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28 results on '"Offner, Felix A."'

4. Lipoxygenase mediates invasion of intrametastatic lymphatic vessels and propagates lymph node metastasis of human mammary carcinoma xenografts in mouse

Author

Kerjaschki, Dontscho, Bago-Horvath, Zsuzsanna, Rudas, Margaretha, Sexl, Veronika, Schneckenleithner, Christine, Wolbank, Susanne, Bartel, Gregor, Krieger, Sigurd, Kalt, Romana, Hantusch, Brigitte, Keller, Thomas, Nagy-Bojarszky, Katalin, Huttary, Nicole, Raab, Ingrid, Lackner, Karin, Krautgasser, Katharina, Schachner, Helga, Kaserer, Klaus, Rezar, Sandra, Madlener, Sybille, Vonach, Caroline, Davidovits, Agnes, Nosaka, Hitonari, Hammerle, Monika, Viola, Katharina, Dolznig, Helmut, Schreiber, Martin, Nader, Alexander, Mikulits, Wolfgang, Gnant, Michael, Hirakawa, Satoshi, Detmar, Michael, Alitalo, Kari, Nijman, Sebastian, Offner, Felix, Maier, Thorsten J., Steinhilber, Dieter, and Krupitza, Georg

Subjects
Lymphatic metastasis -- Risk factors -- Research, Oxidases -- Physiological aspects -- Research, Breast cancer -- Risk factors -- Research, Health care industry
Abstract

In individuals with mammary carcinoma, the most relevant prognostic predictor of distant organ metastasis and clinical outcome is the status of axillary lymph node metastasis. Metastases form initially in axillary [...]

Published
2011
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8. Complications after oesophagectomy with possible contribution of neoadjuvant therapy including an EGFR-antibody to a fatal outcome

Author

Türtscher Martina, Offner Felix, Lang Alois, Ammann Karlheinz, Haid Anton, Knauer Michael, Cerkl Peter, and Wenzl Etienne

Subjects
Surgery, RD1-811, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Different molecular therapies like the EGFR-inhibiting antibody cetuximab have come into clinical practice. Cetuximab is EMEA-approved for metastatic colorectal cancer and advanced squamous-cell head and neck cancer. Administration is said to be safe and well tolerated with common, usually mild dermatologic side effects. Case presentation We present the case of a patient with fatal complications after oesophagectomy and neoadjuvant chemotherapy including cetuximab for squamous-cell esophageal cancer. A transthoracic en-bloc oesophagectomy was performed. Few days later the patient died due to gas exchange dysfunction and circulation instability after a previously unseen combination of drain-erosion of the stomach with subsequent pleurisy and air leak of the left main bronchus. Conclusion So far we have never observed this fatal combination of drain erosion of the stomach with fibrinous pleurisy and unmanageable progressive tracheal defect before. The role of cetuximab in the multifactorial aetiology of damages of stomach and trachea after oesophagectomy remains unclear since we are not able to link the complication directly to cetuximab or definitely exclude it as a sole surgical complication. Clinicians should be aware of the possibility of fatal side effects and careful recording of all complications is necessary in ongoing and planned studies to obtain more evidence about safety and tolerance of targeted therapies.

Published
2007
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13. Paternal chronic colitis causes epigenetic inheritance of susceptibility to colitis

Author

Tschurtschenthaler, Markus, primary, Kachroo, Priyadarshini, additional, Heinsen, Femke-Anouska, additional, Adolph, Timon Erik, additional, Rühlemann, Malte Christoph, additional, Klughammer, Johanna, additional, Offner, Felix Albert, additional, Ammerpohl, Ole, additional, Krueger, Felix, additional, Smallwood, Sébastien, additional, Szymczak, Silke, additional, Kaser, Arthur, additional, and Franke, Andre, additional

Published
2016
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14. ER stress transcription factor Xbp1 suppresses intestinal tumorigenesis and directs intestinal stem cells

Author

Niederreiter, Lukas, primary, Fritz, Teresa M.J., additional, Adolph, Timon E., additional, Krismer, Anna-Maria, additional, Offner, Felix A., additional, Tschurtschenthaler, Markus, additional, Flak, Magdalena B., additional, Hosomi, Shuhei, additional, Tomczak, Michal F., additional, Kaneider, Nicole C., additional, Sarcevic, Edina, additional, Kempster, Sarah L., additional, Raine, Tim, additional, Esser, Daniela, additional, Rosenstiel, Philip, additional, Kohno, Kenji, additional, Iwawaki, Takao, additional, Tilg, Herbert, additional, Blumberg, Richard S., additional, and Kaser, Arthur, additional

Published
2013
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15. 154 ER Stress Transcription Factor XBP1 Suppresses Intestinal Tumorigenesis

Author

Niederreiter, Lukas, primary, Fritz, Teresa M.J., additional, Adolph, Timon, additional, Offner, Felix A., additional, Hosomi, Shuhei, additional, Tomczak, Michal, additional, Tschurtschenthaler, Markus, additional, Kempster, Sarah L., additional, Raine, Tim, additional, Tilg, Herbert, additional, Blumberg, Richard S., additional, and Kaser, Arthur, additional

Published
2013
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16. CYP2D6 Metabolism and Patient Outcome in the Austrian Breast and Colorectal Cancer Study Group Trial (ABCSG) 8

Author

Goetz, Matthew P., primary, Suman, Vera J., additional, Hoskin, Tanya L., additional, Gnant, Michael, additional, Filipits, Martin, additional, Safgren, Stephanie L., additional, Kuffel, Mary, additional, Jakesz, Raimund, additional, Rudas, Margaretha, additional, Greil, Richard, additional, Dietze, Otto, additional, Lang, Alois, additional, Offner, Felix, additional, Reynolds, Carol A., additional, Weinshilboum, Richard M., additional, Ames, Matthew M., additional, and Ingle, James N., additional

Published
2013
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19. Suppressor of Cytokine Signaling-3 Antagonizes cAMP Effects on Proliferation and Apoptosis and Is Expressed in Human Prostate Cancer

Author

Bellezza, Ilaria, primary, Neuwirt, Hannes, additional, Nemes, Constanze, additional, Cavarretta, Ilaria T., additional, Puhr, Martin, additional, Steiner, Hannes, additional, Minelli, Alba, additional, Bartsch, Georg, additional, Offner, Felix, additional, Hobisch, Alfred, additional, Doppler, Wolfgang, additional, and Culig, Zoran, additional

Published
2006
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21. Successful stem cell transplantation following orthotopic liver transplantation from the same haploidentical family donor in a girl with hemophagocytic lymphohistiocytosis

Author

Matthes-Martin, Susanne, primary, Peters, Christina, additional, Königsrainer, Alfred, additional, Fritsch, Gerhard, additional, Lion, Thomas, additional, Heitger, Andreas, additional, Kapelari, Klaus, additional, Kronberger, Martina, additional, Offner, Felix, additional, Wrba, Fritz, additional, Margreiter, Raimund, additional, and Gadner, Helmut, additional

Published
2000
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23. INDUCTION OF HEAT SHOCK PROTEIN 70 BY ZINC-bis-(DLHYDROGENASPARTATE) REDUCES CYTOKINE LIBERATION, APOPTOSIS, AND MORTALITY RATE IN A RAT MODEL OF LD100 ENDOTOXEMIA

Author

Klosterhalfen, Bernd, primary, Hauptmann, Steffen, additional, Offner, Felix-Albert, additional, Amo-Takyi, Baffour, additional, Töns, Christian, additional, Winkeltau, Gerd, additional, Affify, Mamdouh, additional, Kupper, Werner, additional, Kirkpatrick, Charles-James, additional, and Mittermayer, Christian, additional

Published
1997
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25. IL-6 secretion by human peritoneal mesothelial and ovarian cancer cells

Author

Offner, Felix Albert, primary, Obrist, Peter, additional, Stadlmann, Sylvia, additional, Feichtinger, Hans, additional, Klingler, Paul, additional, Herold, Manfred, additional, Zwierzina, Heinz, additional, Hittmair, Anton, additional, Mikuz, Gregor, additional, Abendstein, Burghard, additional, Zeimet, A, additional, and Marth, Christian, additional

Published
1995
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27. ER stress transcription factor Xbp1 suppresses intestinal tumorigenesis and directs intestinal stem cells

Author

Niederreiter, Lukas, Fritz, Teresa M.J., Adolph, Timon E., Krismer, Anna-Maria, Offner, Felix A., Tschurtschenthaler, Markus, Flak, Magdalena B., Hosomi, Shuhei, Tomczak, Michal F., Kaneider, Nicole C., Sarcevic, Edina, Kempster, Sarah L., Raine, Tim, Esser, Daniela, Rosenstiel, Philip, Kohno, Kenji, Iwawaki, Takao, Tilg, Herbert, Blumberg, Richard S., and Kaser, Arthur

Abstract

Unresolved endoplasmic reticulum (ER) stress in the epithelium can provoke intestinal inflammation. Hypomorphic variants of ER stress response mediators, such as X-box–binding protein 1 (XBP1), confer genetic risk for inflammatory bowel disease. We report here that hypomorphic Xbp1 function instructs a multilayered regenerative response in the intestinal epithelium. This is characterized by intestinal stem cell (ISC) expansion as shown by an inositol-requiring enzyme 1α (Ire1α)–mediated increase in Lgr5+ and Olfm4+ ISCs and a Stat3-dependent increase in the proliferative output of transit-amplifying cells. These consequences of hypomorphic Xbp1 function are associated with an increased propensity to develop colitis-associated and spontaneous adenomatous polyposis coli (APC)–related tumors of the intestinal epithelium, which in the latter case is shown to be dependent on Ire1α. This study reveals an unexpected role for Xbp1 in suppressing tumor formation through restraint of a pathway that involves an Ire1α- and Stat3-mediated regenerative response of the epithelium as a consequence of ER stress. As such, Xbp1 in the intestinal epithelium not only regulates local inflammation but at the same time also determines the propensity of the epithelium to develop tumors.

Published
2013
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28. INDUCTION OF HEAT SHOCK PROTEIN 70 BY ZINCbisDLHYDROGENASPARTATE REDUCES CYTOKINE LIBERATION APOPTOSIS AND MORTALITY RATE IN A RAT MODEL OF LD100 ENDOTOXEMIA

Author

Klosterhalfen, Bernd, Hauptmann, Steffen, Offner, Felix-Albert, Amo-Takyi, Baffour, Töns, Christian, Winkeltau, Gerd, Affify, Mamdouh, Kupper, Werner, Kirkpatrick, Charles-James, and Mittermayer, Christian

Abstract

A prospective, randomized model of LD100/24 h endotoxemia was performed in male Wistar rats (n = 26; 250–300 g). The animals were divided into four groups: Group I (n = 5; saline treatment only), Group II (n = 5; Zn2+treatment only), Group III (n = 8; saline pretreatment, lipdpolysaccharide (LPS) treatment), and Group IV (n = 8; Zn2+pretreatment, LPS treatment). Zn2+pretreatment was carried out by intraperitoneal injection of 50 mg/kg zinc-bis-(DL-hydrogenaspartate) (10 mg/kg Zn2+). LD100/24 h endotoxemia was induced by intraperitoneal administration of 20 mg/kg LPS of the Escherichia colistrain WO111:B4. Tumor necrosis factor α, interleukin-1β, and interleukin-6 were detected by enzyme-linked immunosorbent assay (ELISA). HSP70 expression in the lungs, the liver, and the kidneys was determined by immunohistochemistry, Western blotting, and an HSP70 ELISA. Apoptosis was also detected by an in situapoptosis detection kit (TUNEL) and a cell death detection ELISA, respectively. This rat model of endotoxemia proves the close relationship between HSP70 expression, cytokine liberation, and development of apoptosis. The data demonstrate that: 1) Zn2+is a potent inducer of HSP70 expression; 2) the application of Zn2+leads to slightly increased cytokine plasma levels; and 3) the manipulation of the heat shock response by Zn2+significantly increases the survival rate after LD100 endotoxemia. Enhanced survival rate in animals pretreated with Zn2+may be explained by increased tissue levels of HSP70, a subsequent significantly decreased liberation of the proinflammatory cytokines after LPS challenge, and a significantly decreased rate of apoptosis.

Published
1997

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