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6. BAPGAN: GAN-based Bone Age Progression of Femur and Phalange X-ray Images

Author

Nakazawa, Shinji, Han, Changhee, Hasei, Joe, Nakahara, Ryuichi, and Ozaki, Toshifumi

Subjects
Electrical Engineering and Systems Science - Image and Video Processing, Computer Science - Computer Vision and Pattern Recognition, Computer Science - Machine Learning
Abstract

Convolutional Neural Networks play a key role in bone age assessment for investigating endocrinology, genetic, and growth disorders under various modalities and body regions. However, no researcher has tackled bone age progression/regression despite its valuable potential applications: bone-related disease diagnosis, clinical knowledge acquisition, and museum education. Therefore, we propose Bone Age Progression Generative Adversarial Network (BAPGAN) to progress/regress both femur/phalange X-ray images while preserving identity and realism. We exhaustively confirm the BAPGAN's clinical potential via Frechet Inception Distance, Visual Turing Test by two expert orthopedists, and t-Distributed Stochastic Neighbor Embedding., Comment: 6 pages, 5 figures, accepted to SPIE Medical Imaging 2022

Published
2021

11. Protocol for the 2ND-STEP study, Japan Clinical Oncology Group study JCOG1802: a randomized phase II trial of second-line treatment for advanced soft tissue sarcoma comparing trabectedin, eribulin and pazopanib

Author

Endo, Makoto, Kataoka, Tomoko, Fujiwara, Toshifumi, Tsukushi, Satoshi, Takahashi, Masanobu, Kobayashi, Eisuke, Yamada, Yoko, Tanaka, Takaaki, Nezu, Yutaka, Hiraga, Hiroaki, Wasa, Junji, Nagano, Akihito, Nakano, Kenji, Nakayama, Robert, Hamada, Tetsuya, Kawano, Masanori, Torigoe, Tomoaki, Sakamoto, Akio, Asanuma, Kunihiro, Morii, Takeshi, Machida, Ryunosuke, Sekino, Yuta, Fukuda, Haruhiko, Oda, Yoshinao, Ozaki, Toshifumi, and Tanaka, Kazuhiro

Published
2023
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17. Perioperative Adriamycin plus ifosfamide vs. gemcitabine plus docetaxel for high-risk soft tissue sarcomas: randomised, phase II/III study JCOG1306

Author

Tanaka, Kazuhiro, Machida, Ryunosuke, Kawai, Akira, Nakayama, Robert, Tsukushi, Satoshi, Asanuma, Kunihiro, Matsumoto, Yoshihiro, Hiraga, Hiroaki, Hiraoka, Koji, Watanuki, Munenori, Yonemoto, Tsukasa, Abe, Satoshi, Katagiri, Hirohisa, Nishida, Yoshihiro, Nagano, Akihito, Suehara, Yoshiyuki, Kawashima, Hiroyuki, Kawano, Masanori, Morii, Takeshi, Hatano, Hiroshi, Toguchida, Junya, Okuma, Tomotake, Takeyama, Masanobu, Takenaka, Satoshi, Akisue, Toshihiro, Furuta, Taisuke, Emori, Makoto, Hiruma, Toru, Outani, Hidetatsu, Yamamoto, Tetsuji, Kataoka, Tomoko, Fukuda, Haruhiko, Ozaki, Toshifumi, and Iwamoto, Yukihide

Published
2022
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19. The role of chemotherapy and radiotherapy in localized extraskeletal osteosarcoma

Author

Heng, Marilyn, Gupta, Abha, Chung, Peter W, Healey, John H, Vaynrub, Max, Rose, Peter S, Houdek, Matthew T, Lin, Patrick P, Bishop, Andrew J, Hornicek, Francis J, Chen, Yen-Lin, Lozano-Calderon, Santiago, Holt, Ginger E, Han, Ilkyu, Biau, David, Niu, Xiaohui, Bernthal, Nicholas M, Ferguson, Peter C, Wunder, Jay S, Group, Japanese Musculoskeletal Oncology, Ueda, Takafumi, Kakunaga, Shigeki, Kawai, Akira, Sugiura, Hideshi, Kidani, Teruki, Kunisasa, Toshiyuki, Ozaki, Toshifumi, Ae, Keisuke, Nagano, Akihito, Ohno, Takatoshi, Hiraoka, Koji, Yamamoto, Norio, Tsuchiya, Hiroyuki, Matsumoto, Yoshihiro, Yanagawa, Takashi, Nakayama, Robart, Morioka, Hideo, Kubo, Tadahiko, Simose, Shoji, Yamagami, Yoshiki, Yamamoto, Tetsuji, Kawasaki, Motohiro, Torigoe, Tomoaki, Yazawa, Yasuo, Akiyama, Toru, Gokita, Tabu, Manabe, Jun, Kaya, Mitsunori, Emori, Makoto, Nakamura, Tomoki, Matsumine, Akihiko, Sugihara, Shinsuke, Yokouchi, Masahiro, Komiya, Setsuro, Suehara, Yoshiyuki, Takagi, Tatsuya, Kawamoto, Teruya, Wasa, Junji, Yonemoto, Tsukasa, Ishii, Takeshi, Baba, Ichiro, Hoshi, Manabu, Hamada, Kenichiro, Naka, Norifumi, Sotobori, Tsukasa, Araki, Nobuhito, Okuma, Tomotake, Goto, Takahiro, Kobayashi, Hiroshi, Kawano, Hirotaka, Hosaka, Masami, Futani, Hiroyuki, Hiraga, Hiroaski, Nishida, Yoshihiro, Collaborative, Soft Tissue Osteosarcoma International, Griffin, Anthony, Razak, Albiruni R Abdul, Shultz, David Benjamin, Catton, Charles, Robinson, Steven, Patel, Shreyaskumar R, Lewis, Valerae O, Guadagnolo, B Ashleigh, DeLaney, Thomas, Wang, Haotong, Raskin, Kevin, Callan, Alexandra K, Henshaw, Robert, Isler, Marc, Mottard, Sophie, Chen, Wei-Ming, Traub, Frank, Chen, Tom Wei-Wu, Turcotte, Robert E, Davidson, Darin, Tunn, Per-Ulf, Loong, Herbert, Ghert, Michelle, Werier, Joel, and Clarkson, Paul

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Cancer, Patient Safety, Clinical Research, Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Osteosarcoma, Prognosis, Retrospective Studies, Risk Factors, Survival Analysis, Young Adult, Extraskeletal osteosarcoma, Soft-tissue osteosarcoma, Chemotherapy, Radiotherapy, Radiation therapy, Japanese Musculoskeletal Oncology Group, Soft Tissue Osteosarcoma International Collaborative, Public Health and Health Services, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

PurposeThe role of chemotherapy (CT) and radiotherapy (RT) for management of extraskeletal osteosarcoma (ESOS) remains controversial. We examined disease outcomes for ESOS patients and investigated the association between CT/RT with recurrence and survival.Patients and methodsRetrospective review at 25 international sarcoma centers identified patients ≥18 years old treated for ESOS from 1971 to 2016. Patient/tumour characteristics, treatment, local/systemic recurrence, and survival data were collected. Kaplan-Meier survival and Cox proportional-hazards regression and cumulative incidence competing risks analysis were performed.Results370 patients with localized ESOS treated definitively with surgery presented with mainly deep tumours (n = 294, 80%). 122 patients underwent surgical resection alone, 96 (26%) also received CT, 70 (19%) RT and 82 (22%) both adjuvants. Five-year survival for patients with localized ESOS was 56% (95% CI 51%-62%). Almost half of patients (n = 173, 47%) developed recurrence: local 9% (35/370), distant 28% (102/370) or both 10% (36/370). Considering death as a competing event, there was no significant difference in cumulative incidence of local or systemic recurrence between patients who received CT, RT, both or neither (local p = 0.50, systemic p = 0.69). Multiple regression Cox analysis showed a significant association between RT and decreased local recurrence (HR 0.46 [95% CI 0.26-0.80], p = 0.01).ConclusionAlthough the use of RT significantly decreased local recurrences, CT did not decrease the risk of systemic recurrence, and neither CT, nor RT nor both were associated with improved survival in patients with localized ESOS. Our results do not support the use of CT; however, adjuvant RT demonstrates benefit in patients with locally resectable ESOS.

Published
2020

21. Standardization of evaluation method and prognostic significance of histological response to preoperative chemotherapy in high-grade non-round cell soft tissue sarcomas

Author

Oda, Yoshinao, Tanaka, Kazuhiro, Hirose, Takanori, Hasegawa, Tadashi, Hiruta, Nobuyuki, Hisaoka, Masanori, Yoshimoto, Masato, Otsuka, Hiroshi, Bekki, Hirofumi, Ishii, Takeaki, Endo, Makoto, Kunisada, Toshiyuki, Hiruma, Toru, Tsuchiya, Hiroyuki, Katagiri, Hirohisa, Matsumoto, Yoshihiro, Kawai, Akira, Nakayama, Robert, Kawashima, Hiroyuki, Takenaka, Satoshi, Emori, Makoto, Watanuki, Munenori, Yoshida, Yukihiro, Okamoto, Takeshi, Mizusawa, Junki, Fukuda, Haruhiko, Ozaki, Toshifumi, Iwamoto, Yukihide, and Nojima, Takayuki

Published
2022
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26. Utilizing the Metaverse to Provide Innovative Psychosocial Support for Pediatric, Adolescent, and Young Adult Patients with Rare Cancer.

Author

Hasei, Joe, Ishida, Hisashi, Katayama, Hideki, Maeda, Naoko, Nagano, Akihito, Ochi, Motoharu, Okamura, Masako, Iwata, Shintaro, Ikuta, Kunihiro, Yoshida, Shinichirou, Fujiwara, Tomohiro, Nakata, Eiji, Nakahara, Ryuichi, Kunisada, Toshiyuki, and Ozaki, Toshifumi

Subjects
TUMORS in children, RESEARCH funding, RARE diseases, MEDICAL care, DESCRIPTIVE statistics, VIRTUAL reality, TUMORS, SOCIAL support, DATA analysis software, CHILDREN, ADULTS
Abstract

Simple Summary: Pediatric, adolescent, and young adult (AYA) cancer patients, especially those with rare cancers, face unique challenges that traditional support systems may not adequately address. This study explores the potential of the metaverse, a virtual shared space, to provide psychological support and foster a sense of community among these patients. By utilizing customizable avatars and facilitating interactions across geographical and temporal barriers, the metaverse enables patients to connect with peers, share experiences, and receive emotional support. The anonymity provided by avatars helps reduce appearance-related anxiety and the stigma associated with cancer treatment. This research highlights the metaverse's potential to transform the delivery of psychosocial support for patients with rare cancers, offering a novel approach to patient care that transcends physical limitations and fosters a global patient community. The findings suggest that integrating virtual spaces into healthcare models can effectively meet the complex needs of pediatric and AYA cancer patients. This study investigated the potential of the metaverse in providing psychological support for pediatric and AYA cancer patients, with a focus on those with rare cancers. The research involved ten cancer patients and survivors from four distinct regions in Japan, who participated in metaverse sessions using customizable avatars, facilitating interactions across geographical and temporal barriers. Surveys and qualitative feedback were collected to assess the psychosocial impact of the intervention. The results demonstrated that the metaverse enabled patients to connect with peers, share experiences, and receive emotional support. The anonymity provided by avatars helped reduce appearance-related anxiety and stigma associated with cancer treatment. A case study of a 19-year-old male with spinal Ewing's sarcoma highlighted the profound emotional relief fostered by metaverse interactions. The findings suggest that integrating virtual spaces into healthcare models can effectively address the unique needs of pediatric and AYA cancer patients, offering a transformative approach to delivering psychosocial support and fostering a global patient community. This innovative intervention has the potential to revolutionize patient care in the digital age. [ABSTRACT FROM AUTHOR]

Published
2024
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27. Fluorescence-guided assessment of bone and soft-tissue sarcomas for predicting the efficacy of telomerase-specific oncolytic adenovirus

Author

Uotani, Koji, primary, Tazawa, Hiroshi, additional, Hasei, Joe, additional, Fujiwara, Tomohiro, additional, Yoshida, Aki, additional, Yamakawa, Yasuaki, additional, Omori, Toshinori, additional, Sugiu, Kazuhisa, additional, Komatsubara, Tadashi, additional, Kondo, Hiroya, additional, Morita, Takuya, additional, Kiyono, Masahiro, additional, Yokoo, Suguru, additional, Hata, Toshiaki, additional, Kunisada, Toshiyuki, additional, Takeda, Ken, additional, Urata, Yasuo, additional, Fujiwara, Toshiyoshi, additional, and Ozaki, Toshifumi, additional

Published
2024
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29. Inhibitory Effect of a Tankyrase Inhibitor on Mechanical Stress-Induced Protease Expression in Human Articular Chondrocytes

Author

Hotta, Yoshifumi, primary, Nishida, Keiichiro, additional, Yoshida, Aki, additional, Nasu, Yoshihisa, additional, Nakahara, Ryuichi, additional, Naniwa, Shuichi, additional, Shimizu, Noriyuki, additional, Ichikawa, Chinatsu, additional, Lin, Deting, additional, Fujiwara, Tomohiro, additional, and Ozaki, Toshifumi, additional

Published
2024
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39. Mohawk promotes the maintenance and regeneration of the outer annulus fibrosus of intervertebral discs.

Author

Nakamichi, Ryo, Ito, Yoshiaki, Inui, Masafumi, Onizuka, Naoko, Kayama, Tomohiro, Kataoka, Kensuke, Suzuki, Hidetsugu, Mori, Masaki, Inagawa, Masayo, Ichinose, Shizuko, Lotz, Martin K, Sakai, Daisuke, Masuda, Koichi, Ozaki, Toshifumi, and Asahara, Hiroshi

Subjects
Cells, Cultured, Animals, Mice, Inbred C3H, Mice, Inbred C57BL, Mice, Knockout, Humans, Homeodomain Proteins, Regeneration, Gene Expression Regulation, Adult, Middle Aged, Female, Male, Young Adult, Intervertebral Disc, Mesenchymal Stromal Cells, Annulus Fibrosus, Mesenchymal Stem Cells, Cells, Cultured, Mice, Inbred C3H, Inbred C57BL, Knockout
Abstract

The main pathogenesis of intervertebral disc (IVD) herniation involves disruption of the annulus fibrosus (AF) caused by ageing or excessive mechanical stress and the resulting prolapse of the nucleus pulposus. Owing to the avascular nature of the IVD and lack of understanding the mechanisms that maintain the IVD, current therapies do not lead to tissue regeneration. Here we show that homeobox protein Mohawk (Mkx) is a key transcription factor that regulates AF development, maintenance and regeneration. Mkx is mainly expressed in the outer AF (OAF) of humans and mice. In Mkx(-/-) mice, the OAF displays a deficiency of multiple tendon/ligament-related genes, a smaller OAF collagen fibril diameter and a more rapid progression of IVD degeneration compared with the wild type. Mesenchymal stem cells overexpressing Mkx promote functional AF regeneration in a mouse AF defect model, with abundant collagen fibril formation. Our results indicate a therapeutic strategy for AF regeneration.

Published
2016

43. Fracture Line Distributions of Undisplaced Distal Radius Fractures in Relation to Rupture of the Extensor Pollicis Longus Tendon

Author

Kondo, Hidenori, Saito, Taichi, Nakahara, Ryuichi, Nakamichi, Ryo, Shimamura, Yasunori, Harada, Ryozo, Imatani, Junya, and Ozaki, Toshifumi

Subjects
fracture mapping, distal radius fracture, rupture of extensor pollicis longus tendon
Abstract

Rupture of the extensor pollicis longus (EPL) tendon is a known complication after undisplaced distal radius fracture (DRF). However, no report has revealed the relationship between EPL tendon rupture and the fracture pattern. Thus, this study aimed to investigate the characteristics of fractures at risk of EPL tendon rupture using fracture line mapping of undisplaced DRFs. This study used computed tomography imaging data of undisplaced DRFs with (n=18) and without EPL tendon rupture (n=52). Fracture lines obtained from 3D reconstruction data were drawn manually after matching with a 2D template wrist model. Fracture maps represented the fracture line distribution by superimposing the fracture lines of all 70 patients. Heat maps showed the relative frequency of the fracture lines as a gradual color change. Fracture lines of cases with EPL tendon rupture were concentrated in the proximal border of Lister’s tubercle. By contrast, fracture lines of cases without EPL tendon rupture were relatively dispersed.

Published
2023

46. Role of catecholamine synthases in the maintenance of cancer stem‐like cells in malignant peripheral nerve sheath tumors.

Author

Katayama, Haruyoshi, Fujimura, Atsushi, Huang, Rongsheng, Otani, Yusuke, Itano, Takuto, Fujiwara, Tomohiro, Kunisada, Toshiyuki, Nakata, Eiji, and Ozaki, Toshifumi

Abstract

Malignant peripheral nerve sheath tumors (MPNSTs) are malignant tumors that are derived from Schwann cell lineage around peripheral nerves. As in many other cancer types, cancer stem cells (CSCs) have been identified in MPNSTs, and they are considered the cause of treatment resistance, recurrence, and metastasis. As an element defining the cancer stemness of MPNSTs, we previously reported a molecular mechanism by which exogenous adrenaline activates a core cancer stemness factor, YAP/TAZ, through β2 adrenoceptor (ADRB2). In this study, we found that MPNST cells express catecholamine synthases and that these enzymes are essential for maintaining cancer stemness, such as the ability to self‐renew and maintain an undifferentiated state. Through gene knockdown and inhibition of these enzymes, we confirmed that catecholamines are indeed synthesized in MPNST cells. The results confirmed that catecholamine synthase knockdown in MPNST cells reduces the activity of YAP/TAZ. These data suggest that a mechanism of YAP/TAZ activation by de novo synthesized adrenaline, as well as exogenous adrenaline, may exist in the maintenance of cancer stemness of MPNST cells. This mechanism not only helps to understand the pathology of MPNST, but could also contribute to the development of therapeutic strategies for MPNST. [ABSTRACT FROM AUTHOR]

Published
2024
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