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18 results on '"Mereu, Maddalena"'

1. Publisher Correction: Variations in Dysbindin-1 are associated with cognitive response to antipsychotic drug treatment.

Author

Scheggia, Diego, Mastrogiacomo, Rosa, Mereu, Maddalena, Sannino, Sara, Straub, Richard E, Armando, Marco, Managò, Francesca, Guadagna, Simone, Piras, Fabrizio, Zhang, Fengyu, Kleinman, Joel E, Hyde, Thomas M, Kaalund, Sanne S, Pontillo, Maria, Orso, Genny, Caltagirone, Carlo, Borrelli, Emiliana, De Luca, Maria A, Vicari, Stefano, Weinberger, Daniel R, Spalletta, Gianfranco, and Papaleo, Francesco

Abstract

In the original version of this Article, references in the Methods section incorrectly referred to references in the Supplementary References section. The relevant references (now numbered 20, 27, 42, 47, 69-80) have been removed from the Supplementary References section of the Supplementary Information file and added to the References section of the main manuscript, in both the PDF and HTML versions of the Article.

Published
2018

2. Variations in Dysbindin-1 are associated with cognitive response to antipsychotic drug treatment.

Author

Scheggia, Diego, Mastrogiacomo, Rosa, Mereu, Maddalena, Sannino, Sara, Straub, Richard E, Armando, Marco, Managò, Francesca, Guadagna, Simone, Piras, Fabrizio, Zhang, Fengyu, Kleinman, Joel E, Hyde, Thomas M, Kaalund, Sanne S, Pontillo, Maria, Orso, Genny, Caltagirone, Carlo, Borrelli, Emiliana, De Luca, Maria A, Vicari, Stefano, Weinberger, Daniel R, Spalletta, Gianfranco, and Papaleo, Francesco

Subjects
Brain, Prefrontal Cortex, Animals, Mice, Inbred C57BL, Mice, Knockout, Humans, Mice, Risperidone, Receptors, Dopamine D2, Antipsychotic Agents, Cognition, Schizophrenia, Schizophrenic Psychology, Adolescent, Adult, Aged, Middle Aged, Male, Genetic Variation, Young Adult, Executive Function, Dysbindin, Behavioral and Social Science, Neurosciences, Genetics, Brain Disorders, Serious Mental Illness, Mental Health, 2.1 Biological and endogenous factors, Inbred C57BL, Knockout, Receptors, Dopamine D2
Abstract

Antipsychotics are the most widely used medications for the treatment of schizophrenia spectrum disorders. While such drugs generally ameliorate positive symptoms, clinical responses are highly variable in terms of negative symptoms and cognitive impairments. However, predictors of individual responses have been elusive. Here, we report a pharmacogenetic interaction related to a core cognitive dysfunction in patients with schizophrenia. We show that genetic variations reducing dysbindin-1 expression can identify individuals whose executive functions respond better to antipsychotic drugs, both in humans and in mice. Multilevel ex vivo and in vivo analyses in postmortem human brains and genetically modified mice demonstrate that such interaction between antipsychotics and dysbindin-1 is mediated by an imbalance between the short and long isoforms of dopamine D2 receptors, leading to enhanced presynaptic D2 function within the prefrontal cortex. These findings reveal one of the pharmacodynamic mechanisms underlying individual cognitive response to treatment in patients with schizophrenia, suggesting a potential approach for improving the use of antipsychotic drugs.

Published
2018

4. Dopaminergic signaling and behavioral alterations by Comt‐Dtnbp1 genetic interaction and their clinical relevance

Author

Managò, Francesca, primary, Scheggia, Diego, additional, Pontillo, Maria, additional, Mereu, Maddalena, additional, Mastrogiacomo, Rosa, additional, Udayan, Gayatri, additional, Valentini, Paola, additional, Tata, Maria Cristina, additional, Weinberger, Daniel R., additional, Weickert, Cynthia S., additional, Pompa, Pier Paolo, additional, De Luca, Maria A., additional, Vicari, Stefano, additional, and Papaleo, Francesco, additional

Published
2023
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5. Collagen VI deficiency causes behavioral abnormalities and cortical dopaminergic dysfunction

Author

Gregorio, Ilaria, primary, Mereu, Maddalena, additional, Contarini, Gabriella, additional, Bello, Luca, additional, Semplicini, Claudio, additional, Burgio, Francesca, additional, Russo, Loris, additional, Sut, Stefania, additional, Dall'Acqua, Stefano, additional, Braghetta, Paola, additional, Semenza, Carlo, additional, Pegoraro, Elena, additional, Papaleo, Francesco, additional, Bonaldo, Paolo, additional, and Cescon, Matilde, additional

Published
2022
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7. SINEUP Non-coding RNA Targeting GDNF Rescues Motor Deficits and Neurodegeneration in a Mouse Model of Parkinson’s Disease

Author

Espinoza, Stefano, primary, Scarpato, Margherita, additional, Damiani, Devid, additional, Managò, Francesca, additional, Mereu, Maddalena, additional, Contestabile, Andrea, additional, Peruzzo, Omar, additional, Carninci, Piero, additional, Santoro, Claudio, additional, Papaleo, Francesco, additional, Mingozzi, Federico, additional, Ronzitti, Giuseppe, additional, Zucchelli, Silvia, additional, and Gustincich, Stefano, additional

Published
2020
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8. Serotonergic Signaling Controls Input-Specific Synaptic Plasticity at Striatal Circuits

Author

Cavaccini, Anna, primary, Gritti, Marta, additional, Giorgi, Andrea, additional, Locarno, Andrea, additional, Heck, Nicolas, additional, Migliarini, Sara, additional, Bertero, Alice, additional, Mereu, Maddalena, additional, Margiani, Giulia, additional, Trusel, Massimo, additional, Catelani, Tiziano, additional, Marotta, Roberto, additional, De Luca, Maria Antonietta, additional, Caboche, Jocelyne, additional, Gozzi, Alessandro, additional, Pasqualetti, Massimo, additional, and Tonini, Raffaella, additional

Published
2018
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9. Brain-wide Mapping of Endogenous Serotonergic Transmission via Chemogenetic fMRI

Author

Giorgi, Andrea, primary, Migliarini, Sara, additional, Galbusera, Alberto, additional, Maddaloni, Giacomo, additional, Mereu, Maddalena, additional, Margiani, Giulia, additional, Gritti, Marta, additional, Landi, Silvia, additional, Trovato, Francesco, additional, Bertozzi, Sine Mandrup, additional, Armirotti, Andrea, additional, Ratto, Gian Michele, additional, De Luca, Maria Antonietta, additional, Tonini, Raffaella, additional, Gozzi, Alessandro, additional, and Pasqualetti, Massimo, additional

Published
2017
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14. 522 Catechol-O-Methyltransferase Genetic Reduction Evokes Small-Bowel Neuromuscular Adaptive Changes

Author

Marsilio, Ilaria, primary, Caputi, Valentina, additional, Contarini, Gabriella, additional, Mereu, Maddalena, additional, Debetto, Patrizia, additional, Galuppini, Francesca, additional, Lante, Isabella, additional, Filpa, Viviana, additional, Orso, Genny, additional, Rugge, Massimo, additional, Crema, Francesca, additional, Giaroni, Cristina, additional, Papaleo, Francesco, additional, and Giron, Maria Cecilia, additional

Published
2016
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15. Mo2031 Involvement of Catechol-O-Methyltransferase Genetic Reduction in Murine Intestinal Dysmotility: A Possible Link Between Psychiatric Disorders and Irritable Bowel Syndrome

Author

Caputi, Valentina, primary, Marsilio, Ilaria, additional, Cavallo, Lucia, additional, Frizzo, Stefania A., additional, Marinelli, Francesca, additional, Mereu, Maddalena, additional, Lante, Isabella, additional, Orso, Genny, additional, Papaleo, Francesco, additional, and Giron, Maria Cecilia, additional

Published
2015
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16. R-modafinil (armodafinil):a unique dopamine uptake inhibitor and potential medication for psychostimulant abuse

Author

Loland, Claus J, Mereu, Maddalena, Okunola, Oluyomi M, Cao, Jianjing, Prisinzano, Thomas E, Mazier, Sonia, Kopajtic, Theresa, Shi, Lei, Katz, Jonathan L, Tanda, Gianluigi, Newman, Amy Hauck, Loland, Claus J, Mereu, Maddalena, Okunola, Oluyomi M, Cao, Jianjing, Prisinzano, Thomas E, Mazier, Sonia, Kopajtic, Theresa, Shi, Lei, Katz, Jonathan L, Tanda, Gianluigi, and Newman, Amy Hauck

Abstract

(±)-Modafinil has piqued interest as a treatment for attention-deficit/hyperactivity disorder and stimulant dependence. The R-enantiomer of modafinil might have unique pharmacological properties that should be further investigated.

Published
2012

18. Self-Administration of Cocaine Induces Dopamine-Independent Self-Administration of Sigma Agonists.

Author

Hiranita, Takato, Mereu, Maddalena, Soto, Paul L, Tanda, Gianluigi, and Katz, Jonathan L

Subjects
*COCAINE, *DOPAMINE, *DRUG administration, *SUBSTANCE abuse, *PERSONALITY disorders, *DOPAMINERGIC mechanisms, *MICRODIALYSIS
Abstract

Sigma1 receptors (σ1Rs) are intracellularly mobile chaperone proteins implicated in several disease processes, as well as psychiatric disorders and substance abuse. Here we report that although selective σ1R agonists (PRE-084, (+)-pentazocine) lacked reinforcing effects in drug-naive rats, over the course of 28 experimental sessions, which was more than sufficient for acquisition of cocaine self-administration, responding was not maintained by either σ1R agonist. In contrast, after subjects self-administered cocaine σ1R agonists were readily self-administered. The induced reinforcing effects were long lasting; a response for which subjects had no history of reinforcement was newly conditioned with both σ1R agonists, extinguished when injections were discontinued, and reconditioned when σ1R agonists again followed responses. Experience with food reinforcement was ineffective as an inducer of σ1R agonist reinforcement. Although a variety of dopamine receptor antagonists blocked cocaine self-administration, consistent with its dopaminergic mechanism, PRE-084 self-administration was entirely insensitive to these drugs. Conversely, the σR antagonist, BD1063, blocked PRE-084 self-administration but was inactive against cocaine. In microdialysis studies i.v. PRE-084 did not significantly stimulate dopamine at doses that were self-administered in rats either with or without a cocaine self-administration experience. The results indicate that cocaine experience induces reinforcing effects of previously inactive σ1R agonists, and that the mechanism underlying these reinforcing effects is dopamine independent. It is further suggested that induced σ1R mechanisms may have an essential role in treatment-resistant stimulant abuse, suggesting new approaches for the development of effective medications for stimulant abuse. [ABSTRACT FROM AUTHOR]

Published
2013
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