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2. Lung Cancer Risks Associated with Occupational Exposure to Pairs of Five Lung Carcinogens: Results from a Pooled Analysis of Case-Control Studies (SYNERGY)

Author

Olsson, Ann, Bouaoun, Liacine, Schuz, Joachim, Vermeulen, Roel, Behrens, Thomas, Ge, Calvin, Kromhout, Hans, Siemiatycki, Jack, Gustavsson, Per, Boffetta, Paolo, Kendzia, Benjamin, Radoi, Loredana, Barul, Christine, Karrasch, Stefan, Wichmann, Heinz-Erich, Consonni, Dario, Landi, Maria Teresa, Caporaso, Neil E., Merletti, Franco, Migliore, Enrica, Richiardi, Lorenzo, Jockel, Karl-Heinz, Ahrens, Wolfgang, Pohlabeln, Hermann, Fernandez-Tardon, Guillermo, Zaridze, David, Field, John K., Lissowska, Jolanta, Swiatkowska, Beata, McLaughlin, John R., Demers, Paul A., Schejbalova, Miriam, Foretova, Lenka, Janout, Vladimir, Pandics, Tamas, Fabianova, Eleonora, Mates, Dana, Forastiere, Francesco, Straif, Kurt, Bruning, Thomas, Vlaanderen, Jelle, and Peters, Susan

Subjects
Statistics, Risk factors, Health aspects, Environmental aspects, Lung cancer -- Statistics -- Risk factors -- Environmental aspects, Carcinogens -- Statistics -- Health aspects -- Environmental aspects, Occupational exposure -- Statistics, Cocarcinogens -- Statistics -- Health aspects -- Environmental aspects, Occupational health and safety -- Statistics
Abstract

Introduction Occupational carcinogens represent a significant threat on worker's health, and exposed workers may be (simultaneously) exposed to more than one carcinogen. The European CAREX project estimated that 23% of [...], Background: While much research has been done to identify individual workplace lung carcinogens, little is known about joint effects on risk when workers are exposed to multiple agents. Objectives: We investigated the pairwise joint effects of occupational exposures to asbestos, respirable crystalline silica, metals (i.e., nickel, chromium-VI), and polycyclic aromatic hydrocarbons (PAH) on lung cancer risk, overall and by major histologic subtype, while accounting for cigarette smoking. Methods: In the international 14-center SYNERGY project, occupational exposures were assigned to 16,901 lung cancer cases and 20,965 control subjects using a quantitative job-exposure matrix (SYN-JEM). Odds ratios (ORs) and 95% confidence intervals (CIs) were computed for ever vs. never exposure using logistic regression models stratified by sex and adjusted for study center, age, and smoking habits. Joint effects among pairs of agents were assessed on multiplicative and additive scales, the latter by calculating the relative excess risk due to interaction (RERI). Results: All pairwise joint effects of lung carcinogens in men were associated with an increased risk of lung cancer. However, asbestos/metals and metals/PAH resulted in less than additive effects; while the chromium-VI/silica pair showed marginally synergistic effect in relation to adenocarcinoma (RERI: 0.24; CI: 0.02, 0.46; p = 0.05). In women, several pairwise joint effects were observed for small cell lung cancer including exposure to PAH/silica (OR = 5.12; CI: 1.77, 8.48), and to asbestos/silica (OR = 4.32; CI: 1.35, 7.29), where exposure to PAH/silica resulted in a synergistic effect (RERI: 3.45; CI: 0.10, 6.8). Discussion: Small or no deviation from additive or multiplicative effects was observed, but co-exposure to the selected lung carcinogens resulted generally in higher risk than exposure to individual agents, highlighting the importance to reduce and control exposure to carcinogens in workplaces and the general environment. https://doi.org/10.1289/EHP13380

Published
2024
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5. Alcohol consumption and lung cancer risk: A pooled analysis from the International Lung Cancer Consortium and the SYNERGY study

Author

Brenner, Darren R, Fehringer, Gord, Zhang, Zuo-Feng, Lee, Yuan-Chin Amy, Meyers, Travis, Matsuo, Keitaro, Ito, Hidemi, Vineis, Paolo, Stucker, Isabelle, Boffetta, Paolo, Brennan, Paul, Christiani, David C, Diao, Nancy, Hong, Yun-Chul, Landi, Maria T, Morgenstern, Hal, Schwartz, Ann G, Rennert, Gad, Saliba, Walid, McLaughlin, John R, Harris, Curtis C, Orlow, Irene, Dios, Juan M Barros, Raviña, Alberto Ruano, Siemiatycki, Jack, Koushik, Anita, Cote, Michele, Lazarus, Philip, Fernandez-Tardon, Guillermo, Tardon, Adonina, Le Marchand, Loïc, Brenner, Hermann, Saum, Kai-Uwe, Duell, Eric J, Andrew, Angeline S, Consonni, Dario, Olsson, Ann, Hung, Rayjean J, and Straif, Kurt

Subjects
Biomedical and Clinical Sciences, Epidemiology, Health Sciences, Public Health, Oncology and Carcinogenesis, Cancer, Alcoholism, Alcohol Use and Health, Lung Cancer, Lung, Prevention, Substance Misuse, 2.2 Factors relating to the physical environment, Aetiology, Stroke, Good Health and Well Being, Adenocarcinoma, Aged, Alcohol Drinking, Alcoholic Beverages, Carcinoma, Squamous Cell, Case-Control Studies, Cohort Studies, Female, Humans, Lung Neoplasms, Male, Middle Aged, Odds Ratio, Risk Factors, Surveys and Questionnaires, Alcohol, Lung cancer, Pooled analysis, Public Health and Health Services, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

BackgroundThere is inadequate evidence to determine whether there is an effect of alcohol consumption on lung cancer risk. We conducted a pooled analysis of data from the International Lung Cancer Consortium and the SYNERGY study to investigate this possible association by type of beverage with adjustment for other potential confounders.MethodsTwenty one case-control studies and one cohort study with alcohol-intake data obtained from questionnaires were included in this pooled analysis (19,149 cases and 362,340 controls). Adjusted odds ratios (OR) or hazard ratios (HR) with corresponding 95% confidence intervals (CI) were estimated for each measure of alcohol consumption. Effect estimates were combined using random or fixed-effects models where appropriate. Associations were examined for overall lung cancer and by histological type.ResultsWe observed an inverse association between overall risk of lung cancer and consumption of alcoholic beverages compared to non-drinkers, but the association was not monotonic. The lowest risk was observed for persons who consumed 10-19.9 g/day ethanol (OR vs. non-drinkers = 0.78; 95% CI: 0.67, 0.91), where 1 drink is approximately 12-15 g. This J-shaped association was most prominent for squamous cell carcinoma (SCC). The association with all lung cancer varied little by type of alcoholic beverage, but there were notable differences for SCC. We observed an association with beer intake (OR for ≥20 g/day vs nondrinker = 1.42; 95% CI: 1.06, 1.90).ConclusionsWhether the non-monotonic associations we observed or the positive association between beer drinking and squamous cell carcinoma reflect real effects await future analyses and insights about possible biological mechanisms.

Published
2019

6. Application of two job indices for general occupational demands in a pooled analysis of case–control studies on lung cancer

Author

Hovanec, Jan, Siemiatycki, Jack, Conway, David I, Olsson, Ann, Guenel, Pascal, Luce, Danièle, Jöckel, Karl-Heinz, Pohlabeln, Hermann, Ahrens, Wolfgang, Karrasch, Stefan, Wichmann, Heinz-Erich, Gustavsson, Per, Consonni, Dario, Merletti, Franco, Richiardi, Lorenzo, Simonato, Lorenzo, Fortes, Cristina, Parent, Marie-Élise, McLaughlin, John R, Demers, Paul, Landi, Maria Teresa, Caporaso, Neil, Fernández-Tardón, Guillermo, Zaridze, David, Świątkowska, Beata, Pándics, Tamas, Lissowska, Jolanta, Fabianova, Eleonora, Field, John K, Mates, Dana, Bencko, Vladimir, Foretova, Lenka, Janout, Vladimir, Kromhout, Hans, Vermeulen, Roel, Boffetta, Paolo, Straif, Kurt, Schüz, Joachim, Casjens, Swaantje, Pesch, Beate, Brüning, Thomas, and Behrens, Thomas

Published
2021

7. Alcohol and lung cancer risk among never smokers: A pooled analysis from the international lung cancer consortium and the SYNERGY study

Author

Fehringer, Gordon, Brenner, Darren R, Zhang, Zuo‐Feng, Lee, Yuan‐Chin Amy, Matsuo, Keitaro, Ito, Hidemi, Lan, Qing, Vineis, Paolo, Johansson, Mattias, Overvad, Kim, Riboli, Elio, Trichopoulou, Antonia, Sacerdote, Carlotta, Stucker, Isabelle, Boffetta, Paolo, Brennan, Paul, Christiani, David C, Hong, Yun‐Chul, Landi, Maria Teresa, Morgenstern, Hal, Schwartz, Ann G, Wenzlaff, Angela S, Rennert, Gad, McLaughlin, John R, Harris, Curtis C, Olivo‐Marston, Susan, Orlow, Irene, Park, Bernard J, Zauderer, Marjorie, Dios, Juan M Barros, Raviña, Alberto Ruano, Siemiatycki, Jack, Koushik, Anita, Lazarus, Philip, Fernández‐Somoano, Ana, Tardon, Adonina, Le Marchand, Loic, Brenner, Hermann, Saum, Kai‐Uwe, Duell, Eric J, Andrew, Angeline S, Szeszenia‐Dabrowska, Neonila, Lissowska, Jolanta, Zaridze, David, Rudnai, Peter, Fabianova, Eleonora, Mates, Dana, Foretova, Lenka, Janout, Vladimir, Bencko, Vladimir, Holcatova, Ivana, Pesatori, Angela Cecilia, Consonni, Dario, Olsson, Ann, Straif, Kurt, and Hung, Rayjean J

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Lung, Cancer, Substance Misuse, Tobacco, Alcoholism, Alcohol Use and Health, Tobacco Smoke and Health, Prevention, Lung Cancer, Cardiovascular, Stroke, Respiratory, Good Health and Well Being, Aged, Alcohol Drinking, Alcoholic Beverages, Asia, Case-Control Studies, Cohort Studies, Europe, Female, Humans, Lung Neoplasms, Male, Middle Aged, North America, Risk Factors, Smoking, alcohol, lung cancer, wine, beer, liquor, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

It is not clear whether alcohol consumption is associated with lung cancer risk. The relationship is likely confounded by smoking, complicating the interpretation of previous studies. We examined the association of alcohol consumption and lung cancer risk in a large pooled international sample, minimizing potential confounding of tobacco consumption by restricting analyses to never smokers. Our study included 22 case-control and cohort studies with a total of 2548 never-smoking lung cancer patients and 9362 never-smoking controls from North America, Europe and Asia within the International Lung Cancer Consortium (ILCCO) and SYNERGY Consortium. Alcohol consumption was categorized into amounts consumed (grams per day) and also modelled as a continuous variable using restricted cubic splines for potential non-linearity. Analyses by histologic sub-type were included. Associations by type of alcohol consumed (wine, beer and liquor) were also investigated. Alcohol consumption was inversely associated with lung cancer risk with evidence most strongly supporting lower risk for light and moderate drinkers relative to non-drinkers (>0-4.9 g per day: OR = 0.80, 95% CI = 0.70-0.90; 5-9.9 g per day: OR = 0.82, 95% CI = 0.69-0.99; 10-19.9 g per day: OR = 0.79, 95% CI = 0.65-0.96). Inverse associations were found for consumption of wine and liquor, but not beer. The results indicate that alcohol consumption is inversely associated with lung cancer risk, particularly among subjects with low to moderate consumption levels, and among wine and liquor drinkers, but not beer drinkers. Although our results should have no relevant bias from the confounding effect of smoking we cannot preclude that confounding by other factors contributed to the observed associations. Confounding in relation to the non-drinker reference category may be of particular importance.

Published
2017

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Author

Schüz, Joachim, Kovalevskiy, Evgeny V., Olsson, Ann, Moissonnier, Monika, Ostroumova, Evgenia, Ferro, Gilles, Feletto, Eleonora, Schonfeld, Sara J., Byrnes, Graham, Tskhomariia, Iraklii M., Straif, Kurt, Morozova, Tatiana V., Kromhout, Hans, Bukhtiyarov, Igor V., Schüz, Joachim, Kovalevskiy, Evgeny V., Olsson, Ann, Moissonnier, Monika, Ostroumova, Evgenia, Ferro, Gilles, Feletto, Eleonora, Schonfeld, Sara J., Byrnes, Graham, Tskhomariia, Iraklii M., Straif, Kurt, Morozova, Tatiana V., Kromhout, Hans, and Bukhtiyarov, Igor V.

Abstract

Background. We investigated mortality in workers of the world’s largest chrysotile mine and enrichment factories located in the town of Asbest, Russian Federation. Methods. This historical cohort study included all workers employed for at least 1 year between 1975 and 2010 and follow-up until the end of 2015. Cumulative exposure to dust was estimated based on workers’ complete occupational history linked to dust measurements systematically collected from the 1950s. Exposure to chrysotile fibers was estimated using dust-to-fiber conversion factors. Relative risks (RRs) and 95% confidence intervals (CIs) were estimated as mortality rate ratios in Poisson regression models. Results. A total of 30 445 (32% women) workers accumulated 721 312 person-years at risk and 11 110 (36%) died. Of the workers, 54% had more than 30 years since their first exposure. We found an exposure-response between cumulative dust and lung cancer mortality in men. No clear association with dust exposure but a modest increase in the highest category of fiber exposure was seen for lung cancer in women. Mesothelioma mortality was increased (RR=7.64, 95% CI=1.18 to 49.5, to at least 80 fibers per cm3 years and RR=4.56, 95% CI=0.94 to 22.1, to at least 150 mg/m3 years [dust]), based on 13 deaths. For colorectal and stomach cancer, there were inconsistent associations. No associations were seen for laryngeal or ovarian cancer. Conclusion. In this large-scale epidemiological study in the world’s largest active asbestos mine, we confirmed an increased risk of mesothelioma with high fiber exposure and an increasing mortality for lung cancer in men with increasing dust exposure. Less clear-cut increased lung cancer mortality was seen in the women. Continued mortality follow-up is warranted.

Published
2024

9. Respirable crystalline silica and lung cancer in community-based studies: impact of job-exposure matrix specifications on exposure-response relationships

Author

Ohlander, Johan, Kromhout, Hans, Vermeulen, Roel, Portengen, Lützen, Kendzia, Benjamin, Savary, Barbara, Cavallo, Domenico, Cattaneo, Andrea, Migliori, Enrica, Richiardi, Lorenzo, Plato, Nils, Wichmann, Heinz-Erich, Karrasch, Stefan, Consonni, Dario, Landi, Maria Teresa, Caporaso, Neil E, Siemiatycki, Jack, Gustavsson, Per, Jöckel, Karl-Heinz, Ahrens, Wolfgang, Pohlabeln, Hermann, Fernández-Tardón, Guillermo, Zaridze, David, Jolanta Lissowska, Jolanta Lissowska, Beata Swiatkowska, Beata Swiatkowska, John K Field, John K Field, McLaughlin, John R, Demers, Paul A, Pandics, Tamas, Forastiere, Francesco, Fabianova, Eleonora, Schejbalova, Miriam, Foretova, Lenka, Janout, Vladimir, Mates, Dana, Barul, Christine, Brüning, Thomas, Behrens, Thomas, Straif, Kurt, Schüz, Joachim, Olsson, Ann, Peters, Susan, Ohlander, Johan, Kromhout, Hans, Vermeulen, Roel, Portengen, Lützen, Kendzia, Benjamin, Savary, Barbara, Cavallo, Domenico, Cattaneo, Andrea, Migliori, Enrica, Richiardi, Lorenzo, Plato, Nils, Wichmann, Heinz-Erich, Karrasch, Stefan, Consonni, Dario, Landi, Maria Teresa, Caporaso, Neil E, Siemiatycki, Jack, Gustavsson, Per, Jöckel, Karl-Heinz, Ahrens, Wolfgang, Pohlabeln, Hermann, Fernández-Tardón, Guillermo, Zaridze, David, Jolanta Lissowska, Jolanta Lissowska, Beata Swiatkowska, Beata Swiatkowska, John K Field, John K Field, McLaughlin, John R, Demers, Paul A, Pandics, Tamas, Forastiere, Francesco, Fabianova, Eleonora, Schejbalova, Miriam, Foretova, Lenka, Janout, Vladimir, Mates, Dana, Barul, Christine, Brüning, Thomas, Behrens, Thomas, Straif, Kurt, Schüz, Joachim, Olsson, Ann, and Peters, Susan

Abstract

OBJECTIVES: The quantitative job-exposure matrix SYN-JEM consists of various dimensions: job-specific estimates, region-specific estimates, and prior expert ratings of jobs by the semi-quantitative DOM-JEM. We analyzed the effect of different JEM dimensions on the exposure-response relationships between occupational silica exposure and lung cancer risk to investigate how these variations influence estimates of exposure by a quantitative JEM and associated health endpoints.METHODS: Using SYN-JEM, and alternative SYN-JEM specifications with varying dimensions included, cumulative silica exposure estimates were assigned to 16 901 lung cancer cases and 20 965 controls pooled from 14 international community-based case-control studies. Exposure-response relationships based on SYN-JEM and alternative SYN-JEM specifications were analyzed using regression analyses (by quartiles and log-transformed continuous silica exposure) and generalized additive models (GAM), adjusted for age, sex, study, cigarette pack-years, time since quitting smoking, and ever employment in occupations with established lung cancer risk.RESULTS: SYN-JEM and alternative specifications generated overall elevated and similar lung cancer odds ratios ranging from 1.13 (1st quartile) to 1.50 (4th quartile). In the categorical and log-linear analyses SYN-JEM with all dimensions included yielded the best model fit, and exclusion of job-specific estimates from SYN-JEM yielded the poorest model fit. Additionally, GAM showed the poorest model fit when excluding job-specific estimates.CONCLUSION: The established exposure-response relationship between occupational silica exposure and lung cancer was marginally influenced by varying the dimensions of SYN-JEM. Optimized modelling of exposure-response relationships will be obtained when incorporating all relevant dimensions, namely prior rating, job, time, and region. Quantitative job-specific estimates appeared to be the most prominent dimens

Published
2024

10. Cancer mortality in chrysotile miners and millers, Russian Federation: main results (Asbest Chrysotile Cohort-Study)

Author

Schüz, Joachim, Kovalevskiy, Evgeny, Olsson, Ann, Moissonnier, Monika, Ostroumova, Evgenia, Ferro, Gilles, Feletto, Eleonora, Schonfeld, Sara J, Byrnes, Graham, Tskhomariia, Iraklii, Straif, Kurt, Morozova, Tatiana, Kromhout, Hans, Bukhtiyarov, Igor, Schüz, Joachim, Kovalevskiy, Evgeny, Olsson, Ann, Moissonnier, Monika, Ostroumova, Evgenia, Ferro, Gilles, Feletto, Eleonora, Schonfeld, Sara J, Byrnes, Graham, Tskhomariia, Iraklii, Straif, Kurt, Morozova, Tatiana, Kromhout, Hans, and Bukhtiyarov, Igor

Abstract

BACKGROUND: We investigated mortality in workers of the world's largest chrysotile mine and enrichment factories located in the town of Asbest, Russian Federation.METHODS: This historical cohort study included all workers employed for at least 1 year between 1975 and 2010 and follow-up until the end of 2015. Cumulative exposure to dust was estimated based on workers' complete occupational history linked to dust measurements systematically collected from the 1950s. Exposure to chrysotile fibers was estimated using dust-to-fiber conversion factors. Relative risks (RRs) and 95% confidence intervals (CIs) were estimated as mortality rate ratios in Poisson regression models.RESULTS: A total of 30 445 (32% women) workers accumulated 721 312 person-years at risk and 11 110 (36%) died. Of the workers, 54% had more than 30 years since their first exposure. We found an exposure-response between cumulative dust and lung cancer mortality in men. No clear association with dust exposure but a modest increase in the highest category of fiber exposure was seen for lung cancer in women. Mesothelioma mortality was increased (RR = 7.64, 95% CI = 1.18 to 49.5, to at least 80 fibers per cm3 years and RR = 4.56, 95% CI = 0.94 to 22.1, to at least 150 mg/m3 years [dust]), based on 13 deaths. For colorectal and stomach cancer, there were inconsistent associations. No associations were seen for laryngeal or ovarian cancer.CONCLUSION: In this large-scale epidemiological study in the world's largest active asbestos mine, we confirmed an increased risk of mesothelioma with high fiber exposure and an increasing mortality for lung cancer in men with increasing dust exposure. Less clear-cut increased lung cancer mortality was seen in the women. Continued mortality follow-up is warranted.

Published
2024

11. Occupational Benzene Exposure and Lung Cancer Risk: A Pooled Analysis of 14 Case-Control Studies

Author

Wan, Wenxin, Peters, Susan, Portengen, Lützen, Olsson, Ann, Schüz, Joachim, Ahrens, Wolfgang, Schejbalova, Miriam, Boffetta, Paolo, Behrens, Thomas, Brüning, Thomas, Kendzia, Benjamin, Consonni, Dario, Demers, Paul A, Fabiánová, Eleonóra, Fernández-Tardón, Guillermo, Field, John K, Forastiere, Francesco, Foretova, Lenka, Guénel, Pascal, Gustavsson, Per, Jöckel, Karl-Heinz, Karrasch, Stefan, Landi, Maria Teresa, Lissowska, Jolanta, Barul, Christine, Mates, Dana, McLaughlin, John R, Merletti, Franco, Migliore, Enrica, Richiardi, Lorenzo, Pándics, Tamás, Pohlabeln, Hermann, Siemiatycki, Jack, Świątkowska, Beata, Wichmann, Heinz-Erich, Zaridze, David, Ge, Calvin, Straif, Kurt, Kromhout, Hans, Vermeulen, Roel, Wan, Wenxin, Peters, Susan, Portengen, Lützen, Olsson, Ann, Schüz, Joachim, Ahrens, Wolfgang, Schejbalova, Miriam, Boffetta, Paolo, Behrens, Thomas, Brüning, Thomas, Kendzia, Benjamin, Consonni, Dario, Demers, Paul A, Fabiánová, Eleonóra, Fernández-Tardón, Guillermo, Field, John K, Forastiere, Francesco, Foretova, Lenka, Guénel, Pascal, Gustavsson, Per, Jöckel, Karl-Heinz, Karrasch, Stefan, Landi, Maria Teresa, Lissowska, Jolanta, Barul, Christine, Mates, Dana, McLaughlin, John R, Merletti, Franco, Migliore, Enrica, Richiardi, Lorenzo, Pándics, Tamás, Pohlabeln, Hermann, Siemiatycki, Jack, Świątkowska, Beata, Wichmann, Heinz-Erich, Zaridze, David, Ge, Calvin, Straif, Kurt, Kromhout, Hans, and Vermeulen, Roel

Abstract

Rationale: Benzene has been classified as carcinogenic to humans, but there is limited evidence linking benzene exposure to lung cancer. Objectives: We aimed to examine the relationship between occupational benzene exposure and lung cancer. Methods: Subjects from 14 case-control studies across Europe and Canada were pooled. We used a quantitative job-exposure matrix to estimate benzene exposure. Logistic regression models assessed lung cancer risk across different exposure indices. We adjusted for smoking and five main occupational lung carcinogens and stratified analyses by smoking status and lung cancer subtypes. Measurements and Main Results: Analyses included 28,048 subjects (12,329 cases, 15,719 control subjects). Lung cancer odds ratios ranged from 1.12 (95% confidence interval, 1.03–1.22) to 1.32 (95% confidence interval, 1.18–1.48) (Ptrend = 0.002) for groups with the lowest and highest cumulative occupational exposures, respectively, compared with unexposed subjects. We observed an increasing trend of lung cancer with longer duration of exposure (Ptrend , 0.001) and a decreasing trend with longer time since last exposure (Ptrend = 0.02). These effects were seen for all lung cancer subtypes, regardless of smoking status, and were not influenced by specific occupational groups, exposures, or studies. Conclusions: We found consistent and robust associations between different dimensions of occupational benzene exposure and lung cancer after adjusting for smoking and main occupational lung carcinogens. These associations were observed across different subgroups, including nonsmokers. Our findings support the hypothesis that occupational benzene exposure increases the risk of developing lung cancer. Consequently, there is a need to revisit published epidemiological and molecular data on the pulmonary carcinogenicity of benzene.

Published
2024

12. Respirable crystalline silica and lung cancer in community-based studies: impact of job-exposure matrix specifications on exposure–response relationships

Author

Planetary Health & Exposoom, Cancer, Circulatory Health, Ohlander, Johan, Kromhout, Hans, Vermeulen, Roel, Portengen, Lützen, Kendzia, Benjamin, Savary, Barbara, Cavallo, Domenico, Cattaneo, Andrea, Migliori, Enrica, Richiardi, Lorenzo, Plato, Nils, Wichmann, Heinz Erich, Karrasch, Stefan, Consonni, Dario, Landi, Maria Teresa, Caporaso, Neil E., Siemiatycki, Jack, Gustavsson, Per, Jöckel, Karl Heinz, Ahrens, Wolfgang, Pohlabeln, Hermann, Fernández-Tardón, Guillermo, Zaridze, David, Lissowska, Jolanta, Swiatkowska, Beata, Field, John K., McLaughlin, John R., Demers, Paul A., Pandics, Tamas, Forastiere, Franc Esco, Fabianova, Eleonora, Schejbalova, Miriam, Foretova, Lenka, Janout, Vladimir, Mates, Dana, Barul, Christine, Brüning, Thomas, Behrens, Thomas, Straif, Kurt, Schüz, Joachim, Olsson, Ann, Peters, Susan, Planetary Health & Exposoom, Cancer, Circulatory Health, Ohlander, Johan, Kromhout, Hans, Vermeulen, Roel, Portengen, Lützen, Kendzia, Benjamin, Savary, Barbara, Cavallo, Domenico, Cattaneo, Andrea, Migliori, Enrica, Richiardi, Lorenzo, Plato, Nils, Wichmann, Heinz Erich, Karrasch, Stefan, Consonni, Dario, Landi, Maria Teresa, Caporaso, Neil E., Siemiatycki, Jack, Gustavsson, Per, Jöckel, Karl Heinz, Ahrens, Wolfgang, Pohlabeln, Hermann, Fernández-Tardón, Guillermo, Zaridze, David, Lissowska, Jolanta, Swiatkowska, Beata, Field, John K., McLaughlin, John R., Demers, Paul A., Pandics, Tamas, Forastiere, Franc Esco, Fabianova, Eleonora, Schejbalova, Miriam, Foretova, Lenka, Janout, Vladimir, Mates, Dana, Barul, Christine, Brüning, Thomas, Behrens, Thomas, Straif, Kurt, Schüz, Joachim, Olsson, Ann, and Peters, Susan

Published
2024

13. Lung Cancer Risks Associated with Occupational Exposure to Pairs of Five Lung Carcinogens: Results from a Pooled Analysis of Case-Control Studies (SYNERGY)

Author

IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, Olsson, Ann, Bouaoun, Liacine, Schüz, Joachim, Vermeulen, Roel, Behrens, Thomas, Ge, Calvin, Kromhout, Hans, Siemiatycki, Jack, Gustavsson, Per, Boffetta, Paolo, Kendzia, Benjamin, Radoi, Loredana, Barul, Christine, Karrasch, Stefan, Wichmann, Heinz-Erich, Consonni, Dario, Landi, Maria Teresa, Caporaso, Neil E, Merletti, Franco, Migliore, Enrica, Richiardi, Lorenzo, Jöckel, Karl-Heinz, Ahrens, Wolfgang, Pohlabeln, Hermann, Fernández-Tardón, Guillermo, Zaridze, David, Field, John K, Lissowska, Jolanta, Świątkowska, Beata, McLaughlin, John R, Demers, Paul A, Schejbalova, Miriam, Foretova, Lenka, Janout, Vladimir, Pándics, Tamás, Fabianova, Eleonora, Mates, Dana, Forastiere, Francesco, Straif, Kurt, Brüning, Thomas, Vlaanderen, Jelle, Peters, Susan, IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, Olsson, Ann, Bouaoun, Liacine, Schüz, Joachim, Vermeulen, Roel, Behrens, Thomas, Ge, Calvin, Kromhout, Hans, Siemiatycki, Jack, Gustavsson, Per, Boffetta, Paolo, Kendzia, Benjamin, Radoi, Loredana, Barul, Christine, Karrasch, Stefan, Wichmann, Heinz-Erich, Consonni, Dario, Landi, Maria Teresa, Caporaso, Neil E, Merletti, Franco, Migliore, Enrica, Richiardi, Lorenzo, Jöckel, Karl-Heinz, Ahrens, Wolfgang, Pohlabeln, Hermann, Fernández-Tardón, Guillermo, Zaridze, David, Field, John K, Lissowska, Jolanta, Świątkowska, Beata, McLaughlin, John R, Demers, Paul A, Schejbalova, Miriam, Foretova, Lenka, Janout, Vladimir, Pándics, Tamás, Fabianova, Eleonora, Mates, Dana, Forastiere, Francesco, Straif, Kurt, Brüning, Thomas, Vlaanderen, Jelle, and Peters, Susan

Published
2024

14. Occupational Benzene Exposure and Lung Cancer Risk: A Pooled Analysis of 14 Case-Control Studies

Author

IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, Wan, Wenxin, Peters, Susan, Portengen, Lützen, Olsson, Ann, Schüz, Joachim, Ahrens, Wolfgang, Schejbalova, Miriam, Boffetta, Paolo, Behrens, Thomas, Brüning, Thomas, Kendzia, Benjamin, Consonni, Dario, Demers, Paul A, Fabiánová, Eleonóra, Fernández-Tardón, Guillermo, Field, John K, Forastiere, Francesco, Foretova, Lenka, Guénel, Pascal, Gustavsson, Per, Jöckel, Karl-Heinz, Karrasch, Stefan, Landi, Maria Teresa, Lissowska, Jolanta, Barul, Christine, Mates, Dana, McLaughlin, John R, Merletti, Franco, Migliore, Enrica, Richiardi, Lorenzo, Pándics, Tamás, Pohlabeln, Hermann, Siemiatycki, Jack, Świątkowska, Beata, Wichmann, Heinz-Erich, Zaridze, David, Ge, Calvin, Straif, Kurt, Kromhout, Hans, Vermeulen, Roel, IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, Wan, Wenxin, Peters, Susan, Portengen, Lützen, Olsson, Ann, Schüz, Joachim, Ahrens, Wolfgang, Schejbalova, Miriam, Boffetta, Paolo, Behrens, Thomas, Brüning, Thomas, Kendzia, Benjamin, Consonni, Dario, Demers, Paul A, Fabiánová, Eleonóra, Fernández-Tardón, Guillermo, Field, John K, Forastiere, Francesco, Foretova, Lenka, Guénel, Pascal, Gustavsson, Per, Jöckel, Karl-Heinz, Karrasch, Stefan, Landi, Maria Teresa, Lissowska, Jolanta, Barul, Christine, Mates, Dana, McLaughlin, John R, Merletti, Franco, Migliore, Enrica, Richiardi, Lorenzo, Pándics, Tamás, Pohlabeln, Hermann, Siemiatycki, Jack, Świątkowska, Beata, Wichmann, Heinz-Erich, Zaridze, David, Ge, Calvin, Straif, Kurt, Kromhout, Hans, and Vermeulen, Roel

Published
2024

15. Respirable crystalline silica and lung cancer in community-based studies: impact of job-exposure matrix specifications on exposure-response relationships

Author

IRAS OH Epidemiology Chemical Agents, Institute for Risk Assesment Sciences, IRAS – One Health Chemical, Ohlander, Johan, Kromhout, Hans, Vermeulen, Roel, Portengen, Lützen, Kendzia, Benjamin, Savary, Barbara, Cavallo, Domenico, Cattaneo, Andrea, Migliori, Enrica, Richiardi, Lorenzo, Plato, Nils, Wichmann, Heinz-Erich, Karrasch, Stefan, Consonni, Dario, Landi, Maria Teresa, Caporaso, Neil E, Siemiatycki, Jack, Gustavsson, Per, Jöckel, Karl-Heinz, Ahrens, Wolfgang, Pohlabeln, Hermann, Fernández-Tardón, Guillermo, Zaridze, David, Jolanta Lissowska, Jolanta Lissowska, Beata Swiatkowska, Beata Swiatkowska, John K Field, John K Field, McLaughlin, John R, Demers, Paul A, Pandics, Tamas, Forastiere, Francesco, Fabianova, Eleonora, Schejbalova, Miriam, Foretova, Lenka, Janout, Vladimir, Mates, Dana, Barul, Christine, Brüning, Thomas, Behrens, Thomas, Straif, Kurt, Schüz, Joachim, Olsson, Ann, Peters, Susan, IRAS OH Epidemiology Chemical Agents, Institute for Risk Assesment Sciences, IRAS – One Health Chemical, Ohlander, Johan, Kromhout, Hans, Vermeulen, Roel, Portengen, Lützen, Kendzia, Benjamin, Savary, Barbara, Cavallo, Domenico, Cattaneo, Andrea, Migliori, Enrica, Richiardi, Lorenzo, Plato, Nils, Wichmann, Heinz-Erich, Karrasch, Stefan, Consonni, Dario, Landi, Maria Teresa, Caporaso, Neil E, Siemiatycki, Jack, Gustavsson, Per, Jöckel, Karl-Heinz, Ahrens, Wolfgang, Pohlabeln, Hermann, Fernández-Tardón, Guillermo, Zaridze, David, Jolanta Lissowska, Jolanta Lissowska, Beata Swiatkowska, Beata Swiatkowska, John K Field, John K Field, McLaughlin, John R, Demers, Paul A, Pandics, Tamas, Forastiere, Francesco, Fabianova, Eleonora, Schejbalova, Miriam, Foretova, Lenka, Janout, Vladimir, Mates, Dana, Barul, Christine, Brüning, Thomas, Behrens, Thomas, Straif, Kurt, Schüz, Joachim, Olsson, Ann, and Peters, Susan

Published
2024

16. Respirable crystalline silica and lung cancer in community-based studies: impact of job-exposure matrix specifications on exposure–response relationships

Author

Ohlander, Johan, primary, Kromhout, Hans, additional, Vermeulen, Roel, additional, Portengen, Lützen, additional, Kendzia, Benjamin, additional, Savary, Barbara, additional, Cavallo, Domenico, additional, Cattaneo, Andrea, additional, Migliori, Enrica, additional, Richiardi, Lorenzo, additional, Plato, Nils, additional, Wichmann, Heinz-Erich, additional, Karrasch, Stefan, additional, Consonni, Dario, additional, Landi, Maria Teresa, additional, Caporaso, Neil E, additional, Siemiatycki, Jack, additional, Gustavsson, Per, additional, Jöckel, Karl-Heinz, additional, Ahrens, Wolfgang, additional, Pohlabeln, Hermann, additional, Fernández-Tardón, Guillermo, additional, Zaridze, David, additional, Jolanta Lissowska, Jolanta Lissowska, additional, Beata Swiatkowska, Beata Swiatkowska, additional, John K Field, John K Field, additional, McLaughlin, John R, additional, Demers, Paul A, additional, Pandics, Tamas, additional, Forastiere, Francesco, additional, Fabianova, Eleonora, additional, Schejbalova, Miriam, additional, Foretova, Lenka, additional, Janout, Vladimir, additional, Mates, Dana, additional, Barul, Christine, additional, Brüning, Thomas, additional, Behrens, Thomas, additional, Straif, Kurt, additional, Schüz, Joachim, additional, Olsson, Ann, additional, and Peters, Susan, additional

Published
2024
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17. Cancer mortality in chrysotile miners and millers, Russian Federation: main results (Asbest Chrysotile Cohort-Study)

Author

Schüz, Joachim, primary, Kovalevskiy, Evgeny, additional, Olsson, Ann, additional, Moissonnier, Monika, additional, Ostroumova, Evgenia, additional, Ferro, Gilles, additional, Feletto, Eleonora, additional, Schonfeld, Sara J, additional, Byrnes, Graham, additional, Tskhomariia, Iraklii, additional, Straif, Kurt, additional, Morozova, Tatiana, additional, Kromhout, Hans, additional, and Bukhtiyarov, Igor, additional

Published
2024
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18. Parental occupations at birth and risk of adult testicular germ cell tumors in offspring: a French nationwide case–control study

Author

Paul, Adèle, primary, Danjou, Aurélie M. N., additional, Deygas, Floriane, additional, Guth, Margot, additional, Coste, Astrid, additional, Lefevre, Marie, additional, Dananché, Brigitte, additional, Kromhout, Hans, additional, Spinosi, Johan, additional, Béranger, Rémi, additional, Pérol, Olivia, additional, Boyle, Helen, additional, Hersant, Christel, additional, Loup-Cabaniols, Vanessa, additional, Veau, Ségolène, additional, Bujan, Louis, additional, Olsson, Ann, additional, Schüz, Joachim, additional, Fervers, Béatrice, additional, and Charbotel, Barbara, additional

Published
2024
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19. Listening to the voice of children : systemic dialogue coaching : inviting participation and partnership in social work

Author

Olsson, Ann-Margreth E.

Subjects
362.7, systemic, dialogical, social work, dialogue, coaching, children, participatory action research, systemic practice, systemic research
Abstract

This is a study in and about systemic coaching in social work – systemic, and, as it unfolded, dialogical coaching, later named Dialogue Coaching (DC). Focus lies on what the conducted coaching brought forth, generated and created in the context of social work and for the members of the participating social welfare organisations. My specialities as coach became to inspire social workers to invite clients and especially children into partnership, making their voices heard, both in the written text and in the process of social investigations. The study was integral parts of commissions (and vice versa) of the County Administrative Board of Scania, Sweden, in my profession as systemic consultant and supervisor in Sweden. It was a study in how dialogical communication could improve how social workers, listening to the children’s invitation, could make children’s voices more heard in social investigations. In all, 55 social workers in seven municipalities participated in the dialogical participatory action research (DPAR) study, developing coaching and improving the dialogical interaction in social investigations. Focus moved from collecting data for decision-making, about what would be best for the child and other clients, to focusing on the changing process in relation to the participating clients, including children when they wanted to and could, co-creating new orientation on how to go on. The focus on communication and dialogue in the coaching changed and developed the participants’ approach in relation to clients and one another and others. In the emerging awareness of how we reciprocally and reflexively cocreate occurrences and outcomes, including who we become in relation to one another, the participating social workers’ awareness of the impact of their own contributions, and their own importance in relation to children and other clients, also improved. The expressions listening ears and listening questions were invented, capturing my, the coach’s, participation of placing myself completely 8 at the other participants’ disposal, completely accessible in the mutual responsiveness in the moment – being here and now in the present. The systemic methods and techniques were reflexively influenced and adapted from within the relational dynamic of joint actions in the dialogical interplay, metaphorically presented as peloton cycling in a voyage tour, becoming living tools in both the social workers’ practice and the coaching researcher’s practice, facilitating learning-by-doing with methods and approach connected to Appreciative Inquiry (AI). One of the living tools was reflecting teams emerging also into so called delta-reflecting teams with open narrating included.

Published
2010

23. Parental occupations at birth and risk of adult testicular germ cell tumors in offspring: a French nationwide case-control study

Author

Paul, Adèle, Danjou, Aurélie M N, Deygas, Floriane, Guth, Margot, Coste, Astrid, Lefevre, Marie, Dananché, Brigitte, Kromhout, Hans, Spinosi, Johan, Béranger, Rémi, Pérol, Olivia, Boyle, Helen, Hersant, Christel, Loup-Cabaniols, Vanessa, Veau, Ségolène, Bujan, Louis, Olsson, Ann, Schüz, Joachim, Fervers, Béatrice, Charbotel, Barbara, Paul, Adèle, Danjou, Aurélie M N, Deygas, Floriane, Guth, Margot, Coste, Astrid, Lefevre, Marie, Dananché, Brigitte, Kromhout, Hans, Spinosi, Johan, Béranger, Rémi, Pérol, Olivia, Boyle, Helen, Hersant, Christel, Loup-Cabaniols, Vanessa, Veau, Ségolène, Bujan, Louis, Olsson, Ann, Schüz, Joachim, Fervers, Béatrice, and Charbotel, Barbara

Abstract

BACKGROUND: Testicular germ cell tumors (TGCT) are the most frequent cancer in young men in developed countries. Parental occupational exposures during early-life periods are suspected to increase TGCT risk. The objective was to estimate the association between parental occupations at birth and adult TGCT.METHODS: A case-control study was conducted, including 454 TGCT cases aged 18-45 from 20 French university hospitals, matched to 670 controls based on region and year of birth. Data collected from participants included parental jobs at birth coded according to the International Standard Classification of Occupation-1968 and the French nomenclature of activities-1999. Odds ratios (OR) for TGCT and 95% confidence intervals (CI) were estimated using conditional logistic regression, adjusting for TGCT risk factors.RESULTS: Paternal jobs at birth as service workers (OR = 1.98, CI 1.18-3.30), protective service workers (OR = 2.40, CI 1.20-4.81), transport equipment operators (OR = 1.96, CI 1.14-3.37), specialized farmers (OR = 2.66, CI 1.03-6.90), and maternal jobs as secondary education teachers (OR = 2.27, CI 1.09-4.76) or in secondary education (OR = 2.35, CI 1.13-4.88) were significantly associated with adult TGCT. The risk of seminoma was increased for the above-mentioned paternal jobs and that of non-seminomas for public administration and defence; compulsory social security (OR = 1.99, CI 1.09-3.65); general, economic, and social administration (OR = 3.21, CI 1.23-8.39) for fathers; and secondary education teacher (OR = 4.67, CI 1.87-11.67) and secondary education (OR = 3.50, CI 1.36-9.01) for mothers.CONCLUSION: Some paternal jobs, such as service workers, transport equipment operators, or specialized farmers, and maternal jobs in secondary education seem to be associated with an increased risk of TGCT with specific features depending on the histological type. These data allow hypotheses to be put forward for further studies as to the invo

Published
2023

24. Occupational exposure to nickel and hexavalent chromium and the risk of lung cancer in a pooled analysis of case-control studies (SYNERGY)

Author

Behrens, Thomas, Ge, Calvin, Vermeulen, Roel, Kendzia, Benjamin, Olsson, Ann, Schüz, Joachim, Kromhout, Hans, Pesch, Beate, Peters, Susan, Portengen, Lützen, Gustavsson, Per, Mirabelli, Dario, Guénel, Pascal, Luce, Danièle, Consonni, Dario, Caporaso, Neil E., Landi, Maria Teresa, Field, John K., Karrasch, Stefan, Wichmann, Heinz Erich, Siemiatycki, Jack, Parent, Marie Elise, Richiardi, Lorenzo, Simonato, Lorenzo, Jöckel, Karl Heinz, Ahrens, Wolfgang, Pohlabeln, Hermann, Fernández-Tardón, Guillermo, Zaridze, David, McLaughlin, John R., Demers, Paul A., Świątkowska, Beata, Lissowska, Jolanta, Pándics, Tamás, Fabianova, Eleonora, Mates, Dana, Bencko, Vladimir, Foretova, Lenka, Janout, Vladimír, Boffetta, Paolo, Bueno-de-Mesquita, Bas, Forastiere, Francesco, Straif, Kurt, Brüning, Thomas, Behrens, Thomas, Ge, Calvin, Vermeulen, Roel, Kendzia, Benjamin, Olsson, Ann, Schüz, Joachim, Kromhout, Hans, Pesch, Beate, Peters, Susan, Portengen, Lützen, Gustavsson, Per, Mirabelli, Dario, Guénel, Pascal, Luce, Danièle, Consonni, Dario, Caporaso, Neil E., Landi, Maria Teresa, Field, John K., Karrasch, Stefan, Wichmann, Heinz Erich, Siemiatycki, Jack, Parent, Marie Elise, Richiardi, Lorenzo, Simonato, Lorenzo, Jöckel, Karl Heinz, Ahrens, Wolfgang, Pohlabeln, Hermann, Fernández-Tardón, Guillermo, Zaridze, David, McLaughlin, John R., Demers, Paul A., Świątkowska, Beata, Lissowska, Jolanta, Pándics, Tamás, Fabianova, Eleonora, Mates, Dana, Bencko, Vladimir, Foretova, Lenka, Janout, Vladimír, Boffetta, Paolo, Bueno-de-Mesquita, Bas, Forastiere, Francesco, Straif, Kurt, and Brüning, Thomas

Abstract

There is limited evidence regarding the exposure-effect relationship between lung-cancer risk and hexavalent chromium (Cr(VI)) or nickel. We estimated lung-cancer risks in relation to quantitative indices of occupational exposure to Cr(VI) and nickel and their interaction with smoking habits. We pooled 14 case-control studies from Europe and Canada, including 16 901 lung-cancer cases and 20 965 control subjects. A measurement-based job-exposure-matrix estimated job-year-region specific exposure levels to Cr(VI) and nickel, which were linked to the subjects' occupational histories. Odds ratios (OR) and associated 95% confidence intervals (CI) were calculated by unconditional logistic regression, adjusting for study, age group, smoking habits and exposure to other occupational lung carcinogens. Due to their high correlation, we refrained from mutually adjusting for Cr(VI) and nickel independently. In men, ORs for the highest quartile of cumulative exposure to CR(VI) were 1.32 (95% CI 1.19-1.47) and 1.29 (95% CI 1.15-1.45) in relation to nickel. Analogous results among women were: 1.04 (95% CI 0.48-2.24) and 1.29 (95% CI 0.60-2.86), respectively. In men, excess lung-cancer risks due to occupational Cr(VI) and nickel exposure were also observed in each stratum of never, former and current smokers. Joint effects of Cr(VI) and nickel with smoking were in general greater than additive, but not different from multiplicative. In summary, relatively low cumulative levels of occupational exposure to Cr(VI) and nickel were associated with increased ORs for lung cancer, particularly in men. However, we cannot rule out a combined classical measurement and Berkson-type of error structure, which may cause differential bias of risk estimates.

Published
2023

25. Occupational exposure to nickel and hexavalent chromium and the risk of lung cancer in a pooled analysis of case-control studies (SYNERGY)

Author

IRAS OH Epidemiology Chemical Agents, Behrens, Thomas, Ge, Calvin, Vermeulen, Roel, Kendzia, Benjamin, Olsson, Ann, Schüz, Joachim, Kromhout, Hans, Pesch, Beate, Peters, Susan, Portengen, Lützen, Gustavsson, Per, Mirabelli, Dario, Guénel, Pascal, Luce, Danièle, Consonni, Dario, Caporaso, Neil E., Landi, Maria Teresa, Field, John K., Karrasch, Stefan, Wichmann, Heinz Erich, Siemiatycki, Jack, Parent, Marie Elise, Richiardi, Lorenzo, Simonato, Lorenzo, Jöckel, Karl Heinz, Ahrens, Wolfgang, Pohlabeln, Hermann, Fernández-Tardón, Guillermo, Zaridze, David, McLaughlin, John R., Demers, Paul A., Świątkowska, Beata, Lissowska, Jolanta, Pándics, Tamás, Fabianova, Eleonora, Mates, Dana, Bencko, Vladimir, Foretova, Lenka, Janout, Vladimír, Boffetta, Paolo, Bueno-de-Mesquita, Bas, Forastiere, Francesco, Straif, Kurt, Brüning, Thomas, IRAS OH Epidemiology Chemical Agents, Behrens, Thomas, Ge, Calvin, Vermeulen, Roel, Kendzia, Benjamin, Olsson, Ann, Schüz, Joachim, Kromhout, Hans, Pesch, Beate, Peters, Susan, Portengen, Lützen, Gustavsson, Per, Mirabelli, Dario, Guénel, Pascal, Luce, Danièle, Consonni, Dario, Caporaso, Neil E., Landi, Maria Teresa, Field, John K., Karrasch, Stefan, Wichmann, Heinz Erich, Siemiatycki, Jack, Parent, Marie Elise, Richiardi, Lorenzo, Simonato, Lorenzo, Jöckel, Karl Heinz, Ahrens, Wolfgang, Pohlabeln, Hermann, Fernández-Tardón, Guillermo, Zaridze, David, McLaughlin, John R., Demers, Paul A., Świątkowska, Beata, Lissowska, Jolanta, Pándics, Tamás, Fabianova, Eleonora, Mates, Dana, Bencko, Vladimir, Foretova, Lenka, Janout, Vladimír, Boffetta, Paolo, Bueno-de-Mesquita, Bas, Forastiere, Francesco, Straif, Kurt, and Brüning, Thomas

Published
2023

26. Parental occupations at birth and risk of adult testicular germ cell tumors in offspring: a French nationwide case-control study

Author

IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, Paul, Adèle, Danjou, Aurélie M N, Deygas, Floriane, Guth, Margot, Coste, Astrid, Lefevre, Marie, Dananché, Brigitte, Kromhout, Hans, Spinosi, Johan, Béranger, Rémi, Pérol, Olivia, Boyle, Helen, Hersant, Christel, Loup-Cabaniols, Vanessa, Veau, Ségolène, Bujan, Louis, Olsson, Ann, Schüz, Joachim, Fervers, Béatrice, Charbotel, Barbara, IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, Paul, Adèle, Danjou, Aurélie M N, Deygas, Floriane, Guth, Margot, Coste, Astrid, Lefevre, Marie, Dananché, Brigitte, Kromhout, Hans, Spinosi, Johan, Béranger, Rémi, Pérol, Olivia, Boyle, Helen, Hersant, Christel, Loup-Cabaniols, Vanessa, Veau, Ségolène, Bujan, Louis, Olsson, Ann, Schüz, Joachim, Fervers, Béatrice, and Charbotel, Barbara

Published
2023

27. Occupational Exposure to Polycyclic Aromatic Hydrocarbons and Lung Cancer Risk: Results from a Pooled Analysis of Case–Control Studies (SYNERGY)

Author

Olsson, Ann, Guha, Neela, Bouaoun, Liacine, Kromhout, Hans, Peters, Susan, Siemiatycki, Jack, Ho, Vikki, Gustavsson, Per, Boffetta, Paolo, Vermeulen, Roel, Behrens, Thomas, Bruning, Thomas, Kendzia, Benjamin, Guénel, Pascal, Luce, Danièle, Karrasch, Stefan, Wichmann, Heinz-Erich, Consonni, Dario, Landi, Maria Teresa, Caporaso, Neil E, Merletti, Franco, Mirabelli, Dario, Richiardi, Lorenzo, Jöckel, Karl-Heinz, Ahrens, Wolfgang, Pohlabeln, Hermann, Tardon, Adonina, Zaridze, David, Field, John K, Lissowska, Jolanta, Świątkowska, Beata, McLaughlin, John R, Demers, Paul A, Bencko, Vladimir, Foretova, Lenka, Janout, Vladimir, Pandics, Tamas, Fabianova, Eleonora, Mates, Dana, Forastiere, Francesco, Bueno-de-Mesquita, Bas, Schüz, Joachim, Straif, Kurt, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Centre International de Recherche contre le Cancer - International Agency for Research on Cancer (CIRC - IARC), Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Utrecht University [Utrecht], Université de Montréal (UdeM), Karolinska Institutet [Stockholm], University of Bologna/Università di Bologna, Stony Brook University [SUNY] (SBU), State University of New York (SUNY), Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), École des Hautes Études en Santé Publique [EHESP] (EHESP), Ludwig Maximilian University [Munich] (LMU), Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, National Cancer Institute [Bethesda] (NCI-NIH), National Institutes of Health [Bethesda] (NIH), Department of Medical Sciences [Turin, Italy] (DMS), Università degli studi di Torino = University of Turin (UNITO), Universitätsklinikum Essen [Universität Duisburg-Essen] (Uniklinik Essen), Universität Bremen, Leibniz Institute for Prevention Research and Epidemiology - BIPS, Leibniz Association, University of Oviedo, N.N. Blokhin National Medical Research Center of Oncology, University of Liverpool, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology (MCMCC), Nofer Institute of Occupational Medicine (NIOM), University of Toronto, Occupational Cancer Research Centre, First Faculty of Medicine, Charles University [Prague] (CU), Masaryk Memorial Cancer Institute (MMCI), Faculty of Health Sciences [UEF, Kuopio, Finland], University of Eastern Finland, National Public Health Center, National Institute of Public Health [Romania] (INSP), Azienda Sanitaria Locale [ROMA] (ASL), National Institute for Public Health and the Environment [Bilthoven] (RIVM), Instituto de Salud Global - Institute For Global Health [Barcelona] (ISGlobal), Boston College (BC), and Chard-Hutchinson, Xavier

Subjects
Male, Lung Neoplasms, Epidemiology, Medizin, [SDV.CAN]Life Sciences [q-bio]/Cancer, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, [SDV.CAN] Life Sciences [q-bio]/Cancer, Oncology, polycyclic aromatic hydrocarbons, benzo[a]pyrene, lung cancer, occupational exposures, case-control study, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Case-Control Studies, Occupational Exposure, Carcinogens, Humans, [SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Polycyclic Aromatic Hydrocarbons, Lung
Abstract

German Social Accident Insurance (DGUV) between 2007 and 2011, Olsson A, Guha N, Bouaoun L, Kromhout H, Peters S, Siemiatycki J, Ho V, Gustavsson P, Boffetta P, Vermeulen R, Behrens T, Brüning T, Kendzia B, Guénel P, Luce D, Karrasch S, Wichmann HE, Consonni D, Landi MT, Caporaso NE, Merletti F, Mirabelli D, Richiardi L, Jöckel KH, Ahrens W, Pohlabeln H, Tardón A, Zaridze D, Field JK, Lissowska J, Świątkowska B, McLaughlin JR, Demers PA, Bencko V, Foretova L, Janout V, Pándics T, Fabianova E, Mates D, Forastiere F, Bueno-de-Mesquita B, Schüz J, Straif K

Published
2022
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28. Lung cancer among coal miners, ore miners and quarrymen: smoking-adjusted risk estimates from the synergy pooled analysis of case–control studies

Author

Taeger, Dirk, Pesch, Beate, Kendzia, Benjamin, Behrens, Thomas, Jöckel, Karl-Heinz, Dahmann, Dirk, Siemiatycki, Jack, Kromhout, Hans, Vermeulen, Roel, Peters, Susan, Olsson, Ann, Brüske, Irene, Wichmann, Heinz-Erich, Stücker, Isabelle, Guida, Florence, Tardón, Adonina, Merletti, Franco, Mirabelli, Dario, Richiardi, Lorenzo, Pohlabeln, Hermann, Ahrens, Wolfgang, Landi, Maria Teresa, Caporaso, Neil, Pesatori, Angela Cecilia, Mukeriya, Anush, Szeszenia-Dabrowska, Neonila, Lissowska, Jolanta, Gustavsson, Per, Field, John, Marcus, Michael W, Fabianova, Eleonora, 't Mannetje, Andrea, Pearce, Neil, Rudnai, Peter, Bencko, Vladimir, Janout, Vladimir, Dumitru, Rodica Stanescu, Foretova, Lenka, Forastiere, Francesco, McLaughlin, John, Demers, Paul, Bueno-de-Mesquita, Bas, Schüz, Joachim, Straif, Kurt, and Brüning, Thomas

Published
2015

30. Parental occupational exposure to solvents and risk of developing testicular germ cell tumors among sons: a French nationwide case-control study (TESTIS study).

Author

Guth, Margot, Lefevre, Marie, Pilorget, Corinne, Coste, Astrid, Ahmadi, Shukrullah, Danjou, Aurélie, Dananché, Brigitte, Praud, Delphine, Koscinski, Isabelle, Papaxanthos, Aline, Blagosklonov, Oxana, Fauque, Patricia, Pérol, Olivia, Schüz, Joachim, Bujan, Louis, Olsson, Ann, Fervers, Béatrice, and Charbotel, Barbara

Abstract

The article presents the discussion on etiology of testicular germ cell tumors (TGCT) suspected to be related to prenatal environmental risk factors. Topics include examining the association between parental occupational exposure to solvents and TGCT risk among their offspring; and impact of the fetal environment is also supported by large geographical variation in incidence and the evolution of TGCT incidence among migrant populations.

Published
2023
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31. Lung cancer risk among bakers, pastry cooks and confectionary makers: the SYNERGY study

Author

Behrens, Thomas, Kendzia, Benjamin, Treppmann, Tabea, Olsson, Ann, Jöckel, Karl-Heinz, Gustavsson, Per, Pohlabeln, Hermann, Ahrens, Wolfgang, Brüske, Irene, Wichmann, Hans-Erich, Merletti, Franco, Mirabelli, Dario, Richiardi, Lorenzo, Simonato, Lorenzo, Zaridze, David, Szeszenia-Dabrowska, Neonila, Rudnai, Peter, Lissowska, Jolanta, Fabianova, Eleonora, Tardón, Adonina, Field, John, Dumitru, Rodica Stanescu, Bencko, Vladimir, Foretova, Lenka, Janout, Vladimir, Siemiatycki, Jack, Parent, Marie-Elise, McLaughlin, John, Demers, Paul, Landi, Maria Teresa, Caporaso, Neil, Kromhout, Hans, Vermeulen, Roel, Peters, Susan, Benhamou, Simone, Stücker, Isabelle, Guida, Florence, Consonni, Dario, Bueno-de-Mesquita, Bas, Mannetje, Andrea 't, Pearce, Neil, Tse, Lap Ah, Yu, Ignatius Tak-sun, Plato, Nils, Boffetta, Paolo, Straif, Kurt, Schüz, Joachim, Pesch, Beate, and Brüning, Thomas

Published
2013
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33. A Case—Control Study of Lung Cancer Nested in a Cohort of European Asphalt Workers

Author

Olsson, Ann, Kromhout, Hans, Agostini, Michela, Hansen, Johnni, Lassen, Christina Funch, Johansen, Christoffer, Kjaerheim, Kristina, Langård, Sverre, Stücker, Isabelle, Ahrens, Wolfgang, Behrens, Thomas, Lindbohm, Marja-Liisa, Heikkilä, Pirjo, Heederik, Dick, Portengen, Lützen, Shaham, Judith, Ferro, Gilles, de Vocht, Frank, Burstyn, Igor, and Boffetta, Paolo

Published
2010

35. Parental occupational exposures in wood-related jobs and risk of testicular germ cell tumours in offspring in NORD-TEST a registry-based case–control study in Finland, Norway, and Sweden

Author

Corbin, Sara, Togawa, Kayo, Schüz, Joachim, Le Cornet, Charlotte, Fervers, Beatrice, Feychting, Maria, Wiebert, Pernilla, Hansen, Johnni, Dalton, Susanne Oksbjerg, Kjærheim, Kristina, Nordby, Karl Christian, Østrem, Ragnhild Strand, Skakkebæk, Niels E., Uuksulainen, Sanni, Pukkala, Eero, Olsson, Ann, Corbin, Sara, Togawa, Kayo, Schüz, Joachim, Le Cornet, Charlotte, Fervers, Beatrice, Feychting, Maria, Wiebert, Pernilla, Hansen, Johnni, Dalton, Susanne Oksbjerg, Kjærheim, Kristina, Nordby, Karl Christian, Østrem, Ragnhild Strand, Skakkebæk, Niels E., Uuksulainen, Sanni, Pukkala, Eero, and Olsson, Ann

Abstract

Objective: We assessed the association between parental prenatal exposures in wood-related jobs and risk of testicular germ cell tumours (TGCT) in offspring. Methods: NORD-TEST, a registry-based case–control study in Sweden, Finland and Norway, included 8112 TGCT cases diagnosed at ages 14–49 years between 1978 and 2012 with no history of prior cancer, and up to four controls matched to each case on year and country of birth. Parents of cases and controls were identified via linkages with the population registries and their occupational information was retrieved from censuses. The Nordic Occupational Cancer Study Job-Exposure Matrix was used to assign occupational exposures to each parent. Logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CI). Results: Maternal wood-related job was not associated with the risk of TGCT in offspring (OR 1.08, CI 0.55–2.14), while paternal wood-related job was associated with a decreased risk of TGCT in offspring (OR 0.85, CI 0.75–0.96). None of the specific wood-related jobs, such as upholsterers, sawyers, or construction carpenters, were significantly associated with a risk of TGCT. Only exception was observed in a sensitivity analysis which showed an increased risk in the small group of sons of fathers working as ‘cabinetmakers and joiners’ the year before conception (OR of 2.06, CI 1.00–4.25). Conclusion: This large-scale NORD-TEST analysis provided no evidence of an association between parental prenatal exposures in wood-related jobs and TGCT in sons.

Published
2022

36. Developing a company-specific job exposure matrix for the Asbest Chrysotile Cohort Study

Author

Feletto, Eleonora, Kovalevskiy, Evgeny V, Schonfeld, Sara J, Moissonnier, Monika, Olsson, Ann, Kashanskiy, Sergey V, Ostroumova, Evgenia, Bukhtiyarov, Igor V, Schüz, Joachim, Kromhout, Hans, Feletto, Eleonora, Kovalevskiy, Evgeny V, Schonfeld, Sara J, Moissonnier, Monika, Olsson, Ann, Kashanskiy, Sergey V, Ostroumova, Evgenia, Bukhtiyarov, Igor V, Schüz, Joachim, and Kromhout, Hans

Abstract

OBJECTIVES: Exposure assessment for retrospective industrial cohorts are often hampered by limited availability of historical measurements. This study describes the development of company-specific job-exposure matrices (JEMs) based on measurements collected over five decades for a cohort study of 35 837 workers (Asbest Chrysotile Cohort Study) in the Russian Federation to estimate their cumulative exposure to chrysotile containing dust and fibres.METHODS: Almost 100 000 recorded stationary dust measurements were available from 1951-2001 (factories) and 1964-2001 (mine). Linear mixed models were used to extrapolate for years where measurements were not available or missing. Fibre concentrations were estimated using conversion factors based on side-by-side comparisons. Dust and fibre JEMs were developed and exposures were allocated by linking them to individual workers' detailed occupational histories.RESULTS: The cohort covered a total of 515 355 employment-years from 1930 to 2010. Of these individuals, 15% worked in jobs not considered professionally exposed to chrysotile. The median cumulative dust exposure was 26 mg/m3 years for the entire cohort and 37.2 mg/m3 years for those professionally exposed. Median cumulative fibre exposure was 16.4 fibre/cm3 years for the entire cohort and 23.4 fibre/cm3 years for those professionally exposed. Cumulative exposure was highly dependent on birth cohort and gender. Of those professionally exposed, women had higher cumulative exposures than men as they were more often employed in factories with higher exposure concentrations rather than in the mine.CONCLUSIONS: Unique company-specific JEMs were derived using a rich measurement database that overlapped with most employment-years of cohort members and will enable estimation of quantitative exposure-response.

Published
2022

37. Occupational exposure to polycyclic aromatic hydrocarbons and lung cancer risk: results from a pooled analysis of case-control studies (SYNERGY)

Author

IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Olsson, Ann, Guha, Neela, Bouaoun, Liacine, Kromhout, Hans, Peters, Susan, Siemiatycki, Jack, Ho, Vikki, Gustavsson, Per, Boffetta, Paolo, Vermeulen, Roel, Behrens, Thomas, Bruning, Thomas, Kendzia, Benjamin, Guénel, Pascal, Luce, Danièle, Karrasch, Stefan, Wichmann, Heinz-Erich, Consonni, Dario, Landi, Maria Teresa, Caporaso, Neil E, Merletti, Franco, Mirabelli, Dario, Richiardi, Lorenzo, Jöckel, Karl-Heinz, Ahrens, Wolfgang, Pohlabeln, Hermann, Tardon, Adonina, Zaridze, David, Field, John K, Lissowska, Jolanta, Świątkowska, Beata, McLaughlin, John R, Demers, Paul A, Bencko, Vladimir, Foretova, Lenka, Janout, Vladimir, Pandics, Tamas, Fabianova, Eleonora, Mates, Dana, Forastiere, Francesco, Bueno-de-Mesquita, Bas, Schüz, Joachim, Straif, Kurt, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Olsson, Ann, Guha, Neela, Bouaoun, Liacine, Kromhout, Hans, Peters, Susan, Siemiatycki, Jack, Ho, Vikki, Gustavsson, Per, Boffetta, Paolo, Vermeulen, Roel, Behrens, Thomas, Bruning, Thomas, Kendzia, Benjamin, Guénel, Pascal, Luce, Danièle, Karrasch, Stefan, Wichmann, Heinz-Erich, Consonni, Dario, Landi, Maria Teresa, Caporaso, Neil E, Merletti, Franco, Mirabelli, Dario, Richiardi, Lorenzo, Jöckel, Karl-Heinz, Ahrens, Wolfgang, Pohlabeln, Hermann, Tardon, Adonina, Zaridze, David, Field, John K, Lissowska, Jolanta, Świątkowska, Beata, McLaughlin, John R, Demers, Paul A, Bencko, Vladimir, Foretova, Lenka, Janout, Vladimir, Pandics, Tamas, Fabianova, Eleonora, Mates, Dana, Forastiere, Francesco, Bueno-de-Mesquita, Bas, Schüz, Joachim, and Straif, Kurt

Published
2022

38. Developing a company-specific job exposure matrix for the Asbest Chrysotile Cohort Study

Author

IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Feletto, Eleonora, Kovalevskiy, Evgeny V, Schonfeld, Sara J, Moissonnier, Monika, Olsson, Ann, Kashanskiy, Sergey V, Ostroumova, Evgenia, Bukhtiyarov, Igor V, Schüz, Joachim, Kromhout, Hans, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Feletto, Eleonora, Kovalevskiy, Evgeny V, Schonfeld, Sara J, Moissonnier, Monika, Olsson, Ann, Kashanskiy, Sergey V, Ostroumova, Evgenia, Bukhtiyarov, Igor V, Schüz, Joachim, and Kromhout, Hans

Published
2022

39. Nog nu, politiker – ta klimatkrisen på allvar

Author

Gerhardt, Karin, Wolrath Söderberg, Maria, Lindblad, Inger, Diderichsen, Öjvind, Gullström, Martin, Dahlin, Maria, Köping Olsson, Ann-Sofie, Lehtilä, Kari, Rasoal, Chato, Dobers, Peter, Johansson, Johanna, Berndt, Kurt D., Karlholm, Dan, Kjellqvist, Tomas, Lalander, Rickard, Vallström, Maria, Alvarsson-Hjort, Jesper, Sjöholm, Cecilia, Lönngren, Ann-Sofie, Bydler, Charlotte, Färjsjö, Eva, Porseryd, Tove, Sio, Miriam, Yazdanpanah, Soheyla, Pihl Skoog, Emma, Sörbom, Adrienne, Gallardo Fernández, Gloria L., Wadstein MacLeod, Katarina, Garrison, Julie, Andrén, Elinor, Svärd, Veronica, Hajighasemi, Ali, Spånberger Weitz, Ylva, Elmersjö, Magdalena, Persson, Sara, Borevi, Karin, Carlsson, Nina, Löfgren, Isabel, Ghose, Sheila, Bonow, Madeleine, Bornemark, Jonna, Podolian, Olena, Grahn, Mats, Gunnarsson Payne, Jenny, Kaun, Anne, Faber, Hugo, Cederberg, Carl, Gradén, Mattias, Gerhardt, Karin, Wolrath Söderberg, Maria, Lindblad, Inger, Diderichsen, Öjvind, Gullström, Martin, Dahlin, Maria, Köping Olsson, Ann-Sofie, Lehtilä, Kari, Rasoal, Chato, Dobers, Peter, Johansson, Johanna, Berndt, Kurt D., Karlholm, Dan, Kjellqvist, Tomas, Lalander, Rickard, Vallström, Maria, Alvarsson-Hjort, Jesper, Sjöholm, Cecilia, Lönngren, Ann-Sofie, Bydler, Charlotte, Färjsjö, Eva, Porseryd, Tove, Sio, Miriam, Yazdanpanah, Soheyla, Pihl Skoog, Emma, Sörbom, Adrienne, Gallardo Fernández, Gloria L., Wadstein MacLeod, Katarina, Garrison, Julie, Andrén, Elinor, Svärd, Veronica, Hajighasemi, Ali, Spånberger Weitz, Ylva, Elmersjö, Magdalena, Persson, Sara, Borevi, Karin, Carlsson, Nina, Löfgren, Isabel, Ghose, Sheila, Bonow, Madeleine, Bornemark, Jonna, Podolian, Olena, Grahn, Mats, Gunnarsson Payne, Jenny, Kaun, Anne, Faber, Hugo, Cederberg, Carl, and Gradén, Mattias

Abstract

Debattartikel från 1944 svenska forskare och anställda i forskarvärlden.

Published
2022

41. Occupational exposure to nickel and hexavalent chromium and the risk of lung cancer in a pooled analysis of case-control studies (SYNERGY)

Author

Behrens, Thomas, Ge, Calvin, Vermeulen, Roel, Kendzia, Benjamin, Olsson, Ann, Schüz, Joachim, Kromhout, Hans, Pesch, Beate, Peters, Susan, Portengen, Lützen, Gustavsson, Per, Mirabelli, Dario, Guénel, Pascal, Luce, Danièle, Consonni, Dario, Caporaso, Neil E., Landi, Maria Teresa, Field, John K., Karrasch, Stefan, Wichmann, Heinz Erich, Siemiatycki, Jack, Parent, Marie Elise, Richiardi, Lorenzo, Simonato, Lorenzo, Jöckel, Karl Heinz, Ahrens, Wolfgang, Pohlabeln, Hermann, Fernández-Tardón, Guillermo, Zaridze, David, McLaughlin, John R., Demers, Paul A., Świątkowska, Beata, Lissowska, Jolanta, Pándics, Tamás, Fabianova, Eleonora, Mates, Dana, Bencko, Vladimir, Foretova, Lenka, Janout, Vladimír, Boffetta, Paolo, Bueno-de-Mesquita, Bas, Forastiere, Francesco, Straif, Kurt, Brüning, Thomas, IRAS OH Epidemiology Chemical Agents, IRAS OH Epidemiology Chemical Agents, Ruhr University Bochum (RUB), Utrecht University [Utrecht], Centre International de Recherche contre le Cancer - International Agency for Research on Cancer (CIRC - IARC), Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), and Our study was supported by the German Social Accident Insurance, grant FP 271. Grant sponsors of the individual studies were the Canadian Institutes of Health Research and Guzzo-SRC Chair in Environment and Cancer, the Fondation de France, the German Federal Ministry of Education, Science, Research, and Technology (grants 01 HK 173/0 and 01 HK 546/8) and the Ministry of Labour and Social Affairs (grant IIIb7-27/13), EC's INCO-COPERNICUS Program, Polish State Committee for Science Research, Roy Castle Foundation, NIH/NCI/DCEG Intramural Research Program, Lombardy Region, INAIL and the European Union Nuclear Fission Safety Program, Italian Association for Cancer Research, Region Piedmont, Compagnia di San Paolo, Europe Against Cancer Program, the Swedish Council for Work Life Research and the Swedish EPA, the University of Oviedo, the European Regional Development Fund and the State Budget of the Czech Republic (RECAMO, CZ.1.05/2.1.00/03.0101), the Ministry of Health of the Czech Republic—MH CZ—DRO (MMCI, 00209805), CIBERESP and FISS-PI060604.

Subjects
Cancer Research, Oncology, pulmonary cancer, [SDV]Life Sciences [q-bio], welders, Medizin, metals, SYNERGY, smoking
Abstract

Europe Against Cancer Program; European Regional Development Fund [CZ.1.05/2.1.00/03.0101]; European Union Nuclear Fission Safety Program; Universidad de Oviedo; Guzzo-SRC Chair in Environment and Cancer; CIPERESP; INAIL; [FISS-PI060604], Behrens T, Ge C, Vermeulen R, Kendzia B, Olsson A, Schüz J, Kromhout H, Pesch B, Peters S, Portengen L, Gustavsson P, Mirabelli D, Guénel P, Luce D, Consonni D, Caporaso NE, Landi MT, Field JK, Karrasch S, Wichmann HE, Siemiatycki J, Parent ME, Richiardi L, Simonato L, Jöckel KH, Ahrens W, Pohlabeln H, Fernández-Tardón G, Zaridze D, McLaughlin JR, Demers PA, Świątkowska B, Lissowska J, Pándics T, Fabianova E, Mates D, Bencko V, Foretova L, Janout V, Boffetta P, Bueno-de-Mesquita B, Forastiere F, Straif K, Brüning T

Published
2022
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43. Comparison of self-reported occupational exposure to solvents with a job exposure matrix (JEM) in a French case-control study of testicular germ cell tumors

Author

Guth, Margot, primary, Pilorget, Corinne, additional, Deygas, Floriane, additional, Coste, Astrid, additional, Dananché, Brigitte, additional, Paul, Adèle, additional, Ahmadi, Shukrullah, additional, Olsson, Ann, additional, Fervers, Béatrice, additional, and Charbotel, Barbara, additional

Published
2022
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44. Occupational Exposure to Carcinogens and Occupational Epidemiological Cancer Studies in Iran: A Review

Author

Hosseini, Bayan, Hall, Amy L, Zendehdel, Kazem, Kromhout, Hans, Onyije, Felix M, Moradzadeh, Rahmatollah, Zamanian, Maryam, Schüz, Joachim, Olsson, Ann, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, IRAS OH Epidemiology Chemical Agents, and dIRAS RA-2

Subjects
medicine.medical_specialty, Occupational cancer, Cancer Research, Review, occupational exposures, 010501 environmental sciences, Iran, 01 natural sciences, 03 medical and health sciences, 0302 clinical medicine, Occupational epidemiology, exposure measurement, Environmental health, Epidemiology, medicine, occupation, cancer, RC254-282, 0105 earth and related environmental sciences, Cancer, Occupation, Occupational exposures, business.industry, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, Exposure measurement, Increased risk, Construction industry, Oncology, 030220 oncology & carcinogenesis, Cohort, Occupational exposure, business
Abstract

Simple Summary Occupational cancers can be prevented by eliminating hazardous substances or by reducing workers’ exposures. Characterizing the extent of exposure to carcinogens in workplaces and industries is a crucial first step to exposure control. Iran is one of the most industrialized countries in the Middle East, yet lacks an overview of the extent of exposure to carcinogens and comprehensive risk management. This review provides an overview of studies conducted to date and demonstrates the need for interdisciplinary collaboration to inform occupational research and exposure control in Iran and beyond. Abstract Introduction: The extent of exposure to occupational carcinogens is not well characterized in Iran, and little is known about the burden of occupational cancer. Objectives: This study aimed to describe exposure to occupational carcinogens and occupational epidemiology studies in Iran. Methods: Relevant studies up to January 2021 in Iran were identified through three databases (PubMed, Web of Science, and Google Scholar). Results: Forty-nine publications from 2009 to 2020 (one cohort, 11 case-control, 34 exposure monitoring studies, and three cancer burden studies) were included. The exposure monitoring studies were conducted mainly in the petroleum industry, metal industry, manufacturing of electronics, manufacturing of plastics, construction industry, and service industry. A few of the case-control studies also reported increased risk of cancers in relation to work in those industries. Conclusions: Occupational cancer epidemiology in Iran is at an early stage. Both epidemiological and exposure monitoring studies are generally limited in size to provide robust evidence of occupational cancer risks. A coherent strategy to estimate the occupational cancer burden in Iran should start with conducting epidemiological studies along with systematic monitoring of occupational carcinogens for use in hazard control and research.

Published
2021

45. Occupational cancer burden: the contribution of exposure to process-generated substances at the workplace

Author

Olsson, Ann, Kromhout, Hans, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, IRAS OH Epidemiology Chemical Agents, and dIRAS RA-2

Subjects
0301 basic medicine, Occupational cancer, Cancer Research, Process (engineering), Respirable Crystalline Silica, Reviews, Review, occupational exposures, Diesel engine, wood dust, lcsh:RC254-282, complex mixtures, 03 medical and health sciences, Diesel fuel, 0302 clinical medicine, Risk Factors, Environmental health, Neoplasms, Occupational Exposure, medicine, Genetics, Animals, Humans, Workplace, Vehicle Emissions, diesel engine exhaust, General Medicine, medicine.disease, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Silicon Dioxide, occupational cancer burden, respirable crystalline silica, 030104 developmental biology, welding fumes, Oncology, process‐generated substances, 030220 oncology & carcinogenesis, process-generated substances, Environmental science, Molecular Medicine
Abstract

Respirable crystalline silica in mineral dust, wood dust, diesel engine exhaust emissions and welding fumes are among the most common process‐generated substances to which millions of workers are exposed daily. The composition of process‐generated substances can vary substantially, depending on the parameters of the underlying processes; for example, the composition and intensity of diesel motor emissions differs among the various generations of diesel engines and working environments (e.g. surface or underground mining). We illustrate how common these occupational exposures are and discuss challenges in estimating their global prevalence and their contribution to the burden of occupational cancer. Estimates of the number and proportion of workers exposed in most countries and on a global scale are generally scarce. A remarkable exception is based on the proactive bottom‐up estimates generated within the European Network for Silica. Actions to reduce exposures and research to fill gaps in knowledge adapted to local settings are warranted to mitigate the occupational cancer burden, especially in under‐researched settings including low‐ and middle‐income countries., Occupational exposure to respirable crystalline silica, diesel engine exhaust emissions and welding fumes are widespread risk factors for lung cancer and account for approximately half of the occupational lung cancer burden. If employers succeed in controlling workplace exposures to these process‐generated substances, the fraction of lung cancers attributable to occupational exposures could be reduced dramatically.

Published
2021

46. Is Previous Respiratory Disease a Risk Factor for Lung Cancer?

Author

Denholm, Rachel, Schüz, Joachim, Straif, Kurt, Stücker, Isabelle, Jöckel, Karl-Heinz, Brenner, Darren R., De Matteis, Sara, Boffetta, Paolo, Guida, Florence, Brüske, Irene, Wichmann, Heinz-Erich, Landi, Maria Teresa, Caporaso, Neil, Siemiatycki, Jack, Ahrens, Wolfgang, Pohlabeln, Hermann, Zaridze, David, Field, John K., McLaughlin, John, Demers, Paul, Szeszenia-Dabrowska, Neonila, Lissowska, Jolanta, Rudnai, Peter, Fabianova, Eleonora, Dumitru, Rodica Stanescu, Bencko, Vladimir, Foretova, Lenka, Janout, Vladimir, Kendzia, Benjamin, Peters, Susan, Behrens, Thomas, Vermeulen, Roel, Brüning, Thomas, Kromhout, Hans, and C. Olsson, Ann

Published
2014
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47. Påtvingad distansundervisning och desseffekter för lärande : Gymnasielärares erfarenheter kring omställning tilldistansundervisning under Covid-19

Author

Isaksson, Linnea and Olsson, Ann

Subjects
social learning, Socialt lärande, Political Science, Statsvetenskap, Didactics, COVID-19, Distance learning, Distansundervisning, Didaktik, Samarbete, collaboration
Abstract

This study aims to research how social study teachers have experienced the fast adjustment to distance learning in upper secondary school during spring 2020 through semi-structured interviews. The study has focused on the didactics and sociocultural aspects which have been affected in a negative manner by the forced distance learning. The results from this study are consistent with earlier research regarding what kind of students’ distance learning is more or less suited for. Another example is that social interaction has been inadequate between both students and between students and teachers. A positive finding in both our results and earlier research is that distance learning creates flexibility which increases the overall attendance. A new finding from this study is that it expresses teachers’ opinions on didactic opportunities and failures in the social study classroom. Another finding is that teachers' collaborations have changed during distance learning, and this study finds out in what way. Denna studie har genom semistrukturerade intervjuer undersökt hur samhällskunskapslärare uppfattat den snabba omställningen till distansundervisningen för gymnasieskolan under våren 2020. Studien har varit inriktad på de didaktiska och sociokulturella aspekter som förändrats när distansundervisningen har blivit påtvingad. Resultatet från denna studie bekräftar tidigare forskning när det gäller exempelvis de elevgrupper som distansundervisning fungerar bättre och sämre för. Ett annat exempel är försämrad social interaktion mellan både lärare och elever samt mellan elever. Något positivt som både vårt resultat och tidigare forskning kunnat visa är att distansundervisning bidrar till mer flexibilitet, vilket medverkar till en högre närvaro. Något nytt denna studie bidrar med är att redovisa didaktiskt vad som fungerat och inte fungerat i undervisningen enligt lärarna. En annan upptäckt är hur lärares samarbete med kollegor förändrats när de arbetat på distans.

Published
2021

48. Paternal Occupational Exposure to Heavy Metals and Welding Fumes and Testicular Germ Cell Tumours in Sons in France.

Author

Ahmadi, Shukrullah, Guth, Margot, Coste, Astrid, Bouaoun, Liacine, Danjou, Aurélie, Lefevre, Marie, Dananché, Brigitte, Praud, Delphine, Van Tongeren, Martie, Bujan, Louis, Pérol, Olivia, Schüz, Joachim, Charbotel, Barbara, Fervers, Béatrice, and Olsson, Ann

Subjects
HEAVY metals, AIR pollution, GERM cell tumors, NICKEL, CADMIUM, CHROMIUM, IRON, FATHERS, OCCUPATIONAL exposure, CASE-control method, IRON in the body, RISK assessment, TESTIS tumors, ODDS ratio, LOGISTIC regression analysis, ENVIRONMENTAL exposure, LEAD
Abstract

Simple Summary: Testicular cancer is the most common cancer among men below 40 years old, and its causes remain largely unknown. Marked geographic differences in the occurrence along with the relatively young age at diagnosis suggest a possible role of environmental and occupational exposures that occur early in life, probably already during embryonic development. Using data from a French case–control study, we investigated associations between paternal occupational exposure to five heavy metals and welding fumes before and at birth and testicular cancer risk in sons. We estimated exposures from job titles and considered other potential risk factors in the statistical analyses. We found no association. Thus, further research is necessary to identify potentially modifiable risk factors. Testicular cancer is the most common cancer in young men. Its causes are largely unknown, although prenatal occupational and environmental exposures have been suggested. We investigated paternal occupational exposure to heavy metals and welding fumes and the risk of testicular germ cell tumors (TGCT) in their offspring. A total of 454 cases and 670 controls were included from a French nationwide case–control study. The INTEROCC job exposure matrix was used to assign occupational exposures (cadmium, chromium, iron, nickel, lead, and welding fumes) to the fathers' jobs. Odds ratios (ORs) for TGCT were estimated using conditional logistic regression models for frequency-matched sets. Three complementary analytical approaches were used: (1) single-agent analysis, (2) analysis by groups, and (3) principal component analysis (PCA). The proportion of paternal exposure to different heavy metals and welding fumes ranged from 0.7% (cadmium) to 11.3% (lead). Based on PCA, three principal components explained 93.5% of the cumulative variance. No associations were found between heavy metals or welding fumes and TGCT. In this study, paternal occupational exposure to heavy metals or welding fumes was not associated with TGCT development in their sons. [ABSTRACT FROM AUTHOR]

Published
2022
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49. Att se klart, i förundran: konst och organisering

Author

Gawell, Malin, Kostera, Monika, Köping Olsson, Ann-Sofie, Soila-Wadman, Marja, Uniwersytet Jagielloński w Krakowie = Jagiellonian University (UJ), Södertörn University College, Johan Alvehus, and Daniel Ericsson

Subjects
[SHS.GESTION]Humanities and Social Sciences/Business administration, ComputingMilieux_MISCELLANEOUS, [SHS]Humanities and Social Sciences
Abstract

International audience

Published
2020

50. Diesel Engine Exhaust Exposure, Smoking, and Lung Cancer Subtype Risks. A Pooled Exposure-Response Analysis of 14 Case-Control Studies

Author

Ge, Calvin, Peters, Susan, Olsson, Ann, Portengen, Lützen, Schüz, Joachim, Almansa, Josué, Ahrens, Wolfgang, Bencko, Vladimir, Benhamou, Simone, Boffetta, Paolo, Bueno-de-Mesquita, Bas, Caporaso, Neil, Consonni, Dario, Demers, Paul, Fabiánová, Eleonóra, Fernández-Tardón, Guillermo, Field, John, Forastiere, Francesco, Foretova, Lenka, Guénel, Pascal, Gustavsson, Per, Janout, Vladimir, Jöckel, Karl Heinz, Karrasch, Stefan, Teresa Landi, Maria, Lissowska, Jolanta, Luce, Danièle, Mates, Dana, McLaughlin, John, Merletti, Franco, Mirabelli, Dario, Pándics, Tamás, Parent, Marie Élise, Plato, Nils, Pohlabeln, Hermann, Richiardi, Lorenzo, Siemiatycki, Jack, Świątkowska, Beata, Tardón, Adonina, Wichmann, Heinz Erich, Zaridze, David, Straif, Kurt, Kromhout, Hans, Vermeulen, Roel, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Division of Environmental Epidemiology, Utrecht University [Utrecht]-Institute of Risk Assessment Sciences, Centre International de Recherche contre le Cancer - International Agency for Research on Cancer (CIRC - IARC), Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Institute for Risk Assessment Sciences, Utrecht University [Utrecht], Bremen Institute for Prevention Research and Social Medicine (BIPS), Division of Epidemiological Methods and Etiologic Research, University of Bremen, Institute of Hygiene and Epidemiology, Charles University [Prague] (CU)-1st Faculty of Medicine, Variabilité Génétique et Maladies Humaines, Institut Universitaire d'Hématologie (IUH), Université Paris Diderot - Paris 7 (UPD7)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Icahn School of Medicine at Mount Sinai [New York] (MSSM), Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment [Bilthoven] (RIVM), National Cancer Institute [Bethesda] (NCI-NIH), National Institutes of Health [Bethesda] (NIH), Unit of Epidemiology, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, University of Toronto, Regional Authority of Public Health [Slovaquia] (RAPH), Ministry of Health of the Slovak Republic [Slovaquia], Azienda Sanitaria Locale [ROMA] (ASL), Masaryk Memorial Cancer Institute, Masaryk Memorial Cancer Institute (RECAMO), Epidémiologie environnementale des cancers, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), The Institute of Environmental Medicine [Stockholm] (IMM), Karolinska Institutet [Stockholm], Faculty of Medicine, Palacky University Olomouc, Institute for Medical Informatics, Biometry, and Epidemiology, Universität Duisburg-Essen [Essen], Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Épidémiologie en Santé au Travail et Ergonomie (IRSET-ESTER), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Institute of Public Health, Cancer Care Ontario, Occupational Cancer Research Centre, Cancer Epidemiology Unit, Université de Turin, Institut Armand Frappier (INRS-IAF), Réseau International des Instituts Pasteur (RIIP)-Institut National de la Recherche Scientifique [Québec] (INRS), Bremen Institute for Prevention Research and Social Medicine, Centre Hospitalier de l'Université de Montréal (CHUM), Université de Montréal (UdeM), Molecular Epidemiology of Cancer Unit, CIBER de Epidemiología y Salud Pública (CIBERESP), King‘s College London, Institute of Carcinogenesis, Russian Academy of Medical Sciences, Masaryk Memorial Cancer Institute (MMCI), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Universität Duisburg-Essen = University of Duisburg-Essen [Essen], Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), and Institut National de la Recherche Scientifique [Québec] (INRS)-Réseau International des Instituts Pasteur (RIIP)

Subjects
Pulmonary and Respiratory Medicine, Oncology, medicine.medical_specialty, [SDV]Life Sciences [q-bio], Medizin, Cumulative Exposure, lung neoplasms, Critical Care and Intensive Care Medicine, complex mixtures, 03 medical and health sciences, 0302 clinical medicine, Occupational Exposure, Diesel Exhaust, Lung Neoplasms, Epidemiology, Internal medicine, medicine, 030212 general & internal medicine, Lung cancer, Exposure assessment, business.industry, Case-control study, diesel exhaust, Odds ratio, occupational exposure, respiratory system, medicine.disease, Confidence interval, 3. Good health, respiratory tract diseases, 030228 respiratory system, Adenocarcinoma, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, epidemiology, business, human activities
Abstract

Rationale: Although the carcinogenicity of diesel engine exhaust has been demonstrated in multiple studies, little is known regarding exposure-response relationships associated with different exposure subgroups and different lung cancer subtypes.Objectives: We expanded on a previous pooled case-control analysis on diesel engine exhaust and lung cancer by including three additional studies and quantitative exposure assessment to evaluate lung cancer and subtype risks associated with occupational exposure to diesel exhaust characterized by elemental carbon (EC) concentrations.Methods: We used a quantitative EC job-exposure matrix for exposure assessment. Unconditional logistic regression models were used to calculate lung cancer odds ratios and 95% confidence intervals (CIs) associated with various metrics of EC exposure. Lung cancer excess lifetime risks (ELR) were calculated using life tables accounting for all-cause mortality. Additional stratified analyses by smoking history and lung cancer subtypes were performed in men.Measurements and Main Results: Our study included 16,901 lung cancer cases and 20,965 control subjects. In men, exposure response between EC and lung cancer was observed: odds ratios ranged from 1.09 (95% CI, 1.00-1.18) to 1.41 (95% CI, 1.30-1.52) for the lowest and highest cumulative exposure groups, respectively. EC-exposed men had elevated risks in all lung cancer subtypes investigated; associations were strongest for squamous and small cell carcinomas and weaker for adenocarcinoma. EC lung cancer exposure response was observed in men regardless of smoking history, including in never-smokers. ELR associated with 45 years of EC exposure at 50, 20, and 1 mu g/m(3) were 3.0%, 0.99%, and 0.04%, respectively, for both sexes combined.Conclusions: We observed a consistent exposure-response relationship betweenECexposure and lung cancer in men. Reduction of workplace EC levels to background environmental levels will further reduce lung cancer ELR in exposed workers.

Published
2020
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