1,475 results on '"Ognibene, A."'
Search Results
2. Unimib Assistant: designing a student-friendly RAG-based chatbot for all their needs
- Author
-
Antico, Chiara, Giordano, Stefano, Koyuturk, Cansu, and Ognibene, Dimitri
- Subjects
Computer Science - Human-Computer Interaction ,Computer Science - Artificial Intelligence ,Computer Science - Computers and Society - Abstract
Natural language processing skills of Large Language Models (LLMs) are unprecedented, having wide diffusion and application in different tasks. This pilot study focuses on specializing ChatGPT behavior through a Retrieval-Augmented Generation (RAG) system using the OpenAI custom GPTs feature. The purpose of our chatbot, called Unimib Assistant, is to provide information and solutions to the specific needs of University of Milano-Bicocca (Unimib) students through a question-answering approach. We provided the system with a prompt highlighting its specific purpose and behavior, as well as university-related documents and links obtained from an initial need-finding phase, interviewing six students. After a preliminary customization phase, a qualitative usability test was conducted with six other students to identify the strengths and weaknesses of the chatbot, with the goal of improving it in a subsequent redesign phase. While the chatbot was appreciated for its user-friendly experience, perceived general reliability, well-structured responses, and conversational tone, several significant technical and functional limitations emerged. In particular, the satisfaction and overall experience of the users was impaired by the system's inability to always provide fully accurate information. Moreover, it would often neglect to report relevant information even if present in the materials uploaded and prompt given. Furthermore, it sometimes generated unclickable links, undermining its trustworthiness, since providing the source of information was an important aspect for our users. Further in-depth studies and feedback from other users as well as implementation iterations are planned to refine our Unimib Assistant., Comment: Accepted for Italian Workshop on Artificial Intelligence for Human Machine Interaction (AIxHMI 2024), November 26, 2024, Bolzano, Italy
- Published
- 2024
3. Habit Coach: Customising RAG-based chatbots to support behavior change
- Author
-
Arabi, Arian Fooroogh Mand, Koyuturk, Cansu, O'Mahony, Michael, Calati, Raffaella, and Ognibene, Dimitri
- Subjects
Computer Science - Human-Computer Interaction ,Computer Science - Artificial Intelligence ,Computer Science - Computers and Society - Abstract
This paper presents the iterative development of Habit Coach, a GPT-based chatbot designed to support users in habit change through personalized interaction. Employing a user-centered design approach, we developed the chatbot using a Retrieval-Augmented Generation (RAG) system, which enables behavior personalization without retraining the underlying language model (GPT-4). The system leverages document retrieval and specialized prompts to tailor interactions, drawing from Cognitive Behavioral Therapy (CBT) and narrative therapy techniques. A key challenge in the development process was the difficulty of translating declarative knowledge into effective interaction behaviors. In the initial phase, the chatbot was provided with declarative knowledge about CBT via reference textbooks and high-level conversational goals. However, this approach resulted in imprecise and inefficient behavior, as the GPT model struggled to convert static information into dynamic and contextually appropriate interactions. This highlighted the limitations of relying solely on declarative knowledge to guide chatbot behavior, particularly in nuanced, therapeutic conversations. Over four iterations, we addressed this issue by gradually transitioning towards procedural knowledge, refining the chatbot's interaction strategies, and improving its overall effectiveness. In the final evaluation, 5 participants engaged with the chatbot over five consecutive days, receiving individualized CBT interventions. The Self-Report Habit Index (SRHI) was used to measure habit strength before and after the intervention, revealing a reduction in habit strength post-intervention. These results underscore the importance of procedural knowledge in driving effective, personalized behavior change support in RAG-based systems., Comment: Accepted for Italian Workshop on Artificial Intelligence for Human Machine Interaction (AIxHMI 2024), November 26, 2024, Bolzano, Italy
- Published
- 2024
4. One to rule them all: natural language to bind communication, perception and action
- Author
-
Colombani, Simone, Ognibene, Dimitri, and Boccignone, Giuseppe
- Subjects
Computer Science - Robotics ,Computer Science - Artificial Intelligence ,Computer Science - Human-Computer Interaction - Abstract
In recent years, research in the area of human-robot interaction has focused on developing robots capable of understanding complex human instructions and performing tasks in dynamic and diverse environments. These systems have a wide range of applications, from personal assistance to industrial robotics, emphasizing the importance of robots interacting flexibly, naturally and safely with humans. This paper presents an advanced architecture for robotic action planning that integrates communication, perception, and planning with Large Language Models (LLMs). Our system is designed to translate commands expressed in natural language into executable robot actions, incorporating environmental information and dynamically updating plans based on real-time feedback. The Planner Module is the core of the system where LLMs embedded in a modified ReAct framework are employed to interpret and carry out user commands. By leveraging their extensive pre-trained knowledge, LLMs can effectively process user requests without the need to introduce new knowledge on the changing environment. The modified ReAct framework further enhances the execution space by providing real-time environmental perception and the outcomes of physical actions. By combining robust and dynamic semantic map representations as graphs with control components and failure explanations, this architecture enhances a robot adaptability, task execution, and seamless collaboration with human users in shared and dynamic environments. Through the integration of continuous feedback loops with the environment the system can dynamically adjusts the plan to accommodate unexpected changes, optimizing the robot ability to perform tasks. Using a dataset of previous experience is possible to provide detailed feedback about the failure. Updating the LLMs context of the next iteration with suggestion on how to overcame the issue.
- Published
- 2024
5. Time is on my sight: scene graph filtering for dynamic environment perception in an LLM-driven robot
- Author
-
Colombani, Simone, Brini, Luca, Ognibene, Dimitri, and Boccignone, Giuseppe
- Subjects
Computer Science - Robotics ,Computer Science - Artificial Intelligence ,Computer Science - Human-Computer Interaction - Abstract
Robots are increasingly being used in dynamic environments like workplaces, hospitals, and homes. As a result, interactions with robots must be simple and intuitive, with robots perception adapting efficiently to human-induced changes. This paper presents a robot control architecture that addresses key challenges in human-robot interaction, with a particular focus on the dynamic creation and continuous update of the robot state representation. The architecture uses Large Language Models to integrate diverse information sources, including natural language commands, robotic skills representation, real-time dynamic semantic mapping of the perceived scene. This enables flexible and adaptive robotic behavior in complex, dynamic environments. Traditional robotic systems often rely on static, pre-programmed instructions and settings, limiting their adaptability to dynamic environments and real-time collaboration. In contrast, this architecture uses LLMs to interpret complex, high-level instructions and generate actionable plans that enhance human-robot collaboration. At its core, the system Perception Module generates and continuously updates a semantic scene graph using RGB-D sensor data, providing a detailed and structured representation of the environment. A particle filter is employed to ensure accurate object localization in dynamic, real-world settings. The Planner Module leverages this up-to-date semantic map to break down high-level tasks into sub-tasks and link them to robotic skills such as navigation, object manipulation (e.g., PICK and PLACE), and movement (e.g., GOTO). By combining real-time perception, state tracking, and LLM-driven communication and task planning, the architecture enhances adaptability, task efficiency, and human-robot collaboration in dynamic environments.
- Published
- 2024
6. Modeling Social Media Recommendation Impacts Using Academic Networks: A Graph Neural Network Approach
- Author
-
Guidotti, Sabrina, Donabauer, Gregor, Somazzi, Simone, Kruschwitz, Udo, Taibi, Davide, and Ognibene, Dimitri
- Subjects
Computer Science - Social and Information Networks ,Computer Science - Artificial Intelligence ,Computer Science - Information Retrieval ,Computer Science - Machine Learning - Abstract
The widespread use of social media has highlighted potential negative impacts on society and individuals, largely driven by recommendation algorithms that shape user behavior and social dynamics. Understanding these algorithms is essential but challenging due to the complex, distributed nature of social media networks as well as limited access to real-world data. This study proposes to use academic social networks as a proxy for investigating recommendation systems in social media. By employing Graph Neural Networks (GNNs), we develop a model that separates the prediction of academic infosphere from behavior prediction, allowing us to simulate recommender-generated infospheres and assess the model's performance in predicting future co-authorships. Our approach aims to improve our understanding of recommendation systems' roles and social networks modeling. To support the reproducibility of our work we publicly make available our implementations: https://github.com/DimNeuroLab/academic_network_project
- Published
- 2024
7. Generalizability analysis of deep learning predictions of human brain responses to augmented and semantically novel visual stimuli
- Author
-
Piskovskyi, Valentyn, Chimisso, Riccardo, Patania, Sabrina, Foulsham, Tom, Vizzari, Giuseppe, and Ognibene, Dimitri
- Subjects
Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Artificial Intelligence ,Computer Science - Human-Computer Interaction - Abstract
The purpose of this work is to investigate the soundness and utility of a neural network-based approach as a framework for exploring the impact of image enhancement techniques on visual cortex activation. In a preliminary study, we prepare a set of state-of-the-art brain encoding models, selected among the top 10 methods that participated in The Algonauts Project 2023 Challenge [16]. We analyze their ability to make valid predictions about the effects of various image enhancement techniques on neural responses. Given the impossibility of acquiring the actual data due to the high costs associated with brain imaging procedures, our investigation builds up on a series of experiments. Specifically, we analyze the ability of brain encoders to estimate the cerebral reaction to various augmentations by evaluating the response to augmentations targeting objects (i.e., faces and words) with known impact on specific areas. Moreover, we study the predicted activation in response to objects unseen during training, exploring the impact of semantically out-of-distribution stimuli. We provide relevant evidence for the generalization ability of the models forming the proposed framework, which appears to be promising for the identification of the optimal visual augmentation filter for a given task, model-driven design strategies as well as for AR and VR applications.
- Published
- 2024
8. On asymptotics of Robin eigenvalues in the Dirichlet limit
- Author
-
Ognibene, Roberto
- Subjects
Mathematics - Analysis of PDEs ,Mathematics - Spectral Theory ,35P15, 35P05 - Abstract
We investigate the asymptotic behavior of the eigenvalues of the Laplacian with homogeneous Robin boundary conditions, when the (positive) Robin parameter is diverging. In this framework, since the convergence of the Robin eigenvalues to the Dirichlet ones is known, we address the question of quantifying the rate of such convergence. More precisely, in this work we identify the proper geometric quantity representing (asymptotically) the first term in the expansion of the eigenvalue variation: it is a novel notion of torsional rigidity. Then, by performing a suitable asymptotic analysis of both such quantity and its minimizer, we prove the first-order expansion of any Robin eigenvalue, in the Dirichlet limit. Moreover, the convergence rate of the corresponding eigenfunctions is obtained as well. We remark that all our spectral estimates are explicit and sharp, and cover both the cases of convergence to simple and multiple Dirichlet eigenvalues.
- Published
- 2024
9. Learning mental states estimation through self-observation: a developmental synergy between intentions and beliefs representations in a deep-learning model of Theory of Mind
- Author
-
Bianco, Francesca, Rigato, Silvia, Filippetti, Maria Laura, and Ognibene, Dimitri
- Subjects
Computer Science - Neural and Evolutionary Computing ,Computer Science - Artificial Intelligence ,Computer Science - Machine Learning ,Computer Science - Robotics - Abstract
Theory of Mind (ToM), the ability to attribute beliefs, intentions, or mental states to others, is a crucial feature of human social interaction. In complex environments, where the human sensory system reaches its limits, behaviour is strongly driven by our beliefs about the state of the world around us. Accessing others' mental states, e.g., beliefs and intentions, allows for more effective social interactions in natural contexts. Yet, these variables are not directly observable, making understanding ToM a challenging quest of interest for different fields, including psychology, machine learning and robotics. In this paper, we contribute to this topic by showing a developmental synergy between learning to predict low-level mental states (e.g., intentions, goals) and attributing high-level ones (i.e., beliefs). Specifically, we assume that learning beliefs attribution can occur by observing one's own decision processes involving beliefs, e.g., in a partially observable environment. Using a simple feed-forward deep learning model, we show that, when learning to predict others' intentions and actions, more accurate predictions can be acquired earlier if beliefs attribution is learnt simultaneously. Furthermore, we show that the learning performance improves even when observed actors have a different embodiment than the observer and the gain is higher when observing beliefs-driven chunks of behaviour. We propose that our computational approach can inform the understanding of human social cognitive development and be relevant for the design of future adaptive social robots able to autonomously understand, assist, and learn from human interaction partners in novel natural environments and tasks.
- Published
- 2024
10. Local multiplicity for fractional linear equations with Hardy potentials
- Author
-
Mainini, Edoardo, Ognibene, Roberto, and Volzone, Bruno
- Subjects
Mathematics - Analysis of PDEs ,35A02, 35R11, 35B40, 35J75 - Abstract
We exhibit existence of non-trivial solutions of some fractional linear Schr\"odinger equations which are radial and vanish at the origin. This is in stark contrast to what happens in the local case. We also prove analogous results in the presence of a Hardy potential.
- Published
- 2024
11. Boundary regularity of the free interface in spectral optimal partition problems
- Author
-
Ognibene, Roberto and Velichkov, Bozhidar
- Subjects
Mathematics - Analysis of PDEs ,35R35, 35B40, 35J57, 49Q10 - Abstract
We consider the problem of optimal partition of a domain with respect to the sum of the principal eigenvalues and we prove for the first time regularity results for the free interface up to fixed boundary. All our results are quantitative and, in particular, we obtain fine estimates on the continuity of the solutions and the oscillation of the free interface (in terms of the modulus of continuity of the normal vector of the fixed boundary), even in the case of domains with low (Dini-type) regularity. Our analysis is based on an Almgren-type monotonicity formula at boundary points and an epiperimetric inequality at points of low frequency, which, together, yield an explicit rate of convergence for blow-up sequences and the boundary strong unique continuation property. Exploiting our quantitative blow-up analysis, we manage to prove clean-up results near one-phase and two-phase points. We define the notion of free interface inside the fixed boundary, and we prove that the subset of points of minimal frequency is regular and that the interior free interface is approaching the boundary orthogonally in a smooth way.
- Published
- 2024
12. Quantitative spectral stability for the Neumann Laplacian in domains with small holes
- Author
-
Felli, Veronica, Liverani, Lorenzo, and Ognibene, Roberto
- Subjects
Mathematics - Analysis of PDEs ,Mathematics - Spectral Theory ,35P05 35P15 35B25 - Abstract
The aim of the present paper is to investigate the behavior of the spectrum of the Neumann Laplacian in domains with little holes excised from the interior. More precisely, we consider the eigenvalues of the Laplacian with homogeneous Neumann boundary conditions on a bounded, Lipschitz domain. Then, we singularly perturb the domain by removing Lipschitz sets which are "small" in a suitable sense and satisfy a uniform extension property. In this context, we provide an asymptotic expansion for all the eigenvalues of the perturbed problem which are converging to simple eigenvalues of the limit one. The eigenvalue variation turns out to depend on a geometric quantity resembling the notion of (boundary) torsional rigidity: understanding this fact is one of the main contributions of the present paper. In the particular case of a hole shrinking to a point, through a fine blow-up analysis, we identify the exact vanishing order of such a quantity and we establish some connections between the location of the hole and the sign of the eigenvalue variation.
- Published
- 2023
13. Exploration and Comparison of Deep Learning Architectures to Predict Brain Response to Realistic Pictures
- Author
-
Chimisso, Riccardo, Buršić, Sathya, Marocco, Paolo, Vizzari, Giuseppe, and Ognibene, Dimitri
- Subjects
Quantitative Biology - Neurons and Cognition ,Computer Science - Artificial Intelligence ,Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Human-Computer Interaction ,Computer Science - Machine Learning ,Electrical Engineering and Systems Science - Signal Processing - Abstract
We present an exploration of machine learning architectures for predicting brain responses to realistic images on occasion of the Algonauts Challenge 2023. Our research involved extensive experimentation with various pretrained models. Initially, we employed simpler models to predict brain activity but gradually introduced more complex architectures utilizing available data and embeddings generated by large-scale pre-trained models. We encountered typical difficulties related to machine learning problems, e.g. regularization and overfitting, as well as issues specific to the challenge, such as difficulty in combining multiple input encodings, as well as the high dimensionality, unclear structure, and noisy nature of the output. To overcome these issues we tested single edge 3D position-based, multi-region of interest (ROI) and hemisphere predictor models, but we found that employing multiple simple models, each dedicated to a ROI in each hemisphere of the brain of each subject, yielded the best results - a single fully connected linear layer with image embeddings generated by CLIP as input. While we surpassed the challenge baseline, our results fell short of establishing a robust association with the data., Comment: Submitted to The Algonauts Project 2023 - Exploration and Comparison of Deep Learning Architectures to Predict Brain Response to Realistic Pictures - http://algonauts.csail.mit.edu/
- Published
- 2023
14. Multimodal Integration of Olfactory and Visual Processing through DCM analysis: Contextual Modulation of Facial Perception
- Author
-
Rho, Gianluca, Callara, Alejandro Luis, Bossi, Francesco, Ognibene, Dimitri, Cecchetto, Cinzia, Lomonaco, Tommaso, Scilingo, Enzo Pasquale, and Greco, Alberto
- Subjects
Quantitative Biology - Neurons and Cognition - Abstract
This study examines the modulatory effect of contextual hedonic olfactory stimuli on the visual processing of neutral faces using event-related potentials (ERPs) and effective connectivity analysis. The aim is to investigate how odors' valence influences the cortical connectivity underlying face processing, and the role arousal enhanced by faces plays on such visual-odor multimodal integration. To this goal, a novel methodological approach combining electrodermal activity (EDA) and dynamic causal modeling (DCM) was proposed to examine cortico-cortical interactions changes. The results revealed that EDA sympathetic responses were associated with an increase of the N170 amplitude, which may be suggested as a marker of heightened arousal to faces. Hedonic odors had an impact on early visual ERP components, with increased N1 amplitude during the administration of unpleasant odor and decreased vertex positive potential (VPP) amplitude during the administration of both unpleasant and neutral odors. On the connectivity side, unpleasant odors strengthened the forward connection from the inferior temporal gyrus (ITG) to the middle temporal gyrus (MTG), involved in processing changeable facial features. Conversely, the occurrence of sympathetic responses was correlated with an inhibition of the same connection, and with an enhancement of the backward connection from ITG to the fusiform face gyrus. These findings suggest that negative odors may enhance the interpretation of emotional expressions and mental states, while faces capable of enhancing sympathetic arousal prioritize the processing of identity. The proposed methodology provides insights into the neural mechanisms underlying the integration of visual and olfactory stimuli in face processing.
- Published
- 2023
15. Learning to Prompt in the Classroom to Understand AI Limits: A pilot study
- Author
-
Theophilou, Emily, Koyuturk, Cansu, Yavari, Mona, Bursic, Sathya, Donabauer, Gregor, Telari, Alessia, Testa, Alessia, Boiano, Raffaele, Hernandez-Leo, Davinia, Ruskov, Martin, Taibi, Davide, Gabbiadini, Alessandro, and Ognibene, Dimitri
- Subjects
Computer Science - Human-Computer Interaction ,Computer Science - Artificial Intelligence ,Computer Science - Computation and Language - Abstract
Artificial intelligence's (AI) progress holds great promise in tackling pressing societal concerns such as health and climate. Large Language Models (LLM) and the derived chatbots, like ChatGPT, have highly improved the natural language processing capabilities of AI systems allowing them to process an unprecedented amount of unstructured data. However, the ensuing excitement has led to negative sentiments, even as AI methods demonstrate remarkable contributions (e.g. in health and genetics). A key factor contributing to this sentiment is the misleading perception that LLMs can effortlessly provide solutions across domains, ignoring their limitations such as hallucinations and reasoning constraints. Acknowledging AI fallibility is crucial to address the impact of dogmatic overconfidence in possibly erroneous suggestions generated by LLMs. At the same time, it can reduce fear and other negative attitudes toward AI. This necessitates comprehensive AI literacy interventions that educate the public about LLM constraints and effective usage techniques, i.e prompting strategies. With this aim, a pilot educational intervention was performed in a high school with 21 students. It involved presenting high-level concepts about intelligence, AI, and LLMs, followed by practical exercises involving ChatGPT in creating natural educational conversations and applying established prompting strategies. Encouraging preliminary results emerged, including high appreciation of the activity, improved interaction quality with the LLM, reduced negative AI sentiments, and a better grasp of limitations, specifically unreliability, limited understanding of commands leading to unsatisfactory responses, and limited presentation flexibility. Our aim is to explore AI acceptance factors and refine this approach for more controlled future studies., Comment: Accepted for AIXIA 2023 22nd International Conference of the Italian Association for Artificial Intelligence 6 - 9 Nov, 2023, Rome, Italy
- Published
- 2023
16. A proteome-wide structural systems approach reveals insights into protein families of all human herpesviruses
- Author
-
Timothy K. Soh, Sofia Ognibene, Saskia Sanders, Robin Schäper, Benedikt B. Kaufer, and Jens B. Bosse
- Subjects
Science - Abstract
Abstract Structure predictions have become invaluable tools, but viral proteins are absent from the EMBL/DeepMind AlphaFold database. Here, we provide proteome-wide structure predictions for all nine human herpesviruses and analyze them in depth with explicit scoring thresholds. By clustering these predictions into structural similarity groups, we identified new families, such as the HCMV UL112-113 cluster, which is conserved in alpha- and betaherpesviruses. A domain-level search found protein families consisting of subgroups with varying numbers of duplicated folds. Using large-scale structural similarity searches, we identified viral proteins with cellular folds, such as the HSV-1 US2 cluster possessing dihydrofolate reductase folds and the EBV BMRF2 cluster that might have emerged from cellular equilibrative nucleoside transporters. Our HerpesFolds database is available at https://www.herpesfolds.org/herpesfolds and displays all models and clusters through an interactive web interface. Here, we show that system-wide structure predictions can reveal homology between viral species and identify potential protein functions.
- Published
- 2024
- Full Text
- View/download PDF
17. Alpinia zerumbet leaf extract reverses hypertension and improves adverse remodeling in the left ventricle and aorta in spontaneously hypertensive rats
- Author
-
Menezes, M.P., Santos, G.P., Nunes, D.V.Q., Silva, D.L.B., Victorio, C.P., Fernandes-Santos, C., de Bem, G.F., Costa, C.A., Resende, A.C., and Ognibene, D.T.
- Published
- 2025
- Full Text
- View/download PDF
18. Variants in the WDR44 WD40-repeat domain cause a spectrum of ciliopathy by impairing ciliogenesis initiation
- Author
-
Accogli, Andrea, Shakya, Saurabh, Yang, Taewoo, Insinna, Christine, Kim, Soo Yeon, Bell, David, Butov, Kirill R., Severino, Mariasavina, Niceta, Marcello, Scala, Marcello, Lee, Hyun Sik, Yoo, Taekyeong, Stauffer, Jimmy, Zhao, Huijie, Fiorillo, Chiara, Pedemonte, Marina, Diana, Maria C., Baldassari, Simona, Zakharova, Viktoria, Shcherbina, Anna, Rodina, Yulia, Fagerberg, Christina, Roos, Laura Sønderberg, Wierzba, Jolanta, Dobosz, Artur, Gerard, Amanda, Potocki, Lorraine, Rosenfeld, Jill A., Lalani, Seema R., Scott, Tiana M., Scott, Daryl, Azamian, Mahshid S., Louie, Raymond, Moore, Hannah W., Champaigne, Neena L., Hollingsworth, Grace, Torella, Annalaura, Nigro, Vincenzo, Ploski, Rafal, Salpietro, Vincenzo, Zara, Federico, Pizzi, Simone, Chillemi, Giovanni, Ognibene, Marzia, Cooney, Erin, Do, Jenny, Linnemann, Anders, Larsen, Martin J., Specht, Suzanne, Walters, Kylie J., Choi, Hee-Jung, Choi, Murim, Tartaglia, Marco, Youkharibache, Phillippe, Chae, Jong-Hee, Capra, Valeria, Park, Sung-Gyoo, and Westlake, Christopher J.
- Published
- 2024
- Full Text
- View/download PDF
19. On the spectrum of sets made of cores and tubes
- Author
-
Bianchi, Francesca, Brasco, Lorenzo, and Ognibene, Roberto
- Subjects
Mathematics - Analysis of PDEs ,Mathematics - Spectral Theory - Abstract
We analyze the spectral properties of a particular class of unbounded open sets. These are made of a central bounded ``core'', with finitely many unbounded tubes attached to it. We adopt an elementary and purely variational point of view, studying the compactness (or the defect of compactness) of level sets of the relevant constrained Dirichlet integral. As a byproduct of our argument, we also get exponential decay at infinity of variational eigenfunctions. Our analysis includes as a particular case a planar set (sometimes called ``bookcover''), already encountered in the literature on curved quantum waveguides. J. Hersch suggested that this set could provide the sharp constant in the {\it Makai-Hayman inequality} for the bottom of the spectrum of the Dirichlet-Laplacian of planar simply connected sets. We disprove this fact, by means of a singular perturbation technique., Comment: 42 pages, 7 figures. Dedicated to Giuseppe Buttazzo
- Published
- 2023
20. Developing Effective Educational Chatbots with ChatGPT prompts: Insights from Preliminary Tests in a Case Study on Social Media Literacy (with appendix)
- Author
-
Koyuturk, Cansu, Yavari, Mona, Theophilou, Emily, Bursic, Sathya, Donabauer, Gregor, Telari, Alessia, Testa, Alessia, Boiano, Raffaele, Gabbiadini, Alessandro, Hernandez-Leo, Davinia, Ruskov, Martin, and Ognibene, Dimitri
- Subjects
Computer Science - Human-Computer Interaction ,Computer Science - Artificial Intelligence ,Computer Science - Computers and Society - Abstract
Educational chatbots come with a promise of interactive and personalized learning experiences, yet their development has been limited by the restricted free interaction capabilities of available platforms and the difficulty of encoding knowledge in a suitable format. Recent advances in language learning models with zero-shot learning capabilities, such as ChatGPT, suggest a new possibility for developing educational chatbots using a prompt-based approach. We present a case study with a simple system that enables mixed-turn chatbot interactions and discuss the insights and preliminary guidelines obtained from initial tests. We examine ChatGPT's ability to pursue multiple interconnected learning objectives, adapt the educational activity to users' characteristics, such as culture, age, and level of education, and its ability to use diverse educational strategies and conversational styles. Although the results are encouraging, challenges are posed by the limited history maintained for the conversation and the highly structured form of responses by ChatGPT, as well as their variability, which can lead to an unexpected switch of the chatbot's role from a teacher to a therapist. We provide some initial guidelines to address these issues and to facilitate the development of effective educational chatbots., Comment: Poster version accepted at the 31st International Conference on Computers in Education (ICCE)
- Published
- 2023
21. Quantitative spectral stability for Aharonov-Bohm operators with many coalescing poles
- Author
-
Felli, Veronica, Noris, Benedetta, Ognibene, Roberto, and Siclari, Giovanni
- Subjects
Mathematics - Analysis of PDEs ,Mathematical Physics ,Mathematics - Spectral Theory ,35J10, 35P20, 35J75 - Abstract
The behavior of simple eigenvalues of Aharonov-Bohm operators with many coalescing poles is discussed. In the case of half-integer circulation, a gauge transformation makes the problem equivalent to an eigenvalue problem for the Laplacian in a domain with straight cracks, laying along the moving directions of poles. For this problem, we obtain an asymptotic expansion for eigenvalues, in which the dominant term is related to the minimum of an energy functional associated with the configuration of poles and defined on a space of functions suitably jumping through the cracks. Concerning configurations with an odd number of poles, an accurate blow-up analysis identifies the exact asymptotic behaviour of eigenvalues and the sign of the variation in some cases. An application to the special case of two poles is also discussed., Comment: Theorem 2.1 improved
- Published
- 2023
22. Complete Blood Count and Monocyte Distribution Width–Based Machine Learning Algorithms for Sepsis Detection: Multicentric Development and External Validation Study
- Author
-
Andrea Campagner, Luisa Agnello, Anna Carobene, Andrea Padoan, Fabio Del Ben, Massimo Locatelli, Mario Plebani, Agostino Ognibene, Maria Lorubbio, Elena De Vecchi, Andrea Cortegiani, Elisa Piva, Donatella Poz, Francesco Curcio, Federico Cabitza, and Marcello Ciaccio
- Subjects
Computer applications to medicine. Medical informatics ,R858-859.7 ,Public aspects of medicine ,RA1-1270 - Abstract
BackgroundSepsis is an organ dysfunction caused by a dysregulated host response to infection. Early detection is fundamental to improving the patient outcome. Laboratory medicine can play a crucial role by providing biomarkers whose alteration can be detected before the onset of clinical signs and symptoms. In particular, the relevance of monocyte distribution width (MDW) as a sepsis biomarker has emerged in the previous decade. However, despite encouraging results, MDW has poor sensitivity and positive predictive value when compared to other biomarkers. ObjectiveThis study aims to investigate the use of machine learning (ML) to overcome the limitations mentioned earlier by combining different parameters and therefore improving sepsis detection. However, making ML models function in clinical practice may be problematic, as their performance may suffer when deployed in contexts other than the research environment. In fact, even widely used commercially available models have been demonstrated to generalize poorly in out-of-distribution scenarios. MethodsIn this multicentric study, we developed ML models whose intended use is the early detection of sepsis on the basis of MDW and complete blood count parameters. In total, data from 6 patient cohorts (encompassing 5344 patients) collected at 5 different Italian hospitals were used to train and externally validate ML models. The models were trained on a patient cohort encompassing patients enrolled at the emergency department, and it was externally validated on 5 different cohorts encompassing patients enrolled at both the emergency department and the intensive care unit. The cohorts were selected to exhibit a variety of data distribution shifts compared to the training set, including label, covariate, and missing data shifts, enabling a conservative validation of the developed models. To improve generalizability and robustness to different types of distribution shifts, the developed ML models combine traditional methodologies with advanced techniques inspired by controllable artificial intelligence (AI), namely cautious classification, which gives the ML models the ability to abstain from making predictions, and explainable AI, which provides health operators with useful information about the models’ functioning. ResultsThe developed models achieved good performance on the internal validation (area under the receiver operating characteristic curve between 0.91 and 0.98), as well as consistent generalization performance across the external validation datasets (area under the receiver operating characteristic curve between 0.75 and 0.95), outperforming baseline biomarkers and state-of-the-art ML models for sepsis detection. Controllable AI techniques were further able to improve performance and were used to derive an interpretable set of diagnostic rules. ConclusionsOur findings demonstrate how controllable AI approaches based on complete blood count and MDW may be used for the early detection of sepsis while also demonstrating how the proposed methodology can be used to develop ML models that are more resistant to different types of data distribution shifts.
- Published
- 2025
- Full Text
- View/download PDF
23. Ezrin defines TSC complex activation at endosomal compartments through EGFR–AKT signaling
- Author
-
Giuliana Giamundo, Daniela Intartaglia, Eugenio Del Prete, Elena Polishchuk, Fabrizio Andreone, Marzia Ognibene, Sara Buonocore, Bruno Hay Mele, Francesco Giuseppe Salierno, Jlenia Monfregola, Dario Antonini, Paolo Grumati, Alessandra Eva, Rossella De Cegli, and Ivan Conte
- Subjects
EGFR ,EZRIN ,mTORC1 ,TSC complex ,endosome ,lysosome ,Medicine ,Science ,Biology (General) ,QH301-705.5 - Abstract
Endosomes have emerged as major signaling hubs where different internalized ligand–receptor complexes are integrated and the outcome of signaling pathways are organized to regulate the strength and specificity of signal transduction events. Ezrin, a major membrane–actin linker that assembles and coordinates macromolecular signaling complexes at membranes, has emerged recently as an important regulator of lysosomal function. Here, we report that endosomal-localized EGFR/Ezrin complex interacts with and triggers the inhibition of the Tuberous Sclerosis Complex (TSC complex) in response to EGF stimuli. This is regulated through activation of the AKT signaling pathway. Loss of Ezrin was not sufficient to repress TSC complex by EGF and culminated in translocation of TSC complex to lysosomes triggering suppression of mTORC1 signaling. Overexpression of constitutively active EZRINT567D is sufficient to relocalize TSC complex to the endosomes and reactivate mTORC1. Our findings identify EZRIN as a critical regulator of autophagy via TSC complex in response to EGF stimuli and establish the central role of early endosomal signaling in the regulation of mTORC1. Consistently, Medaka fish deficient for Ezrin exhibit defective endo-lysosomal pathway, attributable to the compromised EGFR/AKT signaling, ultimately leading to retinal degeneration. Our data identify a pivotal mechanism of endo-lysosomal signaling involving Ezrin and its associated EGFR/TSC complex, which are essential for retinal function.
- Published
- 2025
- Full Text
- View/download PDF
24. Influence of the Geometry of the world model on Curiosity Based Exploration
- Author
-
Sergeant-Perthuis, Grégoire, Ruet, Nils, Rudrauf, David, Ognibene, Dimitri, and Tisserand, Yvain
- Subjects
Computer Science - Artificial Intelligence ,Electrical Engineering and Systems Science - Systems and Control ,Quantitative Biology - Neurons and Cognition - Abstract
In human spatial awareness, 3-D projective geometry structures information integration and action planning through perspective taking within an internal representation space. The way different perspectives are related and transform a world model defines a specific perception and imagination scheme. In mathematics, such collection of transformations corresponds to a 'group', whose 'actions' characterize the geometry of a space. Imbuing world models with a group structure may capture different agents' spatial awareness and affordance schemes. We used group action as a special class of policies for perspective-dependent control. We explored how such geometric structure impacts agents' behavior, comparing how the Euclidean versus projective groups act on epistemic value in active inference, drive curiosity, and exploration behaviors. We formally demonstrate and simulate how the groups induce distinct behaviors in a simple search task. The projective group's nonlinear magnification of information transformed epistemic value according to the choice of frame, generating behaviors of approach toward an object of interest. The projective group structure within the agent's world model contains the Projective Consciousness Model, which is know to capture key features of consciousness. On the other hand, the Euclidean group had no effect on epistemic value : no action was better than the initial idle state. In structuring a priori an agent's internal representation, we show how geometry can play a key role in information integration and action planning.
- Published
- 2023
25. Sharp behavior of Dirichlet--Laplacian eigenvalues for a class of singularly perturbed problems
- Author
-
Abatangelo, Laura and Ognibene, Roberto
- Subjects
Mathematics - Analysis of PDEs ,Mathematics - Spectral Theory ,35J25, 35P15, 35B25 - Abstract
We deepen the study of Dirichlet eigenvalues in bounded domains where a thin tube is attached to the boundary. As its section shrinks to a point, the problem is spectrally stable and we quantitatively investigate the rate of convergence of the perturbed eigenvalues. We detect the proper quantity which sharply measures the perturbation's magnitude. It is a sort of torsional rigidity of the tube's section relative to the domain. This allows us to sharply describe the asymptotic behavior of the perturbed spectrum, even when eigenvalues converge to a multiple one. The final asymptotics of eigenbranches depend on the local behavior near the junction of eigenfunctions chosen in a special way. The present techniques also apply when the perturbation of the Dirichlet eigenvalue problem consists in prescribing homogeneous Neumann boundary conditions on a small portion of the boundary of the domain.
- Published
- 2023
26. World Models and Predictive Coding for Cognitive and Developmental Robotics: Frontiers and Challenges
- Author
-
Taniguchi, Tadahiro, Murata, Shingo, Suzuki, Masahiro, Ognibene, Dimitri, Lanillos, Pablo, Ugur, Emre, Jamone, Lorenzo, Nakamura, Tomoaki, Ciria, Alejandra, Lara, Bruno, and Pezzulo, Giovanni
- Subjects
Computer Science - Robotics ,Computer Science - Artificial Intelligence ,Computer Science - Machine Learning - Abstract
Creating autonomous robots that can actively explore the environment, acquire knowledge and learn skills continuously is the ultimate achievement envisioned in cognitive and developmental robotics. Their learning processes should be based on interactions with their physical and social world in the manner of human learning and cognitive development. Based on this context, in this paper, we focus on the two concepts of world models and predictive coding. Recently, world models have attracted renewed attention as a topic of considerable interest in artificial intelligence. Cognitive systems learn world models to better predict future sensory observations and optimize their policies, i.e., controllers. Alternatively, in neuroscience, predictive coding proposes that the brain continuously predicts its inputs and adapts to model its own dynamics and control behavior in its environment. Both ideas may be considered as underpinning the cognitive development of robots and humans capable of continual or lifelong learning. Although many studies have been conducted on predictive coding in cognitive robotics and neurorobotics, the relationship between world model-based approaches in AI and predictive coding in robotics has rarely been discussed. Therefore, in this paper, we clarify the definitions, relationships, and status of current research on these topics, as well as missing pieces of world models and predictive coding in conjunction with crucially related concepts such as the free-energy principle and active inference in the context of cognitive and developmental robotics. Furthermore, we outline the frontiers and challenges involved in world models and predictive coding toward the further integration of AI and robotics, as well as the creation of robots with real cognitive and developmental capabilities in the future., Comment: 28 pages, 3 figures
- Published
- 2023
27. Robot Learning Theory of Mind through Self-Observation: Exploiting the Intentions-Beliefs Synergy
- Author
-
Bianco, Francesca and Ognibene, Dimitri
- Subjects
Computer Science - Robotics ,Computer Science - Artificial Intelligence ,Computer Science - Machine Learning - Abstract
In complex environments, where the human sensory system reaches its limits, our behaviour is strongly driven by our beliefs about the state of the world around us. Accessing others' beliefs, intentions, or mental states in general, could thus allow for more effective social interactions in natural contexts. Yet these variables are not directly observable. Theory of Mind (TOM), the ability to attribute to other agents' beliefs, intentions, or mental states in general, is a crucial feature of human social interaction and has become of interest to the robotics community. Recently, new models that are able to learn TOM have been introduced. In this paper, we show the synergy between learning to predict low-level mental states, such as intentions and goals, and attributing high-level ones, such as beliefs. Assuming that learning of beliefs can take place by observing own decision and beliefs estimation processes in partially observable environments and using a simple feed-forward deep learning model, we show that when learning to predict others' intentions and actions, faster and more accurate predictions can be acquired if beliefs attribution is learnt simultaneously with action and intentions prediction. We show that the learning performance improves even when observing agents with a different decision process and is higher when observing beliefs-driven chunks of behaviour. We propose that our architectural approach can be relevant for the design of future adaptive social robots that should be able to autonomously understand and assist human partners in novel natural environments and tasks.
- Published
- 2022
28. Relating trackbed stiffness and behaviour with track performance and maintenance needs
- Author
-
Ognibene, Giacomo, Powrie, William, Le Pen, Louis, and Harkness, John
- Abstract
Differential settlement along the track is a significant concern for railways, especially but not exclusively at transitions onto or from hard substructures. Recent attempts to forecast its development have combined empirical or semi-empirical ballast settlement equations with dynamic vehicle track interaction (VTI) models. Such analyses may demonstrate a relationship between variations in loading and settlement and how track geometry deterioration onsets. However, a generally applicable settlement equation is inexistent, and current VTI simulations run for short track sections or in large steps with settlement predicted forward cycles for computational economy. This study proposes a new track settlement model, named STAM, that accounts for load magnitude and history and the contribution of subgrade layers to the total permanent deformation. The model's functions and parameters are determined using data from cyclic laboratory tests on a single sleeper and Finite Element (FE) analyses. STAM was then integrated into an in-house VTI model and acceleration algorithm to form a Vehicle Track Interaction Long-term Model (VTILM). The capability of VTILM to estimate the development of track differential settlement over 10,000 cycles was tested in two 65-m long track sections with variations in trackbed support conditions: a single-span railway bridge and a plain track section with a stochastic trackbed stiffness. The effect of track stiffness, train speed, earthwork materials and initial settlement profile on the performance of the single-span railway bridge was also evaluated in the short-term using a dynamic 2D FE model. The model demonstrates that variations in track stiffness associated with changes in trackbed condition could onset track geometry degradation. The model can replicate three frequently observed track behaviours: the development of a bump/dip at the ends of transition zones, the increased maintenance needs for poor trackbed conditions, and a relation between the maximum settlement and maximum angular distortion.
- Published
- 2023
29. Chronic exposure to inhaled vaporized cannabis high in Δ9-THC suppresses Adderall-induced brain activity
- Author
-
Jack M. Ognibene, Rajeev I. Desai, Praveen P. Kulkarni, and Craig F. Ferris
- Subjects
basal ganglia ,functional MRI ,awake animal imaging ,BOLD ,accumbens ,Therapeutics. Pharmacology ,RM1-950 - Abstract
BackgroundThere are increasing reports of the misuse of prescription psychostimulants for cognitive enhancement together with recreational cannabis. This raises a concern that chronic use of cannabis high in Δ9-THC may alter the sensitivity to amphetamines. In this exploratory study we hypothesized chronic exposure to Δ9-THC through vaporized cannabis would diminish the central nervous system (CNS) activity of Adderall.MethodsTo address this issue we exposed male and female mice to inhaled vaporized cannabis (10.3% Δ9-THC) or placebo for 30 min each day for ten consecutive days. After 24 h, mice were imaged fully awake for changes in BOLD signal following an IP injection of Adderall (60 µg) during the scanning session. After a 2-week washout, without any cannabis or placebo exposure, mice were again imaged and challenged with Adderall during the scanning session. The data were registered to a mouse 3D MRI atlas with 134 brain regions providing site-specific increases and decreases in global brain activity.ResultsMice exposed to cannabis when compared to placebo showed a decrease in brain activation to Adderall. The blunted Adderall response was characterized by a decrease in positive BOLD signal and increase in negative BOLD. The prefrontal cortex, accumbens, ventral pallidum, caudate/putamen, and thalamus were most affected. After a 2-week wash out there were no significant differences between the cannabis and placebo groups when challenged with Adderall.SummaryThis exploratory study shows that short, daily exposures to inhaled cannabis, something equivalent to recreational use, affects the sensitivity to the psychostimulant Adderall. The reduced Adderall effect on brain activity, particularly circuitry associated with dopaminergic signaling raises concerns about escalation in psychostimulant use.
- Published
- 2024
- Full Text
- View/download PDF
30. Radiation protection and natural building materials in cultural heritage
- Author
-
Giuseppe La Verde, Alessio Ricciardelli, Elisa Ognibene, Fabrizio Ambrosino, and Mariagabriella Pugliese
- Subjects
building material ,measurements ,ionizing radiation ,cultural heritage ,radiation protection ,indoor environment ,Engineering (General). Civil engineering (General) ,TA1-2040 ,City planning ,HT165.5-169.9 - Abstract
IntroductionBuildings that constitute cultural heritage and that are the identity of a defined geographical area are increasingly being restored to offer the community historical places to enjoy. Often the restoration preserves the original structure and building materials, which are usually natural stones. In this study, a radioprotection protocol dedicated to this kind of built environment was proposed and validated.MethodsAfter identifying the two predominant types of building material stones (Rosso ammonitico and Pietra Serena), radiometric measurements for natural gamma-emitting radionuclides (Ra-226, Th-232, and K-40) and measurements of the emanation coefficient and calculation of the exhalation rate of radon gas were carried out.ResultsThe two types of stone have a content of natural radionuclides that do not exceed the levels recommended by the regulations. The difference between the two types of stone is of an order of magnitude indicating that the red ammonite has a greater radiological impact than the pietra serena.DiscussionThe results, in addition to ensuring the radioprotection of the population, highlighted the need to increase the number of this kind of investigations to implement scientific knowledge and serve the stakeholders involved.
- Published
- 2024
- Full Text
- View/download PDF
31. Pre-Hospital Point-of-Care Troponin: Is It Possible to Anticipate the Diagnosis? A Preliminary Report
- Author
-
Cristian Lazzari, Sara Montemerani, Cosimo Fabrizi, Cecilia Sacchi, Antoine Belperio, Marilena Fantacci, Giovanni Sbrana, Agostino Ognibene, Maurizio Zanobetti, and Simone Nocentini
- Subjects
chest pain ,acute myocardial infarction (AMI) ,acute coronary syndromes (ACSs) ,point-of-care testing (POCT) ,high-sensitivity cardiac troponin (hs-cTn) ,non-ST-segment elevation myocardial infarction (NSTEMI) ,Medicine (General) ,R5-920 - Abstract
Background: Thanks to the evolution of laboratory medicine, point-of-care testing (POCT) for troponin levels in the blood (hs-cTn) has been greatly improved in order to quickly diagnose acute myocardial infarction (AMI) with an accuracy similar to standard laboratory tests. The rationale of the HEART POCT study is to propose the application of the 0/1 h European Society of Cardiology (ESC) algorithm in the pre-hospital setting using a POCT device (Atellica VTLi). Methods: This is a prospective study comparing patients who underwent pre-hospital point-of-care troponin testing (Atellica VTLi) with a control group that underwent standard hospital-based troponin testing (Elecsys). The primary objectives were to determine if the 0/1 h algorithm of the Atellica VTLi is non-inferior to the standard laboratory method for diagnosing AMI and to analyze rule-out/rule-in times and emergency department (ED) stay times. The secondary objective was to evaluate the feasibility of pre-hospital troponin testing. Results: The Atellica VTLi demonstrated reasonable sensitivity for detecting AMI, with sensitivity increasing from 60% at the first measurement (time 0) to 80% at the second measurement (time 1 h). Both the Atellica VTLi and the Elecsys method showed high negative predictive value (NPV), indicating that a negative troponin result effectively ruled out AMI in most cases. Patients in the Atellica VTLi group experienced significantly shorter times to diagnosis and discharge from the emergency department compared to the control group (Elecsys). This highlights a potential benefit of point-of-care testing: streamlining the diagnostic and treatment processes. Conclusions: POCT allows for rapid troponin measurement, leading to a faster diagnosis of non-ST-segment elevation myocardial infarction (NSTEMI). This enables earlier initiation of appropriate treatment, potentially improving patient outcomes and the efficiency of emergency department operations. POCT could be particularly beneficial in pre-hospital settings, enabling faster triage and transportation of patients to appropriate care centers.
- Published
- 2025
- Full Text
- View/download PDF
32. Monitoring and mapping of crop fields with UAV swarms based on information gain
- Author
-
Carbone, Carlos, Albani, Dario, Magistri, Federico, Ognibene, Dimitri, Stachniss, Cyrill, Kootstra, Gert, Nardi, Daniele, and Trianni, Vito
- Subjects
Computer Science - Robotics - Abstract
Monitoring crop fields to map features like weeds can be efficiently performed with unmanned aerial vehicles (UAVs) that can cover large areas in a short time due to their privileged perspective and motion speed. However, the need for high-resolution images for precise classification of features (e.g., detecting even the smallest weeds in the field) contrasts with the limited payload and ight time of current UAVs. Thus, it requires several flights to cover a large field uniformly. However, the assumption that the whole field must be observed with the same precision is unnecessary when features are heterogeneously distributed, like weeds appearing in patches over the field. In this case, an adaptive approach that focuses only on relevant areas can perform better, especially when multiple UAVs are employed simultaneously. Leveraging on a swarm-robotics approach, we propose a monitoring and mapping strategy that adaptively chooses the target areas based on the expected information gain, which measures the potential for uncertainty reduction due to further observations. The proposed strategy scales well with group size and leads to smaller mapping errors than optimal pre-planned monitoring approaches.
- Published
- 2022
- Full Text
- View/download PDF
33. Asymptotic behavior of constrained local minimizers in finite elasticity
- Author
-
Mainini, Edoardo, Ognibene, Roberto, and Percivale, Danilo
- Subjects
Mathematics - Analysis of PDEs ,Mathematical Physics ,Mathematics - Optimization and Control - Abstract
We provide an approximation result for the pure traction problem of linearized elasticity in terms of local minimizers of finite elasticity, under the constraint of vanishing average curl for admissible deformation maps. When suitable rotations are included in the constraint, the limit is shown to be the linear elastic equilibrium associated to rotated loads.
- Published
- 2021
34. A quantitative stability inequality for fractional capacities
- Author
-
Cinti, Eleonora, Ognibene, Roberto, and Ruffini, Berardo
- Subjects
Mathematics - Analysis of PDEs ,49Q10, 39B62, 35R11, 32U20 - Abstract
The aim of this work is to show a non-sharp quantitative stability version of the fractional isocapacitary inequality. In particular, we provide a lower bound for the isocapacitary deficit in terms of the Fraenkel asymmetry. In addition, we provide the asymptotic behaviour of the $s$-fractional capacity when $s$ goes to $1$ and the stability of our estimate with respect to the parameter $s$.
- Published
- 2021
35. Eigenvalues of the Laplacian with moving mixed boundary conditions: the case of disappearing Neumann region
- Author
-
Felli, Veronica, Noris, Benedetta, and Ognibene, Roberto
- Subjects
Mathematics - Analysis of PDEs ,Mathematics - Spectral Theory ,35J25, 35P15, 35B25 - Abstract
We deal with eigenvalue problems for the Laplacian with varying mixed boundary conditions, consisting in homogeneous Neumann conditions on a vanishing portion of the boundary and Dirichlet conditions on the complement. By the study of an Almgren type frequency function, we derive upper and lower bounds of the eigenvalue variation and sharp estimates in the case of a strictly star-shaped Neumann region.
- Published
- 2021
- Full Text
- View/download PDF
36. On a weighted two-phase boundary obstacle problem
- Author
-
Danielli, Donatella and Ognibene, Roberto
- Subjects
Mathematics - Analysis of PDEs ,35R35, 35B44, 35B40, 35R11 - Abstract
In this work we consider an inhomogeneous two-phase obstacle-type problem driven by the fractional Laplacian. In particular, making use of the Caffarelli-Silvestre extension, Almgren and Monneau type monotonicity formulas and blow-up analysis, we provide a classification of the possible vanishing orders, which implies the strong unique continuation property. Moreover, we prove a stratification result for the nodal set, together with estimates on its Hausdorff dimensions, for both the regular and the singular part. The main tools come from geometric measure theory and amount to Whitney's Extension Theorem and Federer's Reduction Principle.
- Published
- 2021
37. Challenging Social Media Threats using Collective Well-being Aware Recommendation Algorithms and an Educational Virtual Companion
- Author
-
Ognibene, Dimitri, Taibi, Davide, Kruschwitz, Udo, Wilkens, Rodrigo Souza, Hernandez-Leo, Davinia, Theophilou, Emily, Scifo, Lidia, Lobo, Rene Alejandro, Lomonaco, Francesco, Eimler, Sabrina, Hoppe, H. Ulrich, and Malzahn, Nils
- Subjects
Computer Science - Computers and Society ,Computer Science - Social and Information Networks - Abstract
Social media have become an integral part of our lives, expanding our interlinking capabilities to new levels. There is plenty to be said about their positive effects. On the other hand, however, some serious negative implications of social media have been repeatedly highlighted in recent years, pointing at various threats to society and its more vulnerable members, such as teenagers. We thus propose a theoretical framework based on an adaptive "Social Media Virtual Companion" for educating and supporting an entire community, teenage students, to interact in social media environments in order to achieve desirable conditions, defined in terms of a community-specific and participatory designed measure of Collective Well-Being (CWB). This Companion combines automatic processing with expert intervention and guidance. The virtual Companion will be powered by a Recommender System (CWB-RS) that will optimize a CWB metric instead of engagement or platform profit, which currently largely drives recommender systems thereby disregarding any societal collateral effect.We put an emphasis on experts and educators in the educationally managed social media community of the Companion. They play five key roles: (a) use the Companion in classroom-based educational activities; (b) guide the definition of the CWB; (c) provide a hierarchical structure of learning strategies, objectives and activities that will support and contain the adaptive sequencing algorithms of the CWB-RS based on hierarchical reinforcement learning; (d) act as moderators of direct conflicts between the members of the community; and, finally, (e) monitor and address ethical and educational issues that are beyond the intelligent agent's competence and control. Preliminary results on the performance of the Companion's components and studies of the educational and psychological underlying principles are presented.
- Published
- 2021
38. Host genetics and COVID-19 severity: increasing the accuracy of latest severity scores by Boolean quantum features
- Author
-
Gabriele Martelloni, Alessio Turchi, Chiara Fallerini, Andrea Degl’Innocenti, Margherita Baldassarri, Simona Olmi, Simone Furini, Alessandra Renieri, GEN-COVID Multicenter study, Francesca Mari, Sergio Daga, Ilaria Meloni, Mirella Bruttini, Susanna Croci, Mirjam Lista, Debora Maffeo, Elena Pasquinelli, Giulia Brunelli, Kristina Zguro, Viola Bianca Serio, Enrica Antolini, Simona Letizia Basso, Samantha Minetto, Giulia Rollo, Martina Rozza, Angela Rina, Rossella Tita, Maria Antonietta Mencarelli, Caterina Lo Rizzo, Anna Maria Pinto, Francesca Ariani, Francesca Montagnani, Mario Tumbarello, Ilaria Rancan, Massimiliano Fabbiani, Elena Bargagli, Laura Bergantini, Miriana d’Alessandro, Paolo Cameli, David Bennett, Federico Anedda, Simona Marcantonio, Sabino Scolletta, Federico Franchi, Maria Antonietta Mazzei, Susanna Guerrini, Edoardo Conticini, Luca Cantarini, Bruno Frediani, Danilo Tacconi, Chiara Spertilli Raffaelli, Arianna Emiliozzi, Marco Feri, Alice Donati, Raffaele Scala, Luca Guidelli, Genni Spargi, Marta Corridi, Cesira Nencioni, Leonardo Croci, Gian Piero Caldarelli, Davide Romani, Paolo Piacentini, Maria Bandini, Elena Desanctis, Silvia Cappelli, Anna Canaccini, Agnese Verzuri, Valentina Anemoli, Manola Pisani, Agostino Ognibene, Maria Lorubbio, Alessandro Pancrazzi, Massimo Vaghi, Antonella D’Arminio Monforte, Federica Gaia Miraglia, Mario U. Mondelli, Stefania Mantovani, Raffaele Bruno, Marco Vecchia, Marcello Maffezzoni, Enrico Martinelli, Massimo Girardis, Stefano Busani, Sophie Venturelli, Andrea Cossarizza, Andrea Antinori, Alessandra Vergori, Stefano Rusconi, Matteo Siano, Arianna Gabrieli, Agostino Riva, Daniela Francisci, Elisabetta Schiaroli, Carlo Pallotto, Saverio Giuseppe Parisi, Monica Basso, Sandro Panese, Stefano Baratti, Pier Giorgio Scotton, Francesca Andretta, Mario Giobbia, Renzo Scaggiante, Francesca Gatti, Francesco Castelli, Eugenia Quiros-Roldan, Melania Degli Antoni, Isabella Zanella, Matteo della Monica, Carmelo Piscopo, Mario Capasso, Roberta Russo, Immacolata Andolfo, Achille Iolascon, Giuseppe Fiorentino, Massimo Carella, Marco Castori, Giuseppe Merla, Gabriella Maria Squeo, Filippo Aucella, Pamela Raggi, Rita Perna, Matteo Bassetti, Antonio Di Biagio, Maurizio Sanguinetti, Luca Masucci, Alessandra Guarnaccia, Serafina Valente, Alex Di Florio, Marco Mandalà, Alessia Giorli, Lorenzo Salerni, Patrizia Zucchi, Pierpaolo Parravicini, Elisabetta Menatti, Tullio Trotta, Ferdinando Giannattasio, Gabriella Coiro, Fabio Lena, Gianluca Lacerenza, Cristina Mussini, Luisa Tavecchia, Lia Crotti, Gianfranco Parati, Roberto Menè, Maurizio Sanarico, Marco Gori, Francesco Raimondi, Alessandra Stella, Filippo Biscarini, Tiziana Bachetti, Maria Teresa La Rovere, Maurizio Bussotti, Serena Ludovisi, Katia Capitani, Simona Dei, Sabrina Ravaglia, Annarita Giliberti, Giulia Gori, Rosangela Artuso, Elena Andreucci, Angelica Pagliazzi, Erika Fiorentini, Antonio Perrella, Francesco Bianchi, Paola Bergomi, Emanuele Catena, Riccardo Colombo, Sauro Luchi, Giovanna Morelli, Paola Petrocelli, Sarah Iacopini, Sara Modica, Silvia Baroni, Giulia Micheli, Marco Falcone, Donato Urso, Giusy Tiseo, Tommaso Matucci, Davide Grassi, Claudio Ferri, Franco Marinangeli, Francesco Brancati, Antonella Vincenti, Valentina Borgo, Stefania Lombardi, Mirco Lenzi, Massimo Antonio Di Pietro, Francesca Vichi, Benedetta Romanin, Letizia Attala, Cecilia Costa, Andrea Gabbuti, Alessio Bellucci, Marta Colaneri, Patrizia Casprini, Cristoforo Pomara, Massimiliano Esposito, Roberto Leoncini, Michele Cirianni, Lucrezia Galasso, Marco Antonio Bellini, Chiara Gabbi, and Nicola Picchiotti
- Subjects
COVID-19 ,host genetics ,integrated polygenic score ,genetic algorithm ,logistic regression ,genetic science modeling ,Genetics ,QH426-470 - Abstract
The impact of common and rare variants in COVID-19 host genetics has been widely studied. In particular, in Fallerini et al. (Human genetics, 2022, 141, 147–173), common and rare variants were used to define an interpretable machine learning model for predicting COVID-19 severity. First, variants were converted into sets of Boolean features, depending on the absence or the presence of variants in each gene. An ensemble of LASSO logistic regression models was used to identify the most informative Boolean features with respect to the genetic bases of severity. After that, the Boolean features, selected by these logistic models, were combined into an Integrated PolyGenic Score (IPGS), which offers a very simple description of the contribution of host genetics in COVID-19 severity.. IPGS leads to an accuracy of 55%–60% on different cohorts, and, after a logistic regression with both IPGS and age as inputs, it leads to an accuracy of 75%. The goal of this paper is to improve the previous results, using not only the most informative Boolean features with respect to the genetic bases of severity but also the information on host organs involved in the disease. In this study, we generalize the IPGS adding a statistical weight for each organ, through the transformation of Boolean features into “Boolean quantum features,” inspired by quantum mechanics. The organ coefficients were set via the application of the genetic algorithm PyGAD, and, after that, we defined two new integrated polygenic scores (IPGSph1 and IPGSph2). By applying a logistic regression with both IPGS, (IPGSph2 (or indifferently IPGSph1) and age as inputs, we reached an accuracy of 84%–86%, thus improving the results previously shown in Fallerini et al. (Human genetics, 2022, 141, 147–173) by a factor of 10%.
- Published
- 2024
- Full Text
- View/download PDF
39. Pharmacokinetics, Metabolite Measurement, and Biomarker Identification of Dermal Exposure to Permethrin Using Accelerator Mass Spectrometry
- Author
-
Buchholz, Bruce A, Ahn, Ki Chang, Huang, Huazhang, Gee, Shirley J, Stewart, Benjamin J, Ognibene, Ted J, and Hammock, Bruce D
- Subjects
Pharmacology and Pharmaceutical Sciences ,Biomedical and Clinical Sciences ,Prevention ,Good Health and Well Being ,Animals ,Biomarkers ,Chromatography ,High Pressure Liquid ,Humans ,Insecticides ,Mass Spectrometry ,Permethrin ,Clinical Research ,permethrin ,dermal exposure ,ADME ,pharmacokinetics ,Toxicology ,Pharmacology and pharmaceutical sciences - Abstract
Impregnating military uniforms and outdoor clothing with the insecticide permethrin is an approach to reduce exposure to insect borne diseases and to repel pests and disease vectors such as mosquitos and sandflies, but the practice exposes wearers to prolonged dermal exposure to the pesticide. Key metabolite(s) from a low dose dermal exposure of permethrin were identified using accelerator mass spectrometry. Metabolite standards were synthesized and an HPLC elution protocol to separate individual metabolites in urine was developed. Six human subjects were exposed dermally on the forearm to 25 mg of permethrin containing 1.0 µCi of 14C for 8 h. Blood, saliva and urine samples were taken for 7d. Absorption/elimination rates and metabolite concentrations varied by individual. Average absorption was 0.2% of the dose. Serum concentrations rose until 12-24 h post dermal application then rapidly declined reaching predose levels by 72 h. Maximum saliva excretion occurred 6 h post dosing. The maximum urinary excretion rate occurred during 12-24 h; average elimination half-life was 56 h. 3-Phenoxybenzyl alcohol glucuronide was the most abundant metabolite identified when analyzing elution fractions, but most of the radioactivity was in still more polar fractions suggesting extensive degradative metabolism and for which there were no standards. Analyses of archived urine samples with the UPLC-AMS-MS system isolated a distinct polar metabolite but it was much diminished from the previous analyses a decade earlier.
- Published
- 2021
40. BL-MOL-AR Project, Preliminary Results about Liquid Biopsy: Molecular Approach Experience and Research Activity in Oncological Settings
- Author
-
Pancrazzi Pancrazzi, Bloise Bloise, Moncada Moncada, Perticucci Perticucci, Vecchietti Vecchietti, Pompili Pompili, Ricciarini Ricciarini, Lenzi Lenzi, Gatteschi Gatteschi, Giusti Giusti, Rosito Rosito, Del Buono Del Buono, Belardi Belardi, Bruni Bruni, Borri Borri, Campione Campione, Laurini Laurini, Occhini Occhini, Presenti Presenti, Viticchi Viticchi, Rossi Rossi, Bardi Bardi, D'Urso D'Urso, Dei Dei, Venezia Venezia, Scala Scala, Bengala Bengala, Decarli Decarli, Carnevali Carnevali, Milandri Milandri, and Ognibene Ognibene
- Subjects
liquid biopsy ,cfDNA ,NGS ,Genetics ,QH426-470 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Background Liquid biopsy is mainly used to identify tumor cells in pulmonary neoplasms. It is more often used in research than in clinical practice. The BL-MOL-AR study aims to investigate the efficacy of next-generation sequencing (NGS) and clinical interpretation of the circulating free DNA (cfDNA) levels. This study reports the preliminary results from the first samples analyzed from patients affected by various neoplasms: lung, intestinal, mammary, gastric, biliary, and cutaneous.
- Published
- 2023
- Full Text
- View/download PDF
41. Performance Evaluation of Automated Erythrocyte Sedimentation Rate (ESR) Analyzers in a Multicentric Study
- Author
-
Flaminia Tomassetti, Cinzia Calabrese, Fabio Bertani, Michele Cennamo, Daniela Diamanti, Alfredo Giovannelli, Roberto Guerranti, Roberto Leoncini, Maria Lorubbio, Agostino Ognibene, Eleonora Nicolai, Martina Pelagalli, Carolina Pieroni, Sergio Bernardini, and Massimo Pieri
- Subjects
ESR ,multicentric study ,inflammation ,method validation ,Medicine (General) ,R5-920 - Abstract
Background: Erythrocyte Sedimentation Rate (ESR) is an easy test used to diagnose and monitor inflammatory and infectious diseases. The aim of this study was the evaluation of the performance of three ESR automated analyzers, VES-MATIC 5, CUBE 30 TOUCH, and MINI-CUBE, involving four Italian polyclinics in Rome, Siena, Como, and Arezzo, as well as inter-site variability assessment to detect possible device-dependent and operator-dependent influences. Methods: Accuracy analysis was carried out by analyzing the same samples with all three instruments and comparing them with the Westergren method. Precision was assessed with quality control material through intra-run and inter-run precision. Repeatability was estimated by reanalyzing fresh blood samples belonging to three ESR ranges (low, intermediate, and high) six times. Results: The results showed a strong correlation (Spearman coefficients R2) between the manual method and VES-MATIC 5 (0.978), CUBE 30 TOUCH (0.981), and MINI-CUBE (0.974). The accuracy of all clinics was excellent, with coefficients of variation (CVs) of less than 10% for all instruments. Repeatability confirmed an excellent level for all ESR ranges, with CVs below 10%. Conclusions: The study proved that all three automated instruments offer optimal performance for accuracy and precision and are suitable for both large and small facilities without influences of the laboratory environment.
- Published
- 2024
- Full Text
- View/download PDF
42. Abdominal rhabdoid tumor presenting with symptomatic spinal epidural compression in a newborn. A case report
- Author
-
Shana Montalto, Michela Di Filippo, Valeria Capra, Carla Manzitti, Angela Rita Sementa, Patrizia De Marco, Marzia Ognibene, Fiammetta Sertorio, and Stefania Sorrentino
- Subjects
rhabdoid tumor ,spinal compression ,newborn ,case report ,oncological emergency ,Pediatrics ,RJ1-570 - Abstract
The occurrence of an abdominal tumor invading the spinal canal and causing symptoms of epidural compression is rare in an infant, and exceptional at birth. Peripheral neuroblastic tumors are by far the most common cause. Emergency chemotherapy is commonly curative, though permanent sequelae are possible. Although other malignancies may be involved, no case of rhabdoid tumors at birth has been reported. We describe the case of a neonate who presented symptoms of spinal epidural compression at birth secondary to a rhabdoid tumor. As expected with this highly malignant tumor, the patient experienced a rapidly progressive clinical course and died within three months of diagnosis.
- Published
- 2024
- Full Text
- View/download PDF
43. Identification of a Novel Non-V600E BRAF Mutation in Papillary Thyroid Cancer
- Author
-
Marco Capezzone, Maja Rossi, Elisabetta Macerola, Silvia Cantara, Francesco Pepe, Eugenia Maria Morabito, Gilda Dalmazio, Sara Bardi, Agostino Ognibene, Massimo Alessandri, Gabriele Materazzi, Luigi De Napoli, Michele Cirianni, and Liborio Torregrossa
- Subjects
Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Papillary thyroid cancer (PTC) is a common endocrine malignancy, and its incidence is reported to be constantly increasing. BRAF mutation is detected in approximately 44% of PTCs, and the most common BRAF mutation is thymine (T) to adenine (A) missense mutation in nucleotide 1796 (T1796A, V600E). Although BRAFV600E represents 95% of all BRAF mutations, uncommon BRAF mutations have been reported in thyroid carcinomas and represent an alternative mechanism of BRAF activation with unclear clinical significance. We report a novel non-V600E mutation (c.1799_1812delinsAT, p.V600_W604delinsD), identified preoperatively with next-generation sequencing (NGS) on the material obtained with fine-needle aspiration cytology (FNAC) performed on a thyroid nodule cytologically suspicious for malignancy in a 35-year-old male patient. The presence of this new variant of BRAF mutation was subsequently confirmed in the postoperative phase by direct Sanger sequencing. In conclusion, we report a new non-V600E variant previously undetected in papillary thyroid cancer. In addition, this case report shows that the NGS technique on cytological tissue allows to detect the presence of rare mutations, thus increasing the diagnostic specificity of molecular analysis.
- Published
- 2024
- Full Text
- View/download PDF
44. Eigenvalues of the Laplacian with moving mixed boundary conditions: the case of disappearing Dirichlet region
- Author
-
Felli, Veronica, Noris, Benedetta, and Ognibene, Roberto
- Subjects
Mathematics - Analysis of PDEs ,35J25, 35P20, 35B25 - Abstract
In this work we consider the homogeneous Neumann eigenvalue problem for the Laplacian on a bounded Lipschitz domain and a singular perturbation of it, which consists in prescribing zero Dirichlet boundary conditions on a small subset of the boundary. We first describe the sharp asymptotic behaviour of a perturbed eigenvalue, in the case in which it is converging to a simple eigenvalue of the limit Neumann problem. The first term in the asymptotic expansion turns out to depend on the Sobolev capacity of the subset where the perturbed eigenfunction is vanishing. Then we focus on the case of Dirichlet boundary conditions imposed on a subset which is scaling to a point; by a blow-up analysis for the capacitary potentials, we detect the vanishing order of the Sobolev capacity of such shrinking Dirichlet boundary portion., Comment: 27 pages
- Published
- 2020
45. Elucidating the clinical and molecular spectrum of SMARCC2-associated NDD in a cohort of 65 affected individuals
- Author
-
Bosch, Elisabeth, Popp, Bernt, Güse, Esther, Skinner, Cindy, van der Sluijs, Pleuntje J., Maystadt, Isabelle, Pinto, Anna Maria, Renieri, Alessandra, Bruno, Lucia Pia, Granata, Stefania, Marcelis, Carlo, Baysal, Özlem, Hartwich, Dewi, Holthöfer, Laura, Isidor, Bertrand, Cogne, Benjamin, Wieczorek, Dagmar, Capra, Valeria, Scala, Marcello, De Marco, Patrizia, Ognibene, Marzia, Jamra, Rami Abou, Platzer, Konrad, Carter, Lauren B., Kuismin, Outi, van Haeringen, Arie, Maroofian, Reza, Valenzuela, Irene, Cuscó, Ivon, Martinez-Agosto, Julian A., Rabani, Ahna M., Mefford, Heather C., Pereira, Elaine M., Close, Charlotte, Anyane-Yeboa, Kwame, Wagner, Mallory, Hannibal, Mark C., Zacher, Pia, Thiffault, Isabelle, Beunders, Gea, Umair, Muhammad, Bhola, Priya T., McGinnis, Erin, Millichap, John, van de Kamp, Jiddeke M., Prijoles, Eloise J., Dobson, Amy, Shillington, Amelle, Graham, Brett H., Garcia, Evan-Jacob, Galindo, Maureen Kelly, Ropers, Fabienne G., Nibbeling, Esther A.R., Hubbard, Gail, Karimov, Catherine, Goj, Guido, Bend, Renee, Rath, Julie, Morrow, Michelle M., Millan, Francisca, Salpietro, Vincenzo, Torella, Annalaura, Nigro, Vincenzo, Kurki, Mitja, Stevenson, Roger E., Santen, Gijs W.E., Zweier, Markus, Campeau, Philippe M., Severino, Mariasavina, Reis, André, Accogli, Andrea, and Vasileiou, Georgia
- Published
- 2023
- Full Text
- View/download PDF
46. A Classification Methodology based on Subspace Graphs Learning
- Author
-
La Grassa, Riccardo, Gallo, Ignazio, Calefati, Alessandro, and Ognibene, Dimitri
- Subjects
Computer Science - Machine Learning ,Computer Science - Artificial Intelligence ,Statistics - Machine Learning - Abstract
In this paper, we propose a design methodology for one-class classifiers using an ensemble-of-classifiers approach. The objective is to select the best structures created during the training phase using an ensemble of spanning trees. It takes the best classifier, partitioning the area near a pattern into $\gamma^{\gamma-2}$ sub-spaces and combining all possible spanning trees that can be created starting from $\gamma$ nodes. The proposed method leverages on a supervised classification methodology and the concept of minimum distance. We evaluate our approach on well-known benchmark datasets and results obtained demonstrate that it achieves comparable and, in many cases, state-of-the-art results. Moreover, it obtains good performance even with unbalanced datasets., Comment: 8 pages, Dicta Conference
- Published
- 2019
47. Transferring Adaptive Theory of Mind to social robots: insights from developmental psychology to robotics
- Author
-
Bianco, Francesca and Ognibene, Dimitri
- Subjects
Computer Science - Robotics ,Computer Science - Artificial Intelligence ,Computer Science - Human-Computer Interaction - Abstract
Despite the recent advancement in the social robotic field, important limitations restrain its progress and delay the application of robots in everyday scenarios. In the present paper, we propose to develop computational models inspired by our knowledge of human infants' social adaptive abilities. We believe this may provide solutions at an architectural level to overcome the limits of current systems. Specifically, we present the functional advantages that adaptive Theory of Mind (ToM) systems would support in robotics (i.e., mentalizing for belief understanding, proactivity and preparation, active perception and learning) and contextualize them in practical applications. We review current computational models mainly based on the simulation and teleological theories, and robotic implementations to identify the limitations of ToM functions in current robotic architectures and suggest a possible future developmental pathway. Finally, we propose future studies to create innovative computational models integrating the properties of the simulation and teleological approaches for an improved adaptive ToM ability in robots with the aim of enhancing human-robot interactions and permitting the application of robots in unexplored environments, such as disasters and construction sites. To achieve this goal, we suggest directing future research towards the modern cross-talk between the fields of robotics and developmental psychology.
- Published
- 2019
48. Functional advantages of an adaptive Theory of Mind for robotics: a review of current architectures
- Author
-
Bianco, Francesca and Ognibene, Dimitri
- Subjects
Computer Science - Robotics ,Computer Science - Artificial Intelligence ,Computer Science - Human-Computer Interaction - Abstract
Great advancements have been achieved in the field of robotics, however, main challenges remain, including building robots with an adaptive Theory of Mind (ToM). In the present paper, seven current robotic architectures for human-robot interactions were described as well as four main functional advantages of equipping robots with an adaptive ToM. The aim of the present paper was to determine in which way and how often ToM features are integrated in the architectures analyzed, and if they provide robots with the associated functional advantages. Our assessment shows that different methods are used to implement ToM features in robotic architectures. Furthermore, while a ToM for false-belief understanding and tracking is often built in social robotic architectures, a ToM for proactivity, active perception and learning is less common. Nonetheless, progresses towards better adaptive ToM features in robots are warranted to provide them with full access to the advantages of having a ToM resembling that of humans.
- Published
- 2019
49. Proactive Intention Recognition for Joint Human-Robot Search and Rescue Missions through Monte-Carlo Planning in POMDP Environments
- Author
-
Ognibene, Dimitri, Mirante, Lorenzo, and Marchegiani, Letizia
- Subjects
Computer Science - Robotics ,Computer Science - Artificial Intelligence ,Computer Science - Human-Computer Interaction ,Computer Science - Machine Learning - Abstract
Proactively perceiving others' intentions is a crucial skill to effectively interact in unstructured, dynamic and novel environments. This work proposes a first step towards embedding this skill in support robots for search and rescue missions. Predicting the responders' intentions, indeed, will enable exploration approaches which will identify and prioritise areas that are more relevant for the responder and, thus, for the task, leading to the development of safer, more robust and efficient joint exploration strategies. More specifically, this paper presents an active intention recognition paradigm to perceive, even under sensory constraints, not only the target's position but also the first responder's movements, which can provide information on his/her intentions (e.g. reaching the position where he/she expects the target to be). This mechanism is implemented by employing an extension of Monte-Carlo-based planning techniques for partially observable environments, where the reward function is augmented with an entropy reduction bonus. We test in simulation several configurations of reward augmentation, both information theoretic and not, as well as belief state approximations and obtain substantial improvements over the basic approach.
- Published
- 2019
50. Binary Classification using Pairs of Minimum Spanning Trees or N-ary Trees
- Author
-
La Grassa, Riccardo, Gallo, Ignazio, Calefati, Alessandro, and Ognibene, Dimitri
- Subjects
Computer Science - Machine Learning ,Statistics - Machine Learning - Abstract
One-class classifiers are trained with target class only samples. Intuitively, their conservative modelling of the class description may benefit classical classification tasks where classes are difficult to separate due to overlapping and data imbalance. In this work, three methods are proposed which leverage on the combination of one-class classifiers based on non-parametric models, N-ary Trees and Minimum Spanning Trees class descriptors (MST-CD), to tackle binary classification problems. The methods deal with the inconsistencies arising from combining multiple classifiers and with spurious connections that MST-CD creates in multi-modal class distributions. As shown by our tests on several datasets, the proposed approach is feasible and comparable with state-of-the-art algorithms.
- Published
- 2019
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.