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2. Apolipoprotein E competitively inhibits receptor-dependent low density lipoprotein uptake by the liver but has no effect on cholesterol absorption or synthesis in the mouse

Author

Woollett, Laura A., Osono, Yasunori, Herz, Joachim, and Dietschy, John M.

Subjects
Apolipoproteins -- Physiological aspects, Cholesterol, LDL -- Physiological aspects, Liver -- Physiological aspects, Science and technology
Abstract

A study was conducted to determine the mechanism for the inhibition of low density lipoprotein (LDL) uptake by the liver in mice lacking apolipoprotein E (apoE). The rates of cholesterol absorption and synthesis were measured while the kinetics of hepatic LDL-C transport was monitored in vivo in mice lacking apoE and with normal apoE. The apparent Michaelis constant was higher in mice with zero apoE than in normal mice, suggesting that apoE can act as a potent inhibitor of receptor-dependent LDL uptake.

Published
1995

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