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Abstract Musca domestica L. is a cosmopolitan pest usually reaching high population levels, causing substantial economic losses and also acting as a vector for many diseases. The use of entomopathogenic fungi as a replacement of the chemical insecticides is a possibility already studied. In this study, we isolated three strains of Beauveria bassiana from naturally infected M. domestica individuals and tested their potentiality to act as a biological control agent. The finding of naturally occurring entomopathogenic fungal infections indicates that these fungi are well-adapted to the local environment and can survive and thrive under natural conditions, making them promising candidates for biological pest management.

Abstract Fungi are the most important entomopathogens in the natural regulation of insect populations. They have a wide distribution and significant advantages as biological control agents. Prospecting for new native strains of entomopathogenic fungi in the Pampas region has not yet been carried out. The main objectives of this study were isolating and identifying strains of different species of entomopathogenic fungi that naturally infect grasshopper species in the Pampas region and determining, through laboratory tests, their virulence and pathogenicity on nymphs of the pest grasshopper Dichroplus maculipennis. Furthermore, whether the phylogenetic relationships between Beauveria bassiana isolates would be associated with virulence and pathogenicity or geographical distribution. Thirty-four isolates of entomopathogenic fungi were obtained from different grasshopper species corresponding to eleven sites in three counties in the center of Buenos Aires province. There were 31 isolates of B. bassiana and 3 of Metarhizium genus. These isolates scored 66.6% (LPSc 1443) and 100% (LPSc 1441, LPSc 1445, and LPSc 1476) of mortality against third-instar nymphs of D. maculipennis, and these last cause death at 4.86 ± 0.20, 4.80 ± 0.17 and 5 ± 0.15 MST days, respectively. An association between phylogenetic relationships and geographical distances in B. bassiana was found.

Objetivo: Apresentar um conjunto de competências para empreendedores de healthtechs. Método: É uma pesquisa de natureza aplicada, com abordagem qualitativa e objetivos exploratórios. O método empregado foi o Delphi. O estudo contou com a participação de 22 especialistas, os quais contribuíram para compreender a temática investigada. Principais Resultados: Os resultados apresentam 22 competências para empreendedores das healthtechs, categorizadas em quatro grupos: competências para atuar na saúde, competências para atuar em startups, competências para empreender na saúde e competências para inovar na saúde. Relevância / Originalidade: Este estudo apresenta uma abordagem integrada das competências no campo da saúde, inovação e startups. Outra contribuição original é o uso do método Delphi para estudar competências em healthtechs. Contribuições Teóricas / Metodológicas: Este estudo apresenta uma sistematização de competências essenciais para healthtechs, avançando em relação aos estudos anteriores, pois aborda inovação, saúde e startups de forma integrada.

This Crossing Boundaries stems from two events: the recent STS-Italia conference (Bologna, June 2023) and the 4S/ESOCITE conference (Cholula, December 2022). Both events dedicated a space for reflecting on Bruno Latour’s intellectual legacy, inviting some of the scholars who had the chance and the privilege to work with him. The text opens with a reflection by Madeleine Akrich on her two-decade experience working alongside Latour and on the multifaceted nature of his contributions to sociology, anthropology, and philosophy. The text continues with a contribution by Huub Dijstelbloem, who explores Latour’s magmatic thinking, emphasizing the transformative power of his ideas. Annalisa Pelizza traces two key associations in Bruno Latour’s intellectual trajectory. The first one traces back to Latour’s early engagement with the semiotics of the “École de Paris” and Greimas’ theory of enunciation, emphasizing the local context of the French semiotic debate. The second association delves into Latour’s connection with technofeminism and Donna Haraway’s material-semiotics, highlighting a global dialogue initiated in the late 1980s. Finally, Paolo Landri underlines the transformative potential of Latour’s vocabulary in the context of education, underlying the interdisciplinary connections fostered by following Latour.

Commentary to the Lecture “Moving the immovable: Climate change and the multiple tensions between mobility and immobility”, by Huub Dijstelbloem (this issue).

This editorial by the board of STS Italia (The Italian Society for Social Studies of Science and Technology) introduces a Special Section of the Journal collecting a set of contributions to the IX STS Italia Conference, held in June 2023. The Special Section features an invited Lecture by Huub Dijstelbloem followed by a short commentary by Annalisa Pelizza. In addition, the Section includes the Crossing Boundaries “Drawing Bruno Together” and the Scenario “Bruno Latour and Artificial Intelligence” dedicated to Bruno Latour and both written by long-term colleagues, friends and exegetes of his work.

Abstract Background The purpose of the present review was to summarize the main literature contribution on the relationship between borderline personality disorder (BPD) and early psychosis. While retracing the historical path of the term “borderline”, specific attention was paid to psychotic and psychotic-like symptoms in BPD. Its relationship with At Risk Mental State was evaluated, as well. Methods This search was conducted on PUBMED/MEDLINE and PsycInfo, looking for “Borderline personality disorder, First Episode Psychosis, Early Psychosis, Ultra-High Risk AND/OR Clinical High Risk” for psychosis. Results Eight pertinent papers were identified on this topic. Their main findings were then discussed. The term “borderline” has undergone different changes in meaning and use, despite always referring to states considered on the fence between neurosis and psychosis. However, considering the history of psychopathology and its relationship with diagnostic manuals, little attention has been given to its psychotic features. Being those symptoms highly burdensome, this neglect has often led to misdiagnosis and under-treatment. Conclusions Psychotic symptoms in BPD can be severe and distressing. Nonetheless they can be easily neglected, and when found they challenge clinicians in defining a differential diagnosis to distinguish between BPD and Psychosis Spectrum Disorders. Given specific needs and interventions for these different conditions, a dimensional, rather than categorical, approach should be considered, as well as specific care pathways and monitoring should be advised.

Se presentan los resultados del estudio realizado sobre dos artefactos elaborados sobre piedras bezoares procedentes del sur del valle de Punilla (Sierras de Córdoba, Argentina). Aun cuando los artefactos fueron recolectados asistemáticamente en sitios asignables al Período Prehispánico Tardío (~1220-330 cal. AP), se plantea que es posible obtener datos valiosos de estos objetos a una escala temporal y espacial amplia, principalmente porque se trata de elementos fuertemente conectados con aspectos simbólicos de las sociedades del pasado, cuya recuperación es excepcional en las excavaciones modernas. Los materiales fueron estudiados desde un enfoque tecno-morfológico, explorando a partir de la bibliografía las prácticas en las que pudieron ser utilizados. Uno de los artefactos fue elaborado a partir de un bezoar de morfología esférica, con un surco perimetral que rodea toda la circunferencia de la pieza, posiblemente para asegurar su atadura a un collar, vestimenta u otro tipo de artefacto compuesto. El segundo ejemplar consiste en un fragmento cuya cara exterior fue decorada con incisiones lineales largas y profundas, de sección plana, irradiadas en abanico desde un polo. Toda la pieza exhibe rastros de pintura roja. Es probable que el artefacto emule a moluscos asociados con el mundo ceremonial andino. Se propone que las piedras bezoares analizadas son gastrolitos producidos por cérvidos y/o camélidos, que habrían sido transformados en artefactos para incrementar su relevancia simbólica y ser usados en prácticas rituales o mágico-terapéuticas.

El objetivo de este estudio fue describir las percepciones acerca de la autoconfianza en el deporte. Participaron 30 jugadores (50% mujeres) de voleibol federado de un club de Mar del Plata, Argentina, de entre 14 y 18 años. Se utilizó una encuesta abierta y el procedimiento de análisis de la Teoría Fundamentada. Las categorías emergidas del análisis para describir la autoconfianza fueron: la creencia en uno mismo para el logro de objetivos; el ambiente social, fundamentalmente compañeros y entrenadores; y el autodiálogo positivo y rutinas de pre-ejecución, como estrategias más utilizadas para el aumento de la autoconfianza. Este trabajo constituye un insumo para el trabajo de profesionales del deporte en la búsqueda del bienestar y rendimiento de los deportistas jóvenes.

Introduction Hedonic deficits have been extensively studied in schizophrenia, but little is known about their association with suicidal ideation in early psychosis. Along the clinical staging of psychosis, also Ultra-High Risk (UHR) individuals are characterized by hedonic deficits, which are currently considered as putative predictors of both psychosis conversion and poor social/role functioning. Objectives The aim of this research was to examine the relationship between anhedonia and suicidal thoughts across a 2-year follow-up period in people with First Episode Psychosis (FEP) and at Ultra High Risk (UHR) of psychosis. Methods Ninty-six UHR and 146 FEP, aged 13–35 years, completed the Comprehensive Assessment of At-Risk Mental States (CAARMS) and the Beck Depression Inventory-II (BDI-II). The BDI-II “Anhedonia” subscale score to assess anhedonia and the CAARMS “Depression” item 7.2 subscore to measure depression were used across the 2 years of follow-up. Hierarchical regression analyses were performed. Results No difference in anhedonia scores between FEP and UHR individuals was found. In the FEP group, a significant enduring association between anhedonia and suicidal ideation was found at baseline and across the follow-up, independent of clinical depression. In the UHR subgroup, the enduring relationship between anhedonia and suicidal thoughts were not completely independent from depression severity. Conclusions Anhedonia is relevant in predicting suicidal ideation in early psychosis. Specific pharmacological and/or psychosocial interventions on anhedonia within specialized EIP program could reduce suicide risk overtime. Disclosure of Interest None Declared

Introduction Depression is common in schizophrenia and is correlated with suicide risk and poor long-term outcomes. However, the presence of depressive symptoms is often underestimated in both research and treatment, particularly at the illness onset. Objectives The goals of this study were: (a) to longitudinally observe anxious-depressive symptom levels in patients with First Episode Schizophrenia (FES) during a 24 months of follow-up period, and (b) to examine their associations with other psychopathology and the intervention patients received in an “Early Intervention in Psychosis” (EIP) program during the follow-up period. Methods The Global Assessment of Functioning (GAF) and the Positive And Negative Syndrome Scale (PANSS) were completed by 159 FES patients both at baseline and across the follow-up. Data were analyzed by linear regression analysis and Spearman’s coefficients. Results Anxious-depressive symptoms had significant longitudinal associations with GAF deterioration and PANSS “Positive Symptoms”, “Negative Symptoms” and “Disorganization” subscores. During the follow-up period, FES participants significantly improved the level of anxious-depressive symptoms. This was significantly associated with the number of case management and individual psychotherapy meetings the patient engaged in, as well as with lower antipsychotic doses prescribed during the follow-up period. Conclusions In conclusion, anxious-depressive symptoms are prominent in FES and at the initial entry into EIP programs. Anxious-depressive symptom severity tends to diminish overtime, especially with the provision of specialized EIP treatments. However, since we did not have a control population studied in parallel, we cannot say whether these results are specific to the protocols of EIP programs or just to the intensity of engagement in care. Disclosure of Interest None Declared

Introduction The prognostic prediction of outcomes in individuals at clinical high-risk for psychosis (CHR-P) is still a significant clinical challenge. Among multiple baseline variables of risk calculator models, the role of ongoing pharmacological medications has been partially neglected, despite meta-analytical evidence of higher risk of psychosis transition associated with baseline prescription exposure to antipsychotics (AP) in CHR-P individuals. In particular, baseline AP exposure in CHR-P individuals may be considered as a functional equivalent of the psychometric transition to psychosis, as already postulated in the original ‘Ultra High-Risk’ model. Objectives The main aim of the current study was to test the hypothesis that ongoing AP need at baseline indexes a subgroup of CHR-P individuals with more severe psychopathology and worse prognostic trajectories along a 1-year follow-up period. Methods This research was settled within the ‘Parma At-Risk Mental States’ program. Baseline and 1-year follow-up assessment included the Positive And Negative Syndrome Scale (PANSS) and the Global Assessment of Functioning (GAF). CHR-P individuals who were taking AP medications at entry were included in the CHR-P-AP+ subgroup. The remaining participants were grouped as CHR-P-AP-. The acquisition of drug and outcome information was collected both at baseline and across the follow-up period. Finally, logistic regression analyses with dichotomized 1-year outcome parameters (previously showing statistically significant differences in inter-group comparisons) as dependent measures and sociodemographic and clinical characteristics as independent variables were also performed. Results Hundred and seventy-eight CHR-P individuals (aged 12–25 years) were enrolled (91 CHR-P-AP+, 87 CHR-P-AP-). Compared to CHR-P AP-, CHR-P AP+ individuals had older age, greater baseline PANSS ‘Positive Symptoms’ and ‘Negative Symptoms’ factor subscores and a lower GAF score. At the end of our follow-up, CHR-P-AP+ subjects showed higher rates of psychosis transition, new hospitalizations and urgent/non-planned visits compared to CHRP- AP- individuals. Conclusions The current study suggests that AP need is a significant prognostic variable in cohorts of CHR-P individuals and should be included in the current risk calculators. In particular, the results of this study conducted in a realworld clinical setting indicate that the rate of CHR-P individuals who were already exposed to AP at the time of CHR-P status ascription was higher than those reported in recent meta-analyses on this topic. Moreover, our findings confirm that baseline AP prescription appears to increase psychotic transition risk. Disclosure of Interest None Declared

Rachiplusia nu (Lepidoptera: Noctuidae) is the main soybean plague in Argentina. The main strategy employed to control this pest is chemical control, applying different chemical groups regardless of their harmful effects on the environment and human health. Different biological products using entomopathogenic fungi have been developed and are commercially available to control different insect pests worldwide. The objective of this work was to develop and apply, under field conditions, different fungal formulations using entomopathogenic fungi to control R. nu larvae. The mortality percentages in bioassays of R. nu larvae treated with different colonies of fungal entomopathogens ranged between 86.6 ± 8.4% for Beauveria bassiana (LPSc 1098) and 56.6 ± 4.2% for Metarhizium anisopliae (LPSc 907). Under laboratory conditions using fungal formulations of B. bassiana, the formulation 4 (LPSc 1086) exhibited the highest mortality percentage (100%), followed by formulation 5 (LPSc 1098), 97 ± 1.3%. Under field conditions, larval mortalities were 82.4 ± 5.56% for formulation F4 and 61.8 ± 7.5% for formulation F5. The results obtained in this work indicate that although a greater number of tests under field conditions with the fungal formulation F4 are necessary, the results obtained in this work allow speculating that it is possible to use this fungal formulation under field conditions to control R. nu.

PURPOSE: Facing the research gap of entrepreneurial learning by self-expatriated technology-based entrepreneurs, the purpose of this research is to explore those entrepreneurs’ beliefs and experiences across expatriation to identify the enhancement of their competencies. METHODOLOGY: Within a qualitative and exploratory multiple case theory-building approach, data was collected from twelve technology entrepreneurs from Brazil, Mexico, Germany, and Israel that went to the following destination countries: Spain, United Kingdom, United States, Germany, Ireland, Turkey, and the Netherlands. With interview data as the primary source, the data analysis rests on a qualitative content analysis. FINDINGS: Data allows structuring techpreneurs’ experience of expatriation along the following steps: (a) arrival in the destination country and initial process of socialization, (b) engaging in activities to get familiar with the culture of the destination country, (c) the gradual comprehensive understanding of the new context, and (d) comparisons between the home and destination country. Expatriation had an evident impact on the technology-based entrepreneurs that materializes in three groups of competencies: entrepreneurial competencies, knowledge and innovative competencies, and international competencies. Entrepreneurial competencies relate to relational and behavioral skills and the learning of doing business in different contexts. Concerning knowledge and innovative competencies, creativity, learning new techniques and international innovation environment stand at the fore. Finally, international competencies relate to the acceptance of different cultures (multicultural learning and perception of cultural differences), developing a sense of an international community and an international innovation culture. IMPLICATIONS: This study evidenced the influence of expatriation experiences on the training of skills of technology-based entrepreneurs, in a specific approach to entrepreneurial, innovative, and intercultural competencies. The research portrays self-expatriation as an opportunity for technology-based entrepreneurs to develop different competencies being helpful to innovate, to manage business and to operate in international markets. Universities and innovators may recognize their discretion to develop programs for people like former students who want to self-expatriate. In the same vein, government can design policy to attract self-expatriate in innovations hubs, considering that local inhabitants can benefit from the cultural exchange. ORIGINALITY AND VALUE: This study contributes to better understanding the influence of self-expatriation experiences on the development of skills of technology-based entrepreneurs. Compared to previous studies, it advances research through providing a wider range of learning from expatriation experiences beyond the effect of internationalization on market knowledge and cultural aspects. Furthermore, this study focuses the process, not the results of self-expatriation to understand entrepreneurs’ learning.

Control measures of stored grain pests include the excessive utilization of chemical insecticides that generate negative environmental impact. Current trends in integrated pest management are oriented towards the preservation of the environment using natural biopesticides, among these products arise entomopathogenic fungi. This study aimed to test the efficacy of a native strain of Beauveria bassiana to control two main stored grain pests such as Sitophilus oryzae and Rhyzopertha dominica and also evaluate the persistence of the fungus on wheat grains. The B. bassiana strain controlled 89%±0.07 of R. dominica adults and 80% ±0.14 of S. oryzae. The survival analysis showed that MST was 4.27 ±0.19 days for R. dominica adults and 4.27 ±0.20 days for S. oryzae. Furthermore, results of long rank test for the comparison of the Kaplan-Meier curves did not present significant differences between the survival of both stored grain pests. Dual choice tests demonstrated that B. bassiana LPSc1227 presented a repellent action against both stored grain pests. The seed persistence of conidia was 100% in treated seeds after 45 days. Further research will contribute to elucidate more insecticidal features of the B. bassiana LPSc 1227 strain against S. oryzae and R. dominica, two main stored grain insect pests. Highlights: • bassiana presented insecticidal activity against R. dominica and S. oryzae. • bassiana demonstrated a repellent action against both stored grain pests. • bassiana was able to persist on the surface of wheat grains after 45 days storage.

Grasshoppers affect agriculture worldwide, causing serious economic damage. Currently, the application of chemical insecticides against grasshoppers is the only effective strategy, even considering the significant environmental concern. This study aimed to test the entomopathogenic fungi Beauveria bassiana (LPSc 1067) as biocontrol agent on six harmful grasshopper species in Argentina. Significant differences were observed (DF= 5; F= 9.93; P

Abstract Background The Toad grasshopper pest, Bufonacris claraziana (Saussure) (Orthoptera: Tristiridae) is an endemic species of the Argentine Patagonia region. Among the Tristiridae family, it is the only species recognized as harmful to agricultural and livestock activities in the country. Outbreaks of B. claraziana have become a recurring phenomenon in the recent years, affecting different areas of the Patagonian provinces. The aim of this study was to evaluate, as laboratory bioassays, the mortality in young nymphs of this species treated with bait formulations of the entomopathogenic fungus Beauveria bassiana (Hypocreales: Clavicipitaceae). Results The two treatments performed, one of them (I) with conidia of B. bassiana only and the other (II) with conidia of B. bassiana plus canola oil as phagostimulant, produced significantly higher mortality than the control (p

Soybean (Glycine max) is one of the most important crops worldwide. This crop is prone to diseases caused by the phytopathogenic fungi Macrophomina phaseolina, Fusarium oxysporum, and the lepidopteran pest Rachiplusia nu. Biological control using entomopathogenic fungi is a sustainable alternative to chemical pesticides. In this study, we assessed the antifungal activity of Beauveria bassiana and Metarhizium anisopliae against phytopathogens and the pathogenicity of B. bassiana as an endophyte against R. nu. The antagonic activity of the fungal entomopathogens was evaluated in vitro by dual culture bioassays. The feeding preference of R. nu was evaluated in a “free choice” assay under laboratory conditions. Entomopathogenic fungi inhibited the mycelial growth of the phytopathogens. The best response in all cases was observed when the antagonists were placed in the culture medium two days before the pathogens. B. bassiana was the best antagonist of F. oxysporum, while both antagonists had similar inhibitory effects on M. phaseolina growth. Additionally, B. bassiana, when grown as an endophyte, reduced insects’ food preferences and decreased soybean consumption. Findings suggest that entomopathogenic fungi can fulfill multiple roles in the ecosystem. Therefore, the simultaneous expression of both properties should be considered for their application in integrated pest management programs.

IntroductionThrombotic events in neonates and children represent a rare although severe occurrence in view of the associated risk of mortality and sequelae. Quality evidence is limited in this field, and registry studies provide an essential base for research. The aim of this paper is to present the new Italian Registry of Infantile Thrombosis (RITI), set it into the scene of international thrombosis and stroke registries, and provide some insight on the challenges associated with registry management.MethodsWe present the detailed structure and content of the new RITI registry, a brief overview of its main data, and a reflection on its features, pitfalls and the main challenges related to its management.ResultsThe RITI, initially started in 2007 and officially re-launched in 2017 after structural modifications, is a non-interventional retrospective and prospective registry study collecting data on neonatal and pediatric patients (0–18 years) who experienced a systemic or cerebral thrombotic event in Italy. The RITI is managed by a multidisciplinary team with expertise in pediatric thrombosis, and participation is open to all Italian physicians, on a voluntary basis. The overall aim of the registry is to acquire new evidence to better characterize the population of children with thrombotic events and improve their management and outcome. 48 Italian pediatric and intensive care units are actively involved in the RITI, including 85 medical doctors from 16 Italian regions. A total of 1,001 neonates and children affected by cerebral or systemic thrombosis have been enrolled.DiscussionThe RITI is one of the largest available European registries of neonatal and pediatric thrombosis. National registries like the RITI represent a model for the study of rare conditions based on multidisciplinary and multicenter collaboration, aimed at overcoming the limitations due to small populations of patients, and creating a network of experts for patient referral and continuous education. Moreover, registry studies have a pivotal role in the research on pediatric thrombosis, due to the limited feasibility of high-quality studies. In our experience, the main critical stages, pitfalls and challenges in registry management include adequate registry designing, diffusion, data completeness and quality control.

Ongoing work and theorizing in the field of STS has made important progress in conceptualizing agency, and stressing contingency and dynamic processes in science, technology and society. However, this focus on case studies and micro dynamics has left the field ill equipped to account for obduracy and stability. We suggest a framework for understanding obduracy in STS can be found by reassessing various insights from the social sciences and STS on the processes of maintenance and repair (M&R). To illustrate our framework, we offer a concrete example in one of Europe’s crises: alterity processing or the collection of practices and infrastructures to manage Europe’s “migration crisis” (Pelizza 2019). We make explicit how maintenance and repair can be used to consider the obduracy of large scale orders without losing the empirical edge that the STS offers.

This contribution aims to summarize and highlight the main themes emerged during the panel “Surveillance infrastructures or open platforms? Aid and control of vulnerable populations through digital data” that took place at the VIII STS Italia Conference. The panel invited to reflect upon the ambivalence and ambiguity of digital platforms and data infrastructures for population management as well as on the highly diversified functions and users they support and attract. More precisely, presenters were encouraged to enquire how platforms and data infrastructures affect vulnerable populations and reconfigure the boundaries between the private and public domains: how do they allow empowering and innovative communication and resistance strategies? How, on the contrary, do they produce novel or exacerbate already existing vulnerabilities? How is the modern distinction between government, business, and civil society de facto reshuffled as a consequence? Although panel’s presentations discussed remarkably different types of platforms – from online maps and social networks to public health databases and migration technologies – they overall emphasized that only a careful, situated analysis of the multiple socio-technical factors shaping users’ engagement might help to understand how – and why – those technologies become tools for control and surveillance or empowerment resources.

RESUMO A Síndrome Respiratória Aguda Grave do Coronavírus 2 (SARS-CoV-2), causadora da Coronavírus 2019 (Covid-19), se alastrou, tornando-se em pouco tempo uma pandemia. A doença provocou a escassez de ventiladores mecânicos no mercado brasileiro e mundial. Esta pesquisa teve como objetivo compreender o desenvolvimento de ventiladores mecânicos destinados ao atendimento de pacientes acometidos pela Covid-19, focando em dificuldades e na configuração da inovação. Para tanto, realizou-se uma pesquisa exploratória, com abordagem qualitativa, um estudo de casos múltiplos. A coleta de dados ocorreu por meio de entrevistas semiestruturadas com os agentes inovadores. Os dados foram analisados por meio de análise de conteúdo. Os resultados demonstram que os equipamentos desenvolvidos constituem inovação frugal, uma vez que apresentam pelo menos quatro características desse tipo de inovação: acessibilidade e baixo custo; atendimento a determinada necessidade; uso de peças alternativas; e inovação. Os participantes apresentaram comportamento resiliente para vencer as dificuldades associadas ao custo de homologação; tempo, criatividade e distanciamento social; necessidades de conhecimento específico; e necessidade de trabalhar com margem de custo reduzida. A pesquisa apresenta uma contribuição para a compreensão do desenvolvimento da inovação frugal em contexto contingência, como foi o caso da pandemia, focando em indivíduos criadores e no processo de criação.

Introduction Suicidal thinking is relevant in patients with First Episode Psychosis (FEP). However, longitudinal studies specifically examining treatment response for suicidal ideation in FEP are still relatively scarce, especially with long-term design and in real-world clinical settings. Objectives The aims of this research were (A) to longitudinally assess suicidal thoughts in people with FEP along a 2-year follow-up period and (B) to overtime investigate any significant association of suicidal ideation levels with the specific treatment components of an ‘Early Intervention in Psychosis’ (EIP) protocol along the 2 years of follow-up. Methods At entry, 232 FEP participants (aged 12–35 years) completed the Brief Psychiatric Rating Scale (BPRS), including a ‘Suicidality’ item subscore. Multiple linear regression analysis was then performed. Results Across the follow-up, FEP subjects showed a relevant decrease in suicidal thinking levels overtime. This was specifically predicted by the total number of individual psychotherapy sessions offered within the 2-year EIP protocol and antidepressant dose (at least as regards the first year of our intervention). Image: Conclusions Suicidal ideation is clinically relevant in FEP but seems to improve overtime together with the provision of specific, patient-tailored and integrated EIP treatments, especially individual psychotherapy. Disclosure of Interest None Declared

Introduction Disorganization is a core dimension of schizophrenia, yet it is relatively under-investigated compared to positive and negative ones, especially at the illness onset. Indeed, most of the empirical studies investigating the disorganized domain included patients with prolonged schizophrenia. Objectives Thus, the aims of this research were (1) to monitor the longitudinal stability of disorganized symptoms in young patients with First Episode Schizophrenia (FES) along a 2-year follow-up period, and (2) to examine any significant association of disorganization with functioning, psychopathology and the specific treatment components of an “Early Intervention in Psychosis” (EIP) program across the 2 years of follow-up. Methods At baseline, 159 FES individuals (aged 12–35 years) completed the Positive And Negative Syndrome Scale (PANSS) and the Global Assessment of Functioning (GAF). Spearman’s correlation coefficients and multiple linear regression analysis were carried out. Specifically, the PANSS “Disorganization” dimension included 8 PANSS items: “Conceptual Disorganization”, “Difficulty in Abstract Thinking”, “Stereotyped Thinking”, “Mannerisms and Posturing”, “Disorientation”, “Poor Attention”, “Disturbance of Volition” and “Preoccupation”. Results At baseline, the PANSS “Disorganization” dimension score had significant positive correlations with all other PANSS factor subscores, as well as significant negative correlation with the GAF score. The statistically strongest association was with the PANSS “Negative” domain score. Along the 2-year follow-up period, a significant decrease in the PANSS “Disorganization” dimension subscore was observed. This reduction was related to score decreases in all the other PANSS domains (especially the “Negative” one) and an increase in GAF scores. Furthermore, decreaes in PANSS “Disorganization” dimension scores showed a significant positive correlation with the total number of individual psychotherapy sessions provided to FES patients during the first year of the Pr-EP protocol (also confimed by our multiple linear regression analysis results). Conclusions Disorganization is clinically relevant in FES patients, already at the recruitment within specialized EIP programs. In particular, disorganized dimension in FES had significant enduring associations with functioning deterioration and negative symptoms. However, improvement in disorganization levels seems to be due to the intensity of individual psychotherapy sessions offered to FES individuals in the first year of intervention within specific EIP programs. Disclosure of Interest None Declared

Introduction The clinical relevance of Routine Outcome Monitoring (ROM) to formulate longitudinal evaluations of treatment appropriateness/efficacy and to assist decision making aimed at improving the quality of person-centered interventions has been poorly implemented in forensic psychiatry, also in Italy. Indeed, very few assessment instruments have been developed in this crucial field. Objectives As reliable ROM instruments are lacking, the aim of the current investigation was to examine psychometric properties (i.e. reliability, concurrent validity and sensitivity to measure scores’ longitudinal changes) of the Parma Scale (Pr-Scale) (a new instrument fro the evaluation of offenders with mental disorder) in an Italian sample of forensic psychiatric patients. Methods Participants were male adult offenders with mental disorder recruited within the Parma REMS (“Residence for the Execution of Security Measure”) or the Parma Penitentiary Institute (PPI). Exclusion criteria were known moderate/severe intellectual disability or any other medical condition inducing inability to express a valid consent for participating in the research. The Pr-Scale includes 20 items divided into 3 main domains: “Historical”, “Clinical” (observational) and “Treatment Plannining". To test psychometric properties of the Pr-Scale, we examined interrater reliability, short-term (1-week) test-retest reliability and internal consistency. As measure of concurrent validity, a correlation analysis of Pr-Scale item scores with corresponding HKT-R (the “Historisch, Klinische en Toekomstige – Revisie” instrument) item subscores was performed. Finally, we examined the Pr-Scale sensitivity to measure scores’ longitudinal changes over a 3-month treatment follow-up period. Results 60 male adult patients were recruited in this study. Our findings showed good to excellent interrater and test-retest reliability, concurrent validity and internal consistency for the Pr-Scale. Pr-Scale scores also display a moderate to large changeability over time (Intra-Class Correlation coefficient = 0.963, coefficient of stability = 0.997, Cronbach’s ɑ = 0.736). Statistically significant correlations of Pr-Scale item scores with the corresponding HKT-R scores were found. Across the 3-month follow-up period, we observed statistically significant sensitivity values in measuring longitudinal changes for the Pr-Scale total score and Pr-Scale domain and item subscores. Conclusions Our results support the clinical use of the Pr-Scale in different forensic psychiatric settings (i.e. prison, REMS) as reliable ROM instrument. Disclosure of Interest None Declared

Objetivo: O objetivo deste estudo foi identificar o estado da arte de publicações sobre paixão empreendedora, bem como a evolução e potencial para pesquisas futuras. Metodologia: Foi realizado um estudo bibliométrico nas bases de dados Scopus, Web of Science e Science Direct. Com auxílio do software Start, foram selecionados 665 artigos, após os critérios de exclusão restaram 64 artigos que foram submetidos à análise e revisão da literatura. Resultados: Na análise bibliométrica descreveu-se a evolução de publicações no campo, os estudos mais citados, a contribuição dos periódicos e os principais temas pesquisados. Por meio da análise temática constata-se que há um campo para estudos futuros. Contribuições teóricas/metodológicas: O estudo aponta, por meio das publicações analisadas, quais foram os efeitos da paixão empreendedora, tanto como variável dependente, independente e mediadora ou moderadora. Com isso, apresenta um panorama amplo que permite avaliar os efeitos da paixão no comportamento de empreendedores. Originalidade/Relevância: O estudo aponta um panorama de publicações sobre o tema paixão empreendedora, analisando os seus efeitos determinantes, bem como suas consequências. Contribuições sociais/para a gestão: este estudo pode auxiliar estudantes de pós-graduação e pesquisadores na construção de agendas de pesquisas. Para empreendedores, os resultados apontam os múltiplos efeitos da paixão empreendedora, o que pode estimulá-los a buscar desenvolvê-la. Para instituições de ensino que atuam com empreendedorismo, as discussões podem auxiliar a construir programas e práticas de educação empreendedora. Classificação JEL: L26, L31, G41

O curso de medicina da Universidade Estadual de Maringá (UEM) foi implantado em 1988. Com currículo em essência ainda tradicional, vem ao longo dos anos sofrendo modificações, impulsionado principalmente pelas Diretrizes Curriculares Nacionais. O objetivo do estudo foi descrever a trajetória do ensino da Atenção Primária à Saúde do curso e sua expansão especialmente a partir de 2005 com o internato em Saúde Coletiva, com novas disciplinas e a implantação do Programa de residência em Medicina de Família e Comunidade.

Background: Acupuncture is a spreading and promising intervention, which has proven to be very useful in the treatment and prevention of chronic pain, in particular chronic headaches, in adults; the literature about the treatment of pediatric chronic headaches is scarce. In addition, few guidelines advise its use in children. The aim of this review is to collect all relevant studies with available data about the use, effect, and tolerability of acupuncture as a treatment for pediatric primary headaches. Methods: This is a narrative review based on eight studies selected from 135 papers including pediatric cases treated with acupuncture for headache. Results: Despite the differences in tools, procedures, and application sites, acupuncture demonstrated a positive effect on both the frequency and intensity of headaches and was well tolerated. There are no studies considering the long-term efficacy of acupuncture. Conclusion: Further additional studies are needed on acupuncture in children and adolescents, with larger series and standardized procedures, in order to better assess efficacy, tolerability, and long-term prognosis and to define guidelines for the use of this promising and safe treatment. It is particularly relevant to identify safe and well-tolerated treatment options in pediatric patients affected by recurrent and debilitating headaches.

Purpose – This research aimed to describe the phenomenon of the growth of enterprises in the vision of social entrepreneurs. Design/methodology/approach – This is a qualitative study developed joining eight social entrepreneurs in four organizations, two cooperatives and two associations. Data were obtained in semi structured interviews. Data were analyzed with interpretativist and the classical content analysis. Findings – The main findings indicated the growth phenomenon presented in five categories: growth intentions, growth meanings, support of other organizations and participation in networks, strategies and difficulties. The results of the research have shown that the growth for the social entrepreneurs is a collective phenomenon, characterized by search of economic value and empowerment. Research limitations/implications – The main limitation of the research was study only two types of organizations, one garbage cooperative and two association. Practical implications – The results can help managers of social incubators and stakeholders because it was evidenced the efforts and difficulties that social entrepreneurs face to survive and to search growth. Social implications – Our findings may contribute to the formulation of public policies oriented to social entrepreneurs. Originality/value – This paper presents the first theoretical contribution about the growth in a specific context, the context of social entrepreneurs.

Sharing knowledge is essential in contemporary knowledge-driven organizations. Thus mentoring is a practice used to share knowledge among more and less experienced people. In this sense, this research aims to understand the relationship between the adoption of mentoring practices and the sharing of knowledge in a software development company. This is a qualitative study, using the case study method. Data was collected through questionnaires conducted with those involved in the Mentor Program of this company. The results indicate that mentoring influences the way and amount of knowledge shared among professionals, with implications of the mentor-mentor relationship in both professional development and personal relationships. Mentoring shows types and forms of sharing, such as meetings, pair programming, formal and informal assessments and reading, as well as skills acquired by participants and their experiences.

Purpose: The objective of this research was to identify and analyze the input forms and the knowledge obtained by small software companies in internationalization experiences. Method: It is a qualitative study, conducted with five case studies of small entrepreneurs. Primary and secondary data were used. Primary data were obtained from nine open and semi-structured interviews, and secondary data from company websites. Data were categorized into input forms and knowledge obtained. Data from the latter category were complementarily analyzed using Iramuteq software. Findings: As generated knowledge, six classes of knowledge were identified: a) markets and destinations; b) action to place the product on the international market; c) support and search for external knowledge; d) need for qualification for the internationalization process and local partnerships; e) local market vision; f) complexity of the internationalization process. Originality/value: The study of internationalization experiences and knowledge gained is an original approach as it highlights the ways in which small software companies gain input and experience in internationalization experiences. Theoretical/Methodological Contributions: The results showed that learning in internationalization experiences favored the increase of international market knowledge and contributed to improve competitiveness in the local market.

Introduction Mental health interventions for Italian (and European) prisoners with mental disorders remain a problematic issue, despite radical changes in general psychiatric care and a 2008 major government reform transferring mental health care in prison to the National Health Service. Indeed, according to the American Psychological Association, 64% of incarcerated individuals report mental health concerns. Objectives The aim of this study is to describe the mental health intervention model implemented since January 2020 for prisoners allocated in the Parma Penitentiary Institutes (PPI). This approach is specifically based on specialized, “person-centered” and “person-tailored” therapeutic-rehabilitation plans in line with psychiatric treatments usually provided in community mental health-care centers of the Parma Department of Mental Health. Methods All the processes and procedures included in the PPI intervention model were first carefully described, paying special attention to the service for newly admitted prisoners and each typology of specialized therapeutic-rehabilitation treatment potentially provided. Additionally, a preliminary descriptive process analysis of the first six months of clinical activity was also performed. Results Since January 2020, 178 individuals entered the PPI service for newly admitted prisoners. In total, 83 (46.7%) of them were engaged in the services of the PPI mental health-care team (35 with pathological addiction and 48 with mental disorders): 56 prisoners were offered an integrated mental health intervention and 27 exclusively an individual psychological or psychiatric treatment. Conclusions The results support the potential applicability of an integrated mental health intervention in prison, planning a person-tailored rehabilitation in close collaboration with the prisoners, their families and the local mental health/social services. Disclosure No significant relationships.

Introduction Individual placement and support (IPS) has a considerable body of evidence for its effectiveness in helping people with mental disorder to obtain and maintain competitive jobs in the labour market. IPS closely follows 8 main principles (such as it aims to get people into competitive employment, it is open to all those who want to work, it tries to find jobs consistent with people’s preferences, it works quickly, it brings employment specialists into clinical teams, it provides time unlimited, individualised support, benefits counselling is included). However, little data in young adults are currently available, especially in Europe. Objectives Aim of this study was to evaluate the beneficial effect of IPS in Italian young adults with severe mental illness, examining the main competitive employment outcomes and drop out rates during a 3-year follow-up period. Methods 54 participants were recruited from patients receiving psychiatric treatment in adult Community Mental Health Centers of an Italian Department of Mental Health. Together with drop out rates, we examined job acquisition, job duration (total number of days worked), total hours per week worked and job tenure (weeks worked on the longest-held competitive job). Results A crude competitive employment rate of 40.7% and a crude drop out rate of 22.2% over the 3-year follow-up period were found. However, 66% of 42 clients who remained in the program over 3 years gained competitive employment at some time during the 3-year period. Conclusions This research shows the feasibility of an IPS intervention model in the public mental health care system in Italy, especially for a young adult target population. Disclosure No significant relationships.

Introduction Personal Health Budget (PHB) has been provided to consumers with severe mental illness within a policy shift toward a person-tailored mental healthcare treatment based on individual unmet needs. PHB is an amount of money to support patient’s health and wellbeing needs, which is planned and agreed between patients and their local NHS team. It is not new money, but it may mean spending money differently so that patients can get the care that they need. However, evidence of beneficial effects of PHB is still scarce. Objectives The aim of this study was to provide preliminary data on clinical and social benefits of adding PHB to a standard pharmacotherapy in patients with severe mental illness across a 24-month follow-up period. Methods 137 individuals with severe mental illness (aged 18–50 years) were recruited in one of the adult mental health services of an Italian Department of Mental Health. They completed the Global Assessment of Functioning scale, the Health of the Nation Outcome Scale and the Brief Psychiatric Rating Scale. Friedman’s test for repeated measure was used to assess the longitudinal stability of functioning and clinical parameters. A linear regression analysis was also performed. Results A significant decrease in all GAF scale, HoNOS and BPRS scores along the 24 months of follow-up was observed. Regression analysis results specifically showed a relevant association between a PHB multiaxial intervention and the longitudinal reduction in BPRS ‘Negative Symptoms’ and HoNOS ‘Social Problems’ subscores. Conclusions Our findings support the useful implementation of a PHB approach for severe mental illness patients within the Italian mental health service network. Disclosure No significant relationships.

The literature on cold-stimulus headache (CSH) is relatively sparse compared to other primary headache disorders and the studies on the pediatric population are very limited. This systematic review aims to analyze the evidence on CSH in children and adolescents focusing on epidemiology, clinical features, pathogenic mechanisms, and treatments. Our review included 25 studies, among which 9 papers include pediatric cases (4 pediatric samples, 5 mixed samples of children and adults). The aim of this work is to highlight the features of CSH in children and adolescents. In children, the prevalence of CSH is higher than in adults and it is not gender-specific. There is a relevant family history for CSH and the comorbidity with migraine is significant. The triggers and clinical features of CSH due to ingesting a cold stimulus in children overlap with those in adults. CSH due to external application of a cold stimulus (or to environmentally low temperatures) is not studied in children and adolescents. We describe in detail a new pediatric case of CSH triggered by low ambient temperatures; to the best of our knowledge, this represents the first description in the literature. In conclusion, CSH in children is probably underestimated and has peculiar features compared to adults; further studies are needed to better understand its clinical features and pathophysiology.