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1. Stochastic quantization of the three-dimensional polymer measure via the Dirichlet form method

Author

Albeverio, Sergio, Kusuoka, Seiichiro, Liang, Song, and Nakashima, Makoto

Subjects
Mathematics - Probability, Mathematical Physics, 81S20, 60J65, 60J46, 60H30
Abstract

We prove that there exists a diffusion process whose invariant measure is the three dimensional polymer measure $\nu_\lambda$ for small $\lambda>0$. We follow in part a previous incomplete unpublished work of the first named author with M. R\"ockner and X.Y. Zhou. For the construction of $\nu_\lambda$ we rely on previous work by J. Westwater, E. Bolthausen and X.Y. Zhou. Using $\nu_\lambda$, the diffusion is constructed by means of the theory of Dirichlet forms on infinite-dimensional state spaces. The closability of the appropriate pre-Dirichlet form which is of gradient type is proven, by using a general closability result in [AR89a]. This result does not require an integration by parts formula (which does not even hold for the two-dimensional polymer measure $\nu_\lambda$) but requires the quasi-invariance of $\nu_\lambda$ along a basis of vectors in the classical Cameron-Martin space such that the Radon-Nikodym derivatives have versions which form a continuous process., Comment: 87 pages, 8 figures

Published
2023

2. Mechanisms of action and resistance in histone methylation-targeted therapy

Author

Yamagishi, Makoto, Kuze, Yuta, Kobayashi, Seiichiro, Nakashima, Makoto, Morishima, Satoko, Kawamata, Toyotaka, Makiyama, Junya, Suzuki, Kako, Seki, Masahide, Abe, Kazumi, Imamura, Kiyomi, Watanabe, Eri, Tsuchiya, Kazumi, Yasumatsu, Isao, Takayama, Gensuke, Hizukuri, Yoshiyuki, Ito, Kazumi, Taira, Yukihiro, Nannya, Yasuhito, Tojo, Arinobu, Watanabe, Toshiki, Tsutsumi, Shinji, Suzuki, Yutaka, and Uchimaru, Kaoru

Published
2024
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4. Fluctuations of two-dimensional stochastic heat equation and KPZ equation in subcritical regime for general initial conditions

Author

Nakajima, Shuta and Nakashima, Makoto

Subjects
Mathematics - Probability, 60K37(Primary) 60F05, 60G42, 82D60(Secondary)
Abstract

The solution of Kardar-Parisi-Zhang equation (KPZ equation) is solved formally via Cole-Hopf transformation $h=\log u$, where $u$ is the solution of multiplicative stochastic heat equation(SHE). In earlier works by Chatterjee and Dunlap, Caravenna, Sun, and Zygouras, and Gu, they consider the solution of two dimensional KPZ equation via the solution $u_\varepsilon$ of SHE with flat initial condition and with noise which is mollified in space on scale in $\varepsilon$ and its strength is weakened as $\beta_\varepsilon=\hat{\beta} \sqrt{\frac{2\pi \varepsilon}{-\log \varepsilon}}$, and they prove that when $\hat{\beta}\in (0,1)$, $\frac{1}{\beta_\varepsilon}(\log u_\varepsilon-\mathbb{E}[\log u_\varepsilon])$ converges in distribution to a solution of Edward-Wilkinson model as a random field. In this paper, we consider a stochastic heat equation $u_\varepsilon$ with general initial condition $u_0$ and its transformation $F(u_\varepsilon)$ for $F$ in a class of functions $\mathfrak{F}$, which contains $F(x)=x^p$ ($0

Published
2021

5. Two-sided bounds on free energy of directed polymers on strongly recurrent graphs

Author

Kajino, Naotaka, Konishi, Kosei, and Nakashima, Makoto

Subjects
Mathematics - Probability
Abstract

We study the directed polymers in random environment on an infinite graph $G=(V,E)$ on which the underlying random walk satisfies sub-Gaussian heat kernel bounds with spectral dimension $d_{s}$ strictly less than two. Our goal in this paper is to show (i) the existence and the coincidence of the quenched and the annealed free energy $F_q(\beta)$, $F_a(\beta)$ and (ii) that $F_a(\beta)-F_q(\beta)$ is comparable to $\beta^{\frac{4}{2-d_{s}}}$ for small inverse temperature $\beta$.

Published
2020

6. Law of large numbers and fluctuations in the sub-critical and $L^2$ regions for SHE and KPZ equation in dimension $d\geq 3$

Author

Cosco, Clément, Nakajima, Shuta, and Nakashima, Makoto

Subjects
Mathematics - Probability, Mathematical Physics, Mathematics - Analysis of PDEs, Primary 60K37. Secondary 60F05, 60G42, 82D60
Abstract

There have been recently several works studying the regularized stochastic heat equation (SHE) and Kardar-Parisi-Zhang (KPZ) equation in dimension $d\geq 3$ as the smoothing parameter is switched off, but most of the results did not hold in the full temperature regions where they should. Inspired by martingale techniques coming from the directed polymers literature, we first extend the law of large numbers for SHE obtained in [MSZ16] to the full weak disorder region of the associated polymer model and to more general initial conditions. We further extend the Edwards-Wilkinson regime of the SHE and KPZ equation studied in [GRZ18,MU17,DGRZ20] to the full $L^2$-region, along with multidimensional convergence and general initial conditions for the KPZ equation (and SHE), which were not proven before. To do so, we rely on a martingale CLT combined with a refinement of the local limit theorem for polymers., Comment: 47 pages

Published
2020

7. Diagnostic Value of Anti-HTLV-1-Antibody Quantification in Cerebrospinal Fluid for HTLV-1-Associated Myelopathy.

Author

Sato, Tomoo, Yagishita, Naoko, Araya, Natsumi, Nakashima, Makoto, Horibe, Erika, Takahashi, Katsunori, Kunitomo, Yasuo, Nawa, Yukino, Hamaguchi, Isao, and Yamano, Yoshihisa

Subjects
HTLV-I, CEREBROSPINAL fluid, RECEIVER operating characteristic curves, ANTIBODY titer, REFERENCE values, CEREBROSPINAL fluid examination
Abstract

The diagnostic accuracy of cerebrospinal fluid (CSF) anti-human T-cell leukemia virus type I (HTLV-1) antibody testing for HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM) remains unclear. Therefore, we measured the anti-HTLV-1 antibody levels in CSF using various test kits, evaluated the stability of CSF antibodies, and performed a correlation analysis using the particle agglutination (PA) method, as well as a receiver operating characteristic (ROC) analysis between patients with HAM and carriers. The CSF anti-HTLV-1 antibody levels were influenced by freeze–thaw cycles but remained stable when the CSF was refrigerated at 4 °C for up to 48 h. Measurements from 92 patients (69 patients with HAM and 23 carriers) demonstrated a strong correlation (r > 0.9) with the PA method across all six quantifiable test kits. All six test kits, along with CSF neopterin and CXCL10, exhibited areas under the ROC curve greater than 0.9, indicating a high diagnostic performance for HAM. Among these, five test kits, Lumipulse and Lumipulse Presto HTLV-I/II, HISCL-UD (a kit under development), HTLV-Abbott, and Elecsys HTLV-I/II, established a cutoff with 100% sensitivity and maximum specificity, achieving a sensitivity of 100% and a specificity ranging from 43.5% to 56.5%. This cutoff value, in combination with clinical findings, will aid in the accurate diagnosis of HAM. [ABSTRACT FROM AUTHOR]

Published
2024
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8. RAISING is a high-performance method for identifying random transgene integration sites

Author

Wada, Yusaku, Sato, Tomoo, Hasegawa, Hiroo, Matsudaira, Takahiro, Nao, Naganori, Coler-Reilly, Ariella L. G., Tasaka, Tomohiko, Yamauchi, Shunsuke, Okagawa, Tomohiro, Momose, Haruka, Tanio, Michikazu, Kuramitsu, Madoka, Sasaki, Daisuke, Matsumoto, Nariyoshi, Yagishita, Naoko, Yamauchi, Junji, Araya, Natsumi, Tanabe, Kenichiro, Yamagishi, Makoto, Nakashima, Makoto, Nakahata, Shingo, Iha, Hidekatsu, Ogata, Masao, Muramatsu, Masamichi, Imaizumi, Yoshitaka, Uchimaru, Kaoru, Miyazaki, Yasushi, Konnai, Satoru, Yanagihara, Katsunori, Morishita, Kazuhiro, Watanabe, Toshiki, Yamano, Yoshihisa, and Saito, Masumichi

Published
2022
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10. Free energy of directed polymers in random environment in $1+1$-dimension at high temperature

Author

Nakashima, Makoto

Subjects
Mathematics - Probability
Abstract

We consider the free energy $F(\beta)$ of the directed polymers in random environment in $1+1$-dimension. It is known that $F(\beta)$ is of order $-\beta^4$ as $\beta\to 0$. In this paper, we will prove that under a certain condition of the potential, \begin{align*} \lim_{\beta\to 0}\frac{F(\beta)}{\beta^4}=\lim_{T\to\infty}\frac{1}{T}P_{\mathcal{Z}}\left[\log \mathcal{Z}_{\sqrt{2}}(T)\right] =-\frac{1}{6}, \end{align*} where $\{\mathcal{Z}_\beta(t,x):t\geq 0,x\in\mathbb{R}\}$ is the unique mild solution to the stochastic heat equation \begin{align*} \frac{\partial}{\partial t}\mathcal{Z}=\frac{1}{2}\Delta \mathcal{Z}+\beta \mathcal{Z}{\dot{\mathcal W}},\ \ \lim_{t\to 0}\mathcal{Z}(t,x)dx=\delta_{0}(dx), \end{align*} where $\mathcal{W}$ is a time-space white noise and \begin{align*} \mathcal{Z}_\beta(t)=\int_\mathbb{R}\mathcal{Z}_\beta(t,x)dx. \end{align*}

Published
2016

11. Direct Oral Anticoagulants Versus Vitamin K Antagonists in Patients With Atrial Fibrillation After TAVR

Author

Kawashima, Hideyuki, Watanabe, Yusuke, Hioki, Hirofumi, Kozuma, Ken, Kataoka, Akihisa, Nakashima, Makoto, Nagura, Fukuko, Nara, Yugo, Yashima, Fumiaki, Tada, Norio, Naganuma, Toru, Yamawaki, Masahiro, Yamanaka, Futoshi, Shirai, Shinichi, Mizutani, Kazuki, Tabata, Minoru, Ueno, Hiroshi, Takagi, Kensuke, Yamamoto, Masanori, and Hayashida, Kentaro

Published
2020
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13. A remark on the bound for the free energy of directed polymers in random environment in 1+2 dimension

Author

Nakashima, Makoto

Subjects
Mathematics - Probability
Abstract

We consider the behavior of the quantity $p(\beta)$; the free energy of directed polymers in random environment in $1+2$ dimension, where $\beta$ is inverse temperature. We know that the free energy is strictly negative when $\beta$ is not zero. In this paper, we will prove that $p(\beta)$ is bounded from above by $-\exp\left( -\frac{c_\varepsilon}{\beta^{2+\varepsilon}} \right)$ for small $\beta$, where $c_\varepsilon>0$ is a constant depending on $\varepsilon>0$. Also, we will suggest a strategy to get a sharper asymptotics.

Published
2014
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14. Nonnegative solutions to stochastic heat equation with nonlinear drift

Author

Nakashima, Makoto

Subjects
Mathematics - Probability
Abstract

We consider one-dimensional stochastic heat equation with nonlinear drift, $\displaystyle \partial_t u=\frac{1}{2}\Delta u+b(u)u+\sigma(u)\dot{W}(t,x)$, where $b:\mathbb{R}_{+}\to \mathbb{R}$ is a continuous function and $\sigma:\mathbb{R}_{+}\to \mathbb{R}$ is a continuous function with suitable property. We will construct nonnegative solutions to such SPDEs.

Published
2013

15. Branching random walks in random environment and super-Brownian motion in random environment

Author

Nakashima, Makoto

Subjects
Mathematics - Probability, 60H15, 60J68, 60J80, 60K37
Abstract

We focus on the existence and characterization of the limit for a certain critical branching random walks in time-space random environment in one dimension which was introduced by M. Birnkenr et.al. Each particle performs simple random walk on $\mathbb{Z}$ and branching mechanism depends on the time-space site. The weak limit of this measure valued processes is characterized as a solution to the non-trivial martingale problem and called super-Brownian motions in random environment by L. Mytnik. Moreover, we will show the weak uniqueness of the solutions with some initial condition., Comment: arXiv admin note: substantial text overlap with arXiv:1207.1755

Published
2013

17. Targeting Excessive EZH1 and EZH2 Activities for Abnormal Histone Methylation and Transcription Network in Malignant Lymphomas

Author

Yamagishi, Makoto, Hori, Makoto, Fujikawa, Dai, Ohsugi, Takeo, Honma, Daisuke, Adachi, Nobuaki, Katano, Harutaka, Hishima, Tsunekazu, Kobayashi, Seiichiro, Nakano, Kazumi, Nakashima, Makoto, Iwanaga, Masako, Utsunomiya, Atae, Tanaka, Yuetsu, Okada, Seiji, Tsukasaki, Kunihiro, Tobinai, Kensei, Araki, Kazushi, Watanabe, Toshiki, and Uchimaru, Kaoru

Published
2019
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18. Super-Brownian motion in random environment as a limit point of critical branching random walks in random environment

Author

Nakashima, Makoto

Subjects
Mathematics - Probability
Abstract

We focus on the existence and its characterization of limit for a certain critical branching random walks in time-space random environment in 1 dimension which was introduced by Birkner et.al. Each particle performs simple random walk on $\mathbb{Z}$ and branching mechanism depends on the time-space site. The weak limit points of this measure valued processes are characterized as a solution of the non-trivial martingale problem and called super-Brownian motions in random environment by Mytnik., Comment: This paper has been withdrawn because the results is improved and the title is changed

Published
2012

19. Almost sure central limit theorem for branching random walks in random environment

Author

Nakashima, Makoto

Subjects
Mathematics - Probability
Abstract

We consider the branching random walks in $d$-dimensional integer lattice with time--space i.i.d. offspring distributions. Then the normalization of the total population is a nonnegative martingale and it almost surely converges to a certain random variable. When $d\geq3$ and the fluctuation of environment satisfies a certain uniform square integrability then it is nondegenerate and we prove a central limit theorem for the density of the population in terms of almost sure convergence., Comment: Published in at http://dx.doi.org/10.1214/10-AAP699 the Annals of Applied Probability (http://www.imstat.org/aap/) by the Institute of Mathematical Statistics (http://www.imstat.org)

Published
2011
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23. Establishment of a novel diagnostic test algorithm for human T-cell leukemia virus type 1 infection with line immunoassay replacement of western blotting: a collaborative study for performance evaluation of diagnostic assays in Japan

Author

Okuma, Kazu, Kuramitsu, Madoka, Niwa, Toshihiro, Taniguchi, Tomokuni, Masaki, Yumiko, Ueda, Gohzoh, Matsumoto, Chieko, Sobata, Rieko, Sagara, Yasuko, Nakamura, Hitomi, Satake, Masahiro, Miura, Kiyonori, Fuchi, Naoki, Masuzaki, Hideaki, Okayama, Akihiko, Umeki, Kazumi, Yamano, Yoshihisa, Sato, Tomoo, Iwanaga, Masako, Uchimaru, Kaoru, Nakashima, Makoto, Utsunomiya, Atae, Kubota, Ryuji, Ishitsuka, Kenji, Hasegawa, Hiroo, Sasaki, Daisuke, Koh, Ki-Ryang, Taki, Mai, Nosaka, Kisato, Ogata, Masao, Naruse, Isao, Kaneko, Noriaki, Okajima, Sara, Tezuka, Kenta, Ikebe, Emi, Matsuoka, Sahoko, Itabashi, Kazuo, Saito, Shigeru, Watanabe, Toshiki, and Hamaguchi, Isao

Published
2020
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25. Prognostic impact of postprocedure stroke volume in patients with low-gradient aortic stenosis

Author

Yugo Nara, Akihisa Kataoka, Yusuke Watanabe, Nakashima Makoto, Hirofumi Hioki, Hideyuki Kawashima, Nagura Fukuko, Ken Kozuma, Shinichi Shirai, Norio Tada, Motoharu Araki, Toru Naganuma, Futoshi Yamanaka, Hiroshi Ueno, Minoru Tabata, Kazuki Mizutani, Akihiro Higashimori, Kensuke Takagi, Masanori Yamamoto, and Kentaro Hayashida

Subjects
Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Objective The effect of postoperative blood flow status on the prognosis of patients with low-gradient severe aortic stenosis (AS) has not been examined. Severe AS is associated with a higher mortality rate after transcatheter aortic valve implantation (TAVI). We examined the prognostic value of low-flow status by comparing stroke volume indices (SVi) before and after TAVI in patients with symptomatic, low-gradient severe AS.Methods A total of 1613 patients with severe symptomatic AS who underwent TAVI in 14 Japanese institutes for low-gradient severe AS (418 patients, median age 84 years, 32.5% men) were prospectively enrolled. The primary endpoint was cardiovascular mortality during follow-up after TAVI, and independent predictors were evaluated. Receiver operating characteristic curves were generated to determine the optimal cut-off value of post-TAVI SVi for predicting cardiovascular mortality, and the receiver operating characteristic curves of pre-TAVI and post-TAVI SVi were compared.Results The cardiovascular mortality rate was 4.1% (17 patients) during follow-up (median 9.2 months). Multivariate analysis revealed post-TAVI SVi to be an independent predictor of cardiovascular mortality (per 10 mL/m2 decrease; HR, 2.0; 95% CI 1.28 to 3.12). The optimal cut-off value of post-TAVI SVi was 41.4 mL/m2. Post-TAVI SVi showed significantly larger area under the curve than pre-TAVI SVi (0.74 (95% CI 0.69 to 0.79) vs 0.61 (95% CI 0.56 to 0.65), p

Published
2019
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30. Highly Sensitive Detection Method Reveals Significant Anti-Tumor Activity of Valemetostat in Patients with Relapsed/Refractory Adult T Cell Leukemia

Author

Takayama, Gensuke, primary, Hizukuri, Yoshiyuki, additional, Fujioka, Tomoyuki, additional, Hashimoto, Kazuyuki, additional, Ito, Kazumi, additional, Yamada, Hironori, additional, Yamagishi, Makoto, additional, Nakashima, Makoto, additional, Suzuki, Yutaka, additional, Nannya, Yasuhito, additional, Uchimaru, Kaoru, additional, and Tsutsumi, Shinji, additional

Published
2022
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31. Durable Clinical Impacts and Mechanisms of Action and Resistance in EZH1/2-Targeting Epigenetic Therapy

Author

Yamagishi, Makoto, primary, Kuze, Yuta, additional, Nakashima, Makoto, additional, Kobayashi, Seiichiro, additional, Morishima, Satoko, additional, Kawamata, Toyotaka, additional, Makiyama, Junya, additional, Abe, Kazumi, additional, Imamura, Kiyomi, additional, Watanabe, Eri, additional, Tsuchiya, Kazumi, additional, Yasumatsu, Isao, additional, Takayama, Gensuke, additional, Ito, Kazumi, additional, Nannya, Yasuhito, additional, Tojo, Arinobu, additional, Watanabe, Toshiki, additional, Tsutsumi, Shinji, additional, Suzuki, Yutaka, additional, and Uchimaru, Kaoru, additional

Published
2022
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32. CD30 induces Reed‐Sternberg cell‐like morphology and chromosomal instability in classic Hodgkin lymphoma cell lines.

Author

Watanabe, Mariko, Hatsuse, Hiromi, Nagao, Kazuaki, Nakashima, Makoto, Uchimaru, Kaoru, Otsu, Makoto, Miyazaki, Koji, and Horie, Ryouichi

Abstract

Classic Hodgkin lymphoma (cHL) is characterized by multinucleated cells called Reed‐Sternberg (RS) cells and genetic complexity. Although CD30 also characterizes cHL cells, its biological roles are not fully understood. In this report, we examined the link between CD30 and these characteristics of cHL cells. CD30 stimulation increased multinucleated cells resembling RS cells. We found chromatin bridges, a cause of mitotic errors, among the nuclei of multinucleated cells. CD30 stimulation induced DNA double‐strand breaks (DSBs) and chromosomal imbalances. RNA sequencing showed significant changes in the gene expression by CD30 stimulation. We found that CD30 stimulation increased intracellular reactive oxygen species (ROS), which induced DSBs and multinucleated cells with chromatin bridges. The PI3K pathway was responsible for CD30‐mediated generation of multinucleated cells by ROS. These results suggest that CD30 involves generation of RS cell‐like multinucleated cells and chromosomal instability through induction of DSBs by ROS, which subsequently induces chromatin bridges and mitotic error. The results link CD30 not only to the morphological features of cHL cells, but also to the genetic complexity, both of which are characteristic of cHL cells. [ABSTRACT FROM AUTHOR]

Published
2023
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36. Prognostic Value of Ventricular‐Arterial Coupling After Transcatheter Aortic Valve Replacement on Midterm Clinical Outcomes

Author

Yokoyama, Hiroaki, primary, Yamanaka, Futoshi, additional, Shishido, Koki, additional, Ochiai, Tomoki, additional, Yokota, Shohei, additional, Moriyama, Noriaki, additional, Watanabe, Yusuke, additional, Shirai, Shinichi, additional, Tada, Norio, additional, Araki, Motoharu, additional, Yashima, Fumiaki, additional, Naganuma, Toru, additional, Ueno, Hiroshi, additional, Tabata, Minoru, additional, Mizutani, Kazuki, additional, Takagi, Kensuke, additional, Yamamoto, Masanori, additional, Saito, Shigeru, additional, Hayashida, Kentaro, additional, Tanaka, Makoto, additional, Tsuruta, Hikaru, additional, Hase, Hiromu, additional, Yoshijima, Nobuhiro, additional, Saito, Tetsuya, additional, Myojin, Sosuke, additional, Kobari, Yusuke, additional, Ryuzaki, Toshinobu, additional, Takahashi, Tatsuo, additional, Goto, Shinichi, additional, Imaeda, Shohei, additional, Konami, Yuta, additional, Sakata, Shingo, additional, Inohara, Taku, additional, Katsumata, Yoshinori, additional, Sago, Mitsuru, additional, Tsunaki, Tatsuya, additional, Adachi, Yuya, additional, Yamaguchi, Ryo, additional, Shimizu, Kazuki, additional, Koyama, Yutaka, additional, Shimura, Tetsuro, additional, Tsujimoto, Satoshi, additional, Kagase, Ai, additional, Kobayashi, Toshihiro, additional, Shibata, Kenichi, additional, Tokuda, Takahiro, additional, Sakakura, Tokuya, additional, Kawahata, Ryoutaku, additional, Nishio, Hiroto, additional, Hayashi, Masaomi, additional, Isotani, Akihiro, additional, Kawaguchi, Tomohiro, additional, Arai, Yoshio, additional, Taniguchi, Tomohiko, additional, Ishizu, Kenichi, additional, Fujioka, Shimpei, additional, Mori, Shintaro, additional, Morinaga, Takashi, additional, Fukunaga, Masato, additional, Tabata, Hiroyuki, additional, Kitano, Kazuki, additional, Nara, Yugo, additional, Hioki, Hirofumi, additional, Kataoka, Akihisa, additional, Kawashima, Hideyuki, additional, Nagura, Fukuko, additional, Nakashima, Makoto, additional, Yamamoto, Hirosada, additional, Yukimitsu, Nozomu, additional, Sasaki, Kazuya, additional, Takamura, Shintaro, additional, Katayama, Taiga, additional, Ito, Masaki, additional, Ishibashi, Ruri, additional, Nishikawa, Junichi, additional, Iseki, Yosei, additional, Nomura, Takahiro, additional, Tsuchida, Yasuyuki, additional, Kito, Kento, additional, Fujii, Misako, additional, Harada, Ayumi, additional, Koyano, Yasuki, additional, Mitomo, Satoru, additional, Onishi, Hirokazu, additional, Kawamoto, Hiroyoshi, additional, Yamawaki, Masahiro, additional, Honda, Yohsuke, additional, Makino, Kenji, additional, Nakano, Takahide, additional, Yamada, Chinatsu, additional, Iida, Yasunori, additional, Miyasaka, Masaki, additional, Enta, Yusuke, additional, Matsumoto, Takashi, additional, Nakashima, Masaki, additional, Munehisa, Yoshiko, additional, Inoue, Arata, additional, Ishii, Kazunori, additional, Nomura, Takehiro, additional, Saigan, Makoto, additional, Hirose, Suguru, additional, Mizuno, Shingo, additional, Yamabe, Tsuyoshi, additional, Hattori, Shigeru, additional, Yokoyama, Hiroaki, additional, Miyashita, Hirokazu, additional, Obunai, Kotaro, additional, Noguchi, Masahiko, additional, Kato, Nahoko, additional, Morimura, Hayato, additional, Ito, Joji, additional, Murahsi, Makio, additional, Amano, Hidewo, additional, Kotani, Shinsuke, additional, Azumi, Yuta, additional, Fukuda, Nobuyuki, additional, Sobajima, Mitsuo, additional, Onoda, Hiroshi, additional, Kuwahara, Hiroyuki, additional, Tanaka, Shuhei, additional, Ueno, Yohei, additional, Fukahara, Kazuaki, additional, Doi, Toshio, additional, Yokoyama, Shigeki, additional, Imamura, Teruhiko, additional, Ushijima, Ryuichi, additional, Oshima, Akira, additional, Hida, Yuki, additional, Nishida, Hiroaki, additional, Hashizume, Kenichi, additional, Ueno, Koji, additional, Ikebata, Koki, additional, Oono, Masatoshi, additional, Sudo, Kiwamu, additional, Mori, Takesi, additional, and Huruse, Erito, additional

Published
2021
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39. METHODOLOGY FOR MEMBRANOUS SEPTUM LENGTH EVALUATION TO PREDICT PERMANENT PACEMAKER FOLLOWING TRANSCATHETER AORTIC VALVE REPLACEMENT: AN EVIDENCE-BASED COMPARATIVE STUDY

Author

Nakashima, Makoto, primary, He, Yuxin, additional, Zhao, Zhengang, additional, Du, Run, additional, Querijero, Michael, additional, Staniloae, Cezar, additional, Ibrahim, Homam, additional, Tovar, Joseph, additional, Pushkar, Illya, additional, Williams, Mathew, additional, and Jilaihawi, Hasan, additional

Published
2021
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42. Additional file 2 of Establishment of a novel diagnostic test algorithm for human T-cell leukemia virus type 1 infection with line immunoassay replacement of western blotting: a collaborative study for performance evaluation of diagnostic assays in Japan

Author

Kazu Okuma, Kuramitsu, Madoka, Niwa, Toshihiro, Tomokuni Taniguchi, Masaki, Yumiko, Gohzoh Ueda, Matsumoto, Chieko, Sobata, Rieko, Sagara, Yasuko, Nakamura, Hitomi, Satake, Masahiro, Miura, Kiyonori, Fuchi, Naoki, Masuzaki, Hideaki, Okayama, Akihiko, Umeki, Kazumi, Yamano, Yoshihisa, Sato, Tomoo, Iwanaga, Masako, Uchimaru, Kaoru, Nakashima, Makoto, Atae Utsunomiya, Kubota, Ryuji, Ishitsuka, Kenji, Hasegawa, Hiroo, Sasaki, Daisuke, Ki-Ryang Koh, Taki, Mai, Kisato Nosaka, Ogata, Masao, Naruse, Isao, Kaneko, Noriaki, Okajima, Sara, Tezuka, Kenta, Ikebe, Emi, Sahoko Matsuoka, Itabashi, Kazuo, Saito, Shigeru, Watanabe, Toshiki, and Hamaguchi, Isao

Abstract

Additional file 2: Table S1. For performance (serological sensitivity) comparison between WB and LIA, 110 CLEIA-reactive, WB-indeterminate, and provirus-positive blood samples were collected and tested by LIA. CLEIA-specific antibody titers, the profiles of both WB and LIA blot patterns, the judgments by each test method, and the PVLs by PCR in all the blood samples used in this experiment are listed. NT: not tested, R: reactive, and I: indeterminate.

Published
2020
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43. Additional file 4 of Establishment of a novel diagnostic test algorithm for human T-cell leukemia virus type 1 infection with line immunoassay replacement of western blotting: a collaborative study for performance evaluation of diagnostic assays in Japan

Author

Kazu Okuma, Kuramitsu, Madoka, Niwa, Toshihiro, Tomokuni Taniguchi, Masaki, Yumiko, Gohzoh Ueda, Matsumoto, Chieko, Sobata, Rieko, Sagara, Yasuko, Nakamura, Hitomi, Satake, Masahiro, Miura, Kiyonori, Fuchi, Naoki, Masuzaki, Hideaki, Okayama, Akihiko, Umeki, Kazumi, Yamano, Yoshihisa, Sato, Tomoo, Iwanaga, Masako, Uchimaru, Kaoru, Nakashima, Makoto, Atae Utsunomiya, Kubota, Ryuji, Ishitsuka, Kenji, Hasegawa, Hiroo, Sasaki, Daisuke, Ki-Ryang Koh, Taki, Mai, Kisato Nosaka, Ogata, Masao, Naruse, Isao, Kaneko, Noriaki, Okajima, Sara, Tezuka, Kenta, Ikebe, Emi, Sahoko Matsuoka, Itabashi, Kazuo, Saito, Shigeru, Watanabe, Toshiki, and Hamaguchi, Isao

Abstract

Additional file 4. Diagnostic Guidelines for Human T-Cell Leukemia Virus Type 1 Infection in Japan, Version 2 (November 2019).

Published
2020
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44. Targeting Excessive EZH1 and EZH2 Activities for Abnormal Histone Methylation and Transcription Network in Malignant Lymphomas

Author

Yamagishi, Makoto, Hori, Makoto, Fujikawa, Dai, Ohsugi, Takeo, Honma, Daisuke, Adachi, Nobuaki, Katano, Harutaka, Hishima, Tsunekazu, Kobayashi, Seiichiro, Nakano, Kazumi, Nakashima, Makoto, Iwanaga, Masako, Utsunomiya, Atae, Tanaka, Yuetsu, Okada, Seiji, Tsukasaki, Kunihiro, Tobinai, Kensei, Araki, Kazushi, Watanabe, Toshiki, Uchimaru, Kaoru, Yamagishi, Makoto, Hori, Makoto, Fujikawa, Dai, Ohsugi, Takeo, Honma, Daisuke, Adachi, Nobuaki, Katano, Harutaka, Hishima, Tsunekazu, Kobayashi, Seiichiro, Nakano, Kazumi, Nakashima, Makoto, Iwanaga, Masako, Utsunomiya, Atae, Tanaka, Yuetsu, Okada, Seiji, Tsukasaki, Kunihiro, Tobinai, Kensei, Araki, Kazushi, Watanabe, Toshiki, and Uchimaru, Kaoru

Abstract

type:Article, Although global H3K27me3 reprogramming is a hallmark of cancer, no effective therapeutic strategy for H3K27me3-high malignancies harboring EZH2^ has yet been established. We explore epigenome and transcriptome in EZH2^ and EZH2^ aggressive lymphomas and show that mutual interference and compensatory function of co-expressed EZH1 and EZH2 rearrange their own genome-wide distribution, thereby establishing restricted chromatin and gene expression signatures. Direct comparison of leading compounds introduces potency and a mechanism of action of the EZH1/2 dual inhibitor (valemetostat). The synthetic lethality is observed in all lymphoma models and primary adult T cell leukemia-lymphoma (ATL) cells. Opposing actions of EZH1/2-polycomb and SWI/SNF complexes are required for facultative heterochromatin formation. Inactivation of chromatin-associated genes (ARID1A, SMARCA4/BRG1, SMARCB1/SNF5, KDM6A/UTX, BAP1, KMT2D/MLL2) and oncovirus infection (HTLV-1, EBV) trigger EZH1/2 perturbation and H3K27me3 deposition. Our study provides the mechanism-based rationale for chemical dual targeting of EZH1/2 in cancer epigenome.

Published
2020

45. Association between periodontal bacteria and degenerative aortic stenosis: a pilot study

Author

Kataoka, Akihisa, primary, Katagiri, Sayaka, additional, Kawashima, Hideyuki, additional, Nagura, Fukuko, additional, Nara, Yugo, additional, Hioki, Hirofumi, additional, Nakashima, Makoto, additional, Sasaki, Naoki, additional, Hatasa, Masahiro, additional, Maekawa, Shogo, additional, Ohsugi, Yujin, additional, Shiba, Takahiko, additional, Watanabe, Yusuke, additional, Shimokawa, Tomoki, additional, Iwata, Takanori, additional, and Kozuma, Ken, additional

Published
2021
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46. DYNAMIC CHANGES IN THE MITRAL ANNULUS IMPLICATIONS FOR SCREENING FOR TRANSCATHETER MITRAL VALVE REPLACEMENT

Author

Pushkar, Illya, primary, Nakashima, Makoto, additional, Tovar, Joseph, additional, Kalish, Chloe, additional, Vainrib, Alan, additional, Ibrahim, Homam, additional, Hisamoto, Kazuhiro, additional, Peter, Neuberger, additional, Latson, Larry, additional, Querijero, Michael, additional, Saric, Muhamed, additional, Williams, Mathew, additional, and Jilaihawi, Hasan, additional

Published
2020
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48. IMAGING EVALUATION FOR MITRAL LEAFLET MORPHOLOGY CORRELATION OF COMPUTED TOMOGRAPHY WITH TRANSESOPHAGEAL ECHOCARDIOGRAPHY

Author

Vainrib, Alan, primary, Jilaihawi, Hasan, additional, Nakashima, Makoto, additional, Paschke, Sonja, additional, Tovar, Joseph, additional, Staniloae, Cezar, additional, Ibrahim, Homam, additional, Querijero, Michael, additional, Hisamoto, Kazuhiro, additional, L, Larry Latson, additional, Gonzalez, Carlos, additional, Fuentes, Jorge, additional, Saric, Muhamed, additional, and Williams, Mathew, additional

Published
2020
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50. IS CORONARY ANGIOGRAPHY REQUIRED IN ALL PATIENTS UNDERGOING TAVR? UTILITY OF CT ANGIOGRAPHY FOR EVALUATING CORONARY ARTERY DISEASE IN PATIENTS WITH SEVERE AORTIC STENOSIS

Author

Yuxin He, Carlos Gonzalez-Lengua, Cezar Staniloae, Stephanie Gaudio, Nakashima Makoto, Michael Querijero, Jorge Fuentes, Mathew Williams, Peter J. Neuburger, Samantha Vidal, Hasan Jilaihawi, Joseph Tovar, and Homam Ibrahim

Subjects
Coronary angiography, medicine.medical_specialty, medicine.diagnostic_test, business.industry, medicine.disease, Coronary artery disease, Stenosis, Internal medicine, Angiography, medicine, Cardiology, In patient, Cardiology and Cardiovascular Medicine, business
Published
2021
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