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Present study was undertaken to evaluate analgesic activity of root of Nelsonia canescens (Lam.) Spreng, a folklore medicinal plant used as the one of the source plant of Rasna. Study was carried out at two dose levels (270 mg/kg and 540 mg/kg) in albino rats. Analgesic activity was evaluated in formalin induced paw licking, and tail flick methods whereas indomethacin and pentazocine were used as standard analgesic drugs, respectively. At both the dose levels, test drug non-significantly decreased paw licking response at both time intervals. In tail flick model, the administration of the test drug increased pain threshold response in a dose dependent manner. In therapeutically equivalent dose level, analgesic activity was observed only after 180 min while in TED x 2 treated group analgesia was observed at 30 min and lasted even up to 240 min. The results suggested that N.canescens root possess moderate analgesic activity. [ABSTRACT FROM AUTHOR]

Objectives: Cancer has always been a life-threatening condition among humans. Various methods have been applied with the help of natural products and medicinal plants for the control and treatment of different cancers. Ayurveda is an ancient system of traditional Indian medicine, practiced to enhance patients' health and natural treatment. Ayurvedic literature categorizes cancer into two main types: swelling with inflammation or without inflammation, also known as Arbuda (major neoplasm) or Granthi (minor neoplasm). Materials and Methods: For cancer treatment and control, Ayurveda focuses on health improvement, restoration to the normal status, spiritual approaches and treatment with natural products, especially medicinal herb combinations. Personalized medicines with herbal preparations are used according to specific constitutional types (doshas) in the body. Healthy diet, internal and external purification (e.g., Shodhana and Panchakarma), decoctions, medicated oils, mineral supplements and herbal formulations with other Rasayanas are suggested for cancer treatment, although in advanced conditions, surgical removal of the tumor is performed. Results: The literature review indicated the effects of medicinal herb preparation on the purification and detoxification of internal organs, as well as the systemic and topical effects of these compounds for enhancing the immune system and treating the affected organs via multiple biochemical pathways. Conclusion: The observed effects could be related to different active phytoconstituents, which act as antioxidant and antineoplastic agents to support various organs affected by the tumor and promote cancer prevention, health improvement and disease control. [ABSTRACT FROM AUTHOR]