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2. Development of an urban molecular xenomonitoring system for lymphatic filariasis in the Recife Metropolitan Region, Brazil

Author

Ramesh, Anita, primary, Cameron, Mary, additional, Spence, Kirstin, additional, Hoek Spaans, Remy, additional, Melo-Santos, Maria A. V., additional, Paiva, Marcelo H. S., additional, Guedes, Duschinka R. D., additional, Barbosa, Rosangela M. R., additional, Oliveira, Claudia M. F., additional, Sá, André, additional, Jeffries, Claire L., additional, Castanha, Priscila M. S., additional, Oliveira, Paula A. S., additional, Walker, Thomas, additional, Alexander, Neal, additional, and Braga, Cynthia, additional

Published
2018
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4. Does Zika virus infection affect mosquito response to repellents?

Author

Leal, Walter S., primary, Barbosa, Rosângela M. R., additional, Zeng, Fangfang, additional, Faierstein, Gabriel B., additional, Tan, Kaiming, additional, Paiva, Marcelo H. S., additional, Guedes, Duschinka R. D., additional, Crespo, Mônica M., additional, and Ayres, Constância F. J., additional

Published
2017
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5. Identification of a major Quantitative Trait Locus determining resistance to the organophosphate temephos in the dengue vector mosquito Aedes aegypti.

Author

Paiva MH, Lovin DD, Mori A, Melo-Santos MA, Severson DW, and Ayres CF

Subjects
Aedes drug effects, Animals, Chromosomes, Insect genetics, Insecticides toxicity, Temefos toxicity, Aedes genetics, Insecticide Resistance genetics, Quantitative Trait Loci
Abstract

Organophosphate insecticides (OP) have extensively been used to control mosquitoes, such as the vector Aedes aegypti. Unfortunately, OP resistance has hampered control programs worldwide. We used Quantitative Trait Locus (QTL) mapping to evaluate temephos resistance in two F1 intercross populations derived from crosses between a resistant Ae. aegypti strain (RecR) and two susceptible strains (MoyoD and Red). A single major effect QTL was identified on chromosome 2 of both segregating populations, named rtt1 (resistance to temephos 1). Bioinformatics analyses identified a cluster of carboxylesterase genes (CCE) within the rtt1 interval. qRT-PCR demonstrated that different CCEs were up-regulated in F2 resistant individuals from both crosses. However, none exceeded the 2-fold expression. Primary mechanisms for temephos resistance may vary between Ae. aegypti populations, yet also appear to support previous findings suggesting that multiple linked esterase genes may contribute to temephos resistance in the RecR strain as well as other populations., (Copyright © 2015 Elsevier Inc. All rights reserved.)

Published
2016
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