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8. Epidemiology of Cardiopulmonary Arrest and Outcome of Resuscitation in PICU Across China: A Prospective Multicenter Cohort Study

Author

Ding, Xin, primary, Liu, Gang, additional, Qian, Suyun, additional, Zeng, Jiansheng, additional, Wang, Ying, additional, Chu, Jianping, additional, Chen, Qing, additional, Chen, Jianli, additional, Duan, Yuanyuan, additional, Jin, Danqun, additional, Huang, Jiaotian, additional, Lu, Xiulan, additional, Guo, Yanmei, additional, Shi, Xiaona, additional, Huo, Ximin, additional, Su, Jun, additional, Cheng, Yibing, additional, Yin, Yi, additional, Xin, Xiaowei, additional, Sun, Zhengyun, additional, Zhao, Shaodong, additional, Miao, Hongjun, additional, Lou, Zixuan, additional, Li, Jun, additional, Jiang, Jinghui, additional, and Dong, Shengying, additional

Published
2022
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12. Study on the Clinical Significance of ACE2 and Its Age-Related Expression

Author

Gu,Jie, Yin,JiangWen, Zhang,MengJie, Li,JinHui, Wu,YeMing, Chen,Jun, Miao,HongJun, Gu,Jie, Yin,JiangWen, Zhang,MengJie, Li,JinHui, Wu,YeMing, Chen,Jun, and Miao,HongJun

Abstract

Jie Gu,1,&ast; JiangWen Yin,1,&ast; MengJie Zhang,1,&ast; JinHui Li,1 YeMing Wu,2 Jun Chen,1 HongJun Miao1 1Department of Emergency/Critical care Medicine, Children’s Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, 210008, People’s Republic of China; 2Center of Interventional Radiology and Vascular Surgery, Department of Radiology, Zhongda Hospital, Medical School of Southeast University, Nanjing, Jiangsu Province, 210009, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Jun Chen; HongJun MiaoDepartment of Emergency/Critical care Medicine, Children’s Hospital of Nanjing Medical University, No. 72 GuangZhou Road, Nanjing, Jiangsu Province, 210008, People’s Republic of ChinaTel +86 13813951884; +86 18951769627Fax +86 02583117488Email chenjundr850@21cn.com; drmiaohj16@88.comBackground: ACE2 plays a particular role in the changes in multiple organ functions. However, whether ACE2 expression differs at different ages and whether it plays a role in infection-related organ dysfunction remains unclear.Methods: Female and male C57BL/6 mice in four different age groups were included in this study. Immunohistochemical and Western blot analyses were performed to evaluate ACE2 expression characteristics in lung tissues. At the same time, we detected the changes of ACE2 in human blood of different ages and evaluated its clinical significance in sepsis-associated organ dysfunction (SAOD).Results: This study indicated that ACE2 is expressed differently in mouse lung tissues at four different ages (P < 0.05). The peak expression distribution of ACE2 in lung tissues was in the newborn and middle-aged cohorts (P < 0.05). Infants younger than one year had a significantly higher concentration of ACE2 in serum and enhanced susceptibility compared with other ages (P < 0.05). Serum APTT, D-dimer, LDH, and PCT, as well as ACE2 in sepsis and SAOD groups, were statistically significant (P < 0.

Published
2021

13. Performance of Three Mortality Prediction Scores and Evaluation of Important Determinants in Eight Pediatric Intensive Care Units in China

Author

Zhang, Zhengzheng, primary, Huang, Xiangyuan, additional, Wang, Ying, additional, Li, Ying, additional, Miao, Hongjun, additional, Zhang, Chenmei, additional, Pan, Guoquan, additional, Zhang, Yucai, additional, Zhu, Xiaodong, additional, Chen, Weiming, additional, Li, Juanzhen, additional, Su, Dongni, additional, Bi, Yanlong, additional, Chen, Zhenjie, additional, Jin, Bingxin, additional, Miao, Huijie, additional, Kong, Xiangmei, additional, Cheng, Ye, additional, Chen, Yang, additional, Yan, Gangfeng, additional, Yan, Weili, additional, and Lu, Guoping, additional

Published
2020
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17. Incidence, outcome, and prognostic factors of prolonged mechanical ventilation among children in Chinese mainland: a multi-center survey.

Author

Zhang Z, Cai X, Ming M, Huang L, Liu C, Ren H, Qu D, Gao H, Cheng Y, Zhang F, Yang Z, Xu W, Miao H, Liu P, Liu Y, Lu G, and Chen W

Abstract

Objective: To evaluate the incidence, outcome, and prognostic factors of prolonged mechanical ventilation (PMV) in children in Mainland China., Methods: A prospective study was conducted in 11 pediatric intensive care units (PICUs) from May 1, 2021, to April 30, 2022. All pediatric patients on mechanical ventilation meeting the criteria for PMV were included in the study., Results: Out of 5,292 patients receiving mechanical ventilation, 278 children met the criteria for PMV (5.3%). After excluding case with incomplete data or lost to follow-up, the study included 250 patients. Among them, 115 were successfully weaned from mechanical ventilation, 90 died, and 45 were still on mechanical ventilation. The 6-month survival rate was 64%. The primary associated conditions of PMV were lower airway diseases (36%), central nervous system diseases (32%), and neuromuscular diseases (14%). The stepwise multiple logistic regression analysis indicated that the utilization of vasoactive agents and an elevated pediatric logistic organ dysfunction-2 (PELOD-2) score on the day of PMV diagnosis were significantly associated with an increased of PMV death. Specifically, the odds ratio (OR) for vasoactive agent use was 2.86; (95% CI: 0.15-0.84; P  = 0.018), and for the PELOD-2 score, it was 1.37; 95% CI: 1.17-1.61; P  < .001). Conversely, early rehabilitation intervention was negatively associated with the risk of PMV death (OR = 0.45; 95% CI: 0.22-0.93; P  = .032). Furthermore, the tracheotomy timing emerged as an independent predictor of failure to wean from PMV, with an OR of 1.08, (95% CI: 1.01-1.16; P   =  .030)., Conclusions: The study revealed a 5.3% incidence of PMV in children requiring mechanical ventilation in China. The use of vasoactive agents and a higher PELOD-2 score at PMV diagnosis were significantly associated with an increased risk of PMV death, whereas early rehabilitation intervention was identified as crucial for improving patient outcomes. The timing of tracheostomy was identified as a high-risk factor for failure to wean from mechanical ventilation., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (© 2024 Zhang, Cai, Ming, Huang, Liu, Ren, Qu, Gao, Cheng, Zhang, Yang, Xu, Miao, Liu, Liu, Lu and Chen.)

Published
2024
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