1. Taming neuroinflammation in Alzheimer's disease: The protective role of phytochemicals through the gut-brain axis.
- Author
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Kim Y, Lim J, and Oh J
- Subjects
- Humans, Animals, Brain drug effects, Brain metabolism, Brain pathology, Neuroprotective Agents pharmacology, Neuroprotective Agents therapeutic use, Antioxidants pharmacology, Oxidative Stress drug effects, Alzheimer Disease drug therapy, Alzheimer Disease metabolism, Alzheimer Disease prevention & control, Phytochemicals pharmacology, Phytochemicals therapeutic use, Gastrointestinal Microbiome drug effects, Neuroinflammatory Diseases drug therapy, Neuroinflammatory Diseases metabolism, Neuroinflammatory Diseases prevention & control, Brain-Gut Axis drug effects, Brain-Gut Axis physiology, Anti-Inflammatory Agents pharmacology, Anti-Inflammatory Agents therapeutic use
- Abstract
Alzheimer's disease (AD) is a progressive degenerative neurological condition characterized by cognitive decline, primarily affecting memory and logical thinking, attributed to amyloid-β plaques and tau protein tangles in the brain, leading to neuronal loss and brain atrophy. Neuroinflammation, a hallmark of AD, involves the activation of microglia and astrocytes in response to pathological changes, potentially exacerbating neuronal damage. The gut-brain axis is a bidirectional communication pathway between the gastrointestinal and central nervous systems, crucial for maintaining brain health. Phytochemicals, natural compounds found in plants with antioxidant and anti-inflammatory properties, such as flavonoids, curcumin, resveratrol, and quercetin, have emerged as potential modulators of this axis, suggesting implications for AD prevention. Intake of phytochemicals influences the gut microbial composition and its metabolites, thereby impacting neuroinflammation and oxidative stress in the brain. Consumption of phytochemical-rich foods may promote a healthy gut microbiota, fostering the production of anti-inflammatory and neuroprotective substances. Early dietary incorporation of phytochemicals offers a non-invasive strategy for modulating the gut-brain axis and potentially reducing AD risk or delaying its onset. The exploration of interventions targeting the gut-brain axis through phytochemical intake represents a promising avenue for the development of preventive or therapeutic strategies against AD initiation and progression., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)
- Published
- 2024
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