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Background: Research on the effects of intestinal microbiota transplantation (IMT) on chronic HBV infection (CHB) progression associated liver disease (HBV-CLD) and alterations in the microbiota post-IMT are quite limited for the moment., Methods: By integrating microbiome with metabolome analyses, we aimed to the function of IMT and the alterations of gut microbiota in patients with HBV-CLD. First, this study included 20 patients with HBV-CLD and ten healthy controls. Then, 16 patients with CHB were given IMT with donor feces (heterologous) via oral capsule. Fecal samples from CHB patients were obtained before and after IMT, as well as healthy controls, for 16S rDNA sequencing and untargeted metabolomics analysis., Results: The proalbuminemia were significantly increased after IMT, and the HBsAg and TBA showed a significant decrease after IMT in the HBV-CLD patients. There was statistical difference in the Chaol indexes between between CHB patients and healthy controls, suggesting a lower abundance of the gut microbiota in HBV-CLD patients. In addition, there was statistical difference in the Shannon and Simpson indexes between prior to IMT and post-IMT, indicating that the impaired abundance of the gut microbiota had been improved after IMT. The host-microbiota-metabolite interplay, amino acid metabolism, nicotinate and nicotinamide metabolism, starch and sucrose metabolism, steroid biosynthesis, and vitamins metabolism, were significantly lower in HBV-CLD patients than healthy controls., Conclusion: IMT may improve the therapeutic effects on patients HBV-CLD. Furthermore, IMT appears to improve amino acid metabolism by impaired abundance of the gut microbiota and therefore improve liver prealbumin synthesis., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Deng, Guo, Chen, Li, Liu, Xia, Ou and Hong.)

Objective: To explore the difference in anxiety and mental health of patients with liver cirrhosis with different compensatory abilities, so as to provide comprehensive treatment measures such as individualized psychological support for patients., Methods: In this retrospective study, a total of 175 patients with liver cirrhosis admitted to the Department of Infectious Diseases, Fifth Hospital of Sun Yat-sen University from January to December 2019 were included and divided into a compensated group (n=77) and a decompensated group (n=98). The anxiety of patients was evaluated on the day of admission, one week after hospitalization, and the day of discharge using the Self-Rating Anxiety Scale (SAS). Psychological investigations were conducted on the two groups of patients with cirrhosis., Results: The SAS score of patients in the decompensated group was higher than that of the compensated group on the day of admission (48.62±6.35 vs. 37.68±8.94, F=20.313), one week after hospitalization (56.95±7.47 vs. 42.79±10.77, F=29.879), and on the day of discharge (42.95±7.85 vs. 36.43±9.29, F=7.110) (P<0.05). The SAS score of male patients in the decompensated group was higher than that of the compensated group on the day of admission (47.50±6.25 vs. 36.70±9.92, t=-4.112), one week after hospitalization (57.25±5.80 vs. 42.10±13.24, t=-4.538) and on the day of discharge (42.33±7.34 vs. 36.19±9.65, t=-2.162) (all P<0.05). The SAS score of 40-59 year-old patients of the decompensated group was higher than that of patients in the compensated group of the same age on the day of admission (51.80±6.26 vs. 36.84±8.57, t=-4.372), one week after hospitalization (60.6±7.06 vs. 42.94±10.33, t=-4.382), and on the day of discharge (48.60±4.16 vs. 37.32±10.23, t=-3.768) (P<0.05). The SAS score of female patients in the decompensated group was higher than that in the compensated group at one week after hospitalization (56.56±9.65 vs. 35.45±18.66, t=-4.617) (P<0.05). There was no difference in the SAS score between patients of different groups on the day of admission and the day of discharge (P>0.05)., Conclusion: The anxiety of patients with different compensatory abilities of the liver is adversely affected by the severity of their illness and the length of hospitalization. The anxiety of male patients in the decompensated group is more significant than that of patients in the compensated group, while no significant difference was observed in anxiety between female patients in the decompensated group and those in the compensated group on the day of admission and discharge. It is necessary to strengthen psychological intervention, optimize the treatment methods, and reduce the average hospital stay in decompensated patients., Competing Interests: None., (AJTR Copyright © 2022.)