7 results on '"Nicita, R."'
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2. Metal stents for malignant colorectal obstruction
- Author
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Alberto Malesci, Cristina Marfinati Hervoso, Silvio Danese, Nico Pagano, Alessandro Repici, Rinaldo Nicita, Paoletta Preatoni, Repici, A., Pagano, N., Hervoso, C. M., Danese, S., Nicita, R., Preatoni, P., Malesci, A., Repici A., Pagano N., Hervoso C.M., Danese S., Nicita R., Preatoni P., and Malesci A.
- Subjects
medicine.medical_specialty ,Colorectal cancer ,medicine.medical_treatment ,Perforation (oil well) ,Colonic tumors ,Colonic Diseases ,Laparotomy ,medicine ,Ascending colon ,Humans ,Colonic tumor ,Large bowel obstruction ,Colonic stenting ,business.industry ,Mortality rate ,Colostomy ,Stent ,Endoscopic treatment ,medicine.disease ,Surgery ,Treatment Outcome ,Metals ,Stents ,Complication ,business ,Colorectal Neoplasms ,Intestinal Obstruction - Abstract
Malignant obstruction of the colon occurs in 7-25% of patients with colorectal cancer. As emergency laparotomy is reported to have relatively high morbidity and mortality rate, there is a need for alternative procedures with reduced complication rates. Over the last decade colorectal stenting has been reported as an alternative endoscopic method to relieve acute colonic obstruction. With the availability of more sophisticated stents and stent delivery systems, this approach has been used as a palliative method and as a pre-operative bridge to facilitate one-stage surgical resection of primary colonic tumors. Technical and clinical successes have been reported in 80-100% of treated patients. Distal lesions are more common and theoretically easier to stent although lesions within the ascending colon have been succesfully managed. Minor complications include transient anorectal pain, tenesmus and rectal bleeding. However, stent migration and colonic perforation are also well recognized. Despite the fact that no randomized controlled studies have yet been performed, literature data show that colonic stenting is a safe and effective procedure and can reduce costs, avoiding the need for colostomy and improving the quality of life of patients with advanced disease. Malignant obstruction of the colon occurs in 7-25% of patients with colorectal cancer. As emergency laparotomy is reported to have relatively high morbidity and mortality rate, there is a need for alternative procedures with reduced complication rates.Over the last decade colorectal stenting has been reported as an alternative endoscopic method to relieve acute colonic obstruction. With the availability of more sophisticated stents and stent delivery systems, this approach has been used as a palliative method and as a pre-operative bridge to facilitate one-stage surgical resection of primary colonic tumors. Technical and clinical successes have been reported in 80-100% of treated patients. Distal lesions are more common and theoretically easier to stent although lesions within the ascending colon have been successfully managed. Minor complications include transient anorectal pain, tenesmus and rectal bleeding. However, stent migration and colonic perforation are also well recognized. Despite the fact that no randomized controlled studies have yet been performed, literature data show that colonic stenting is a safe and effective procedure and can reduce costs, avoiding the need for colostomy and improving the quality of life of patients with advanced disease
- Published
- 2006
3. Endoscopic submucosal dissection in patients with early esophageal squamous cell carcinoma: results from a prospective Western series
- Author
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Cesare Hassan, Nico Pagano, Rinaldo Nicita, G. Strangio, Giacomo Rando, Alessandro Repici, Fabio Romeo, Riccardo Rosati, Angelo Zullo, Alessandra Carlino, Alberto Malesci, A., Repici, C., Hassan, A., Carlino, N., Pagano, A., Zullo, G., Rando, G., Strangio, F., Romeo, R., Nicita, Rosati, Riccardo, A., Malesci, Repici A., Hassan C., Carlino A., Pagano N., Zullo A., Rando G., Strangio G., Romeo F., Nicita R., Rosati R., and Malesci A.
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Male ,medicine.medical_specialty ,Esophageal Neoplasms ,Perforation (oil well) ,Disease-Free Survival ,Esophagus ,Postoperative Complications ,Carcinoma ,medicine ,Animals ,Humans ,Radiology, Nuclear Medicine and imaging ,Prospective Studies ,esd, squamocellular, esophagus ,Prospective cohort study ,Aged ,Aged, 80 and over ,medicine.diagnostic_test ,business.industry ,Esophageal disease ,Gastroenterology ,Cancer ,Middle Aged ,medicine.disease ,Surgery ,Endoscopy ,medicine.anatomical_structure ,Mediastinal Emphysema ,Carcinoma, Squamous Cell ,Female ,Esophagoscopy ,business ,Follow-Up Studies - Abstract
Background: Although endoscopic submucosal dissection (ESD) is becoming accepted as an established treatment for superficial esophageal squamous cell neoplasia, the majority of data on this endoscopic modality has been provided by Japanese series. Objective: To assess the efficacy and safety of ESD for esophageal squamous cell neoplasia in a consecutive series of patients treated in a Western setting. Design and Setting: Single-center, prospective observational study. Patients and Intervention: From January 2005 to July 2008, 20 patients with superficial esophageal squamous cell neoplasia were treated by ESD. Main Outcome Measurements: Rates of en bloc resection, complete resection, and complications were evaluated as short-term outcomes. Overall survival, local or distant recurrence, and postoperative stricture rates were evaluated as long-term outcomes. Results: ESD was performed in 20 patients (mean age 64 years, range 46-81 years; 16 men). The mean size of the lesion was 32 mm (range 15-60 mm); it was 30 mm or larger in 14 patients (70%). The mean time of ESD was 89 minutes (range 58-180 minutes). En bloc resection with resection-free margins was achieved in 18 patients (90%), whereas 2 patients presented with incomplete or indeterminate resection. Two cases (10%) of mediastinal emphysema without overt perforation and 1 case (5%) of post-ESD symptomatic stricture were reported. No local or distant post-ESD recurrence occurred in those with resection-free margins at a median follow-up of 18 months. Limitations: Small number of patients and limited follow-up. Conclusion: This Western series study confirms that ESD is a potentially curative treatment for superficial esophageal squamous cell neoplasia. Early and late complication rates were comparable to those of Japanese series. ESD should be probably considered as the treatment of choice in all large lesions amenable to endoscopic treatment. © 2010 American Society for Gastrointestinal Endoscopy.
- Published
- 2010
4. Emerging from gastroesophageal reflux (EMERGE): An Italian survey - II the viewpoint of the patient.
- Author
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Bianchetti M, Peralta S, Nicita R, Aragona SE, and Ciprandi G
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- Adult, Aged, Female, Humans, Italy, Male, Middle Aged, Surveys and Questionnaires, Gastroesophageal Reflux drug therapy, Gastrointestinal Agents therapeutic use
- Abstract
Gastroesophageal reflux disease (GERD) is a very common disease, as about a quarter of the Western population has GERD symptoms at least weekly and GERD is the most frequent reason for outpatient gastroenterology consultation. GERD treatment is based on proton pump inhibitor (PPI) use, but PPI may be ineffective in some patients and potentially unsafe if administered for very long time. A new medical compound (Marial®) has been introduced on the Italian market. This product contains magnesium alginate and a phytopolymer: it may be able to repair ulcer/erosion, protect mucosal tissue, and contrast acid contents. The current survey was conducted on a large group of GERD patients visited at 56 Italian gastroenterological offices. Patients were treated with PPI alone, PPI plus add-on, or Marial® for 4 weeks: the choice was decided by each gastroenterologist on the basis of the best practice criterion. A reflux symptoms index (RSI) questionnaire was used to weekly assess the clinical features. Marial® and PPI plus add-on significantly reduced RSI scores, from the second week. Noteworthy, Marial® was more effective than PPI plus add-on. In conclusion, the current survey demonstrated that patients with GERD perceived a significant improvement of GERD symptoms measured by the RSI questionnaire. Marial® was as effective as PPI plus add-on., (Copyright © by BIOLIFE, s.a.s. This publication and/or article is for individual use only and may not be further reproduced without written permission from the copyright holder. Unauthorized reproduction may result in financial and other penalties.)
- Published
- 2018
5. Correlation between the reflux finding score and the GERD impact scale in patients with gastroesophageal reflux disease.
- Author
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Bianchetti M, Peralta S, Nicita R, Aragona SE, and Ciprandi G
- Subjects
- Adult, Aged, Female, Humans, Male, Middle Aged, Gastroesophageal Reflux diagnosis, Severity of Illness Index, Surveys and Questionnaires
- Abstract
Gastroesophageal reflux disease (GERD) is a very common disorder. As there is no gold standard diagnostic tool, patient-based strategy is adopted in clinical practice. In this regard, there are questionnaires able to easily and rapidly assess symptom severity directly by the patient. The GERD Impact Scale (GIS) and the Reflux Symptom Index (RSI) have been validated as diagnostic tools in routine clinical care. The present study aimed to correlate RIS values with GIS scores in a large cohort of GERD patients visited at gastroenterological clinics. Globally, 785 subjects (51.2% males, 48.8% females, mean age: 49.59 years) were visited in 56 Italian gastroenterological offices. The current study demonstrates that a GIS value >19 may be a reliable cut-off to define the positivity of the test, and GIS and RSI were significantly correlated. Therefore, both tests may be recommended for GERD patients in clinical practice., (Copyright © by BIOLIFE, s.a.s. This publication and/or article is for individual use only and may not be further reproduced without written permission from the copyright holder. Unauthorized reproduction may result in financial and other penalties)
- Published
- 2018
6. Emerging from gastroesophageal reflux (EMERGE): an Italian survey - I the viewpoint of the gastroenterologist.
- Author
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Bianchetti M, Peralta S, Nicita R, Aragona SE, and Ciprandi G
- Subjects
- Adult, Aged, Female, Gastroenterologists statistics & numerical data, Humans, Italy, Male, Middle Aged, Surveys and Questionnaires, Gastroesophageal Reflux drug therapy, Gastrointestinal Agents therapeutic use, Practice Patterns, Physicians' statistics & numerical data
- Abstract
Gastroesophageal reflux disease (GERD) is defined as a “disease that develops when the reflux of stomach contents induces troublesome symptoms and/or complications”. From a therapeutic point of view, many options have been proposed, including proton pump inhibitors (PPI), antihistamines (H2- receptor antagonists), antacid chemical compounds, antireflux barrier (using alginates), prokinetics, inhibitors of gastric sphincters, protection of mucosal tissue, neuromodulators, nociceptor antagonists, lifestyle modification, and surgery. A new medical compound has been recently launched in Italy: Marial® (manufactured by Aurora, Milan, Italy) containing magnesium alginate and E-Gastryal®. The aim of this survey was to analyse the patients’ characteristics and the prescriptive approach considering both the past or current treatments and clinical features during a visit in 56 gastroenterological centers, distributed in the whole of Italy. One thousand eight hundred forty-nine patients (46.5% males, and 53.5% females, mean age 48.59 years) were visited. Patients with positive reflux symptoms index (RSI+) had higher GIS scores than RSI- subjects. PPIs (both as monotherapy or plus add-on) were the most common medication prescribed before the visit. There was a significant change of prescription to Marial® at the visit. More precisely,, Marial® was preferentially prescribed to about a quarter of the patients, particularly to those with lower GIS score, whereas PPI plus add-on option was preferred for patients with higher GIS score. In conclusion, the current experience demonstrated that GERD may be managed considering a patient-centred work-up by using the GIS questionnaire. GIS score may be able to define the medication choice that includes also the new medical compound Marial®., (Copyright © by BIOLIFE, s.a.s. This publication and/or article is for individual use only and may not be further reproduced without written permission from the copyright holder. Unauthorized reproduction may result in financial and other penalties)
- Published
- 2018
7. The role of cVEMPs and vHIT in the evaluation of otosclerosis and its eventual vestibular impairment: preliminary findings.
- Author
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Catalano N, Cammaroto G, Galletti B, Freni F, Nicita RA, Azielli C, and Galletti F
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- Adult, Case-Control Studies, Female, Humans, Male, Middle Aged, Otosclerosis complications, Otosclerosis physiopathology, Prospective Studies, Vestibular Diseases etiology, Head Impulse Test, Otosclerosis diagnosis, Otosclerosis surgery, Stapes Surgery, Vestibular Diseases physiopathology, Vestibular Evoked Myogenic Potentials
- Abstract
The role of cVEMPs and vHIT in the evaluation of otosclerosis and its eventual vestibular impairment: preliminary findings., Objectives: Otosclerosis is one of the most common causes of hearing loss in adults, with a prevalence of 0.3% to 0.4% in Caucasians. Vestibular symptoms may occur, with an incidence ranging between 5% and 57% of patients. The aim of our study is to evaluate the vestibular function and its eventual changes after stapes surgery in patients affected by otosclerosis., Methods: Prospective case-control study. Twenty patients (17 females; age range 33-58; mean age 44) who underwent surgery for otosclerotic disease between April 2012 and February 2014 were prospectively studied. These patients underwent preoperative and postoperative audiological tests. Furthermore, vestibular function was evaluated using the cervical evoked myogenic potentials test (cVEMPs) and video head impulse test (vHIT), preoperatively and postoperatively. A case-control study was also performed. Quantitative and statistical analysis of patients' vestibular function was carried out both before and after stapes surgery., Results: The means of the vHIT gains in the case group were 1.03 on the right side and 1.01 on the left side. A significant difference between case and control groups was seen, with a lower left gain registered in the control group. No cases with a gain of less than 0.8 were found in either group. Moreover, a significant postoperative reduction in P1/NI amplitude was seen in patients complaining of postoperative dizziness or vertigo., Conclusions: These findings indicate a probable traumatic saccular impairment in patients with vestibular symptoms. However, a longer follow-up may help in understanding the behaviour of cVEMPs in post-stapes surgery vertigo.
- Published
- 2017
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