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BACKGROUND: Two important aspects for the development of anxiety disorders are genetic predisposition and alterations in the hypothalamic-pituitary-adrenal (HPA) axis. In order to identify genetic risk-factors for anxiety, the aim of this exploratory study was to investigate possible relationships between genetic polymorphisms in genes important for the regulation and activity of the HPA axis and self-assessed anxiety in healthy individuals. METHODS: DNA from 72 healthy participants, 37 women and 35 men, were included in the analyses. Their DNA was extracted and analysed for the following Single Nucleotide Polymorphisms (SNP)s: rs41423247 in the NR3C1 gene, rs1360780 in the FKBP5 gene, rs53576 in the OXTR gene, 5-HTTLPR in SLC6A4 gene and rs6295 in the HTR1A gene. Self-assessed anxiety was measured by the State and Trait Anxiety Inventory (STAI) questionnaire. RESULTS: Self-assessed measure of both STAI-S and STAI-T were significantly higher in female than in male participants (p = 0.030 and p = 0.036, respectively). For SNP rs41423247 in the NR3C1 gene, there was a significant difference in females in the score for STAI-S, where carriers of the G allele had higher scores compared to the females that were homozygous for the C allele (p < 0.01). For the SNP rs53576 in the OXTR gene, there was a significant difference in males, where carriers of the A allele had higher scores in STAI-T compared to the males that were homozygous for the G allele (p < 0.01). CONCLUSION: This study shows that SNP rs41423247 in the NR3C1 gene and SNP rs53576 in the OXTR gene are associated with self-assessed anxiety in healthy individuals in a gender-specific manner. This suggests that these SNP candidates are possible genetic risk-factors for anxiety.

This study was conducted to assess the techno-economic feasibility of converting the Canadian housing stock (CHS) into net/near zero energy buildings by introducing and integrating high efficient and renewable/alternative energy technologies in new construction and existing houses. Performance assessment of energy retrofit and renewable/alternative energy technologies in existing houses in regional and national scale is necessary to devise feasible strategies and incentive measures. The Canadian Hybrid Residential End-Use Energy and GHG Emissions model (CHREM) that utilizes a bottom-up modeling approach is used to investigate the techno-economic feasibility of air to water heat pump retrofit in the Canadian housing stock. The proposed energy retrofit includes an air to water heat pump, auxiliary boiler, thermal storage tank, hydronic heat delivery and domestic hot water (DHW) heating. Energy savings, GHG emission changes and economic feasibility of the air source heat pump retrofit are considered in this study. Results show that there is a potential to reduce 36% of energy consumption and 23% of GHG emissions of the CHS if all eligible houses undertake the retrofit. Economic analysis indicates that the feasibility of air to water heat pump systems is strongly affected by the current status of primary energy use for electricity generation and space and DHW heating as well as energy prices and economic conditions. Legislation, economic incentives and education for homeowners are necessary to enhance the penetration level of air to water heat pump retrofits in the CHS.

An improved understanding of the consumption patterns, end-uses, and temporal variations of electrical loads in houses is warranted because a significant fraction of a society's total electricity consumption occurs within residential buildings. In general, there is a lack of high-temporal-resolution data describing occupant electrical consumption that are available to researchers in this field. To address this, new measurements were performed and combined with data emanating from an earlier study to provide a database of annual measurements for 23 houses at a 1-min resolution that characterizes whole-house, non-HVAC, air conditioner, and furnace fan electrical draws, as well as the draw patterns of some major appliances. All houses were located in Ottawa, Canada. The non-HVAC measurements of this 23-house sample were shown to be in agreement with published estimates for the housing stock. The furnace fan was found to be the most significant end-use. These high-temporal-resolution data of electrical demands in houses can be used by researchers to increase the fidelity of building performance simulation analyses of different micro-generation technologies in residential buildings.

Fuel cells with nominal outputs of approximately 1kW AC are emerging as a prime-mover of a micro-cogeneration system potentially well-suited to compete, on an energy basis, with conventional methods for satisfying occupant electrical and thermal demands in a residential application. As the energy benefits of these systems can be incremental when compared to efficient conventional methods, it is especially important to consider the uncertainties of the models on which simulation results are based. However, researchers have yet to take this aspect into account.This article makes a contribution by demonstrating how these model uncertainties may be propagated to the simulation results of a micro-cogeneration system for comparison to a reference scenario using a case study. This case study compares the energy performance of a fuel-cell based micro-cogeneration system serving only domestic hot water demands to an efficient reference scenario where the conventional methods for providing electrical and thermal demands are considered to be a central gas-fired combined-cycle plant and a condensing tankless water heater respectively. The simulation results demonstrated that if model uncertainties were ignored, it would have been possible to demonstrate that the considered micro-cogeneration system was more efficient than the reference scenario for average consumption levels of domestic hot water. However, when model uncertainties were considered, the efficiency of the considered micro-cogeneration system could not reliably exceed that of the reference scenario by serving the domestic hot water needs of a single-family home.

Techno-economic impact of retrofitting houses in the Canadian housing stock with PV and BIPV/T systems is evaluated using the Canadian Hybrid End-use Energy and Emission Model. Houses with south, south-east and south-west facing roofs are considered eligible for the retrofit since solar irradiation is maximum on south facing surfaces in the northern hemisphere. The PV system is used to produce electricity and supply the electrical demand of the house, with the excess electricity sold to the grid in a net-metering arrangement. The BIPV/T system produces electricity as well as thermal energy to supply the electrical as well as the thermal demands for space and domestic hot water heating. The PV system consists of PV panels installed on the available roof surface while the BIPV/T system adds a heat pump, thermal storage tank, auxiliary heater, domestic hot water heating equipment and hydronic heat delivery system, and replaces the existing heating system in eligible houses. The study predicts the energy savings, GHG emission reductions and tolerable capital costs for regions across Canada. Results indicate that the PV system retrofit yields 3% energy savings and 5% GHG emission reduction, while the BIPV/T system yields 18% energy savings and 17% GHG emission reduction in the Canadian housing stock. While the annual electricity use slightly increases, the fossil fuel use of the eligible houses substant

The techno-economic feasibility of retrofitting existing Canadian houses with solar assisted heat pump (SAHP) is investigated. The SAHP architecture is adopted from previous studies conducted for the Canadian climate. The system utilizes two thermal storage tanks to store excess solar energy for use later in the day. The control strategy is defined in order to prioritise the use of solar energy for space and domestic hot water heating purposes. Due to economic and technical constraints a series of eligibility criteria are introduced for a house to qualify for the retrofit. A model was built in ESP-r and the retrofit was introduced into all eligible houses in the Canadian Hybrid Residential End-Use Energy and GHG Emissions model. Simulations were conducted for an entire year to estimate the annual energy savings, and GHG emission reductions. Results show that the SAHP system performance is strongly affected by climatic conditions, auxiliary energy sources and fuel mixture for electricity generation. Energy consumption and GHG emission of the Canadian housing stock can be reduced by about 20% if all eligible houses receive the SAHP system retrofit. Economic analysis indicates that the incentive measures will likely be necessary to promote the SAHP system in the Canadian residential market.

The design and analysis of community-scale energy systems and incentives is a non-trivial task. The challenge of such undertakings is the well-documented uncertainty of building occupant behaviours. This is especially true in the residential sector, where occupants are given more freedom of activity compared to work environments. Further complicating matters is the dearth of available measured data. Building performance simulation tools are one approach to community energy analysis, however such tools often lack realistic models for occupant-driven demands, such as appliance and lighting (AL) loads. For community-scale analysis, such AL models must also be able to capture the temporal and inter-dwelling variation to achieve realistic estimates of aggregate electrical demand. This work adapts the existing Centre for Renewable Energy Systems Technology (CREST) residential energy model to simulate Canadian residential AL demands. The focus of the analysis is to determine if the daily, seasonal, and inter-dwelling variation of AL demands estimated by the CREST model is realistic. An in-sample validation is conducted on the model using 22 high-resolution measured AL demand profiles from dwellings located in Ottawa, Canada. The adapted CREST model is shown to broadly capture the variation of AL demand variations observed in the measured data, however seasonal variation in daily AL demand behaviour was found to be under-estimated by the model. The average and variance of daily load factors was found to be similar between measured and modelled. The model was found to under-predict the daily coincidence factors of aggregated demands, although the variance of coincident factors was shown to be similar between measured and modelled. A stochastic baseload input developed for t

The more social aspects of touch, despite their relevance to numerous domains of human behavior, from cultural anthropology to cognitive neuroscience, and from virtual reality through to linguistics, have not been extensively studied by scientists. That is, psychologists and neuroscientists are only now beginning to uncover some of the neurocognitive mechanisms responsible for these important real-world interactions. In this chapter, we summarize the latest developments in this field of research. In particular, we highlight a number of studies where touch, no matter whether direct or mediated by technological devices, has been shown to affect our behavior, as well as our physiological reactions. We show how this sensory modality often acts as a powerful interface allowing us to interact socially and emotionally with the world around us. The available research also suggests that touch plays an important role in supporting our well-being.

Large amounts of south facing windows can help reduce heating demand in the winter and shoulder seasons by allowing high levels of solar radiation to enter the building. One problem that may arise from large areas of south facing glazing is overheating of the adjacent rooms, even during winter in a cold climate. Cooling of the floors may provide a means to prevent overheating in such a situation. Cooling a floor prevents solar gains absorbed by the floor from being transferred to the space by convection or infrared radiation. This cooling can be achieved with the use of water pipes in the floor. The heat removed can be upgraded to a higher temperature with a heat pump, and then may be stored in a thermal storage tank for space heating and domestic hot water heating. This paper shows preliminary simulation results of such a system for a house in Ottawa, Canada. The house contains a much larger south facing window area than is typical. In periods of overheating, the solar gains are absorbed by the floor cover and collected by the cold pipes in the floor. The heat is upgraded by a heat pump and stored in a hot storage tank. Preliminary modelling results show that, with the use of a large thermal storage tank (2 m3), space heating and domestic hot water demand with this type of system may be reduced by as much as 24%, when compared with a more conventional house.

We provide an overview of the exciting capabilities of the SKA in the Cradle of Life theme. With the deployment of the high frequency band 5 receivers, the phase 1 of the SKA can conduct headline science in the study of the earliest stages of grain growth in proto-planetary disks. SKA1-MID can map the 2 cm continuum emission at a resolution of 4 au in the nearest systems and therefore begin to probe the distribuion of cm-sized particles across the snow line. This frequency range will also enable deep searches for pre-biotic molecules such as amino acids from pre-stellar cores to the cold, outer regions of proto-planetary disks where cometary material forms. The lowest frequency capabilities of SKA1 can be used to examine the magnetic fields of exo-planets via their auroral radio emission. This gives unique insight into their interiors and could potentially detect exo-moons. Across the full frequency range, the SKA1 will also carry out systematic, volume-limited searches of exo-planet systems for signals from technologically advanced civilizations. The sensitivity of SKA1 means that these only need to be at the level of typical airport radar signals in the nearest systems. Hence, the SKA1 can conduct high impact science from the first steps on the road to planets and life, through areas affecting the habitability of planets, and ultimately, to whether we are alone in the Galaxy. These inspirational themes will greatly help in the effort to bring SKA1 science to a wide audience and to ensure the progression to the full SKA.