240 results on '"Navarro, Ferran"'
Search Results
2. Titers of IgG and IgA against SARS-CoV-2 proteins and their association with symptoms in mild COVID-19 infection
- Author
-
Abril, Andrés G., Alejandre, Jose, Mariscal, Anais, Alserawan, Leticia, Rabella, Nuria, Roman, Eva, Lopez-Contreras, Joaquin, Navarro, Ferran, Serrano, Elena, Nomdedeu, Josep F., and Vidal, Silvia
- Published
- 2024
- Full Text
- View/download PDF
3. Comparing the in vitro efficacy of chlorhexidine and povidone-iodine in the prevention of post-surgical endophthalmitis
- Author
-
Batista, Celso Soares Pereira, Loscos-Giménez, Irene, Gámez, María, Altaba, Raul, de Miniac, Daniela, Martí, Neus, Bassaganyas, Francisca, Juanes, Elena, Rivera, Alba, and Navarro, Ferran
- Published
- 2024
- Full Text
- View/download PDF
4. Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes
- Author
-
Chen, Zhishan, Guo, Xingyi, Tao, Ran, Huyghe, Jeroen R., Law, Philip J., Fernandez-Rozadilla, Ceres, Ping, Jie, Jia, Guochong, Long, Jirong, Li, Chao, Shen, Quanhu, Xie, Yuhan, Timofeeva, Maria N., Thomas, Minta, Schmit, Stephanie L., Díez-Obrero, Virginia, Devall, Matthew, Moratalla-Navarro, Ferran, Fernandez-Tajes, Juan, Palles, Claire, Sherwood, Kitty, Briggs, Sarah E. W., Svinti, Victoria, Donnelly, Kevin, Farrington, Susan M., Blackmur, James, Vaughan-Shaw, Peter G., Shu, Xiao-Ou, Lu, Yingchang, Broderick, Peter, Studd, James, Harrison, Tabitha A., Conti, David V., Schumacher, Fredrick R., Melas, Marilena, Rennert, Gad, Obón-Santacana, Mireia, Martín-Sánchez, Vicente, Oh, Jae Hwan, Kim, Jeongseon, Jee, Sun Ha, Jung, Keum Ji, Kweon, Sun-Seog, Shin, Min-Ho, Shin, Aesun, Ahn, Yoon-Ok, Kim, Dong-Hyun, Oze, Isao, Wen, Wanqing, Matsuo, Keitaro, Matsuda, Koichi, Tanikawa, Chizu, Ren, Zefang, Gao, Yu-Tang, Jia, Wei-Hua, Hopper, John L., Jenkins, Mark A., Win, Aung Ko, Pai, Rish K., Figueiredo, Jane C., Haile, Robert W., Gallinger, Steven, Woods, Michael O., Newcomb, Polly A., Duggan, David, Cheadle, Jeremy P., Kaplan, Richard, Kerr, Rachel, Kerr, David, Kirac, Iva, Böhm, Jan, Mecklin, Jukka-Pekka, Jousilahti, Pekka, Knekt, Paul, Aaltonen, Lauri A., Rissanen, Harri, Pukkala, Eero, Eriksson, Johan G., Cajuso, Tatiana, Hänninen, Ulrika, Kondelin, Johanna, Palin, Kimmo, Tanskanen, Tomas, Renkonen-Sinisalo, Laura, Männistö, Satu, Albanes, Demetrius, Weinstein, Stephanie J., Ruiz-Narvaez, Edward, Palmer, Julie R., Buchanan, Daniel D., Platz, Elizabeth A., Visvanathan, Kala, Ulrich, Cornelia M., Siegel, Erin, Brezina, Stefanie, Gsur, Andrea, Campbell, Peter T., Chang-Claude, Jenny, Hoffmeister, Michael, Brenner, Hermann, Slattery, Martha L., Potter, John D., Tsilidis, Kostas K., Schulze, Matthias B., Gunter, Marc J., Murphy, Neil, Castells, Antoni, Castellví-Bel, Sergi, Moreira, Leticia, Arndt, Volker, Shcherbina, Anna, Bishop, D. Timothy, Giles, Graham G., Southey, Melissa C., Idos, Gregory E., McDonnell, Kevin J., Abu-Ful, Zomoroda, Greenson, Joel K., Shulman, Katerina, Lejbkowicz, Flavio, Offit, Kenneth, Su, Yu-Ru, Steinfelder, Robert, Keku, Temitope O., van Guelpen, Bethany, Hudson, Thomas J., Hampel, Heather, Pearlman, Rachel, Berndt, Sonja I., Hayes, Richard B., Martinez, Marie Elena, Thomas, Sushma S., Pharoah, Paul D. P., Larsson, Susanna C., Yen, Yun, Lenz, Heinz-Josef, White, Emily, Li, Li, Doheny, Kimberly F., Pugh, Elizabeth, Shelford, Tameka, Chan, Andrew T., Cruz-Correa, Marcia, Lindblom, Annika, Hunter, David J., Joshi, Amit D., Schafmayer, Clemens, Scacheri, Peter C., Kundaje, Anshul, Schoen, Robert E., Hampe, Jochen, Stadler, Zsofia K., Vodicka, Pavel, Vodickova, Ludmila, Vymetalkova, Veronika, Edlund, Christopher K., Gauderman, W. James, Shibata, David, Toland, Amanda, Markowitz, Sanford, Kim, Andre, Chanock, Stephen J., van Duijnhoven, Franzel, Feskens, Edith J. M., Sakoda, Lori C., Gago-Dominguez, Manuela, Wolk, Alicja, Pardini, Barbara, FitzGerald, Liesel M., Lee, Soo Chin, Ogino, Shuji, Bien, Stephanie A., Kooperberg, Charles, Li, Christopher I., Lin, Yi, Prentice, Ross, Qu, Conghui, Bézieau, Stéphane, Yamaji, Taiki, Sawada, Norie, Iwasaki, Motoki, Le Marchand, Loic, Wu, Anna H., Qu, Chenxu, McNeil, Caroline E., Coetzee, Gerhard, Hayward, Caroline, Deary, Ian J., Harris, Sarah E., Theodoratou, Evropi, Reid, Stuart, Walker, Marion, Ooi, Li Yin, Lau, Ken S., Zhao, Hongyu, Hsu, Li, Cai, Qiuyin, Dunlop, Malcolm G., Gruber, Stephen B., Houlston, Richard S., Moreno, Victor, Casey, Graham, Peters, Ulrike, Tomlinson, Ian, and Zheng, Wei
- Published
- 2024
- Full Text
- View/download PDF
5. Identification of intergenerational epigenetic inheritance by whole genome DNA methylation analysis in trios
- Author
-
Díez-Villanueva, Anna, Martín, Berta, Moratalla-Navarro, Ferran, Morón-Duran, Francisco D., Galván-Femenía, Iván, Obón-Santacana, Mireia, Carreras, Anna, de Cid, Rafael, Peinado, Miguel A., and Moreno, Victor
- Published
- 2023
- Full Text
- View/download PDF
6. Pseudomonas aeruginosa antibiotic susceptibility profiles, genomic epidemiology and resistance mechanisms: a nation-wide five-year time lapse analysis
- Author
-
Galán-Sánchez, Fátima, Gracia-Ahufinger, Irene, Martínez-Martínez, Luis, Liébana-Martos, Carmen, Roldán, Carolina, Sánchez-Calvo, Juan Manuel, Clavijo, Encarnación, Mora-Navas, Laura, Aznar, Javier, Lepe, José Antonio, Rodríguez-Villodres, Ángel, Recacha, Esther, Casas-Círia, Francisco Javier, Martínez-Rubio, Carmen, Sempere-Alcocer, Marco Antonio, Martín-Hita, Lina, Seral, Cristina, López-Calleja, Ana Isabel, Aspiroz, Carmen, Monforte, Marisa, Iglesia-Martínez, Pedro de la, Jimenez-Guerra, Gemma, Riera-Pérez, Elena, Collado, Carmen, Gallegos, Carmen, Mulet, Xavier, Fernández-Muñoz, Almudena, Sastre-Femenía, Miquel Àngel, Gomis-Font, María Antonia, Zamorano, Laura, Oliver, Antonio, Siller-Ruiz, María, Calvo, Jorge, Quesada, Dolores, Wang, Jun Hao, Pitart, Cristina, Marco, Francesc, Prim, Nuria, Horcajada, Juan Pablo, Padilla, Eduardo, Del Barrio-Tofiño, Ester, Viñado-Pérez, Belen, Larrosa, Nieves, Tubau, Fe, Capilla, Silvia, Casabella, Antonio, Pérez-Moreno, Mar Olga, Padilla, Emma, Ballestero, Mónica, Rivera, Alba, Navarro, Ferrán, Gómez-Bertomeu, Fréderic, Pardo-Granell, Sergio, Picó-Plana, Ester, Guerrero, Dolores, Sarvisé-Buil, Carolina, Belles-Belles, Alba, Fernández-Esgueva, Marta, Ortega-Lafont, María del Pilar, García, Inmaculada, Arenal-Andrés, Noelia, Hernando-Real, Susana, Ibáñez, Rosario, Martínez, Jesús, Becerra, Federico, Aldea-Mansilla, Carmen, Alaoui-Sosse, Asmaa, González, José Carlos, Guzman-Puche, Julia, Blázquez-Andrada, Miguel Ángel, Martínez-Ramírez, Nora Mariela, Beteta, Alicia, Gomila-Sard, Bárbara, Almaraz, Salvador Giner, Garduño, Eugenio, Juiz-González, Pedro Miguel, Arca-Suárez, Jorge, Alba, Javier, Alonso, Pilar, Rodríguez, Ana Isabel, Paz-Vidal, María Isabel, García-Campello, Marta, Camacho, Pablo, Pallarés, María de los Ángeles, Pérez del Molino, María Luisa, Coira, Amparo, Barbeito, Gema, Rincón, Anniris, Vasallo-Vidal, Francisco José, Alonso-Acero, Laura, Iglesias-Llorente, Laura, Bordes-Benites, Ana, Florén-Zabala, Laura, Azcona, José Manuel, Alonso, Carla Andrea, Sáenz, Yolanda, Lamata-Subero, Marta, Molina, David, González-Torralba, Ana, Villa, Jennifer, Viedma, Esther, Cercenado, Emilia, Alarcón, Teresa, Vargas, Paula, Díez, María, Cantón, Rafael, Ruiz, Patricia, Sánchez-Romero, María Isabel, Pérez-García, Felipe, Yagüe-Guirao, Genoveva, Oteiza, Amaia Concepción, Leiva, José, Portillo, María Eugenia, Canut-Blasco, Andrés, Vidal, Matxalen, Alonso, Iker, Zuriarrain, Maider, Barrios-Andrés, José Luis, Sastre-Femenia, Miquel Àngel, Taltavull, Biel, López-Causapé, Carla, and Oteo-Iglesias, Jesús
- Published
- 2023
- Full Text
- View/download PDF
7. Author Correction: COLONOMICS - integrative omics data of one hundred paired normal-tumoral samples from colon cancer patients
- Author
-
Díez-Villanueva, Anna, Sanz-Pamplona, Rebeca, Solé, Xavier, Cordero, David, Crous-Bou, Marta, Guinó, Elisabet, Lopez-Doriga, Adriana, Berenguer, Antoni, Aussó, Susanna, Paré-Brunet, Laia, Obón-Santacana, Mireia, Moratalla-Navarro, Ferran, Salazar, Ramon, Sanjuan, Xavier, Santos, Cristina, Biondo, Sebastiano, Diez-Obrero, Virginia, Garcia-Serrano, Ainhoa, Alonso, Maria Henar, Carreras-Torres, Robert, Closa, Adria, and Moreno, Víctor
- Published
- 2022
- Full Text
- View/download PDF
8. COLONOMICS - integrative omics data of one hundred paired normal-tumoral samples from colon cancer patients
- Author
-
Díez-Villanueva, Anna, Sanz-Pamplona, Rebeca, Solé, Xavier, Cordero, David, Crous-Bou, Marta, Guinó, Elisabet, Lopez-Doriga, Adriana, Berenguer, Antoni, Aussó, Susanna, Paré-Brunet, Laia, Obón-Santacana, Mireia, Moratalla-Navarro, Ferran, Salazar, Ramon, Sanjuan, Xavier, Santos, Cristina, Biondo, Sebastiano, Diez-Obrero, Virginia, Garcia-Serrano, Ainhoa, Alonso, Maria Henar, Carreras-Torres, Robert, Closa, Adria, and Moreno, Víctor
- Published
- 2022
- Full Text
- View/download PDF
9. Genetic Effects on Transcriptome Profiles in Colon Epithelium Provide Functional Insights for Genetic Risk Loci
- Author
-
Díez-Obrero, Virginia, Dampier, Christopher H., Moratalla-Navarro, Ferran, Devall, Matthew, Plummer, Sarah J., Díez-Villanueva, Anna, Peters, Ulrike, Bien, Stephanie, Huyghe, Jeroen R., Kundaje, Anshul, Ibáñez-Sanz, Gemma, Guinó, Elisabeth, Obón-Santacana, Mireia, Carreras-Torres, Robert, Casey, Graham, and Moreno, Víctor
- Published
- 2021
- Full Text
- View/download PDF
10. Heterozygote advantage at HLA class I and II loci and reduced risk of colorectal cancer
- Author
-
Tsai, Ya-Yu, primary, Qu, Chenxu, additional, Bonner, Joseph D., additional, Sanz-Pamplona, Rebeca, additional, Lindsey, Sidney S., additional, Melas, Marilena, additional, McDonnell, Kevin J., additional, Idos, Gregory E., additional, Walker, Christopher P., additional, Tsang, Kevin K., additional, Da Silva, Diane M., additional, Moratalla-Navarro, Ferran, additional, Maoz, Asaf, additional, Rennert, Hedy S., additional, Kast, W. Martin, additional, Greenson, Joel K., additional, Moreno, Victor, additional, Rennert, Gad, additional, Gruber, Stephen B., additional, and Schmit, Stephanie L., additional
- Published
- 2023
- Full Text
- View/download PDF
11. Identification of a Twelve-microRNA Signature with Prognostic Value in Stage II Microsatellite Stable Colon Cancer
- Author
-
Moratalla-Navarro, Ferran, primary, Díez-Villanueva, Anna, additional, Garcia-Serrano, Ainhoa, additional, Closa, Adrià, additional, Cordero, David, additional, Solé, Xavier, additional, Guinó, Elisabet, additional, Sanz-Pamplona, Rebeca, additional, Sanjuan, Xavier, additional, Santos, Cristina, additional, Biondo, Sebastiano, additional, Salazar, Ramón, additional, and Moreno, Victor, additional
- Published
- 2023
- Full Text
- View/download PDF
12. In vitro and in vivo efficacy of combinations of colistin and different endolysins against clinical strains of multi-drug resistant pathogens
- Author
-
Blasco, Lucia, Ambroa, Anton, Trastoy, Rocio, Bleriot, Ines, Moscoso, Miriam, Fernández-Garcia, Laura, Perez-Nadales, Elena, Fernández-Cuenca, Felipe, Torre-Cisneros, Julian, Oteo-Iglesias, Jesus, Oliver, Antonio, Canton, Rafael, Kidd, Tim, Navarro, Ferran, Miró, Elisenda, Pascual, Alvaro, Bou, German, Martínez-Martínez, Luis, and Tomas, Maria
- Published
- 2020
- Full Text
- View/download PDF
13. Unravelling the consequences of the bacteriophages in human samples
- Author
-
Blanco-Picazo, Pedro, Fernández-Orth, Dietmar, Brown-Jaque, Maryury, Miró, Elisenda, Espinal, Paula, Rodríguez-Rubio, Lorena, Muniesa, Maite, and Navarro, Ferran
- Published
- 2020
- Full Text
- View/download PDF
14. CARB-ES-19 Multicenter Study of Carbapenemase-Producing Klebsiella pneumoniae and Escherichia coli From All Spanish Provinces Reveals Interregional Spread of High-Risk Clones Such as ST307/OXA-48 and ST512/KPC-3.
- Author
-
Cañada-García, Javier E., Moure, Zaira, Sola-Campoy, Pedro J., Delgado-Valverde, Mercedes, Cano, María E., Gijón, Desirèe, González, Mónica, Gracia-Ahufinger, Irene, Larrosa, Nieves, Mulet, Xavier, Pitart, Cristina, Rivera, Alba, Bou, Germán, Calvo, Jorge, Cantón, Rafael, González-López, Juan José, Martínez-Martínez, Luis, Navarro, Ferran, Oliver, Antonio, and Palacios-Baena, Zaira R.
- Subjects
KLEBSIELLA pneumoniae ,MOLECULAR cloning ,ESCHERICHIA coli ,MICROBIAL sensitivity tests ,SINGLE nucleotide polymorphisms ,NUCLEOTIDE sequencing - Abstract
Objectives: CARB-ES-19 is a comprehensive, multicenter, nationwide study integrating whole-genome sequencing (WGS) in the surveillance of carbapenemase-producing K. pneumoniae (CP-Kpn) and E. coli (CP-Eco) to determine their incidence, geographical distribution, phylogeny, and resistance mechanisms in Spain. Methods: In total, 71 hospitals, representing all 50 Spanish provinces, collected the first 10 isolates per hospital (February to May 2019); CPE isolates were first identified according to EUCAST (meropenem MIC > 0.12 mg/L with immunochromatography, colorimetric tests, carbapenem inactivation, or carbapenem hydrolysis with MALDI-TOF). Prevalence and incidence were calculated according to population denominators. Antibiotic susceptibility testing was performed using the microdilution method (EUCAST). All 403 isolates collected were sequenced for high-resolution single-nucleotide polymorphism (SNP) typing, core genome multilocus sequence typing (cgMLST), and resistome analysis. Results: In total, 377 (93.5%) CP-Kpn and 26 (6.5%) CP-Eco isolates were collected from 62 (87.3%) hospitals in 46 (92%) provinces. CP-Kpn was more prevalent in the blood (5.8%, 50/853) than in the urine (1.4%, 201/14,464). The cumulative incidence for both CP-Kpn and CP-Eco was 0.05 per 100 admitted patients. The main carbapenemase genes identified in CP-Kpn were blaOXA−48 (263/377), blaKPC−3 (62/377), blaVIM−1 (28/377), and blaNDM−1 (12/377). All isolates were susceptible to at least two antibiotics. Interregional dissemination of eight high-risk CP-Kpn clones was detected, mainly ST307/OXA-48 (16.4%), ST11/OXA-48 (16.4%), and ST512-ST258/KPC (13.8%). ST512/KPC and ST15/OXA-48 were the most frequent bacteremia-causative clones. The average number of acquired resistance genes was higher in CP-Kpn (7.9) than in CP-Eco (5.5). Conclusion: This study serves as a first step toward WGS integration in the surveillance of carbapenemase-producing Enterobacterales in Spain. We detected important epidemiological changes, including increased CP-Kpn and CP-Eco prevalence and incidence compared to previous studies, wide interregional dissemination, and increased dissemination of high-risk clones, such as ST307/OXA-48 and ST512/KPC-3. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
15. Heterozygote advantage at HLA class I and II loci and reduced risk of colorectal cancer.
- Author
-
Ya-Yu Tsai, Chenxu Qu, Bonner, Joseph D., Sanz-Pamplona, Rebeca, Lindsey, Sidney S., Melas, Marilena, McDonnell, Kevin J., Idos, Gregory E., Walker, Christopher P., Tsang, Kevin K., Da Silva, Diane M., Moratalla-Navarro, Ferran, Maoz, Asaf, Rennert, Hedy S., Kast, W. Martin, Greenson, Joel K., Moreno, Victor, Rennert, Gad, Gruber, Stephen B., and Schmit, Stephanie L.
- Subjects
COLORECTAL cancer ,LOCUS (Genetics) ,DISEASE risk factors ,HLA histocompatibility antigens ,T cell receptors ,HEREDITARY nonpolyposis colorectal cancer - Abstract
Objective: Reduced diversity at Human Leukocyte Antigen (HLA) loci may adversely affect the host’s ability to recognize tumor neoantigens and subsequently increase disease burden. We hypothesized that increased heterozygosity at HLA loci is associated with a reduced risk of developing colorectal cancer (CRC). Methods: We imputed HLA class I and II four-digit alleles using genotype data from a population-based study of 5,406 cases and 4,635 controls from the Molecular Epidemiology of Colorectal Cancer Study (MECC). Heterozygosity at each HLA locus and the number of heterozygous genotypes at HLA class -I (A, B, and C) and HLA class -II loci (DQB1, DRB1, and DPB1) were quantified. Logistic regression analysis was used to estimate the risk of CRC associated with HLA heterozygosity. Individuals with homozygous genotypes for all loci served as the reference category, and the analyses were adjusted for sex, age, genotyping platform, and ancestry. Further, we investigated associations between HLA diversity and tumor-associated T cell repertoire features, as measured by tumor infiltrating lymphocytes (TILs; N=2,839) and immunosequencing (N=2,357). Results: Individuals with all heterozygous genotypes at all three class I genes had a reduced odds of CRC (OR: 0.74; 95% CI: 0.56-0.97, p= 0.031). A similar association was observed for class II loci, with an OR of 0.75 (95% CI: 0.60-0.95, p= 0.016). For class-I and class-II combined, individuals with all heterozygous genotypes had significantly lower odds of developing CRC (OR: 0.66, 95% CI: 0.49-0.87, p= 0.004) than those with 0 or one heterozygous genotype. HLA class I and/or II diversity was associated with higher T cell receptor (TCR) abundance and lower TCR clonality, but results were not statistically significant. Conclusion: Our findings support a heterozygote advantage for the HLA class-I and -II loci, indicating an important role for HLA genetic variability in the etiology of CRC. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
16. Meta-Analysis and Validation of a Colorectal Cancer Risk Prediction Model Using Deep Sequenced Fecal Metagenomes
- Author
-
Obón-Santacana, Mireia, primary, Mas-Lloret, Joan, additional, Bars-Cortina, David, additional, Criado-Mesas, Lourdes, additional, Carreras-Torres, Robert, additional, Díez-Villanueva, Anna, additional, Moratalla-Navarro, Ferran, additional, Guinó, Elisabet, additional, Ibáñez-Sanz, Gemma, additional, Rodríguez-Alonso, Lorena, additional, Mulet-Margalef, Núria, additional, Mata, Alfredo, additional, García-Rodríguez, Ana, additional, Duell, Eric J., additional, Pimenoff, Ville Nikolai, additional, and Moreno, Victor, additional
- Published
- 2022
- Full Text
- View/download PDF
17. Crisis económica y patología infecciosa. Informe SESPAS 2014
- Author
-
Llácer, Alicia, Fernández-Cuenca, Rafael, and Martínez-Navarro, Ferrán
- Published
- 2014
- Full Text
- View/download PDF
18. CARB-ES-19 Multicenter Study of Carbapenemase-Producing Klebsiella pneumoniae and Escherichia coli From All Spanish Provinces Reveals Interregional Spread of High-Risk Clones Such as ST307/OXA-48 and ST512/KPC-3
- Author
-
Cañada García, Javier E., Moure, Zaira, Sola Campoy, Pedro J., Delgado Valverde, Mercedes, Cano, María E., Gijón, Desirèe, González, Mónica, Gracia Ahufinger, Irene, Larrosa, Nieves, Mulet, Xavier, Pitart, Cristina, Rivera, Alba, Bou, Germán, Calvo, Jorge, Cantón, Rafael, González-López, Juan José, Martínez-Martínez, Luis, Navarro, Ferran, Oliver, Antonio, Palacios Baena, Zaira R., Pascual, Alvaro, Ruiz Carrascoso, Guillermo, Vila Estapé, Jordi, Aracil, Belén, Pérez-Vázquez, María, Oteo Iglesias, Jesús, GEMARA/GEIRAS-SEIMC/REIPI CARB-ES-19 Study Group, Instituto de Salud Carlos III, Red Española de Investigación en Patología Infecciosa, European Commission, Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (España), Universidad de Sevilla. Departamento de Microbiología, Universidad de Sevilla. CTS210: Resistencia a antimicrobianos., Ministerio de Economía y Competitividad (MINECO). España, Universidad de Cantabria, Institut Català de la Salut, [Cañada-García JE, Moure Z, Sola-Campoy PJ] Laboratorio de Referencia e Investigación en Resistencia a Antibióticos e Infecciones Relacionadas con la Asistencia Sanitaria, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain. [Delgado-Valverde M] Unidad de Enfermedades Infecciosas y Microbiología, Hospital Universitario Virgen Macarena, Instituto de Biomedicina de Sevilla (Hospital Universitario Virgen Macarena/CSIC/Universidad de Sevilla), Seville, Spain. CIBER de Enfermedades Infecciosas (CIBERINFEC), REIPI, Instituto de Salud Carlos III, Madrid, Spain. [Cano ME] Servicio de Microbiología, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain. [Gijón D] CIBER de Enfermedades Infecciosas (CIBERINFEC), REIPI, Instituto de Salud Carlos III, Madrid, Spain. Servicio de Microbiología, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain. [Larrosa N, González-López JJ] CIBER de Enfermedades Infecciosas (CIBERINFEC), REIPI, Instituto de Salud Carlos III, Madrid, Spain. Servei de Microbiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Departament de Genètica i Microbiologia, Universitat Autònoma de Barcelona, Bellaterra, Spain, Vall d'Hebron Barcelona Hospital Campus, Plan Nacional de I+D+i (España), Ministerio de Economía y Competitividad (España), Red de Investigación Cooperativa en Investigación en Patología Infecciosa (España), Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF), Centro de Investigación Biomédica en Red - CIBERINFEC (Enfermedades Infecciosas), and Unión Europea
- Subjects
Microbiology (medical) ,Enzimologia ,Human genome ,Bacteria::bacterias gramnegativas::bacilos gramnegativos anaerobios facultativos::Enterobacteriaceae::Escherichia::Escherichia coli [ORGANISMOS] ,acciones y usos químicos::acciones farmacológicas::usos terapéuticos::antiinfecciosos::antibacterianos [COMPUESTOS QUÍMICOS Y DROGAS] ,Otros calificadores::Otros calificadores::Otros calificadores::/enzimología [Otros calificadores] ,Carbapenemases ,Genoma humà ,Microbiology ,Enterobacteriàcies ,Klebsiella pneumoniae ,Bacteria::Gram-Negative Bacteria::Gram-Negative Facultatively Anaerobic Rods::Enterobacteriaceae::Escherichia::Escherichia coli [ORGANISMS] ,Escheríchia coli ,Bacteria::Gram-Negative Bacteria::Gram-Negative Facultatively Anaerobic Rods::Enterobacteriaceae::Klebsiella::Klebsiella pneumoniae [ORGANISMS] ,Enterobacteriaceae ,Whole genome sequencing ,Bacteria::bacterias gramnegativas::bacilos gramnegativos anaerobios facultativos::Enterobacteriaceae::Klebsiella::Klebsiella pneumoniae [ORGANISMOS] ,Escherichia coli ,Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents::Anti-Bacterial Agents [CHEMICALS AND DRUGS] ,Antibiòtics betalactàmics ,Medicaments antibacterians ,CARB-ES-19 study ,Other subheadings::Other subheadings::Other subheadings::/enzymology [Other subheadings] ,High-risk clones ,Beta lactam antibiotics - Abstract
CARB-ES-19 is a comprehensive, multicenter, nationwide study integrating whole-genome sequencing (WGS) in the surveillance of carbapenemase-producing K. pneumoniae (CP-Kpn) and E. coli (CP-Eco) to determine their incidence, geographical distribution, phylogeny, and resistance mechanisms in Spain., This research was supported by grants from the Instituto de Salud Carlos III (numbers PI18CIII/00030 and PI21CIII/00039). It was also supported by Plan Nacional de I + D + i 2013–2016, Instituto de Salud Carlos III, Subdirección General de Redes y Centros de Investigación Cooperativa, Ministerio de Economía y Competitividad, Spanish Network for Research in Infectious Diseases (grants RD16CIII/0004/0002, RD16/0016/0001, RD16/0016/0003, RD16/0016/0004, RD16/0016/0006, RD16/0016/0007, RD16/0016/0008, RD16/0016/0010, and RD16/0016/0011). Cofinanced by the European Development Regional Fund “A way to achieve Europe,” Operative Program Intelligent Growth 2014–2020. CIBER – Consorcio Centro de Investigación Biomédica en Red (CB21/13/00095, CB21/13/00012, CB21/13/00049, CB21/13/00054, CB21/13/00055, CB21/13/00068, CB21/13/00081, CB21/13/00084, and CB21/13/00099) (CIBERINFEC) and Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación and Unión Europea – NextGenerationEU also supported this work.
- Published
- 2022
19. Evaluating the Potential of Polygenic Risk Score to Improve Colorectal Cancer Screening
- Author
-
Arnau-Collell, Coral, primary, Díez-Villanueva, Anna, additional, Bellosillo, Beatriz, additional, Augé, Josep M., additional, Muñoz, Jenifer, additional, Guinó, Elisabet, additional, Moreira, Leticia, additional, Serradesanferm, Anna, additional, Pozo, Àngels, additional, Torà-Rocamora, Isabel, additional, Bonjoch, Laia, additional, Ibañez-Sanz, Gemma, additional, Obon-Santacana, Mireia, additional, Moratalla-Navarro, Ferran, additional, Sanz-Pamplona, Rebeca, additional, Márquez Márquez, Carmen, additional, Rueda Miret, Rebeca, additional, Pérez Berbegal, Rocio, additional, Piquer Velasco, Gabriel, additional, Hernández Rodríguez, Cristina, additional, Grau, Jaume, additional, Castells, Antoni, additional, Borràs, Josep M., additional, Bessa, Xavier, additional, Moreno, Victor, additional, and Castellví-Bel, Sergi, additional
- Published
- 2022
- Full Text
- View/download PDF
20. Evaluating the Potential of Polygenic Risk Score to Improve Colorectal Cancer Screening
- Author
-
Arnau Collell, Coral, Díez Villanueva, Anna, Bellosillo Paricio, Beatriz, Augé, Josep M., Muñoz, Jenifer, Guinó, Elisabet, Moreira, Leticia, Serradesanferm, Anna, Pozo, Àngels, Torà Rocamora, Isabel, Bonjoch, Laia, Ibañez Sanz, Gemma, Obon Santacana, Mireia, Moratalla Navarro, Ferran, Sanz Pamplona, Rebeca, Márquez Márquez, Carmen, Rueda Miret, Rebeca, Pérez Berbegal, Rocio, Piquer Velasco, Gabriel, Hernández Rodríguez, Cristina, Grau, Jaume, Castells, Antoni, Borràs, Josep Maria, Bessa i Caserras, Xavier, Moreno, Víctor, Castellví Bel, Sergi, and CRIPREV consortium
- Subjects
Male ,Multifactorial Inheritance ,Factors de risc en les malalties ,Medical screening ,Risk factors in diseases ,Epidemiology ,Colonoscopy ,Colorectal cancer ,Còlon--Càncer ,Cribratge ,Oncology ,Càncer colorectal ,Risk Factors ,Occult Blood ,Marcadors bioquímics ,Mortalitat ,Humans ,Mass Screening ,Female ,Colorectal Neoplasms ,Early Detection of Cancer - Abstract
Background: Colorectal cancer has high incidence and associated mortality worldwide. Screening programs are recommended for men and women over 50. Intermediate screens such as fecal immunochemical testing (FIT) select patients for colonoscopy with suboptimal sensitivity. Additional biomarkers could improve the current scenario. Methods: We included 2,893 individuals with a positive FIT test. They were classified as cases when a high-risk lesion for colorectal cancer was detected after colonoscopy, whereas the control group comprised individuals with low-risk or no lesions. 65 colorectal cancer risk genetic variants were genotyped. Polygenic risk score (PRS) and additive models for risk prediction incorporating sex, age, FIT value, and PRS were generated. Results: Risk score was higher in cases compared with controls [per allele OR = 1.04; 95% confidence interval (CI), 1.02–1.06; P < 0.0001]. A 2-fold increase in colorectal cancer risk was observed for subjects in the highest decile of risk alleles (≥65), compared with those in the first decile (≤54; OR = 2.22; 95% CI, 1.59–3.12; P < 0.0001). The model combining sex, age, FIT value, and PRS reached the highest accuracy for identifying patients with a high-risk lesion [cross-validated area under the ROC curve (AUROC): 0.64; 95% CI, 0.62–0.66]. Conclusions: This is the first investigation analyzing PRS in a two-step colorectal cancer screening program. PRS could improve current colorectal cancer screening, most likely for higher at-risk subgroups. However, its capacity is limited to predict colorectal cancer risk status and should be complemented by additional biomarkers. Impact: PRS has capacity for risk stratification of colorectal cancer suggesting its potential for optimizing screening strategies alongside with other biomarkers.
- Published
- 2022
21. A New Variant of the aadE-sat4-aphA-3 Gene Cluster Found in a Conjugative Plasmid from a MDR Campylobacter jejuni Isolate
- Author
-
Guirado, Pedro, primary, Miró, Elisenda, additional, Iglesias-Torrens, Yaidelis, additional, Navarro, Ferran, additional, Campoy, Susana, additional, Alioto, Tyler Scott, additional, Gómez-Garrido, Jessica, additional, Madrid, Cristina, additional, and Balsalobre, Carlos, additional
- Published
- 2022
- Full Text
- View/download PDF
22. Prevalence and seasonality of viral respiratory infections in a temperate climate region: A 24‐year study (1997–2020)
- Author
-
García‐Arroyo, Laura, primary, Prim, Núria, additional, Del Cuerpo, Marga, additional, Marín, Pilar, additional, Roig, Maria Carme, additional, Esteban, Mnontserrat, additional, Labeaga, Rosa, additional, Martí, Neus, additional, Berengua, Carla, additional, Gich, Ignasi, additional, Navarro, Ferran, additional, and Rabella, Núria, additional
- Published
- 2022
- Full Text
- View/download PDF
23. Epidemiological characteristics and outcomes of COVID-19 cases: mortality inequalities by socio-economic status, Barcelona, Spain, 24 February to 4 May 2020
- Author
-
Politi, Julieta, Martín-Sánchez, Mario, Mercuriali, Lilas, Borras-Bermejo, Blanca, Lopez-Contreras, Joaquín, Vilella, Anna, Villar, Judit, Orcau, Angels, de Olalla, Patricia Garcia, Rius, Cristina, de Andres, Anna, Alamo-Junquera, Dolores, Gallego, Carmen, G Abiétar, Daniel, Guillaumes, Montse, Millet, Joan P, Molinero, Emilia, Pérez León, Daniela, Rodríguez, Raquel, Ros, Miriam, Antón, Andrés, Martínez-Gómez, Xavier, Pumarola, Tomás, Campins, Magda, Pomar, Virginia, Navarro, Ferran, Puig, Teresa, Blazquez, Marta, Soriano, Inmaculada, Barón, Lourdes, Marín, Clara, de la Torre, Laura, Castells, Xavier, Posso, Margarita, Horcajada, Juan P, Vàrez, Maria A, Sentís, Laia, Gómez, Miquel, Invernon, Leonor, Padilla, Eduardo, Karaim, Mara, Bordon, Noel, Fatjò, Francesc, Berbel, Cristina, González-Nieto, Isabel, González, José L, Pelegrín, Iván, Bargalló, Eva, Salas, Antoni, Planes, Maria C, García, Gloria, de Mendoza, Diego, Tortajada, Sònia, Juan, Natàlia, Casabon, Jordi, Institut Català de la Salut, [Politi J, Martín-Sánchez M] Epidemiology Service, Public Health Agency of Barcelona (PHAB), Barcelona, Spain. Preventive Medicine and Public Health Training Unit, PSMar-UPF-PHAB (Parc de Salut Mar - Pompeu Fabra University - Public Health Agency of Barcelona), Barcelona, Spain. [Mercuriali L] Epidemiology Service, Public Health Agency of Barcelona (PHAB), Barcelona, Spain. [Borras-Bermejo B] Servei de Medicina Preventiva i Epidemiologia, Vall d'Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Lopez-Contreras J] Infectious Diseases-Internal Medicine, Hospital de Sant Pau-Universitat Autònoma de Barcelona, Bellaterra, Spain. [Vilella A] Preventive Medicine and Epidemiology Department, Hospital Clínic, Barcelona, Spain, and Vall d'Hebron Barcelona Hospital Campus
- Subjects
Male ,Epidemiology ,Other subheadings::Other subheadings::/epidemiology [Other subheadings] ,01 natural sciences ,Estudios Poblacionales en Salud Pública::estadísticas vitales::tasas, razones y proporciones::mortalidad [SALUD PÚBLICA] ,Estudios Poblacionales en Salud Pública::Población::Características de la Población::factores socioeconómicos [SALUD PÚBLICA] ,0302 clinical medicine ,Interquartile range ,virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus [ENFERMEDADES] ,Economic Status ,Medicine ,030212 general & internal medicine ,Population Studies in Public Health::Vital Statistics::Rates, Ratios and Proportions::Mortality [PUBLIC HEALTH] ,Health inequalities ,education.field_of_study ,Surveillance ,Incidence ,Mortality rate ,Incidence (epidemiology) ,Otros calificadores::Otros calificadores::/epidemiología [Otros calificadores] ,Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections [DISEASES] ,Population Studies in Public Health::Population::Population Characteristics::Socioeconomic Factors [PUBLIC HEALTH] ,Middle Aged ,Quartile ,surveillance ,Female ,Barcelona ,medicine.medical_specialty ,socio-economic status ,Socio-economic status ,Population ,COVID-19 (Malaltia) - Epidemiologia - Barcelona (Catalunya) ,03 medical and health sciences ,Virology ,Mortalitat ,Humans ,Mortality ,0101 mathematics ,education ,Desigualtat social ,SARS-CoV-2 ,business.industry ,Research ,010102 general mathematics ,Public Health, Environmental and Occupational Health ,COVID-19 ,health inequalities ,Odds ratio ,mortality ,Confidence interval ,Socioeconomic Factors ,Spain ,business ,Demography - Abstract
Background Population-based studies characterising outcomes of COVID-19 in European settings are limited, and effects of socio-economic status (SES) on outcomes have not been widely investigated. Aim We describe the epidemiological characteristics of COVID-19 cases, highlighting incidence and mortality rate differences across SES during the first wave in Barcelona, Catalonia, Spain. Methods This population-based study reports individual-level data of laboratory-confirmed COVID-19 cases diagnosed from 24 February to 4 May 2020, notified to the Public Health Agency of Barcelona and followed until 15 June 2020. We analysed end-of-study vital status and the effects of chronic conditions on mortality using logistic regression. Geocoded addresses were linked to basic health area SES data, estimated using the composed socio-economic index. We estimated age-standardised incidence, hospitalisation, and mortality rates by SES. Results Of 15,554 COVID-19-confirmed cases, the majority were women (n = 9,028; 58%), median age was 63 years (interquartile range: 46–83), 8,046 (54%) required hospitalisation, and 2,287 (15%) cases died. Prevalence of chronic conditions varied across SES, and multiple chronic conditions increased risk of death (≥ 3, adjusted odds ratio: 2.3). Age-standardised rates (incidence, hospitalisation, mortality) were highest in the most deprived SES quartile (incidence: 1,011 (95% confidence interval (CI): 975–1,047); hospitalisation: 619 (95% CI: 591–648); mortality: 150 (95% CI: 136–165)) and lowest in the most affluent (incidence: 784 (95% CI: 759–809); hospitalisation: 400 (95% CI: 382–418); mortality: 121 (95% CI: 112–131)). Conclusions COVID-19 outcomes varied markedly across SES, underscoring the need to implement effective preventive strategies for vulnerable populations.
- Published
- 2021
24. Novel insights into the molecular mechanisms underlying risk of colorectal cancer from smoking and red/processed meat carcinogens by modeling exposure in normal colon organoids
- Author
-
Devall, Matthew, primary, Dampier, Christopher H., additional, Eaton, Stephen, additional, Ali, Mourad W., additional, Díez-Obrero, Virginia, additional, Moratalla-Navarro, Ferran, additional, Bryant, Jennifer, additional, Jennelle, Lucas T., additional, Moreno, Victor, additional, Powell, Steven M., additional, Peters, Ulrike, additional, and Casey, Graham, additional
- Published
- 2021
- Full Text
- View/download PDF
25. The first wave of the COVID-19 epidemic in Spain was associated with early introductions and fast spread of a dominating genetic variant
- Author
-
López, Mariana G., Chiner-Oms, Álvaro, García de Viedma, Darío, Ruiz-Rodriguez, Paula, Bracho, Maria Alma, Cancino-Muñoz, Irving, D’Auria, Giuseppe, de Marco, Griselda, García-González, Neris, Goig, Galo Adrian, Gómez-Navarro, Inmaculada, Jiménez-Serrano, Santiago, Martinez-Priego, Llúcia, Ruiz-Hueso, Paula, Ruiz-Roldán, Lidia, Torres-Puente, Manuela, Alberola, Juan, Albert, Eliseo, Aranzamendi Zaldumbide, Maitane, Bea-Escudero, María Pilar, Boga, Jose Antonio, Bordoy, Antoni E., Canut-Blasco, Andrés, Carvajal, Ana, Cilla Eguiluz, Gustavo, Cordón Rodríguez, Maria Luz, Costa-Alcalde, José J., de Toro, María, de Toro Peinado, Inmaculada, del Pozo, Jose Luis, Duchêne, Sebastián, Fernández-Pinero, Jovita, Fuster Escrivá, Begoña, Gimeno Cardona, Concepción, González Galán, Verónica, Gonzalo Jiménez, Nieves, Hernáez Crespo, Silvia, Herranz, Marta, Lepe, José Antonio, López-Causapé, Carla, López-Hontangas, José Luis, Martín, Vicente, Martró, Elisa, Milagro Beamonte, Ana, Montes Ros, Milagrosa, Moreno-Muñoz, Rosario, Navarro, David, Navarro-Marí, José María, Not, Anna, Oliver, Antonio, Palop-Borrás, Begoña, Parra Grande, Mónica, Pedrosa-Corral, Irene, Pérez González, Maria Carmen, Pérez-Lago, Laura, Pérez-Ruiz, Mercedes, Piñeiro Vázquez, Luis, Rabella, Nuria, Rezusta, Antonio, Robles Fonseca, Lorena, Rodríguez-Villodres, Ángel, Sanbonmatsu-Gámez, Sara, Sicilia, Jon, Soriano, Alex, Tirado Balaguer, María Dolores, Torres, Ignacio, Tristancho, Alexander, Marimón, José María, Pérez-Tur, Jordi, Catalán-Alonso, Pilar, Suárez González, Julia, Muñoz, Patricia, Ruiz-Rodríguez, Paula, Bracho, María Alma, Martínez Priego, Llúcia, Galán-Vendrell, Inmaculada, De Marco, Griselda, Ferrús-Abad, María Loreto, Carbó-Ramírez, Sandra, Nogueira, Jose Miguel, Camarena, Juan José, Martínez Expósito, Óscar, Antona Urieta, Nerea, Castelló-Abietar, Cristian, Rojo-Alba, Susana, Álvarez-Argüelles, Marta Elena, Melón, Santiago, Antuori, Adrián, Fernández-Navarro, Anabel, Lecaroz Agara, Maria Concepción, Gómez-González, Carmen, Aguirre-Quiñonero, Amaia, López-Mirones, José Israel, Fernández-Torres, Marina, Almela-Ferrer, Maria Rosario, Fregeneda-Grandes, Juan Miguel, Argüello, Héctor, Sorarrain, Ane, Trastoy, Rocío, Barbeito Castiñeiras, Gema, Coira, Amparo, Pérez del Molino, María Luisa, Aguilera, Antonio, Mediavilla Gradolph, Maria Concepción, Fernández-Alonso, Mirian, González-Recio, Oscar, Gutiérrez-Rivas, Mónica, Jiménez Clavero, Miguel Ángel, Ocete Mochón, María Dolores, Medina-Gonzalez, Rafael, Reina, Jordi, Gómez-Ruiz, Maria Dolores, Gonzalez-Barbera, Eva M., Molina, Antonio J., Fernandez-Villa, Tania, Martínez-Cameo, Nieves Felisa, Gracia-Grataloup, Yolanda, Tirado Balaguer, Maria Dolores, Gómez Alonso, Bárbara, Arjona Zaragozí, Francisco José, Chamizo López, Francisco Javier, Bordes-Benítez, Ana, Rabella, Núria, Navarro, Ferran, Miró, Elisenda, Simarro Córdoba, Encarnación, Lozano-Serra, Julia, Soriano, Álex, Roig Sena, Francisco Javier, Vanaclocha Luna, Hermelinda, Sanmartín, Isabel, García-Souto, Daniel, Pequeño-Valtierra, Ana, Tubio, Jose M. C., Temes, Javier, Rodríguez-Castro, Jorge, Santamarina García, Martín, Rodríguez-Iglesias, Manuel, Galán-Sanchez, Fátima, Rodríguez-Pallares, Salud, Azcona-Gutiérrez, José Manuel, Blasco-Alberdi, Miriam, Mayor, Alfredo, García-Basteiro, Alberto L., Moncunill, Gemma, Dobaño, Carlota, Cisteró, Pau, Mitjà, Oriol, González-Beiras, Camila, Vall-Mayans, Martí, Corbacho-Monné, Marc, Alemany, Andrea, Muñoz-Cuevas, Cristina, Rodríguez-Rodríguez, Guadalupe, Benito, Rafael, Algarate, Sonia, Bueno, Jessica, Vergara-Gómez, Andrea, Martínez, Miguel J., Vila, Jordi, Rubio, Elisa, Peiró-Mestres, Aida, Navero-Castillejos, Jessica, Posada, David, Valverde, Diana, Estévez, Nuria, Fernández-Silva, Iria, de Chiara, Loretta, Gallego-García, Pilar, Varela, Nair, Gómez-Pinedo, Ulises, Gozalo-Margüello, Mónica, Cano García, Maria Eliecer, Méndez-Legaza, José Manuel, Rodríguez-Lozano, Jesus, Siller, María, Pablo-Marcos, Daniel, Ruiz-García, Maria Montserrat, Galiana, Antonio, Sánchez-Almendro, Judith, Gascón Ros, Maria Isabel, Torregrosa-Hetland, Cristina Juana, Pastor Boix, Eva María, Cascales Ramos, Paloma, Garcinuño Enríquez, Pedro Luis, Raga Borja, Salvador, González Cantó, Julia, Martínez Macias, Olalla, de Salazar, Adolfo, Viñuela González, Laura, Chueca, Natalia, García, Federico, Gómez-Camarasa, Cristina, Farga Martí, Amparo, Falcón, Rocío, Domínguez-Márquez, Victoria, Planas, Anna M., Fernández-Cádenas, Israel, Marcos, Maria Ángeles, Ezpeleta, Carmen, Navascués, Ana, Miqueleiz Zapatero, Ana, Segovia, Manuel, Moreno-Docón, Antonio, Viedma, Esther, Recio Martínez, Raúl, Muñoz-Gallego, Irene, Gonzalez-Bodi, Sara, Folgueira, Maria Dolores, Mingorance, Jesús, Dahdouh, Elias, Lázaro-Perona, Fernando, Rodríguez-Tejedor, María, Romero-Gómez, María Pilar, García-Rodríguez, Julio, Galán, Juan Carlos, Rodríguez-Dominguez, Mario, Martínez-García, Laura, Abreu Di Berardino, Melanie, Ponce-Alonso, Manuel, González-Alba, Jose Maria, Sanz-Muñoz, Ivan, Pérez San José, Diana, Gil Fortuño, Maria, Bellido-Blasco, Juan B., Yagüe Muñoz, Alberto, Hernández Pérez, Noelia, Buj Jordá, Helena, Pérez Olaso, Óscar, González Praetorius, Alejandro, Martínez Ramírez, Nora Mariela, Ramírez Marinero, Aida, Padilla León, Eduardo, Vilas Basil, Alba, Canal Aranda, Mireia, Bernet Sánchez, Albert, Bellés Bellés, Alba, López González, Eric, Prats Sánchez, Iván, García-González, Mercè, Martínez-Lirola, Miguel José, Rodríguez Maresca, Manuel Ángel, Cabezas Fernández, Maria Teresa, Carrillo Gil, María Eugenia, Ventero Martín, Maria Paz, Molina Pardines, Carmen, Orta Mira, Nieves, Navarro Cots, María, Vidal Catalá, Inmaculada, García Nava, Isabel, Illescas Fernández-Bermejo, Soledad, Martínez-Alarcón, José, Torres-Narbona, Marta, Colmenarejo, Cristina, García-Agudo, Lidia, Pérez García, Jorge A., Yago López, Martín, Goberna Bravo, María Ángeles, Simón García, Victoria, Llop Furquet, Gonzalo, Iranzo Tatay, Agustín, Moreno-Marro, Sandra, Lozano Rodríguez, Noelia, Broseta Tamarit, Amparo, Badiola Díez, Juan José, Martínez-Ramírez, Amparo, Dopazo, Ana, Callejas, Sergio, Benguría, Alberto, Aguado, Begoña, Alcamí, Antonio, Bermejo Bermejo, Marta, Ramos-Ruíz, Ricardo, Fernández Soria, Víctor Manuel, Simón Soria, Fernando, Roig Cardells, Mercedes, Coscolla, Mireia, González-Candelas, Fernando, Comas, Iñaki, Instituto de Salud Carlos III, Consejo Superior de Investigaciones Científicas (España), Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), European Research Council, European Commission, Generalitat Valenciana, Chiner-Oms, Álvaro [0000-0002-0463-0101], Ruiz-Rodríguez, Paula [0000-0003-0727-5974], D'Auria, Giuseppe [0000-0003-0672-2541], Gómez-Navarro, Inmaculada [0000-0002-5235-7365], Jiménez Serrano, Santiago [0000-0003-2917-6053], Aranzamendi Zaldumbide, Maitane [0000-0003-2432-7078], Boga, José Antonio [0000-0002-5500-9972], Bordoy, Antoni E. [0000-0002-1165-542X], Costa-Alcalde, José J. [0000-0002-1916-2216], Toro Peinado, Inmaculada de [0000-0002-8151-3275], López-Causapé, Carla [0000-0003-2228-2005], Martín, Vicente [0000-0003-0552-2804], Moreno-Muñoz, Rosario [0000-0002-0185-5612], Parra Grande, Mónica [0000-0002-8330-7467], Balaguer, María Dolores [0000-0003-3808-7300], Coscolla, Mireia [0000-0003-0752-0538], González-Candelas, Fernando [0000-0002-0879-5798], Comas, Iñaki [0000-0001-5504-9408], Ministerio de Ciencia (España), Generalitat Valenciana (España), Chiner-Oms, Álvaro, Ruiz-Rodríguez, Paula, D'Auria, Giuseppe, Gómez-Navarro, Inmaculada, Jiménez Serrano, Santiago, Aranzamendi Zaldumbide, Maitane, Boga, José Antonio, Bordoy, Antoni E., Costa-Alcalde, José J., Toro Peinado, Inmaculada de, López-Causapé, Carla, Martín, Vicente, Moreno-Muñoz, Rosario, Parra Grande, Mónica, Balaguer, María Dolores, Coscolla, Mireia, González-Candelas, Fernando, Comas, Iñaki, and Marimon, Jose Maria
- Subjects
DYNAMICS ,Coronavirus disease 2019 (COVID-19) ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Physical Distancing ,Biology ,Severity of Illness Index ,Article ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,law ,Pandemic ,Quarantine ,Genetics ,Humans ,Clade ,Phylogeny ,030304 developmental biology ,0303 health sciences ,Models, Statistical ,SARS-CoV-2 ,Incidence (epidemiology) ,Incidence ,Genetic variants ,COVID-19 ,Genomics ,New variant ,Dynamics ,Virus ,3. Good health ,Spain ,Communicable Disease Control ,VIRUS ,030217 neurology & neurosurgery ,Demography - Abstract
SeqCOVID-Spain consortium: Álvaro Chiner-Oms, Irving Cancino-Muñoz, Mariana G. López, Manuela Torres-Puente, Inmaculada Gómez-Navarro, Santiago Jiménez-Serrano, Jordi Pérez-Tur, Darío García de Viedma, Laura Pérez-Lago, Marta Herranz, Jon Sicilia, Pilar Catalán-Alonso, Julia Suárez González, Patricia Muñoz, Mireia Coscolla, Paula Ruiz-Rodríguez, Fernando González-Candelas, Iñaki Comas, Lidia Ruiz-Roldán, María Alma Bracho, Neris García-González, Llúcia Martínez Priego, Inmaculada Galán-Vendrell, Paula Ruiz-Hueso, Griselda De Marco, María Loreto Ferrús-Abad, Sandra Carbó-Ramírez, Giuseppe D’Auria, Galo Adrian Goig, Juan Alberola, Jose Miguel Nogueira, Juan José Camarena, David Navarro, Eliseo Albert, Ignacio Torres, Maitane Aranzamendi Zaldumbide, Óscar Martínez Expósito, Nerea Antona Urieta, María de Toro, María Pilar Bea-Escudero, Jose Antonio Boga, Cristian Castelló-Abietar, Susana Rojo-Alba, Marta Elena Álvarez-Argüelles, Santiago Melón, Elisa Martró, Antoni E. Bordoy, Anna Not, Adrián Antuori, Anabel Fernández-Navarro, Andrés Canut-Blasco, Silvia Hernáez Crespo, Maria Luz Cordón Rodríguez, Maria Concepción Lecaroz Agara, Carmen Gómez-González, Amaia Aguirre-Quiñonero, José Israel López-Mirones, Marina Fernández-Torres, Maria Rosario Almela-Ferrer, Ana Carvajal, Juan Miguel Fregeneda-Grandes, Héctor Argüello, Gustavo Cilla Eguiluz, Milagrosa Montes Ros, Luis Piñeiro Vázquez, Ane Sorarrain, José María Marimón, José J. Costa-Alcalde, Rocío Trastoy, Gema Barbeito Castiñeiras, Amparo Coira, María Luisa Pérez del Molino, Antonio Aguilera, Begoña Palop-Borrás, Inmaculada de Toro Peinado, Maria Concepción Mediavilla Gradolph, Mercedes Pérez-Ruiz, Mirian Fernández-Alonso, Jose Luis del Pozo, Oscar González-Recio, Mónica Gutiérrez-Rivas, Jovita Fernández-Pinero, Miguel Ángel Jiménez Clavero, Begoña Fuster Escrivá, Concepción Gimeno Cardona, María Dolores Ocete Mochón, Rafael Medina-Gonzalez, José Antonio Lepe, Verónica González Galán, Ángel Rodríguez-Villodres, Nieves Gonzalo Jiménez, Jordi Reina, Carla López-Causapé, Maria Dolores Gómez-Ruiz, Eva M. Gonzalez-Barbera, José Luis López-Hontangas, Vicente Martín, Antonio J. Molina, Tania Fernandez-Villa, Ana Milagro Beamonte, Nieves Felisa Martínez-Cameo, Yolanda Gracia-Grataloup, Rosario Moreno-Muñoz, Maria Dolores Tirado Balaguer, José María Navarro-Marí, Irene Pedrosa-Corral, Sara Sanbonmatsu-Gámez, Antonio Oliver, Mónica Parra Grande, Bárbara Gómez Alonso, Francisco José Arjona Zaragozí, Maria Carmen Pérez González, Francisco Javier Chamizo López, Ana Bordes-Benítez, Núria Rabella, Ferran Navarro, Elisenda Miró, Antonio Rezusta, Alexander Tristancho, Encarnación Simarro Córdoba, Julia Lozano-Serra, Lorena Robles Fonseca, Álex Soriano, Francisco Javier Roig Sena, Hermelinda Vanaclocha Luna, Isabel Sanmartín, Daniel García-Souto, Ana Pequeño-Valtierra, Jose M. C. Tubio, Javier Temes, Jorge Rodríguez-Castro, Martín Santamarina García, Manuel Rodríguez-Iglesias, Fátima Galán-Sanchez, Salud Rodríguez-Pallares, José Manuel Azcona-Gutiérrez, Miriam Blasco-Alberdi, Alfredo Mayor, Alberto L. García-Basteiro, Gemma Moncunill, Carlota Dobaño, Pau Cisteró, Oriol Mitjà, Camila González-Beiras, Martí Vall-Mayans, Marc Corbacho-Monné, Andrea Alemany, Cristina Muñoz-Cuevas, Guadalupe Rodríguez-Rodríguez, Rafael Benito, Sonia Algarate, Jessica Bueno, Andrea Vergara-Gómez, Miguel J. Martínez, Jordi Vila, Elisa Rubio, Aida Peiró-Mestres, Jessica Navero-Castillejos, David Posada, Diana Valverde, Nuria Estévez, Iria Fernández-Silva, Loretta de Chiara, Pilar Gallego-García, Nair Varela, Ulises Gómez-Pinedo, Mónica Gozalo-Margüello, Maria Eliecer Cano García, José Manuel Méndez-Legaza, Jesus Rodríguez-Lozano, María Siller, Daniel Pablo-Marcos, Maria Montserrat Ruiz-García, Antonio Galiana, Judith Sánchez-Almendro, Maria Isabel Gascón Ros, Cristina Juana Torregrosa-Hetland, Eva María Pastor Boix, Paloma Cascales Ramos, Pedro Luis Garcinuño Enríquez, Salvador Raga Borja, Julia González Cantó, Olalla Martínez Macias, Adolfo de Salazar, Laura Viñuela González, Natalia Chueca, Federico García, Cristina Gómez-Camarasa, Amparo Farga Martí, Rocío Falcón, Victoria Domínguez-Márquez, Anna M. Planas, Israel Fernández-Cádenas, Maria Ángeles Marcos, Carmen Ezpeleta, Ana Navascués, Ana Miqueleiz Zapatero, Manuel Segovia, Antonio Moreno-Docón, Esther Viedma, Raúl Recio Martínez, Irene Muñoz-Gallego, Sara Gonzalez-Bodi, Maria Dolores Folgueira, Jesús Mingorance, Elias Dahdouh, Fernando Lázaro-Perona, María Rodríguez-Tejedor, María Pilar Romero-Gómez, Julio García-Rodríguez, Juan Carlos Galán, Mario Rodríguez-Dominguez, Laura Martínez-García, Melanie Abreu Di Berardino, Manuel Ponce-Alonso, Jose Maria González-Alba, Ivan Sanz-Muñoz, Diana Pérez San José, Maria Gil Fortuño, Juan B. Bellido-Blasco, Alberto Yagüe Muñoz, Noelia Hernández Pérez, Helena Buj Jordá, Óscar Pérez Olaso, Alejandro González Praetorius, Nora Mariela Martínez Ramírez, Aida Ramírez Marinero, Eduardo Padilla León, Alba Vilas Basil, Mireia Canal Aranda, Albert Bernet Sánchez, Alba Bellés Bellés, Eric López González, Iván Prats Sánchez, Mercè García-González, Miguel José Martínez-Lirola, Manuel Ángel Rodríguez Maresca, Maria Teresa Cabezas Fernández, María Eugenia Carrillo Gil, Maria Paz Ventero Martín, Carmen Molina Pardines, Nieves Orta Mira, María Navarro Cots, Inmaculada Vidal Catalá, Isabel García Nava, Soledad Illescas Fernández-Bermejo, José Martínez-Alarcón, Marta Torres-Narbona, Cristina Colmenarejo, Lidia García-Agudo, Jorge A. Pérez García, Martín Yago López, María Ángeles Goberna Bravo, Victoria Simón García, Gonzalo Llop Furquet, Agustín Iranzo Tatay, Sandra Moreno-Marro, Noelia Lozano Rodríguez, Amparo Broseta Tamarit, Juan José Badiola Díez, Amparo Martínez-Ramírez, Ana Dopazo, Sergio Callejas, Alberto Benguría, Begoña Aguado, Antonio Alcamí, Marta Bermejo Bermejo, Ricardo Ramos-Ruíz, Víctor Manuel Fernández Soria, Fernando Simón Soria & Mercedes Roig Cardells, The coronavirus disease 2019 (COVID-19) pandemic has affected the world radically since 2020. Spain was one of the European countries with the highest incidence during the first wave. As a part of a consortium to monitor and study the evolution of the epidemic, we sequenced 2,170 samples, diagnosed mostly before lockdown measures. Here, we identified at least 500 introductions from multiple international sources and documented the early rise of two dominant Spanish epidemic clades (SECs), probably amplified by superspreading events. Both SECs were related closely to the initial Asian variants of SARS-CoV-2 and spread widely across Spain. We inferred a substantial reduction in the effective reproductive number of both SECs due to public-health interventions (Re, This work was mainly funded by the Instituto de Salud Carlos III project COV20/00140, with additional funding by Spanish National Research Council project CSIC-COV19-021, Ministerio de Ciencia project PID2019-104477RB-100, ERC StG 638553 and ERC CoG 101001038 to I.C., and BFU2017-89594R to F.G.C. M.C. is supported by Ramón y Cajal program from Ministerio de Ciencia and grants RTI2018-094399-A-I00 and Generalitat Valenciana (Regional Government) project SEJI/2019/011. We gratefully acknowledge Hospital Universitari Vall d’Hebron, Instituto de Salud Carlos III, IrsiCaixa AIDS Research Lab and all the international researchers and institutions that submitted sequenced SARS-CoV-2 genomes to the GISAID’s EpiCov Database (Supplementary Table 1), as an important part of our analyses has been made possible by the sharing of their work. We also thank Unidad de Bioinformática y Estadística, Centro de Investigación Príncipe Felipe, for allowing us to use the Computer Cluster to perform some of the bioinformatic analysis.
- Published
- 2021
26. Intraoperative Bacterial Contamination and Activity of Different Antimicrobial Prophylaxis Regimens in Primary Knee and Hip Replacement
- Author
-
Rivera, Alba, Sánchez, Alba, Luque Pardos, Sònia, Mur, Isabel, Puig, Lluís, Crusi, Xavier, González, José Carlos, Sorli Redó, M. Luisa, González, Aránzazu, Horcajada Gallego, Juan Pablo, Navarro, Ferran, and Benito, Natividad
- Subjects
musculoskeletal diseases ,0301 basic medicine ,Microbiology (medical) ,medicine.medical_specialty ,Prosthetic joint infection ,medicine.medical_treatment ,030106 microbiology ,Cefazolin ,Antibiotic levels ,knee arthroplasty ,surgical antimicrobial prophylaxis ,Biochemistry ,Microbiology ,Prosthetic joint infection prevention ,Article ,Intraoperative cultures ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Hip replacement ,Serum bactericidal titer ,medicine ,Surgical antimicrobial prophylaxis ,surgical site infection prevention ,Pharmacology (medical) ,General Pharmacology, Toxicology and Pharmaceutics ,prosthetic joint infection ,hip arthroplasty ,030222 orthopedics ,intraoperative cultures ,prosthetic joint infection prevention ,business.industry ,lcsh:RM1-950 ,Surgical wound ,antibiotic levels ,Antimicrobial ,Arthroplasty ,Knee arthroplasty ,Surgical site infection prevention ,Infectious Diseases ,lcsh:Therapeutics. Pharmacology ,Vancomycin ,Hip arthroplasty ,Gentamicin ,serum bactericidal titer ,business ,Cefuroxime ,medicine.drug - Abstract
Surgical antimicrobial prophylaxis (SAP) is important for the prevention of prosthetic joint infections (PJIs) and must be effective against the microorganisms most likely to contaminate the surgical site. Our aim was to compare different SAP regimens (cefazolin, cefuroxime, or vancomycin, alone or combined with gentamicin) in patients undergoing total knee (TKA) and hip (THA) arthroplasty. In this preclinical exploratory analysis, we analyzed the results of intraoperative sample cultures, the ratio of plasma antibiotic levels to the minimum inhibitory concentrations (MICs) for bacteria isolated at the surgical wound and ATCC strains, and serum bactericidal titers (SBT) against the same microorganisms. A total of 132 surgical procedures (68 TKA, 64 THA) in 128 patients were included. Cultures were positive in 57 (43.2%) procedures (mostly for coagulase-negative staphylococci and Cutibacterium spp.), the rate was lower in the group of patients receiving combination SAP (adjusted OR 0.475, CI95% 0.229&ndash, 0.987). The SAP regimens evaluated achieved plasma levels above the MICs in almost all of intraoperative isolates (93/94, 98.9%) and showed bactericidal activity against all of them (SBT range 1:8&ndash, 1:1024), although SBTs were higher in patients receiving cefazolin and gentamicin-containing regimens. The potential clinical relevance of these findings in the prevention of PJIs remains to be determined.
- Published
- 2021
27. CARB-ES-19 Multicenter Study of Carbapenemase-Producing Klebsiella pneumonia e and Escherichia coli From All Spanish Provinces Reveals Interregional Spread of High-Risk Clones Such as ST307/OXA-48 and ST512/KPC-3.
- Author
-
Cañada-García, Javier E., Moure, Zaira, Sola-Campoy, Pedro J., Delgado-Valverde, Mercedes, Cano, María E., Gijón, Desirèe, González, Mónica, Gracia-Ahufinger, Irene, Larrosa, Nieves, Mulet, Xavier, Pitart, Cristina, Rivera, Alba, Bou, Germán, Calvo, Jorge, Cantón, Rafael, González-López, Juan José, Martínez-Martínez, Luis, Navarro, Ferran, Oliver, Antonio, and Palacios-Baena, Zaira R.
- Subjects
KLEBSIELLA pneumoniae ,ESCHERICHIA coli ,MOLECULAR cloning ,MICROBIAL sensitivity tests ,SINGLE nucleotide polymorphisms ,NUCLEOTIDE sequencing - Abstract
Objectives: CARB-ES-19 is a comprehensive, multicenter, nationwide study integrating whole-genome sequencing (WGS) in the surveillance of carbapenemase-producing K. pneumoniae (CP-Kpn) and E. coli (CP-Eco) to determine their incidence, geographical distribution, phylogeny, and resistance mechanisms in Spain. Methods: In total, 71 hospitals, representing all 50 Spanish provinces, collected the first 10 isolates per hospital (February to May 2019); CPE isolates were first identified according to EUCAST (meropenem MIC > 0.12 mg/L with immunochromatography, colorimetric tests, carbapenem inactivation, or carbapenem hydrolysis with MALDI-TOF). Prevalence and incidence were calculated according to population denominators. Antibiotic susceptibility testing was performed using the microdilution method (EUCAST). All 403 isolates collected were sequenced for high-resolution single-nucleotide polymorphism (SNP) typing, core genome multilocus sequence typing (cgMLST), and resistome analysis. Results: In total, 377 (93.5%) CP-Kpn and 26 (6.5%) CP-Eco isolates were collected from 62 (87.3%) hospitals in 46 (92%) provinces. CP-Kpn was more prevalent in the blood (5.8%, 50/853) than in the urine (1.4%, 201/14,464). The cumulative incidence for both CP-Kpn and CP-Eco was 0.05 per 100 admitted patients. The main carbapenemase genes identified in CP-Kpn were bla
OXA–48 (263/377), blaKPC–3 (62/377), blaVIM–1 (28/377), and blaNDM–1 (12/377). All isolates were susceptible to at least two antibiotics. Interregional dissemination of eight high-risk CP-Kpn clones was detected, mainly ST307/OXA-48 (16.4%), ST11/OXA-48 (16.4%), and ST512-ST258/KPC (13.8%). ST512/KPC and ST15/OXA-48 were the most frequent bacteremia-causative clones. The average number of acquired resistance genes was higher in CP-Kpn (7.9) than in CP-Eco (5.5). Conclusion: This study serves as a first step toward WGS integration in the surveillance of carbapenemase-producing Enterobacterales in Spain. We detected important epidemiological changes, including increased CP-Kpn and CP-Eco prevalence and incidence compared to previous studies, wide interregional dissemination, and increased dissemination of high-risk clones, such as ST307/OXA-48 and ST512/KPC-3. [ABSTRACT FROM AUTHOR]- Published
- 2022
- Full Text
- View/download PDF
28. Taxonomic Identification of Different Species of the Genus Aeromonas by Whole-Genome Sequencing and Use of Their Species-Specific β-Lactamases as Phylogenetic Markers
- Author
-
Bertran, Xavier, primary, Rubio, Marc, additional, Gómez, Laura, additional, Llovet, Teresa, additional, Muñoz, Carme, additional, Navarro, Ferran, additional, and Miro, Elisenda, additional
- Published
- 2021
- Full Text
- View/download PDF
29. GASVeM: A New Machine Learning Methodology for Multi-SNP Analysis of GWAS Data Based on Genetic Algorithms and Support Vector Machines
- Author
-
Díez Díaz, Fidel, primary, Sánchez Lasheras, Fernando, additional, Moreno, Víctor, additional, Moratalla-Navarro, Ferran, additional, Molina de la Torre, Antonio José, additional, and Martín Sánchez, Vicente, additional
- Published
- 2021
- Full Text
- View/download PDF
30. Bacteriophages immunomodulate the response of monocytes
- Author
-
Perea, Lídia, primary, Rodríguez-Rubio, Lorena, additional, Nieto, Juan C, additional, Zamora, Carlos, additional, Cantó, Elisabet, additional, Soriano, German, additional, Poca, Maria, additional, Blanco-Picazo, Pedro, additional, Navarro, Ferran, additional, Muniesa, Maite, additional, and Vidal, Silvia, additional
- Published
- 2021
- Full Text
- View/download PDF
31. Molecular diagnosis of bloodstream infections with a new dual-priming oligonucleotide-based multiplex PCR assay
- Author
-
Carrara, Lucrecia, Navarro, Ferran, Turbau, Miquel, Seres, Montse, Morán, Indalecio, Quintana, Isabel, Martino, Rodrigo, González, Yesica, Brell, Albert, Cordon, Oscar, Diestra, Karol, Mata, Caterina, Mirelis, Beatriz, and Coll, Pere
- Published
- 2013
- Full Text
- View/download PDF
32. Intraoperative Bacterial Contamination and Activity of Different Antimicrobial Prophylaxis Regimens in Primary Knee and Hip Replacement
- Author
-
Rivera, Alba, primary, Sánchez, Alba, additional, Luque, Sonia, additional, Mur, Isabel, additional, Puig, Lluís, additional, Crusi, Xavier, additional, González, José Carlos, additional, Sorlí, Luisa, additional, González, Aránzazu, additional, Horcajada, Juan Pablo, additional, Navarro, Ferran, additional, and Benito, Natividad, additional
- Published
- 2020
- Full Text
- View/download PDF
33. MorbiNet Study: Hypothyroidism Comorbidity Networks in the Adult General Population
- Author
-
Moratalla-Navarro, Ferran, primary, Moreno, Victor, additional, López-Simarro, Flora, additional, and Aguado, Alba, additional
- Published
- 2020
- Full Text
- View/download PDF
34. Do Prosthetic Joint Infections Worsen the Functional Ambulatory Outcome of Patients with Joint Replacements? A Retrospective Matched Cohort Study
- Author
-
Mur, Isabel, primary, Jordán, Marcos, additional, Rivera, Alba, additional, Pomar, Virginia, additional, González, José Carlos, additional, López-Contreras, Joaquín, additional, Crusi, Xavier, additional, Navarro, Ferran, additional, Gurguí, Mercè, additional, and Benito, Natividad, additional
- Published
- 2020
- Full Text
- View/download PDF
35. Cephalosporin-resistant Escherichia coli among summer camp attendees with Salmonellosis
- Author
-
Prats, Guillem, Mirelis, Baetriz, Miro, Elisenda, Navarro, Ferran, Llovet, Teresa, Johnson, James R., Camps, Neus, Domiguez, Angela, and Salleras, Lluis
- Subjects
Gastroenteritis -- Causes of ,Gastroenteritis -- Surveys - Abstract
Investigation of an acute gastroenteritis outbreak involving >100 persons at a summer camp in Girona, Spain, in June 2002 led to the detection of Salmonella enterica and extended-spectrum cephalosporin-resistant Escherichia [...]
- Published
- 2003
36. DNA methylation events in transcription factors and gene expression changes in colon cancer
- Author
-
Díez-Villanueva, Anna, primary, Sanz-Pamplona, Rebeca, additional, Carreras-Torres, Robert, additional, Moratalla-Navarro, Ferran, additional, Alonso, M Henar, additional, Paré-Brunet, Laia, additional, Aussó, Susanna, additional, Guinó, Elisabet, additional, Solé, Xavier, additional, Cordero, David, additional, Salazar, Ramón, additional, Berdasco, Maria, additional, Peinado, Miguel A, additional, and Moreno, Victor, additional
- Published
- 2020
- Full Text
- View/download PDF
37. Genomic analysis of 40 prophages located in the genomes of 16 carbapenemase-producing clinical strains of Klebsiella pneumoniae
- Author
-
Bleriot, Ines, primary, Trastoy, Rocío, additional, Blasco, Lucia, additional, Fernández-Cuenca, Felipe, additional, Ambroa, Antón, additional, Fernández-García, Laura, additional, Pacios, Olga, additional, Perez-Nadales, Elena, additional, Torre-Cisneros, Julian, additional, Oteo-Iglesias, Jesús, additional, Navarro, Ferran, additional, Miró, Elisenda, additional, Pascual, Alvaro, additional, Bou, German, additional, Martínez-Martínez, Luis, additional, and Tomas, Maria, additional
- Published
- 2020
- Full Text
- View/download PDF
38. Comparison of Commensal and Clinical Isolates for Diversity of Plasmids in Escherichia coli and Klebsiella pneumoniae
- Author
-
Rodríguez-Navarro, Judith, primary, Miró, Elisenda, additional, Brown-Jaque, Maryury, additional, Hurtado, Juan Carlos, additional, Moreno, Albert, additional, Muniesa, Maite, additional, González-López, Juan José, additional, Vila, Jordi, additional, Espinal, Paula, additional, and Navarro, Ferran, additional
- Published
- 2020
- Full Text
- View/download PDF
39. Differential Distribution of the wlaN and cgtB Genes, Associated with Guillain-Barré Syndrome, in Campylobacter jejuni Isolates from Humans, Broiler Chickens, and Wild Birds
- Author
-
Guirado, Pedro, primary, Paytubi, Sonia, additional, Miró, Elisenda, additional, Iglesias-Torrens, Yaidelis, additional, Navarro, Ferran, additional, Cerdà-Cuéllar, Marta, additional, Stephan-Otto Attolini, Camille, additional, Balsalobre, Carlos, additional, and Madrid, Cristina, additional
- Published
- 2020
- Full Text
- View/download PDF
40. MorbiNet: multimorbidity networks in adult general population. Analysis of type 2 diabetes mellitus comorbidity
- Author
-
Aguado, Alba, primary, Moratalla-Navarro, Ferran, additional, López-Simarro, Flora, additional, and Moreno, Victor, additional
- Published
- 2020
- Full Text
- View/download PDF
41. Core/Whole Genome Multilocus Sequence Typing and Core Genome SNP-Based Typing of OXA-48-Producing Klebsiella pneumoniae Clinical Isolates From Spain
- Author
-
Miro, Elisenda, primary, Rossen, John W. A., additional, Chlebowicz, Monika A., additional, Harmsen, Dag, additional, Brisse, Sylvain, additional, Passet, Virginie, additional, Navarro, Ferran, additional, Friedrich, Alex W., additional, and García-Cobos, S., additional
- Published
- 2020
- Full Text
- View/download PDF
42. Corrigendum: CARB-ES-19 multicenter study of carbapenemase-producing Klebsiella pneumoniae and Escherichia coli from all Spanish provinces reveals interregional spread of high-risk clones such as ST307/OXA-48 and ST512/KPC-3.
- Author
-
Cañada-García, Javier E., Moure, Zaira, Sola-Campoy, Pedro J., Delgado-Valverde, Mercedes, Cano, María E., Gijón, Desirèe, Gonázlez, Monica, Gracia-Ahufinger, Irene, Larrosa, Nieves, Mulet, Xavier, Pitart, Cristina, Rivera, Alba, Bou, Germàn, Calvo, Jorge, Canton, Rafael, González-López, Juan José, Martínez-Martínez, Luis, Navarro, Ferran, Oliver, Antonio, and Palacios-Baena, Zaira R.
- Subjects
KLEBSIELLA pneumoniae ,MOLECULAR cloning ,ESCHERICHIA coli ,WHOLE genome sequencing ,PROVINCES - Published
- 2023
- Full Text
- View/download PDF
43. Superantigen gene profile, emm type and antibiotic resistance genes among group A streptococcal isolates from Barcelona, Spain
- Author
-
Rivera, Alba, Rebollo, Montserrat, Miró, Elisenda, Mateo, Míriam, Navarro, Ferran, Gurguí, Mercé, Mirelis, Beatriz, and Coll, Pere
- Published
- 2006
- Full Text
- View/download PDF
44. Population Structure, Antimicrobial Resistance, and Virulence-Associated Genes in Campylobacter jejuni Isolated From Three Ecological Niches: Gastroenteritis Patients, Broilers, and Wild Birds
- Author
-
Iglesias-Torrens, Y., Miró, Elisenda, Guirado, P., Llovet, Teresa, Muñoz, C., Cerdà Cuéllar, Marta, Madrid Xufré, Cristina, Balsalobre Parra, Carlos, Navarro, Ferran, Universitat de Barcelona, Producció Animal, and Sanitat Animal
- Subjects
Microbiology (medical) ,Campylobacter jejuni ,pathogenicity genes ,Pathogenic bacteria ,Drug resistance ,Bacteris patògens ,PFGE ,antimicrobial resistance ,619 - Veterinària ,Microbiology ,Resistència als medicaments ,MLST - Abstract
Campylobacter jejuni is the causal agent of the food-borne infection with the highest incidence in Europe. Both poultry and wild birds are a major reservoir. To gain insight into the population structure, virulence potential, and antimicrobial resistance (AMR), a collection of 150 isolates from three different ecological niches (broilers, wild birds, and human patients) was studied. Despite the high genetic diversity found, the population structure defined two distinct clusters, one formed mostly by broiler and human isolates and another one by most wild bird isolates. The ST-21 complex exhibits highest prevalence (in humans and broilers), followed by ST-1275 complex (only in wild birds). The ST-48, -45, and -354 complexes were found in all three niches, but represent only 22 out of 150 studied strains. A higher occurrence of AMR and multidrug resistance was detected among broiler and human isolates. Moreover, significant differences were found in the distribution of certain putative virulence genes. Remarkably, many wild bird strains were negative for either cdtA, cdtB, or cdtC from the canonical strain 81-176, whereas all broiler and human strains were positive. These data suggest that the different variants of the cdt genes might be relevant for the efficient colonization of certain hosts by C. jejuni. Our study contributes to the understanding of the role of the diverse Campylobacter reservoirs in the transmission of campylobacteriosis to humans info:eu-repo/semantics/publishedVersion
- Published
- 2018
45. In Memoriam: Dionisio José Herrera Guibert
- Author
-
Navarro, Ferran Martinez, primary
- Published
- 2019
- Full Text
- View/download PDF
46. MorbiNet Study: Hypothyroidism Comorbidity Networks in the Adult General Population.
- Author
-
Moratalla-Navarro, Ferran, Moreno, Victor, López-Simarro, Flora, and Aguado, Alba
- Subjects
HYPOTHYROIDISM ,THYROID hormone regulation ,ATRIAL flutter ,DIGESTIVE system diseases ,CARDIOVASCULAR diseases ,COMORBIDITY ,RESEARCH ,CHRONIC diseases ,INFORMATION services ,RESEARCH methodology ,CASE-control method ,COMMUNITY health services ,MEDICAL cooperation ,EVALUATION research ,COMPARATIVE studies ,DISEASE prevalence ,DISEASE complications - Abstract
Purpose: Multimorbidity impacts quality of life. We constructed hypothyroidism comorbidity networks to identify positive and negative associations with other prevalent diseases.Methods: We analyzed data of 285 342 patients with hypothyroidism from 3 135 948 adults with multimorbidity in a population-based study in Catalonia, Spain, (period: 2006-2017). We constructed hypothyroidism comorbidity networks using logistic regression models, adjusted by age and sex, and for men and women separately. We considered relevant associations those with odds ratios (OR) >1.2 or <0.8 and P value < 1e-5 to identify coexistence greater (or smaller) than the expected by the prevalence of diseases. Multivariate models considering comorbidities were used to further adjust OR values.Results: The conditions associated included larynx cancer (adjusted OR: 2.48), congenital anomalies (2.26), thyroid cancer (2.13), hyperthyroidism (1.66), vitamin B12/folate deficiency anemia (1.57), and goiter (1.56). The network restricted to men had more connections (mental, cardiovascular, and neurological) and stronger associations with thyroid cancer (7.26 vs 2.55), congenital anomalies (5.11 vs 2.13), hyperthyroidism (4.46 vs 1.69), larynx cancer (3.55 vs 1.67), and goiter (3.94 vs 1.64). After adjustment for comorbidities, OR values were more similar in men and women. The strongest negative associations after adjusting for comorbidities were with HIV/AIDS (OR: 0.71) and tobacco abuse (0.77).Conclusions: Networks show direct and indirect hypothyroidism multimorbidity associations. The strongest connections were thyroid and larynx cancer, congenital anomalies, hyperthyroidism, anemia, and goiter. Negative associations included HIV/AIDS and tobacco abuse. The network restricted to men had more and stronger associations, but not after adjusting for comorbidities, suggesting important indirect interactions. [ABSTRACT FROM AUTHOR]- Published
- 2021
- Full Text
- View/download PDF
47. Phages in the Human Body
- Author
-
Navarro, Ferran and Muniesa, Maite
- Subjects
metagenomics ,virome ,bacteriophages ,diagnosis ,homeostasis ,human biomes ,Microbiology - Abstract
Bacteriophages, viruses that infect bacteria, have re-emerged as powerful regulators of bacterial populations in natural ecosystems. Phages invade the human body, just as they do other natural environments, to such an extent that they are the most numerous group in the human virome. This was only revealed in recent metagenomic studies, despite the fact that the presence of phages in the human body was reported decades ago. The influence of the presence of phages in humans has yet to be evaluated; but as in marine environments, a clear role in the regulation of bacterial populations could be envisaged, that might have an impact on human health. Moreover, phages are excellent vehicles of genetic transfer, and they contribute to the evolution of bacterial cells in the human body by spreading and acquiring DNA horizontally. The abundance of phages in the human body does not pass unnoticed and the immune system reacts to them, although it is not clear to what extent. Finally, the presence of phages in human samples, which most of the time is not considered, can influence and bias microbiological and molecular results; and, in view of the evidences, some studies suggest that more attention needs to be paid to their interference.
- Published
- 2017
- Full Text
- View/download PDF
48. The Carbapenemase-Producing Klebsiella pneumoniae Population Is Distinct and More Clonal than the Carbapenem-Susceptible Population
- Author
-
Esteban-Cantos, Andrés, Aracil, Belen, Bautista, Veronica, Ortega, Adriana, Lara Fuella, Noelia, Saez, David, Fernandez-Romero, Sara, Perez-Vazquez, Maria Dolores, Navarro, Ferran, Grundmann, Hajo, Campos, Jose, Oteo-Iglesias, Jesus, EuSCAPE-Spain Network, Instituto de Salud Carlos III, Ministerio de Economía y Competitividad (España), Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF), Red de Investigación Cooperativa en Investigación en Patología Infecciosa, and European Centre for Disease Prevention and Control
- Subjects
0301 basic medicine ,Carbapenem ,Cefotaxime ,Klebsiella pneumoniae ,Carbapenem resistance ,030106 microbiology ,Population ,Context (language use) ,Drug resistance ,Microbial Sensitivity Tests ,Biology ,Population structure ,beta-Lactamases ,Epidemiology and Surveillance ,Microbiology ,03 medical and health sciences ,Bacterial Proteins ,Drug Resistance, Bacterial ,medicine ,Pharmacology (medical) ,education ,Pharmacology ,education.field_of_study ,biology.organism_classification ,Carbapenemases ,Anti-Bacterial Agents ,Infectious Diseases ,Carbapenems ,Susceptible individual ,Multilocus sequence typing ,medicine.drug ,MLST ,Multilocus Sequence Typing - Abstract
We studied in parallel the population structure of 90 carbapenemase-producing and 88 carbapenemase-susceptible Klebsiella pneumoniae isolates collected in 20 Spanish hospitals, in the context of the EuSCAPE project. Fourteen and 50 multilocus sequence types (MLSTs) were detected among the carbapenemase-producing and carbapenem-susceptible isolates, respectively. ST11 and ST15 clones were more frequent in the carbapenemase-producing group than in the carbapenemase-susceptible group (P < 0.0001). Among the members of the carbapenem-suceptible group, the cefotaxime-resistant population showed population parameters that differed between the populations of the wild-type strains and the carbapenemase producers. This study was part of the European Survey on Carbapenemase-Producing Enterobacteriaceae (EuSCAPE) project coordinated by the University Medical Center Groningen and funded by ECDC through a specific framework contract (ECDC/2012/055) following an open call for tender (OJ/25/04/2012-PROC/2012/036). This work was also supported by a grant from the Instituto de Salud Carlos III (grant number MPY 1135/16) and by the Ministerio de Economía y Competitividad, Instituto de Salud Carlos III, cofinanced by the European Development Regional Fund “A way to achieve Europe” ERDF, and the Spanish Network for the Research in Infectious Diseases (REIPI RD12/0015). Sí
- Published
- 2017
49. Ascitic fluid regulates the local innate immune response of patients with cirrhosis
- Author
-
Nieto, Juan C, primary, Perea, Lídia, additional, Soriano, Germán, additional, Zamora, Carlos, additional, Cantó, Elisabet, additional, Medina, Aina, additional, Poca, Maria, additional, Sanchez, Elisabet, additional, Roman, Eva, additional, Julià, Germà, additional, Navarro, Ferran, additional, Gely, Cristina, additional, Alvarado, Edilmar A, additional, Guarner, Carlos, additional, Juarez, Cándido, additional, and Vidal, Sílvia, additional
- Published
- 2018
- Full Text
- View/download PDF
50. De la información a la acción: la vigilancia de la salud pública
- Author
-
Martínez Navarro Ferran
- Subjects
Medicine ,Public aspects of medicine ,RA1-1270 - Published
- 2000
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.