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15 results on '"Meyhöfer, Svenja"'

1. The reactive pyruvate metabolite dimethylglyoxal mediates neurological consequences of diabetes

Author

Rhein, Sina, Costalunga, Riccardo, Inderhees, Julica, Gürtzgen, Tammo, Faupel, Teresa Christina, Shaheryar, Zaib, Arrulo Pereira, Adriana, Othman, Alaa, Begemann, Kimberly, Binder, Sonja, Stölting, Ines, Dorta, Valentina, Nawroth, Peter P., Fleming, Thomas, Oexle, Konrad, Prevot, Vincent, Nogueiras, Ruben, Meyhöfer, Svenja, Meyhöfer, Sebastian M., and Schwaninger, Markus

Published
2024
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11. Dynamics of HbA1c, BMI and rates of severe hypoglycemia in 4,434 adults with type 1 or type 2 diabetes after initiation of continuous glucose monitoring

Author

Lanzinger, Stefanie, Best, Frank, Bergmann, Tanja, Laimer, Markus, Lipovsky, Boris, Danne, Thomas, Zimny, Stefan, Bramlage, Peter, Meyhöfer, Svenja, and Holl, Reinhard W

Subjects
endocrine system diseases, nutritional and metabolic diseases, 610 Medicine & health
Abstract

BACKGROUND Continuous glucose monitoring (CGM) might have beneficial effects on glycemic control and body-mass-index (BMI) in adults with type 1 (T1D) or type 2 diabetes (T2D). METHODS The diabetes prospective follow-up registry was used to identify individuals with T1D or T2D ≥18 years starting CGM management in 2015 or later and follow-up information available. HbA1c, BMI and event rates of severe hypoglycemia in the year prior to CGM start were compared to two follow-up periods: 1) CGM use for 3-6 months and 2) CGM use for >6 months. Repeated measurements linear and negative binomial regression were used (adjustment for sex, age at diabetes onset and baseline parameters) and stratified by diabetes type. RESULTS Mean follow-up time was 1.8 years in T1D (n=2,994) and 1.9 years in T2D (n=1,440). In T1D, adjusted mean HbA1c decreased significantly from 7.65% (95%-confidence interval: 7.62-7.68) at baseline to 7.54% (7.51-7.57) during follow-up. BMI increased slightly (baseline: 25.4 kg/m2 (25.3-25.5), follow-up >6 months: 25.8 kg/m2 (25.7-25.9)), whereas event rates of severe hypoglycemia were significantly lower after >6 months with CGM (9.0 events/100 PY (8.0-10.1)) compared to baseline (11.3 events/100 PY (10.4-12.2)) in adults with T1D. In T2D, HbA1c decreased from 7.21% (7.17-7.25) to 7.00% (6.95-7.04%) and BMI did not change after CGM initiation. CONCLUSION Our results provide real world evidence on CGM management in adult individuals with T1D or T2D. We suggest to strengthen patients' and physicians' readiness towards diabetes technology in T2D and more openness of health insurance to cover cost based on proven benefits.

Published
2022
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13. CaMKII activity contributes to homeometric autoregulation of the heart: A novel mechanism for the Anrep effect

Author

Reil, Jan‐Christian, primary, Reil, Gert‐Hinrich, additional, Kovács, Árpád, additional, Sequeira, Vasco, additional, Waddingham, Mark T., additional, Lodi, Maria, additional, Herwig, Melissa, additional, Ghaderi, Shahrooz, additional, Kreusser, Michael M., additional, Papp, Zoltán, additional, Voigt, Niels, additional, Dobrev, Dobromir, additional, Meyhöfer, Svenja, additional, Langer, Harald F., additional, Maier, Lars S., additional, Linz, Dominik, additional, Mügge, Andreas, additional, Hohl, Mathias, additional, Steendijk, Paul, additional, and Hamdani, Nazha, additional

Published
2020
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15. Disturbed ventricular-arterial coupling and increased left atrial stiffness in a patient with heart failure with preserved ejection fraction and hyperaldosteronism: a case report.

Author

Meyhöfer S, Schmid SM, Hohl M, and Reil JC

Abstract

Background: Aldosterone is involved in almost all parts of the cardiovascular system. Hyperaldosteronism causes arterial hypertension and might predispose to stroke, atrial fibrillation, and heart failure., Case Summary: A 60-year-old obese woman with long-standing hypertension, hypokalaemia, and shortness of breath was admitted to our hospital. Hypertension was caused by primary hyperaldosteronism due to an adenoma of the adrenal gland. Detailed transthoracic echocardiography revealed diastolic dysfunction, disturbed ventricular-arterial interaction, and atrial compliance resulting in heart failure with preserved ejection fraction (HFPEF). Three months of aldosterone antagonist treatment improved ventricular-arterial coupling, while left ventricular diastolic and atrial dysfunction remained unchanged., Discussion: Presumably, hyperaldosteronism is the reason for HFPEF in this case. Standard criteria to diagnose HFPEF include clinical symptoms of heart failure and an ejection fraction (EF) >50% as well as echocardiographically or invasively assessed elevated filling pressures. Single beat pressure-volume analysis gives insights on the pathophysiology of increased filling pressures, showing in our case diastolic dysfunction as well as disturbed ventricular-arterial interaction. Three months of aldosterone antagonist treatment reduced blood pressure with concomitant improvement of ventricular-arterial interaction, thereby reducing stroke work while stroke volume remained nearly unchanged. Diastolic dysfunction and increased atrial stiffness were unaltered., (© The Author(s) 2019. Published by Oxford University Press on behalf of the European Society of Cardiology.)

Published
2019
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