, Gaurav, additional, Dua, Kamal, additional, Lotfi, Marzieh, additional, Bakshi, Hamid A, additional, and Tambuwala, Murtaza M, additional

Published
2021
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13. Correction: Aljabali, A.A.A.; et al. Albumin Nano-Encapsulation of Piceatannol Enhances Its Anticancer Potential in Colon Cancer via down Regulation of Nuclear p65 and HIF-1α. Cancers 2020, 12, 113

Author

Aljabali, Alaa A. A., primary, Bakshi, Hamid A., additional, Hakkim, Faruck L., additional, Haggag, Yusuf A., additional, Al-Batanyeh, Khalid M., additional, Zoubi, Mazhar S. Al, additional, Al-Trad, Bahaa, additional, Nasef, Mohamed M., additional, Satija, Saurabh, additional, Mehta, Meenu, additional, Pabreja, Kavita, additional, Mishra, Vijay, additional, Khan, Mohammed, additional, Abobaker, Salem, additional, Azzouz, Ibrahim M., additional, Dureja, Harish, additional, Pabari, Ritesh M., additional, Dardouri, Ashref Ali K., additional, Kesharwani, Prashant, additional, Gupta, Gaurav, additional, Dhar Shukla, Shakti, additional, Prasher, Parteek, additional, Charbe, Nitin B., additional, Negi, Poonam, additional, Kapoor, Deepak N., additional, Chellappan, Dinesh Kumar, additional, Webba da Silva, Mateus, additional, Thompson, Paul, additional, Dua, Kamal, additional, McCarron, Paul, additional, and Tambuwala, Murtaza M., additional

Published
2020
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15. Antiproliferative effects of boswellic acid-loaded chitosan nanoparticles on human lung cancer cell line A549

Author

Solanki, Neeta, primary, Mehta, Meenu, additional, Chellappan, Dinesh Kumar, additional, Gupta, Gaurav, additional, Hansbro, Nicole G, additional, Tambuwala, Murtaza M, additional, AA Aljabali, Alaa, additional, Paudel, Keshav Raj, additional, Liu, Gang, additional, Satija, Saurabh, additional, Hansbro, Philip M, additional, Dua, Kamal, additional, and Dureja, Harish, additional

Published
2020
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17. Perspectives and advancements in the design of nanomaterials for targeted cancer theranostics

Author

Tan, Yoke Ying, primary, Yap, Pui Khee, additional, Xin Lim, Griselda Loo, additional, Mehta, Meenu, additional, Chan, Yinghan, additional, Ng, Sin Wi, additional, Kapoor, Deepak N., additional, Negi, Poonam, additional, Anand, Krishnan, additional, Singh, Sachin Kumar, additional, Jha, Niraj Kumar, additional, Lim, Lay Cheng, additional, Madheswaran, Thiagarajan, additional, Satija, Saurabh, additional, Gupta, Gaurav, additional, Dua, Kamal, additional, and Chellappan, Dinesh Kumar, additional

Published
2020
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19. Plants derived therapeutic strategies targeting chronic respiratory diseases: Chemical and immunological perspective

Author

Prasher, Parteek, primary, Sharma, Mousmee, additional, Mehta, Meenu, additional, Paudel, Keshav R., additional, Satija, Saurabh, additional, Chellappan, Dinesh K., additional, Dureja, Harish, additional, Gupta, Gaurav, additional, Tambuwala, Murtaza M., additional, Negi, Poonam, additional, Wich, Peter R., additional, Hansbro, Nicole G., additional, Hansbro, Philip M., additional, and Dua, Kamal, additional

Published
2020
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20. Dietary Crocin is Protective in Pancreatic Cancer while Reducing Radiation-Induced Hepatic Oxidative Damage

Author

Bakshi, Hamid, primary, Zoubi, Mazhar, additional, Faruck, Hakkim, additional, Aljabali, Alaa, additional, Rabi, Firas, additional, Hafiz, Amin, additional, Al-Batanyeh, Khalid, additional, Al-Trad, Bahaa, additional, Ansari, Prawej, additional, Nasef, Mohamed, additional, Charbe, Nitin, additional, Satija, Saurabh, additional, Mehta, Meenu, additional, Mishra, Vijay, additional, Gupta, Gaurav, additional, Abobaker, Salem, additional, Negi, Poonam, additional, Azzouz, Ibrahim, additional, Dardouri, Ashref, additional, Dureja, Harish, additional, Prasher, Parteek, additional, Chellappan, Dinesh, additional, Dua, Kamal, additional, Webba da Silva, Mateus, additional, Tanani, Mohamed, additional, McCarron, Paul, additional, and Tambuwala, Murtaza, additional

Published
2020
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23. Albumin Nano-Encapsulation of Piceatannol Enhances Its Anticancer Potential in Colon Cancer Via Downregulation of Nuclear p65 and HIF-1α

Author

A. A. Aljabali, Alaa, primary, A. Bakshi, Hamid, additional, L. Hakkim, Faruck, additional, Haggag, Yusuf A., additional, M. Al-Batanyeh, Khalid, additional, S. Al Zoubi, Mazhar, additional, Al-Trad, Bahaa, additional, M. Nasef, Mohamed, additional, Satija, Saurabh, additional, Mehta, Meenu, additional, Pabreja, Kavita, additional, Mishra, Vijay, additional, Khan, Mohammed, additional, Abobaker, Salem, additional, M. Azzouz, Ibrahim, additional, Dureja, Harish, additional, M. Pabari, Ritesh, additional, Ali K. Dardouri, Ashref, additional, Kesharwani, Prashant, additional, Gupta, Gaurav, additional, Dhar Shukla, Shakti, additional, Prasher, Parteek, additional, B. Charbe, Nitin, additional, Negi, Poonam, additional, N. Kapoor, Deepak, additional, Chellappan, Dinesh Kumar, additional, Webba da Silva, Mateus, additional, Thompson, Paul, additional, Dua, Kamal, additional, McCarron, Paul, additional, and M. Tambuwala, Murtaza, additional

Published
2020
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24. Emerging trends in the novel drug delivery approaches for the treatment of lung cancer

Author

Sharma, Parvarish, primary, Mehta, Meenu, additional, Dhanjal, Daljeet Singh, additional, Kaur, Simran, additional, Gupta, Gaurav, additional, Singh, Harjeet, additional, Thangavelu, Lakshmi, additional, Rajeshkumar, S., additional, Tambuwala, Murtaza, additional, Bakshi, Hamid A., additional, Chellappan, Dinesh Kumar, additional, Dua, Kamal, additional, and Satija, Saurabh, additional

Published
2019
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25. Formulation and characterization of glibenclamide and quercetin-loaded chitosan nanogels targeting skin permeation

Author

Chellappan, Dinesh Kumar, primary, Yee, Neoh Jia, additional, Kaur Ambar Jeet Singh, Bhalqish Jeet, additional, Panneerselvam, Jithendra, additional, Madheswaran, Thiagarajan, additional, Chellian, Jestin, additional, Satija, Saurabh, additional, Mehta, Meenu, additional, Gulati, Monica, additional, Gupta, Gaurav, additional, and Dua, Kamal, additional

Published
2019
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26. Increasing complexity and interactions of oxidative stress in chronic respiratory diseases: An emerging need for novel drug delivery systems

Author

Dua, Kamal, primary, Malyla, Vamshikrishna, additional, Singhvi, Gautam, additional, Wadhwa, Ridhima, additional, Krishna, Rapalli Vamshi, additional, Shukla, Shakti Dhar, additional, Shastri, Madhur D., additional, Chellappan, Dinesh Kumar, additional, Maurya, Pawan Kumar, additional, Satija, Saurabh, additional, Mehta, Meenu, additional, Gulati, Monica, additional, Hansbro, Nicole, additional, Collet, Trudi, additional, Awasthi, Rajendra, additional, Gupta, Gaurav, additional, Hsu, Alan, additional, and Hansbro, Philip M., additional

Published
2019
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27. Curcumin-loaded niosomes downregulate mRNA expression of pro-inflammatory markers involved in asthma: an in vitro study.

Author

Jin-Ying Wong, Yin Ng, Zhao, Mehta, Meenu, Shukla, Shakti D, Panneerselvam, Jithendra, Madheswaran, Thiagarajan, Gupta, Gaurav, Negi, Poonam, Kumar, Pradeep, Pillay, Viness, Hsu, Alan, Hansbro, Nicole G, Wark, Peter, Bebawy, Mary, Hansbro, Philip Michael, Dua, Kamal, and Chellappan, Dinesh Kumar

Abstract

Aim: In this study, curcumin was encapsulated in niosomes (Nio-Curc) to increase its effectiveness for the treatment of asthma. Materials & methods: The formulation underwent various physicochemical characterization experiments, an in vitro release study, molecular simulations and was evaluated for in vitro anti-inflammatory activity. Results: Results showed that Nio-Curc had a mean particle size of 284.93 ± 14.27 nm, zeta potential of -46.93 and encapsulation efficacy of 99.62%, which demonstrates optimized physicochemical characteristics. Curcumin release in vitro could be sustained for up to 24 h. Additionally, Nio-Curc effectively reduced mRNA transcript expression of pro-inflammatory markers; IL-6, IL-8, IL-1β and TNF-α in immortalized human airway basal cell line (BCi-NS1.1). Conclusion: In this study, we have demonstrated that Nio-Curc mitigated the mRNA expression of pro-inflammatory markers in an in vitro study, which could be applied to treatment of asthma with further studies. [ABSTRACT FROM AUTHOR]

Published
2020
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28. Oligonucleotide therapy: An emerging focus area for drug delivery in chronic inflammatory respiratory diseases.

Author

Mehta, Meenu, Deeksha, Tewari, Devesh, Gupta, Gaurav, Awasthi, Rajendra, Singh, Harjeet, Pandey, Parijat, Chellappan, Dinesh Kumar, Wadhwa, Ridhima, Collet, Trudi, Hansbro, Philip M., Kumar, S Rajesh, Thangavelu, Lakshmi, Negi, Poonam, Dua, Kamal, and Satija, Saurabh

Subjects
*OLIGONUCLEOTIDES, *RESPIRATORY diseases, *BASE pairs, *OBSTRUCTIVE lung diseases, *GENE silencing, *RNA interference
Abstract

Oligonucleotide-based therapies are advanced novel interventions used in the management of various respiratory diseases such as asthma and Chronic Obstructive Pulmonary Disease (COPD). These agents primarily act by gene silencing or RNA interference. Better methodologies and techniques are the need of the hour that can deliver these agents to tissues and cells in a target specific manner by which their maximum potential can be reached in the management of chronic inflammatory diseases. Nanoparticles play an important role in the target-specific delivery of drugs. In addition, oligonucleotides also are extensively used for gene transfer in the form of polymeric, liposomal and inorganic carrier materials. Therefore, the current review focuses on various novel dosage forms like nanoparticles, liposomes that can be used efficiently for the delivery of various oligonucleotides such as siRNA and miRNA. We also discuss the future perspectives and targets for oligonucleotides in the management of respiratory diseases. • Oligonucleotides are polynucleic acids consists of five base pairs. • They act by altering gene expression of an affected individual. • In respiratory diseases they are emerging as a newer therapy. [ABSTRACT FROM AUTHOR]

Published
2019
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29. Interactions with the macrophages: An emerging targeted approach using novel drug delivery systems in respiratory diseases.

Author

Mehta, Meenu, Deeksha, Sharma, Neha, Vyas, Manish, Khurana, Navneet, Maurya, Pawan Kumar, Singh, Harjeet, Andreoli de Jesus, Terezinha Pinto, Dureja, Harish, Chellappan, Dinesh Kumar, Gupta, Gaurav, Wadhwa, Ridhima, Collet, Trudi, Hansbro, Philip M, Dua, Kamal, and Satija, Saurabh

Subjects
*DRUG delivery systems, *RESPIRATORY organs, *RESPIRATORY diseases, *DRUG side effects, *HEMATOPOIETIC system, *THERAPEUTICS
Abstract

Macrophages are considered as the most flexible cells of the hematopoietic system that are distributed in the tissues to act against pathogens and foreign particles. Macrophages are essential in maintaining homeostatic tissue processes, repair and immunity. Also, play important role in cytokine secretion and signal transduction of the infection so as to develop acquired immunity. Accounting to their involvement in pathogenesis, macrophages present a therapeutic target for the treatment of inflammatory respiratory diseases. This review focuses on novel drug delivery systems (NDDS) including nanoparticles, liposomes, dendrimers, microspheres etc that can target alveolar macrophage associated with inflammation, intracellular infection and lung cancer. The physiochemical properties and functional moieties of the NDDS attributes to enhanced macrophage targeting and uptake. The NDDS are promising for sustained drug delivery, reduced therapeutic dose, improved patient compliance and reduce drug toxicity. Further, the review also discuss about modified NDDS for specificity to the target and molecular targeting via anti-microbial peptides, kinases, NRF-2 and phosphodiesterase. • Macrophages are well-known immune cells present in the airways. • Macrophages essentially retain pulmonary homeostasis and anti-inflammatory function. • Macrophages present a therapeutic target for the treatment of respiratory diseases. • Novel drug delivery system are gaining attention to target airways macrophages. • Vesicular drug delivery provides improved patient compliance with lesser side effects. [ABSTRACT FROM AUTHOR]

Published
2019
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33. Albumin Nano-Encapsulation of Piceatannol Enhances Its Anticancer Potential in Colon Cancer Via Downregulation of Nuclear p65 and HIF-1α.

Author

Aljabali AAA, Bakshi HA, Hakkim FL, Haggag YA, Al-Batanyeh KM, Al Zoubi MS, Al-Trad B, Nasef MM, Satija S, Mehta M, Pabreja K, Mishra V, Khan M, Abobaker S, Azzouz IM, Dureja H, Pabari RM, Dardouri AAK, Kesharwani P, Gupta G, Dhar Shukla S, Prasher P, Charbe NB, Negi P, Kapoor DN, Chellappan DK, Webba da Silva M, Thompson P, Dua K, McCarron P, and Tambuwala MM

Abstract

Piceatannol (PIC) is known to have anticancer activity, which has been attributed to its ability to block the proliferation of cancer cells via suppression of the NF-kB signaling pathway. However, its effect on hypoxia-inducible factor (HIF) is not well known in cancer. In this study, PIC was loaded into bovine serum albumin (BSA) by desolvation method as PIC-BSA nanoparticles (NPs). These PIC-BSA nanoparticles were assessed for in vitro cytotoxicity, migration, invasion, and colony formation studies and levels of p65 and HIF-1α. Our results indicate that PIC-BSA NPs were more effective in downregulating the expression of nuclear p65 and HIF-1α in colon cancer cells as compared to free PIC. We also observed a significant reduction in inflammation induced by chemical colitis in mice by PIC-BSA NPs. Furthermore, a significant reduction in tumor size and number of colon tumors was also observed in the murine model of colitis-associated colorectal cancer, when treated with PIC-BSA NPs as compared to free PIC. The overall results indicate that PIC, when formulated as PIC-BSA NPs, enhances its therpautice potential. Our work could prompt further research in using natural anticancer agents as nanoparticels with possiable human clinical trails. This could lead to the development of a new line of safe and effective therapeutics for cancer patients., Competing Interests: The authors declare no conflicts of interest.

Published
2020
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