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9 results on '"Pakulska, Urszula"'

1. P986: COMBINATION JAK1/2 AND CDK8/19 INHIBITION DEMONSTRATES ENHANCED EFFICACY IN MYELOPROLIFERATIVE NEOPLASMS

Author

Zaroogian, Zachary, primary, Adamczyk, Elżbieta, additional, Moszyńska, Adrianna, additional, Obacz, Marta, additional, Pakulska, Urszula, additional, Durham, Benjamin, additional, Mazan, Milena, additional, Mowla, Shoron, additional, Wnęk, Katarzyna, additional, Somasundara, Amritha Varshini Hanasoge, additional, Barczuk, Beata, additional, Gołas, Aniela, additional, Levine, Ross, additional, Rzymski, Tomasz, additional, and Rampal, Raajit K, additional

Published
2023
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2. Multiomics Analysis Confirms Effective Target Engagement for RVU120 - a First-in-Class CDK8/19 Kinase Inhibitor in AML and MR-MDS Patients and Reveals the Mechanism of Action

Author

Rzymski, Tomasz, primary, Sroka-Porada, Agnieszka, additional, Kozakowska, Magdalena, additional, Głowniak-Kwitek, Urszula, additional, Bukowska-Strakova, Karolina, additional, Obacz, Marta, additional, Littlewood, Peter, additional, Kuś, Kamil, additional, Goller, Kristina, additional, Kęska, Kinga, additional, Pakulska, Urszula, additional, Kozłowska-Tomczyk, Kamila, additional, Madej, Monika, additional, Mazan, Milena, additional, Juszczynski, Przemyslaw, additional, Zaucha, Jan M., additional, Zarzycka, Agnieszka, additional, Angelosanto, Noemi, additional, Nogai, Hendrik, additional, and Brzózka, Krzysztof, additional

Published
2022
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3. Abstract 2647: RVU120, a selective CDK8/CDK19 inhibitor, demonstrates efficacy against hormone-independent breast cancer cells in vitro and in vivo

Author

Pakulska, Urszula, primary, Obacz, Marta, additional, Gołas, Aniela, additional, Mazan, Milena, additional, Masiejczyk, Magdalena, additional, Stachowicz, Agata, additional, Martyka, Justyna, additional, Combik, Michał, additional, Kęska, Kinga, additional, Wiklik, Katarzyna, additional, Goller, Kristina, additional, Adamczyk, Elżbieta, additional, Brzózka, Krzysztof, additional, and Rzymski, Tomasz, additional

Published
2022
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4. Abstract P5-17-13: Selective CDK8/CDK19 inhibitor RVU120 demonstrates efficacy against hormone-independent breast cancer cells in vitro and in vivo

Author

Rzymski, Tomasz, primary, Gołas, Aniela, additional, Mazan, Milena, additional, Pakulska, Urszula, additional, Masiejczyk, Magdalena, additional, Stachowicz, Agata, additional, Martyka, Justyna, additional, Combik, Michał, additional, Wiklik, Katarzyna, additional, Goller, Kristina, additional, Obacz, Marta, additional, Adamczyk, Elżbieta, additional, and Brzózka, Krzysztof, additional

Published
2022
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5. RVU120 (SEL120) CDK8/19 Inhibitor - a Drug Candidate for the Treatment of MDS Can Induce Erythroid Differentiation

Author

Pakulska, Urszula, primary, Obacz, Marta, additional, Goller, Kristina, additional, Combik, Michal, additional, Keska, Kinga, additional, Zaucha, Jan, additional, Zarzycka, Ewa, additional, Mazan, Milena, additional, Mikula, Michal, additional, Cybulska, Magdalena, additional, Polak, Anna, additional, Juszczynski, Przemyslaw, additional, Flygare, Johan, additional, Chen, Jun, additional, Brzozka, Krzysztof, additional, Järås, Marcus, additional, Dziedzic, Katarzyna, additional, Angelosanto, Noemi, additional, Shamsili, Setareh, additional, and Rzymski, Tomasz, additional

Published
2021
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6. Preclinical and Clinical Signs of Efficacy of RVU120 (SEL120), a Specific CDK8/19 Inhibitor in DNMT3A-Mutated AML

Author

Rzymski, Tomasz, primary, Pakulska, Urszula, additional, Abboud, Camille, additional, Burris, Howard A., additional, Solomon, Scott R., additional, Obacz, Marta, additional, Goller, Kristina, additional, Combik, Michal, additional, Zaucha, Jan, additional, Mazan, Milena, additional, Mikula, Michal, additional, Cybulska, Magdalena, additional, Polak, Anna, additional, Juszczynski, Przemyslaw, additional, Järås, Marcus, additional, Chapellier, Marion, additional, Flygare, Johan, additional, Zawadzka, Magdalena, additional, Strakova, Karolina Bukowska, additional, Brzozka, Krzysztof, additional, Shamsili, Setareh, additional, and Angelosanto, Noemi, additional

Published
2021
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8. Targeting CDK8/CDK19 to Disrupt Leukemic Stem Cell-like Population in Acute Myeloid Leukemia: Exploring RVU120 As a Promising Frontline Therapy

Author

Mazan, Milena, Pakulska, Urszula, Moszyńska, Adrianna, Sroka-Porada, Agnieszka, Szade, Krzysztof Tomasz, Mikula, Michał, Kozakowska, Magdalena, Juszczyński, Przemysław, Wiklik, Katarzyna, Göller, Kristina, Obacz, Marta, Abboud, Camille N., Zaucha, Jan Maciej, Marańda, Ewa Lech, Angelosanto, Noemi, Nogai, Hendrik, and Rzymski, Tomasz

Published
2023
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9. Novel Clinically Useful Inhibitor of Mediator Complex, RVU120, Relives Differentiation Block in MDS/AML

Author

Ajibade, Opeyemi, Pakulska, Urszula, Rabinovich, Emma, Fromowitz, Ariel, Sahu, Srabani, Aminov, Sarah, Ramachandra, Nandini, Aluri, Srinivas, Gordon Mitchell, Shanisha, Carbajal, Milagros, Keska-Izworska, Kinga, Combik, Michał, Obacz, Marta, Adamczyk, Elżbieta, Zaucha, Jan M., Zarzycka, Ewa, Juszczynski, Przemyslaw, Boultwood, Jacqueline, Pellagatti, Andrea, Pradhan, Kith, Steidl, Ulrich, Shastri, Aditi, Zhao, Rongbao, Mazan, Milena, Rzymski, Tomasz, and Verma, Amit

Published
2023
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