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1. Sodium Disorders: Hyponatraemia

Author

Noel Somasundaram, Chandrika Wijeyarathne, Henry Rajaratnam, Prasad Katulanda, Uditha Bulugahapitiya, Sajith Siyambalapitiya, Charles Antonypillai, Manilka Sumanathilake, Chaminda Garusinghe, Dimuthu Muthukuda, MWS Niranjala, Muditha Weerakkody, Sivatharshya Pathmanathan, Sachith Abeyarathne, Shyaminda Kahandawa, Samanthi Cooray, Kavinga Gunawardena, Nayananjani Karunasena, WST Swarnasri, M Aravinthan, DC Kottahachchi, and NAS Ariyawansa

Subjects
sodium disorders, hyponatraemia, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

DOI: http://dx.doi.org/10.4038/sjdem.v3i2.6382 Sri Lanka Journal of Diabetes, Endocrinology and Metabolism 2013; 3: 114-122

Published
2014
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2. Diabetes Mellitus: Glucose Control

Author

Noel P Somasundaram, Chandrika N Wijeyaratne, Shamya De Silva, Sisira Siribaddana, Upali Illangasekera, Henry Rajaratnam, Prasad Katulanda, Uditha Bulugahapitiya, Sajith Siyambalapitiya, Charles Antonypillai, Manilka Sumanatilleke, Gaya Katulanda, Priyankara Jayawardena, N. Sudheera Kalupahana, Renuka Jayatissa, Chaminda Garusinghe, Dimuthu Muthukuda, Niranjala Meegoda Widanege, Muditha Weerakkody, Sivatharshya Pathmanathan, Sachith Abhayaratna, Shyaminda Kahandawa, Kavinga Gunawardane, Nayananjani Karunasena, M Aravindhan, WST Swarnasri, and Navoda Atapattu

Subjects
diabetes mellitus, glucose control, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

DOI: http://dx.doi.org/10.4038/sjdem.v3i1.5505 Sri Lanka Journal of Diabetes, Endocrinology and Metabolism 2013; 3: 45-37

Published
2013
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3. Cushing syndrome

Author

Noel Somasundaram, Henry Rajaratnam, Chandrika Wijeyarathne, Prasad Katulanda, Uditha Bulugahapitiya, Sajith Siyambalapitiya, Charles Antonypillai, Manilka Sumanathilake, Chaminda Garusinghe, Dimuthu Muthukuda, MWS Niranjala, Kavinga Gunawardena, Nayananjani Karunasena, WST Swarnasri, M Aravinthan, DC Kottahachchi, NAS Ariyawansa, LD Ranasinghe, and KD Liyanarachchi

Subjects
cushing syndrome, clinical guidelines, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

DOI: http://dx.doi.org/10.4038/sjdem.v4i1.7260 Sri Lanka Journal of Diabetes, Endocrinology and Metabolism 2014; 4: S1-S12

Published
2014
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4. Thyroid Diseases

Author

Noel Somasundaram, Henry Rajaratnam, Chandrika Wijeyarathne, Shamya De Silva, Channa Ratnathunga, Ranil Fernando, Sisira Siribaddana, Prasad Katulanda, Uditha Bulugahapitiya, Sajith Siyambalapitiya, Charles Antonypillai, Manilka Sumanathilake, Chaminda Garusinghe, Dimutha Muthukuda, MWS Niranjala, Muditha Weerakkody, Dharshini Karuppiah, Sivatharshya Pathmanathan, Sachith Abeyarathne, Shaminda Kahandawa, Samanthi Cooray, Kavinga Gunawardena, and Nayananjani Karunasena

Subjects
Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

Sri Lanka Journal of Diabetes, Endocrinology and Metabolism 2012; 2: S1-S20 DOI: http://dx.doi.org/10.4038/sjdem.v2i2.4786

Published
2012
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5. Impact of food, alcohol and pH on modified-release hydrocortisone developed to treat congenital adrenal hyperplasia

Author

Daniel Margetson, Richard Ross, Nayananjani Karunasena, Greg Neal, and Martin J. Whitaker

Subjects
Adult, Male, medicine.medical_specialty, Hydrocortisone, Endocrinology, Diabetes and Metabolism, Cmax, Anti-Inflammatory Agents, 030209 endocrinology & metabolism, Alcohol, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, Internal medicine, medicine, Humans, Congenital adrenal hyperplasia, In patient, Cross-Over Studies, Adrenal Hyperplasia, Congenital, Ethanol, business.industry, General Medicine, Hydrogen-Ion Concentration, medicine.disease, Crossover study, Bioavailability, Gastric ph, chemistry, Food, 030220 oncology & carcinogenesis, Clinical Study, Female, business, medicine.drug
Abstract

Background We developed a modified-release hydrocortisone, Chronocort, to replace the cortisol rhythm in patients with congenital adrenal hyperplasia. Food, alcohol and pH affect drug absorption, and it is important to assess their impact when replicating a physiological rhythm. Subjects and methods In vitro dissolution to study impact of alcohol and pH on Chronocort. A phase 1, three-period, cross over study in 18 volunteers to assess the impact of food on Chronocort and to compare bioavailability to immediate-release hydrocortisone. Results In vitro dissolution of Chronocort was not affected by gastrointestinal pH up to 6.0 nor by an alcohol content up to 20% v/v. Food delayed and reduced the rate of absorption of Chronocort as reflected by a longer Tmax (fed vs fasted: 6.75 h vs 4.5 h, P = 0005) and lower Cmax (549.49 nmol/L vs 708.46 nmol/L, ratio 77% with CI 71–85). Cortisol exposure was similar in fed and fasted state: Geo LSmean ratio (CI) AUC0t for fed/fasted was 108.33% (102.30–114.72%). Cortisol exposure was higher for Chronocort compared to immediate-release hydrocortisone: Geo LSmean ratios (CI) 118.83% (111.58–126.54%); however, derived free cortisol showed cortisol exposure CIs were within 80.0–125.0%: Geo LSmean ratio (CI) for AUC0t 112.73% (105.33–120.65%). Conclusions Gastric pH ≤6.0 and alcohol do not affect hydrocortisone release from Chronocort. Food delays Chronocort absorption, but cortisol exposure is similar in the fasted and fed state and exposure as assessed by free cortisol is similar between Chronocort and immediate-release hydrocortisone.

Published
2016

6. Adrenal crisis and sick day episodes among CAH patients: preliminary report based on international CAH (I-CAH) registry

Author

Tania A. S. S. Bachega, Nils Krone, Richard J. Ross, Uta Neumann, Ahmed S Faisal, Oliver Blankenstein, Jillian Bryce, Nayananjani Karunasena, Klaus Mohnike, Walter Bonfig, Berenice B. Mendonca, Heba Elsedfy, Tulay Guran, Eleni Daniel, Birgit Koehler, Carlo L. Acerini, and Jipu Jiang

Subjects
Pediatrics, medicine.medical_specialty, Preliminary report, business.industry, medicine, Adrenal crisis, medicine.symptom, business
Published
2016
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