Search

Dyslipidemia due to genetic and multifactorial dyslipidemia has a predisposition to early-onset atherosclerotic cardiovascular disease (ASCVD), and consensus and guidelines regarding lipid lowering in adults are well established, but the benefits of lipid screening and treatment in childhood and adolescence for this population are not well established. The United States Preventive Medicine Task Force (USPSTF) issued the Recommendation Statement: Screening for Dyslipidemia in Children and Adolescents based on a systematic review of evidence with meta-analysis conducted in a large number of randomized controlled trials, large cohort studies in European and American countries, with the aim of assessing evidences whether initiation of lipid screening and early initiation of treatment in childhood and adolescence has long-term benefits for this population. This article provides a detailed interpretation of the guideline, which aims to provide reference to clinical healthcare workers to improve the understanding of dyslipidaemia in children and to decide whether to screen them with a view to reducing the incidence of cardiovascular disease in adulthood.

In order to study the effect of heat treatment in air on the hydrogen permeation in/through Pd membrane, Pd membrane was deposited via the electroless plating method and the hydrogen permeation flux of Pd membrane before and after heat treatment in air at 573 K was measured. The membranes were characterized by XRD, SEM, AFM and hydrogen permeation tests. The results show that Pd membrane is compact and defect-free and has a thickness of 5 μm. The hydrogen permeability of Pd membrane at 673 K, 723 K and 773 K are 3.62×10-9, 5.12×10-9 mol/(m·s·Pa0.5) and 6.80×10-9 mol/(m·s·Pa0.5), respectively. The membrane treated in air at 573 K has higher surface roughness, larger surface area and more dissociation adsorption sites than the as-deposited membrane, thus improving the hydrogen permeability of the Pd membrane. After heat treatment, the hydrogen permeability of Pd membrane at 673, 723 K and 773 K are 5.32×10-9, 6.44×10-9 mol/(m·s·Pa0.5) and 7.31×10-9 mol/(m·s·Pa0.5), respectively. The hydrogen permeability of such Pd membrane is 1.1-1.5 times higher than that of the as-deposited one.

By connecting the consumption and demand of the city and the countryside through the use of e-commerce platforms and logistics as an intermediary bridge, this study creates a model for the synergistic growth of rural e-commerce and logistics. A multi-dimensional index system is created by combining the actual state of rural e-commerce and logistics, using Shaanxi Province as an example. The degree of coordination between logistics and e-commerce can be ascertained by applying the coupling coordination model. Determine the weights of the indicators to solve for the level of coordinated development, the degree of linked coordination, the degree of rural e-commerce and logistics coupling, and the coordination level of each year using the entropy value technique. Together with the gray correlation degree, we will examine the crucial elements of optimizing the logistics chain for rural e-commerce. According to the study, rural e-commerce and logistics have a coupling coordination degree of 0.0913 in 2010 and 0.6347 in 2019. The degree of coupling coordination between the two is increasing, indicating a major coordination degree in 2019.

The ability to selectively target disease-related tissues with molecules is critical to the design of effective therapeutic and diagnostic reagents. Recognizing the differences between the in vivo environment and in vitro conditions, we employed an in vivo selection strategy to identify RNA aptamers (targeting motifs) that could localize to tumor in situ. One of the selected molecules is an aptamer that binds to the protein DHX9, an RNA helicase that is known to be upregulated in colorectal cancer. Upon systemic administration, the aptamer preferentially localized to the nucleus of cancer cells in vivo and thus has the potential to be used for targeted delivery.

A series of novel quinoline-O-carbamate derivatives was rationally designed for treating Alzheimer's disease (AD) by multi-target-directed ligands (MTDLs) strategy. The target compounds were synthesised and evaluated by AChE/BuChE inhibition and anti-inflammatory property. The in vitro activities showed that compound 3f was a reversible dual eeAChE/eqBuChE inhibitor with IC50 values of 1.3 µM and 0.81 µM, respectively. Moreover, compound 3f displayed good anti-inflammatory property by decreasing the production of IL-6, IL-1β and NO. In addition, compound 3f presented significant neuroprotective effect on Aβ25-35-induced PC12 cell injury. Furthermore, compound 3f presented good stabilities in artificial gastrointestinal fluids, liver microsomes in vitro and plasma. Furthermore, compound 3f could improve AlCl3-induced zebrafish AD model by increasing the level of ACh. Therefore, compound 3f was a promising multifunctional agent for the treatment of AD. [ABSTRACT FROM AUTHOR]

Alzheimer's disease (AD) is a chronic, progressive brain degenerative disease that is common in the elderly. So far, there is no effective treatment. The multi-target-directed ligands (MTDLs) strategy has been recognised as the most promising approach due to the complexity of the pathogenesis of AD. Herein, novel salicylic acid–donepezil–rivastigmine hybrids were designed and synthesised. The bioactivity results exhibited that 5a was a reversible and selective eqBChE inhibitor (IC50 = 0.53 μM), and the docking provided the possible mechanism. Compound 5a also displayed potential anti-inflammatory effects and significant neuroprotective effect. Moreover, 5a exhibited favourable stabilities in artificial gastrointestinal solution and plasma. Finally, 5a demonstrated potential cognitive improvement in scopolamine-induced cognitive dysfunction. Hence, 5a was a potential multifunctional lead compound against AD. [ABSTRACT FROM AUTHOR]

The effect of depositing 8YSZ between serving as an intermediate layer of the P92/Al2O3 was analyzed via finite element analysis. The result shows that depositing an 8YSZ buffer coat beneath the Al2O3 will dramatically decrease the maximum principal stress in the coating system in thermal shock. The stress intensity factor, KI, and J-integral are also decreased which indicates the crack propagation resistance is improved. Inserting a 100 nm 8YSZ buffer layer could reduce the KI and J-integral by 2 orders of magnitude. Thus, cracks are less likely to initiate and propagate. Moreover, coating an 8YSZ layer between the P92/Al2O3 can significantly change the stress distribution pattern in the Al2O3 coating. The 8YSZ with a proper coefficient of thermal expansion between that of the Al2O3 and P92 and good deformability is an ideal buffer layer to improve the thermal cycle endurance and prolong the service life of the Al2O3 coating. [ABSTRACT FROM AUTHOR]

Location information is the core data in IoT applications, which is the essential foundation for scene interpretation and interconnection of everything, and thus high-precision positioning is becoming an immediate need. However, the non-line-of-sight (NLOS) effect of indoor complex environment on UWB signal occlusion has been a major factor limiting the improvement in ultra-wideband (UWB) positioning accuracy, and the optimization of NLOS error has not yet been studied in a targeted manner. To this end, this paper deeply analyzes indoor scenes, divides NLOS into two forms of spatial occlusion and human occlusion, and proposes a particle filtering algorithm based on LOS/NLOS mapping and NLOS error optimization. This algorithm is targeted to optimize the influence of two different forms of NLOS, using spatial a priori information to accurately judge the LOS/NLOS situation of the anchor, optimizing the NLOS anchor ranging using IMU to project the virtual position, judging whether the LOS anchor is affected by human occlusion, and correcting the affected LOS anchor using the established human occlusion error model. Through experimental verification, the algorithm can effectively suppress two different NLOS errors of spatial structure and human occlusion and can achieve continuous and reliable high-precision positioning and tracking in complex indoor environments. [ABSTRACT FROM AUTHOR]