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1. The FARCOS project — Status and perspective

Author

Pagano E.V., Acosta L., Auditore L., Bassini R., Boiano C., Cardella G., Castoldi A., D’Andrea M., De Filippo E., Fichera F., Francalanza L., Giudice N., Gnoffo B., Grimaldi A., Guazzoni C., Lanzalone G., Lombardo I., Minniti T., Morgana E., Pagano A., Papa M., Passaro G., Pirrone S., Politi G., Porto F., Quattrocchi L., Rizzo F., Rosato E., Russotto P., Saccà G., Trifirò A., Trimarchi M., Verde G., and Vigilante M.

Subjects
Physics, QC1-999
Abstract

Nuclear matter under extreme conditions can be studied in the laboratory with heavy-ion collisions. In this case one can indeed vary the incident energy and explore different impact parameter and rapidity regions to access densities that extend above and below saturation. This opportunity allows one to learn about the nuclear equation of state and its implications in astrophysics phenomena such as supernovae explosions and neutron stars properties. All these phenomena involve time scales that need to be accessed with two- and multi-particle correlation measurements. In this contribution a brief report of the FARCOS array will be presented. In particular, tests with alpha sources and beams and preliminary results from a recent experiment INKIISSY performed using a FARCOS prototype made of four telescopes will be presented.

Published
2015
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2. The KM3NeT potential for the next core-collapse supernova observation with neutrinos

Author

KM3NeT Collaboration, Aiello, S., Albert, A., Garre, S. Alves, Aly, Z., Ambrosone, A., Ameli, F., Andre, M., Androulakis, G., Anghinolfi, M., Anguita, M., Anton, G., Ardid, M., Ardid, S., Aublin, J., Bagatelas, C., Baret, B., Pree, S. Basegmez du, Bendahman, M., Benfenati, F., Berbee, E., Berg, A. M. van den, Bertin, V., Biagi, S., Bissinger, M., Boettcher, M., Cabo, M. Bou, Boumaaza, J., Bouta, M., Bouwhuis, M., Bozza, C., Brânzaş, H., Bruijn, R., Brunner, J., Buis, E., Buompane, R., Busto, J., Caiffi, B., Calvo, D., Capone, A., Carretero, V., Castaldi, P., Celli, S., Chabab, M., Chau, N., Chen, A., Cherubini, S., Chiarella, V., Chiarusi, T., Circella, M., Cocimano, R., Coelho, J. A. B., Coleiro, A., Molla, M. Colomer, Coniglione, R., Coyle, P., Creusot, A., Cuttone, G., Dallier, R., De Martino, B., De Palma, M., Di Marino, M., Di Palma, I., Dıaz, A. F., Diego-Tortosa, D., Distefano, C., Domi, A., Donzaud, C., Dornic, D., Dörr, M., Drouhin, D., Eberl, T., Eddyamoui, A., van Eeden, T., van Eijk, D., Bojaddaini, I. El, Elsaesser, D., Enzenhöfer, A., Espinosa, V., Fermani, P., Ferrara, G., Filipović, M. D., Filippini, F., Fusco, L. A., Gabella, O., Gal, T., Soto, A. Garcia, Garufi, F., Gatelet, Y., Geißelbrecht, N., Gialanella, L., Giorgio, E., Gozzini, S. R., Gracia, R., Graf, K., Grasso, D., Grella, G., Guderian, D., Guidi, C., Haefner, J., Hamdaoui, H., van Haren, H., Heijboer, A., Hekalo, A., Hennig, L., Hernández-Rey, J. J., Hofestädt, J., Huang, F., Ibnsalih, W. Idrissi, Illuminati, G., James, C. W., de Jong, M., de Jong, P., Jung, B. J., Kadler, M., Kalaczyński, P., Kalekin, O., Katz, U. F., Chowdhury, N. R. Khan, Kistauri, G., van der Knaap, F., Kooijman, P., Kouchner, A., Kreter, M., Kulikovskiy, V., Lahmann, R., Lamoureux, M., Larosa, G., Breton, R. Le, Stum, S. Le, Leonardi, O., Leone, F., Leonora, E., Lessing, N., Levi, G., Lincetto, M., Clark, M. Lindsey, Lipreau, T., Longhitano, F., Lopez-Coto, D., Maderer, L., Mańczak, J., Mannheim, K., Margiotta, A., Marinelli, A., Markou, C., Martin, L., Martınez-Mora, J. A., Martini, A., Marzaioli, F., Mastroianni, S., Mazzou, S., Melis, K. W., Miele, G., Migliozzi, P., Migneco, E., Mijakowski, P., Miranda, L. S., Mollo, C. M., Morganti, M., Moser, M., Moussa, A., Muller, R., Musumeci, M., Nauta, L., Navas, S., Nicolau, C. A., Fearraigh, B. Ó, O'Sullivan, M., Organokov, M., Orlando, A., González, J. Palacios, Papalashvili, G., Papaleo, R., Passaro, G., Pastore, C., Păun, A. M., Păvălaş, G. E., Pellegrino, C., Perrin-Terrin, M., Pestel, V., Piattelli, P., Pieterse, C., Pikounis, K., Pisanti, O., Poirè, C., Popa, V., Pradier, T., Pühlhofer, G., Pulvirenti, S., Rabyang, O., Raffaelli, F., Randazzo, N., Razzaque, S., Real, D., Reck, S., Riccobene, G., Rivoire, S., Romanov, A., Rovelli, A., Greus, F. Salesa, Samtleben, D. F. E., Losa, A. Sánchez, Sanguineti, M., Santangelo, A., Santonocito, D., Sapienza, P., Schnabel, J., Schneider, M. F., Schumann, J., Schutte, H. M., Seneca, J., Sgura, I., Shanidze, R., Sharma, A., Simeone, F., Sinopoulou, A., Spisso, B., Spurio, M., Stavropoulos, D., Stellacci, S. M., Taiuti, M., Tayalati, Y., Tenllado, E., Thakore, T., Thiersen, H., Tingay, S., Tsourapis, V., Tzamariudaki, E., Tzanetatos, D., Unbehaun, T., Van Elewyck, V., Vannoye, G., Vasileiadis, G., Vermariën, G., Versari, F., Viola, S., Vivolo, D., de Wasseige, G., Wilms, J., Wojaczyński, R., de Wolf, E., Zavatarelli, S., Zegarelli, A., Zito, D., Zornoza, J. D., Zúñiga, J., and Zywucka, N.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

The KM3NeT research infrastructure is under construction in the Mediterranean Sea. It consists of two water Cherenkov neutrino detectors, ARCA and ORCA, aimed at neutrino astrophysics and oscillation research, respectively. Instrumenting a large volume of sea water with $\sim$ 6,200 optical modules comprising a total of $\sim$ 200,000 photomultiplier tubes, KM3NeT will achieve sensitivity to $\sim$ 10 MeV neutrinos from Galactic and near-Galactic core-collapse supernovae through the observation of coincident hits in photomultipliers above the background. In this paper, the sensitivity of KM3NeT to a supernova explosion is estimated from detailed analyses of background data from the first KM3NeT detection units and simulations of the neutrino signal. The KM3NeT observational horizon (for a $5\,\sigma$ discovery) covers essentially the Milky-Way and for the most optimistic model, extends to the Small Magellanic Cloud ($\sim$ 60 kpc). Detailed studies of the time profile of the neutrino signal allow assessment of the KM3NeT capability to determine the arrival time of the neutrino burst with a few milliseconds precision for sources up to 5$-$8 kpc away, and detecting the peculiar signature of the standing accretion shock instability if the core-collapse supernova explosion happens closer than 3$-$5 kpc, depending on the progenitor mass. KM3NeT's capability to measure the neutrino flux spectral parameters is also presented., Comment: submitted to EPJC

Published
2021
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3. The KM3NeT multi-PMT optical module

Author

Aiello, S., Albert, A., Alshamsi, M., Alves Garre, S., Aly, Z., Ambrosone, A., Ameli, F., Andre, M., Androulakis, G., Anghinolfi, M., Anguita, M., Ardid, M., Ardid, S., Aublin, J., Avgitas, T., Bagatelas, C., Bailly-Salins, L., Baret, B., Basegmez, S., Pree, Bendahman, M., Benfenati, F., Berbee, E., Den Berg, A. M., Bertin, V., Beveren, V., Biagi, S., Boer, R., Boettcher, M., Cabo, M. Bou, Boumaaza, J., Bouta, M., Bouwhuis, M., Bozza, C., Brânzaş, H., Bruijn, R., Brunner, J., Bruno, R., Buis, E., Buompane, R., Busto, J., Cacopardo, G., Caiffi, B., Calvo, D., Campion, S., Capone, A., Víctor Carretero, Castaldi, P., Celli, S., Chabab, M., Champion, C., Chau, N., Chen, A., Cherubini, S., Chiarella, V., Chiarusi, T., Circella, M., Cocimano, Ai R., Coelho, J. A. B., Coleiro, A., Colomer Molla, M., Coniglione, R., Coyle, P., Creusot, A., Cruz, A., Cuttone, G., D Amato, C., D Amico, A., Dallier, R., Benedittis, A., Martino, B., Wasseige, G., Palma, I. Di, Díaz, A. F., Diego-Tortosa, D., Distefano, C., Domi, A., Donzaud, C., Dornic, D., Dörr, M., Drakopoulou, Al E., Drouhin, D., Eberl, T., Eddyamoui, A., Eeden, T., Eijk, D., El Bojaddaini, I., Hedri, S. El, Enzenhöfer, A., Espinosa, V., Fermani, P., Ferrara, G., Filipović, M. D., Filippini, An F., Fransen, J., Fusco, L. A., Gajanana, D., Gal, T., García Méndez, J., Soto, A. García, Garufi, F., Gatelet, Y., Gatius Oliver, C., Geißelbrecht, N., Gialanella, L., Giorgio, E., Gozzini, S. R., Gracia, R., Graf, K., Grella, G., Grmek, A., Gromov, I., Guderian, D., Guidi, C., Guillon, B., Gutiérrez, M., Häfner, J., Haegel, L., Hallmann, S., Hamdaoui, H., Haren, H., Heijboer, A., Hekalo, A., Hennig, Al L., Hernández-Rey, J. J., Hofestädt, J., Huang, F., Idrissi Ibnsalih, W., Ilioni, A., Illuminati, G., James, C. W., Janezashvili, D., Jansweijer, P., Jong, M., Jong, P., Jung, B. J., Kalaczyński, P., Kalekin, O., Katz, U. F., Kayzel, F., Khan Chowdhury, N. R., Kistauri, G., Knaap, F., Kooijman, P., Koopstra, J., Kouchner, A., Kulikovskiy, V., Labalme, M., Lahmann, R., Lamoureux, M., Larosa, G., Lastoria, C., Lazo, A., Le Breton, R., Le Stum, S., Lehaut, G., Leonardi, O., Leone, F., Leonora, E., Lessing, N., Levi, G., Lincetto, M., Clark, M. Lindsey, Llorens Alvarez, C., Longhitano, F., Lopez-Coto, D., Maderer, L., Majumdar, J., Mańczak, J., Margiotta, A., Marinelli, A., Markou, C., Martin, L., Martínez-Mora, J. A., Martini, A., Marzaioli, F., Mastroianni, S., Melis, K. W., Miele, G., Migliozzi, P., Migneco, E., Mijakowski, P., Miranda, L. S., Mollo, C. M., Mongelli, M., Moussa, Ai A., Muller, R., Musumeci, M., Nauta, L., Navas, S., Nicolau, C. A., Nkosi, B., Fearraigh, B. Ó, O Sullivan, M., Organokov, M., Orlando, A., Palacios González, J., Papalashvili, G., Papaleo, R., Passaro, G., Pastore, C., Păun, A. M., Păvălaş, G. E., Pellegrini, G., Pellegrino, C., Perrin-Terrin, M., Pestel, V., Piattelli, P., Pieterse, C., Pisanti, O., Poirè, C., Popa, V., Pradier, T., Probst, I., Pulvirenti, S., Quéméner, G., Randazzo, N., Razzaque, S., Real, D., Reck, S., Riccobene, G., Rocco, R., Romanov, A., Rovelli, A., Salesa Greus, F., Samtleben, D. F. E., Sánchez Losa, A., Sanguineti, M., Santonocito, D., Sapienza, P., Schmeitz, R., Schmelling, J., Schnabel, J., Schneider, M. F., Schumann, J., Schutte, H. M., Seneca, J., Sgura, I., Shanidze, Ai R., Sharma, A., Sinopoulou, A., Smirnov, M. V., Spisso, B., Spurio, M., Stavropoulos, D., Stellacci, S. M., Taiuti, M., Tatone, F., Tayalati, Ai Y., Tedjditi, H., Thiersen, H., Timmer, P., Tingay, S., Tsagkli, S., Tsourapis, V., Tzamariudaki, E., Tzanetatos, D., Valieri, C., Elewyck, V., Vasileiadis, G., Versari, F., Viola, S., Vivolo, D., Wilms, J., Wojaczyński, R., Wolf, E., Yousfi, T., Zavatarelli, S., Zegarelli, A., Zito, D., Zornoza, J. D., Zúñiga, J., Zywucka, N., Aiello S., Albert A., Alshamsi M., Alves Garre S., Aly Z., Ambrosone A., Ameli F., Andre M., Androulakis G., Anghinolfi M., Anguita M., Ardid M., Ardid S., Aublin J., Avgitas T., Bagatelas C., Bailly-Salins L., Baret B., Basegmez Du Pree S., Bendahman M., Benfenati F., Berbee E., Van Den Berg A.M., Bertin V., Van Beveren V., Biagi S., De Boer R., Boettcher M., Bou Cabo M., Boumaaza J., Bouta M., Bouwhuis M., Bozza C., Branzas H., Bruijn R., Brunner J., Bruno R., Buis E., Buompane R., Busto J., Cacopardo G., Caiffi B., Calvo D., Campion S., Capone A., Carretero V., Castaldi P., Celli S., Chabab M., Champion C., Chau N., Chen A., Cherubini S., Chiarella V., Chiarusi T., Circella M., Cocimano R., Coelho J.A.B., Coleiro A., Colomer Molla M., Coniglione R., Coyle P., Creusot A., Cruz A., Cuttone G., D'Amato C., D'Amico A., Dallier R., De Benedittis A., De Martino B., De Wasseige G., Di Palma I., Diaz A.F., Diego-Tortosa D., Distefano C., Domi A., Donzaud C., Dornic D., Dorr M., Drakopoulou E., Drouhin D., Eberl T., Eddyamoui A., Van Eeden T., Van Eijk D., El Bojaddaini I., El Hedri S., Enzenhofer A., Espinosa V., Fermani P., Ferrara G., Filipovic M.D., Filippini F., Fransen J., Fusco L.A., Gajanana D., Gal T., Garcia Mendez J., Garcia Soto A., Garufi F., Gatelet Y., Gatius Oliver C., Geisselbrecht N., Gialanella L., Giorgio E., Gozzini S.R., Gracia R., Graf K., Grella G., Grmek A., Gromov I., Guderian D., Guidi C., Guillon B., Gutierrez M., Hafner J., Haegel L., Hallmann S., Hamdaoui H., Van Haren H., Heijboer A., Hekalo A., Hennig L., Hernandez-Rey J.J., Hofestadt J., Huang F., Idrissi Ibnsalih W., Ilioni A., Illuminati G., James C.W., Janezashvili D., Jansweijer P., De Jong M., De Jong P., Jung B.J., Kalaczynski P., Kalekin O., Katz U.F., Kayzel F., Khan Chowdhury N.R., Kistauri G., Van Der Knaap F., Kooijman P., Koopstra J., Kouchner A., Kulikovskiy V., Labalme M., Lahmann R., Lamoureux M., Larosa G., Lastoria C., Lazo A., Le Breton R., Le Stum S., Lehaut G., Leonardi O., Leone F., Leonora E., Lessing N., Levi G., Lincetto M., Lindsey Clark M., Llorens Alvarez C., Longhitano F., Lopez-Coto D., Maderer L., Majumdar J., Manczak J., Margiotta A., Marinelli A., Markou C., Martin L., Martinez-Mora J.A., Martini A., Marzaioli F., Mastroianni S., Melis K.W., Miele G., Migliozzi P., Migneco E., Mijakowski P., Miranda L.S., Mollo C.M., Mongelli M., Moussa A., Muller R., Musumeci M., Nauta L., Navas S., Nicolau C.A., Nkosi B., Fearraigh B.O., O'Sullivan M., Organokov M., Orlando A., Palacios Gonzalez J., Papalashvili G., Papaleo R., Passaro G., Pastore C., Paun A.M., Pavalas G.E., Pellegrini G., Pellegrino C., Perrin-Terrin M., Pestel V., Piattelli P., Pieterse C., Pisanti O., Poire C., Popa V., Pradier T., Probst I., Pulvirenti S., Quemener G., Randazzo N., Razzaque S., Real D., Reck S., Riccobene G., Rocco R., Romanov A., Rovelli A., Salesa Greus F., Samtleben D.F.E., Sanchez Losa A., Sanguineti M., Santonocito D., Sapienza P., Schmeitz R., Schmelling J., Schnabel J., Schneider M.F., Schumann J., Schutte H.M., Seneca J., Sgura I., Shanidze R., Sharma A., Sinopoulou A., Smirnov M.V., Spisso B., Spurio M., Stavropoulos D., Stellacci S.M., Taiuti M., Tatone F., Tayalati Y., Tedjditi H., Thiersen H., Timmer P., Tingay S., Tsagkli S., Tsourapis V., Tzamariudaki E., Tzanetatos D., Valieri C., Van Elewyck V., Vasileiadis G., Versari F., Viola S., Vivolo D., Wilms J., Wojaczynski R., De Wolf E., Yousfi T., Zavatarelli S., Zegarelli A., Zito D., Zornoza J.D., Zuniga J., Zywucka N., Groupe de Recherche en Physique des Hautes Energies (GRPHE), Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-IUT de Colmar, Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA)), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Laboratoire de physique subatomique et des technologies associées (SUBATECH), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Nantes université - UFR des Sciences et des Techniques (Nantes univ - UFR ST), Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Laboratoire de physique corpusculaire de Caen (LPCC), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), Laboratoire Univers et Particules de Montpellier (LUPM), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), KM3NeT, Aiello, S., Albert, A., Alshamsi, M., Alves Garre, S., Aly, Z., Ambrosone, A., Ameli, F., Andre, M., Androulakis, G., Anghinolfi, M., Anguita, M., Ardid, M., Ardid, S., Aublin, J., Avgitas, T., Bagatelas, C., Bailly-Salins, L., Baret, B., Basegmez Du Pree, S., Bendahman, M., Benfenati, F., Berbee, E., Van Den Berg, A. M., Bertin, V., Van Beveren, V., Biagi, S., De Boer, R., Boettcher, M., Bou Cabo, M., Boumaaza, J., Bouta, M., Bouwhuis, M., Bozza, C., Branzas, H., Bruijn, R., Brunner, J., Bruno, R., Buis, E., Buompane, R., Busto, J., Cacopardo, G., Caiffi, B., Calvo, D., Campion, S., Capone, A., Carretero, V., Castaldi, P., Celli, S., Chabab, M., Champion, C., Chau, N., Chen, A., Cherubini, S., Chiarella, V., Chiarusi, T., Circella, M., Cocimano, R., Coelho, J. A. B., Coleiro, A., Colomer Molla, M., Coniglione, R., Coyle, P., Creusot, A., Cruz, A., Cuttone, G., D'Amato, C., D'Amico, A., Dallier, R., De Benedittis, A., De Martino, B., De Wasseige, G., Di Palma, I., Diaz, A. F., Diego-Tortosa, D., Distefano, C., Domi, A., Donzaud, C., Dornic, D., Dorr, M., Drakopoulou, E., Drouhin, D., Eberl, T., Eddyamoui, A., Van Eeden, T., Van Eijk, D., El Bojaddaini, I., El Hedri, S., Enzenhofer, A., Espinosa, V., Fermani, P., Ferrara, G., Filipovic, M. D., Filippini, F., Fransen, J., Fusco, L. A., Gajanana, D., Gal, T., Garcia Mendez, J., Garcia Soto, A., Garufi, F., Gatelet, Y., Gatius Oliver, C., Geisselbrecht, N., Gialanella, L., Giorgio, E., Gozzini, S. R., Gracia, R., Graf, K., Grella, G., Grmek, A., Gromov, I., Guderian, D., Guidi, C., Guillon, B., Gutierrez, M., Hafner, J., Haegel, L., Hallmann, S., Hamdaoui, H., Van Haren, H., Heijboer, A., Hekalo, A., Hennig, L., Hernandez-Rey, J. J., Hofestadt, J., Huang, F., Idrissi Ibnsalih, W., Ilioni, A., Illuminati, G., James, C. W., Janezashvili, D., Jansweijer, P., De Jong, M., De Jong, P., Jung, B. J., Kalaczynski, P., Kalekin, O., Katz, U. F., Kayzel, F., Khan Chowdhury, N. R., Kistauri, G., Van Der Knaap, F., Kooijman, P., Koopstra, J., Kouchner, A., Kulikovskiy, V., Labalme, M., Lahmann, R., Lamoureux, M., Larosa, G., Lastoria, C., Lazo, A., Le Breton, R., Le Stum, S., Lehaut, G., Leonardi, O., Leone, F., Leonora, E., Lessing, N., Levi, G., Lincetto, M., Lindsey Clark, M., Llorens Alvarez, C., Longhitano, F., Lopez-Coto, D., Maderer, L., Majumdar, J., Manczak, J., Margiotta, A., Marinelli, A., Markou, C., Martin, L., Martinez-Mora, J. A., Martini, A., Marzaioli, F., Mastroianni, S., Melis, K. W., Miele, G., Migliozzi, P., Migneco, E., Mijakowski, P., Miranda, L. S., Mollo, C. M., Mongelli, M., Moussa, A., Muller, R., Musumeci, M., Nauta, L., Navas, S., Nicolau, C. A., Nkosi, B., Fearraigh, B. O., O'Sullivan, M., Organokov, M., Orlando, A., Palacios Gonzalez, J., Papalashvili, G., Papaleo, R., Passaro, G., Pastore, C., Paun, A. M., Pavalas, G. E., Pellegrini, G., Pellegrino, C., Perrin-Terrin, M., Pestel, V., Piattelli, P., Pieterse, C., Pisanti, O., Poire, C., Popa, V., Pradier, T., Probst, I., Pulvirenti, S., Quemener, G., Randazzo, N., Razzaque, S., Real, D., Reck, S., Riccobene, G., Rocco, R., Romanov, A., Rovelli, A., Salesa Greus, F., Samtleben, D. F. E., Sanchez Losa, A., Sanguineti, M., Santonocito, D., Sapienza, P., Schmeitz, R., Schmelling, J., Schnabel, J., Schneider, M. F., Schumann, J., Schutte, H. M., Seneca, J., Sgura, I., Shanidze, R., Sharma, A., Sinopoulou, A., Smirnov, M. V., Spisso, B., Spurio, M., Stavropoulos, D., Stellacci, S. M., Taiuti, M., Tatone, F., Tayalati, Y., Tedjditi, H., Thiersen, H., Timmer, P., Tingay, S., Tsagkli, S., Tsourapis, V., Tzamariudaki, E., Tzanetatos, D., Valieri, C., Van Elewyck, V., Vasileiadis, G., Versari, F., Viola, S., Vivolo, D., Wilms, J., Wojaczynski, R., De Wolf, E., Yousfi, T., Zavatarelli, S., Zegarelli, A., Zito, D., Zornoza, J. D., Zuniga, J., Zywucka, N., Research unit Astroparticle Physics, Centre Tecnològic de Vilanova i la Geltrú, and Universitat Politècnica de Catalunya. LAB - Laboratori d'Aplicacions Bioacústiques

Subjects
Astrofísica, Physics - Instrumentation and Detectors, data acquisition, Physics::Instrumentation and Detectors, tube, water, Física::Física de partícules [Àrees temàtiques de la UPC], FOS: Physical sciences, radiation: induced, GeV, Physique [physics]/Physique [physics], model: production, optical, Cherenkov detectors, Large detector systems for particle and astroparticle physics, Neutrino detectors, Neutrins, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Instrumentation, Instrumentation and Methods for Astrophysics (astro-ph.IM), KM3NeT, Mathematical Physics, neutrino: interaction, background: suppression, glass, photomultiplier, Telescopis, photon, Astrophysics::Instrumentation and Methods for Astrophysics, Instrumentation and Detectors (physics.ins-det), radiation: Cherenkov, calibration, sensitivity, cascade, neutrino: detector, FISICA APLICADA, Large detector systems for particle and astroparticle physic, ddc:520, readout, sphere, Òptica -- Aparells i instruments, Astrophysics - Instrumentation and Methods for Astrophysics, Telescopes, Cherenkov detector
Abstract

The optical module of the KM3NeT neutrino telescope is an innovative multi-faceted large area photodetection module. It contains 31 three-inch photomultiplier tubes in a single 0.44m diameter pressure-resistant glass sphere. The module is a sensory device also comprising calibration instruments and electronics for power, readout and data acquisition. It is capped with a breakout-box with electronics for connection to an electro-optical cable for power and long-distance communication to the onshore control station. The design of the module was qualified for the first time in the deep sea in 2013. Since then, the technology has been further improved to meet requirements of scalability, cost-effectiveness and high reliability. The module features a sub-nanosecond timing accuracy and a dynamic range allowing the measurement of a single photon up to a cascade of thousands of photons, suited for the measurement of the Cherenkov radiation induced in water by secondary particles from interactions of neutrinos with energies in the range of GeV to PeV. A distributed production model has been implemented for the delivery of more than 6000 modules in the coming few years with an average production rate of more than 100 modules per month. In this paper a review is presented of the design of the multi-PMT KM3NeT optical module with a proven effective background suppression and signal recognition and sensitivity to the incoming direction of photons., French National Research Agency (ANR) ANR-15-CE31-0020 Centre National de la Recherche Scientifique (CNRS), Commission Europeenne (FEDER fund) Commission Europeenne (Marie Curie Program), Institut Universitaire de France (IUF), LabEx UnivEarthS ANR-10-LABX-0023 ANR-18-IDEX-0001, Paris Ile-de-France Region, France, Shota Rustaveli National Science Foundation of Georgia (SRNSFG), Georgia FR-18-1268, German Research Foundation (DFG), Greek Ministry of Development-GSRT, Istituto Nazionale di Fisica Nucleare (INFN), Ministero dell'Universita e della Ricerca (MIUR), PRIN 2017 program, Italy NAT-NET 2017W4HA7S, Ministry of Higher Education, Scientific Research and Innovation, Morocco, Arab Fund for Economic and Social Development, Nederlandse organisatie voor Wetenschappelk Onderzoek (NWO), the Netherlands, National Science Centre, Poland 2015/18/E/ST2/00758, National Authority for Scientific Research (ANCS), Romania, Ministerio de Ciencia, Innovacion, Investigacion y Universidades (MCIU): Programa Estatal de Generacion de Conocimiento PGC2018-096663-B-C41 PGC2018-096663-A C42 PGC2018-096663-B-C43 PGC2018-096663-B-C44, Center for Forestry Research & Experimentation (CIEF) PROMETEO/2020/019, Generalitat Valenciana: Grisolia program GRISOLIA/2018/119 GRISOLIA/2021/192 Generalitat Valenciana: GenT program CIDEGENT/2018/034 CIDEGENT/2019/043 CIDEGENT/2020/049 CIDEGENT/2021/023, Junta de Andalucia AFQM-053-UGR18, La Caixa Foundation LCF/BQ/IN17/11620019, EU: MSC program, Spain 101025085

Published
2022
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4. Management of antithrombotic treatment and bleeding disorders in patients requiring venous access devices: A systematic review and a GAVeCeLT consensus statement

Author

Annetta, Maria Giuseppina, Bertoglio, Sergio, Biffi, R., Brescia, F., Giarretta, Igor, Greca, A. L., Panocchia, Nicola, Passaro, G., Perna, Francesco, Pinelli, F., Pittiruti, Mauro, Prisco, D., Sanna, Tommaso, Scoppettuolo, Giancarlo, Annetta M. G. (ORCID:0000-0001-7574-1311), Bertoglio S., Giarretta I. (ORCID:0000-0001-5380-0843), Panocchia N., Perna F., Pittiruti M. (ORCID:0000-0003-4541-7566), Sanna T. (ORCID:0000-0002-5760-6885), Scoppettuolo G., Annetta, Maria Giuseppina, Bertoglio, Sergio, Biffi, R., Brescia, F., Giarretta, Igor, Greca, A. L., Panocchia, Nicola, Passaro, G., Perna, Francesco, Pinelli, F., Pittiruti, Mauro, Prisco, D., Sanna, Tommaso, Scoppettuolo, Giancarlo, Annetta M. G. (ORCID:0000-0001-7574-1311), Bertoglio S., Giarretta I. (ORCID:0000-0001-5380-0843), Panocchia N., Perna F., Pittiruti M. (ORCID:0000-0003-4541-7566), Sanna T. (ORCID:0000-0002-5760-6885), and Scoppettuolo G.

Abstract

Insertion of venous access devices (VAD) is usually considered a procedure with low risk of bleeding. Nonetheless, insertion of some devices is invasive enough to be associated with bleeding, especially in patients with previous coagulopathy or in treatment with antithrombotic drugs for cardiovascular disease. The current practices of platelet/plasma transfusion in coagulopathic patients and of temporary suspension of the antithrombotic treatment before VAD insertion are based on local policies and are often inadequately supported by evidence, since many of the clinical studies on this topic are not recent and are not of high quality. Furthermore, the protocols of antithrombotic treatment have changed during the last decade, after the introduction of new oral anticoagulant drugs. Though some guidelines address some of these issues in relation with specific procedures (port insertion, etc.), no evidence-based document covering all the aspects of this clinical problem is currently available. Thus, the Italian Group of Venous Access Devices (GAVeCeLT) has decided to develop a consensus on the management of antithrombotic treatment and bleeding disorders in patients requiring VADs. After a systematic review of the available evidence, the panel of the consensus (which included vascular access specialists, surgeons, intensivists, anesthetists, cardiologists, vascular medicine experts, nephrologists, infective disease specialists, and thrombotic disease specialists) has structured the final recommendations as detailed answers to three sets of questions: (1) which is an appropriate classification of VAD-related procedures based on the specific bleeding risk? (2) Which is the appropriate management of the patient with bleeding disorders candidate to VAD insertion/removal? (3) Which is the appropriate management of the patient on antithrombotic treatment candidate to VAD insertion/removal? Only statements reaching a complete agreement were included in the final recommendation

Published
2022

5. Post-mortem diagnosis of sepsis: when it's too late

Author

Passaro, G., Dell'Aquila, M., de Filippis, A., Baronti, A., Costantino, A., Iannaccone, F., and de Matteis, A.

Subjects
Male, forensic medicine, immunoassays, immunohistochemistry, microbiological diagnosis, pathological anatomy, post-mortem diagnosis, proteomics, sepsis, Reproducibility of Results, Forensic Medicine, Immunohistochemistry, Sepsis, Humans, Female, Autopsy, Aged
Abstract

Post-mortem diagnosis of sepsis is often very difficult to make, especially in the elderly affected by multiple comorbidities. However, clinical evaluation following histology, immunohistochemistry, microbiological tests, immunoassays and proteomics can improve reliability of this post-mortem diagnosis.

Published
2020

6. Widening the application range of the FARCOS frontend electronics

Author

Castoldi, A., Guazzoni, C., Sicari, V. L., Acosta, L., Auditore, L., de Luca, S., Norella, S., Trifiro, A., Trimarchi, M., Boiano, C., Cardella, G., D'Andrea, M., de Filippo, E., Favela, F., Fichera, F., Grimaldi, A., Librizzi, F., Pagano, A., Papa, M., Pirrone, S., Sacca, G., Salemi, G., Sciliberto, D., Geraci, E., Giudice, N., Gnoffo, B., Politi, G., Quattrocchi, L., Lanzalone, G., Maiolino, C., Pagano, E. V., Passaro, G., Russotto, P., Martorana, N. S., and Rizzo, F.

Subjects
Correlation , Conferences , Detectors , Telescopes , Tools , Dynamic range , Calibration, Dynamic range, sezele, Computer science, business.industry, Detector, Conferences, Detectors, Modular design, Correlation, Tools, Range (aeronautics), Calibration, Granularity, Electronics, business, Computer hardware, Telescopes
Abstract

FARCOS is a modular detection system intended to extend the capacity of 4π detectors both with higher granularity and resolution and with the ability to perform correlation measurements. The system, equipped at the present stage with the first 10 telescopes worked properly in the first experiments on beam paving the way to the construction of the remaining 10 telescopes that is presently under the way. To cope with the updated experimental cases FARCOS can investigate, we redesigned the frontend electronics board, widening the granularity of the selectable dynamic ranges and optimizing the slow control and calibration tools. In addition, we report on the successful commissioning of the FARCOS system.

Published
2020
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7. Delta-procalcitonin and vitamin d can predict mortality of internal medicine patients with microbiological identified sepsis

Author

Tosoni, A., Cossari, A., Paratore, M., Impagnatiello, M., Passaro, G., Vallone, C. V., Zaccone, V., Gasbarrini, A., Addolorato, G., De Cosmo, S., Mirijello, A., Tosoni A., Paratore M., Impagnatiello M., Gasbarrini A. (ORCID:0000-0002-7278-4823), Addolorato G. (ORCID:0000-0002-1522-9946), Mirijello A., Tosoni, A., Cossari, A., Paratore, M., Impagnatiello, M., Passaro, G., Vallone, C. V., Zaccone, V., Gasbarrini, A., Addolorato, G., De Cosmo, S., Mirijello, A., Tosoni A., Paratore M., Impagnatiello M., Gasbarrini A. (ORCID:0000-0002-7278-4823), Addolorato G. (ORCID:0000-0002-1522-9946), and Mirijello A.

Abstract

Background: The management of septic patients hospitalized in Internal Medicine wards represents a challenge due to their complexity and heterogeneity, and a high mortality rate. Among the available prognostic tools, procalcitonin (PCT) is considered a marker of bacterial infection. Fur-thermore, an association between vitamin D deficiency and poor sepsis-related outcomes has been described. Objectives: To evaluate the prognostic accuracy of two consecutive PCT determinations (Delta-PCT) and of vitamin D levels in predicting mortality in a population of patients with microbiological identified sepsis admitted to Internal Medicine wards. Methods: This is a sub-analysis of a previous prospective study. A total of 80 patients had at least two available consecutive PCT determinations, while 63 had also vitamin D. Delta-PCT was defined as a reduction of PCT > 50% after 48 h, >75% after 72 h, and >85% after 96 h. Mortality rate at 28-and 90-days were considered as main outcome. Results: Mortality rate was 18.7% at 28-days and 30.0% at 90-days. Baseline PCT levels did not differ between survived and deceased patients (28-days: p = 0.525; 90-days: p = 0.088). A significantly higher proportion of survived patients showed Delta-PCT (28-days: p = 0.002; 90-days: p < 0.001). Delta-PCT was associated with a lower 28-days (p = 0.007; OR = 0.12, 95%CI 0.02–0.46) and 90-days mortality (p = 0.001; OR = 0.17, 95%CI 0.06–0.48). A significantly higher proportion of deceased patients showed severe vitamin D deficiency (28-days: p = 0.047; 90-days: p = 0.049). Severe vitamin D deficiency was associated with a higher 28-days (p = 0.058; OR = 3.95, 95%CI 1.04–19.43) and 90-days mortality (p = 0.054; OR = 2.94, 95%CI 1.00–9.23). Conclusions: Delta-PCT and vitamin D represent two useful tests for predicting prognosis of septic patients admitted to Internal Medicine wards.

Published
2021

8. The KM3NeT potential for the next core-collapse supernova observation with neutrinos

Author

Aiello, S., primary, Albert, A., additional, Garre, S. Alves, additional, Aly, Z., additional, Ambrosone, A., additional, Ameli, F., additional, Andre, M., additional, Androulakis, G., additional, Anghinolfi, M., additional, Anguita, M., additional, Anton, G., additional, Ardid, M., additional, Ardid, S., additional, Aublin, J., additional, Bagatelas, C., additional, Baret, B., additional, Pree, S. Basegmez du, additional, Bendahman, M., additional, Benfenati, F., additional, Berbee, E., additional, Berg, A. M. van den, additional, Bertin, V., additional, Biagi, S., additional, Bissinger, M., additional, Boettcher, M., additional, Cabo, M. Bou, additional, Boumaaza, J., additional, Bouta, M., additional, Bouwhuis, M., additional, Bozza, C., additional, Brânzaş, H., additional, Bruijn, R., additional, Brunner, J., additional, Buis, E., additional, Buompane, R., additional, Busto, J., additional, Caiffi, B., additional, Calvo, D., additional, Capone, A., additional, Carretero, V., additional, Castaldi, P., additional, Celli, S., additional, Chabab, M., additional, Chau, N., additional, Chen, A., additional, Cherubini, S., additional, Chiarella, V., additional, Chiarusi, T., additional, Circella, M., additional, Cocimano, R., additional, Coelho, J. A. B., additional, Coleiro, A., additional, Molla, M. Colomer, additional, Coniglione, R., additional, Coyle, P., additional, Creusot, A., additional, Cuttone, G., additional, Dallier, R., additional, De Martino, B., additional, De Palma, M., additional, Di Marino, M., additional, Di Palma, I., additional, Díaz, A. F., additional, Diego-Tortosa, D., additional, Distefano, C., additional, Domi, A., additional, Donzaud, C., additional, Dornic, D., additional, Dörr, M., additional, Drouhin, D., additional, Eberl, T., additional, Eddyamoui, A., additional, van Eeden, T., additional, van Eijk, D., additional, El Bojaddaini, I., additional, Elsaesser, D., additional, Enzenhöfer, A., additional, Espinosa, V., additional, Fermani, P., additional, Ferrara, G., additional, Filipović, M. D., additional, Filippini, F., additional, Fusco, L. A., additional, Gabella, O., additional, Gal, T., additional, Soto, A. Garcia, additional, Garufi, F., additional, Gatelet, Y., additional, Geißelbrecht, N., additional, Gialanella, L., additional, Giorgio, E., additional, Gozzini, S. R., additional, Gracia, R., additional, Graf, K., additional, Grasso, D., additional, Grella, G., additional, Guderian, D., additional, Guidi, C., additional, Haefner, J., additional, Hamdaoui, H., additional, van Haren, H., additional, Heijboer, A., additional, Hekalo, A., additional, Hennig, L., additional, Hernández-Rey, J. J., additional, Hofestädt, J., additional, Huang, F., additional, Ibnsalih, W. Idrissi, additional, Illuminati, G., additional, James, C. W., additional, de Jong, M., additional, de Jong, P., additional, Jung, B. J., additional, Kadler, M., additional, Kalaczyński, P., additional, Kalekin, O., additional, Katz, U. F., additional, Chowdhury, N. R. Khan, additional, Kistauri, G., additional, van der Knaap, F., additional, Kooijman, P., additional, Kouchner, A., additional, Kreter, M., additional, Kulikovskiy, V., additional, Lahmann, R., additional, Lamoureux, M., additional, Larosa, G., additional, Le Breton, R., additional, Le Stum, S., additional, Leonardi, O., additional, Leone, F., additional, Leonora, E., additional, Lessing, N., additional, Levi, G., additional, Lincetto, M., additional, Clark, M. Lindsey, additional, Lipreau, T., additional, Longhitano, F., additional, Lopez-Coto, D., additional, Maderer, L., additional, Mańczak, J., additional, Mannheim, K., additional, Margiotta, A., additional, Marinelli, A., additional, Markou, C., additional, Martin, L., additional, Martínez-Mora, J. A., additional, Martini, A., additional, Marzaioli, F., additional, Mastroianni, S., additional, Mazzou, S., additional, Melis, K. W., additional, Miele, G., additional, Migliozzi, P., additional, Migneco, E., additional, Mijakowski, P., additional, Miranda, L. S., additional, Mollo, C. M., additional, Morganti, M., additional, Moser, M., additional, Moussa, A., additional, Muller, R., additional, Musumeci, M., additional, Nauta, L., additional, Navas, S., additional, Nicolau, C. A., additional, Fearraigh, B. Ó, additional, O’Sullivan, M., additional, Organokov, M., additional, Orlando, A., additional, González, J. Palacios, additional, Papalashvili, G., additional, Papaleo, R., additional, Passaro, G., additional, Pastore, C., additional, Păun, A. M., additional, Păvălaş, G. E., additional, Pellegrino, C., additional, Perrin-Terrin, M., additional, Pestel, V., additional, Piattelli, P., additional, Pieterse, C., additional, Pikounis, K., additional, Pisanti, O., additional, Poirè, C., additional, Popa, V., additional, Pradier, T., additional, Pühlhofer, G., additional, Pulvirenti, S., additional, Rabyang, O., additional, Raffaelli, F., additional, Randazzo, N., additional, Razzaque, S., additional, Real, D., additional, Reck, S., additional, Riccobene, G., additional, Rivoire, S., additional, Romanov, A., additional, Rovelli, A., additional, Greus, F. Salesa, additional, Samtleben, D. F. E., additional, Losa, A. Sánchez, additional, Sanguineti, M., additional, Santangelo, A., additional, Santonocito, D., additional, Sapienza, P., additional, Schnabel, J., additional, Schneider, M. F., additional, Schumann, J., additional, Schutte, H. M., additional, Seneca, J., additional, Sgura, I., additional, Shanidze, R., additional, Sharma, A., additional, Simeone, F., additional, Sinopoulou, A., additional, Spisso, B., additional, Spurio, M., additional, Stavropoulos, D., additional, Stellacci, S. M., additional, Taiuti, M., additional, Tayalati, Y., additional, Tenllado, E., additional, Thakore, T., additional, Thiersen, H., additional, Tingay, S., additional, Tsourapis, V., additional, Tzamariudaki, E., additional, Tzanetatos, D., additional, Unbehaun, T., additional, Van Elewyck, V., additional, Vannoye, G., additional, Vasileiadis, G., additional, Versari, F., additional, Viola, S., additional, Vivolo, D., additional, de Wasseige, G., additional, Wilms, J., additional, Wojaczyński, R., additional, de Wolf, E., additional, Zavatarelli, S., additional, Zegarelli, A., additional, Zito, D., additional, Zornoza, J. D., additional, Zúñiga, J., additional, and Zywucka, N., additional

Published
2021
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9. Narcos project for nuclear physics and applications

Author

Pagano, E. V., Auditore, L., Cardella, G., D'Andrea, M., de Filippo, E., Geraci, E., Gnoffo, B., Guazzoni, C., Grimaldi, A., Lanzalone, G., Maiolino, C., Martorana, N. S., Pagano, A., Papa, M., Passaro, G., Pirrone, S., Politi, G., Porto, F., Rizzo, F., Russotto, P., Sacca, G., and Trimarchi, M.

Subjects
sezele
Published
2020

10. MEDS score and vitamin D status are independent predictors of mortality in a cohort of Internal Medicine patients with microbiological identified sepsis

Author

Mirijello, Antonio, Tosoni, A, Zaccone, V, Impagnatiello, M, Passaro, G, Vallone, C V, Cossari, A, Ventura, Giulio, Gambassi, Giovanni, De Cosmo, S, Gasbarrini, Antonio, Addolorato, Giovanni, Landolfi, Raffaele, Mirijello, A, Ventura, G (ORCID:0000-0002-0304-7264), Gambassi, G (ORCID:0000-0002-7030-9359), Gasbarrini, A (ORCID:0000-0002-7278-4823), Addolorato, G (ORCID:0000-0002-1522-9946), Landolfi, R (ORCID:0000-0002-7913-8576), Mirijello, Antonio, Tosoni, A, Zaccone, V, Impagnatiello, M, Passaro, G, Vallone, C V, Cossari, A, Ventura, Giulio, Gambassi, Giovanni, De Cosmo, S, Gasbarrini, Antonio, Addolorato, Giovanni, Landolfi, Raffaele, Mirijello, A, Ventura, G (ORCID:0000-0002-0304-7264), Gambassi, G (ORCID:0000-0002-7030-9359), Gasbarrini, A (ORCID:0000-0002-7278-4823), Addolorato, G (ORCID:0000-0002-1522-9946), and Landolfi, R (ORCID:0000-0002-7913-8576)

Abstract

N/A

Published
2019

11. Past and future detector arrays for complete event reconstruction in heavy-ion reactions

Author

Cardella, Giuseppe, Acosta, L., Auditore, L., Boiano, C., Castoldi, Andrea, D'Andrea, M., De Filippo, E., Dell'Aquila, D., De Luca, S., Fichera, F., Giudice, N., Gnoffo, B., Grimaldi, A., Guazzoni, Chiara, Lanzalone, G., Librizzi, F., Lombardo, I., Maiolino, C., Maffesanti, Stefano, Martorana, N. S., Norella, S., Pagano, A., Pagano, E. V., Papa, M., Parsani, Tommaso, Passaro, G., Pirrone, S., Politi, Greta, Previdi, Fabio, Quattrocchi, L., Rizzo, F., Russotto, P., Sacca, G., Salemi, Giuseppe, Sciliberto, D., Trifiro, A., Trimarchi, M., Vigilante, M., Cardella, G., Acosta, L., Auditore, L., Boiano, C., Castoldi, A., D'Andrea, M., De Filippo, E., Dell Aquila, D., De Luca, S., Fichera, F., Giudice, N., Gnoffo, B., Grimaldi, A., Guazzoni, C., Lanzalone, G., Librizzi, F., Lombardo, I., Maiolino, C., Maffesanti, S., Martorana, N. S., Norella, S., Pagano, A., Pagano, E. V., Papa, M., Parsani, T., Passaro, G., Pirrone, S., Politi, G., Previdi, F., Quattrocchi, L., Rizzo, F., Russotto, P., Saccà, G., Salemi, G., Sciliberto, D., Trifirò, A., Trimarchi, M., and Vigilante, M.

Subjects
sezele, Physics and Astronomy (miscellaneous), PERFORMANCE, Astronomy and Astrophysic, LNS, particle physics, particle detector, detector array, nuclear instrumentation, CATANIA, Settore ING-INF/04 - Automatica, EXOTIC BEAMS, CHIMERA, FRAGMENTATION, PERFORMANCE, CATANIA, LNS, EXOTIC BEAMS, CHIMERA, FRAGMENTATION
Published
2016

12. Integration of the GET electronics for the CHIMERA and FARCOS devices

Author

De Filippo, E, primary, Acosta, L, additional, Auditore, L, additional, Boiano, C, additional, Cardella, G, additional, Castoldi, A, additional, D’Andrea, M, additional, De Luca, S, additional, Favela, F, additional, Fichera, F, additional, Giudice, N, additional, Gnoffo, B, additional, Grimaldi, A, additional, Guazzoni, C, additional, Lanzalone, G, additional, Librizzi, F, additional, Litrico, P, additional, Maiolino, C, additional, Maffesanti, S, additional, Martorana, NS, additional, Pagano, A, additional, Pagano, EV, additional, Papa, M, additional, Parsani, T, additional, Passaro, G, additional, Pirrone, S, additional, Politi, G, additional, Previdi, F, additional, Quattrocchi, L, additional, Rizzo, F, additional, Russotto, P, additional, Saccà, G, additional, Salemi, G, additional, Sciliberto, D, additional, Trifirò, A, additional, and Trimarchi, M, additional

Published
2018
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13. Sepsis in Internal Medicine wards: current knowledge, uncertainties and new approaches for management optimization

Author

Zaccone, V., Tosoni, Alessio, Passaro, G., Vallone, C. V., Impagnatiello, M., Li Puma, Domenica Donatella, De Cosmo, S., Landolfi, Raffaele, Mirijello, Antonio, Carughi, S., Greco, Anna Lucia, Cossari, A., Malci, F., and Ventura, Giulio

Subjects
medicine.medical_specialty, Point-of-Care Systems, Settore BIO/09 - FISIOLOGIA, Population, Risk Assessment, Severity of Illness Index, Procalcitonin, Sepsis, 03 medical and health sciences, 0302 clinical medicine, qSOFA, Cost of Illness, Intensive care, Internal medicine, medicine, Internal Medicine, Prevalence, SOFA, Humans, 030212 general & internal medicine, Hospital Mortality, Risk factor, Intensive care medicine, education, Ultrasonography, education.field_of_study, business.industry, Organ dysfunction, 030208 emergency & critical care medicine, General Medicine, medicine.disease, Anti-Bacterial Agents, Hospitalization, Intensive Care Units, Practice Guidelines as Topic, SOFA score, medicine.symptom, Risk assessment, business
Abstract

Sepsis represents a global health problem in terms of morbidity, mortality, social and economic costs. Although usually managed in Intensive Care Units, sepsis showed an increased prevalence among Internal Medicine wards in the last decade. This is substantially due to the ageing of population and to multi-morbidity. These characteristics represent both a risk factor for sepsis and a relative contra-indication for the admission to Intensive Care Units. Although there is a lack of literature on the management of sepsis in Internal Medicine, the outcome of these patients seems to be gradually improving. This is due to Internists' increased adherence to guidelines and "bundles". The routine use of SOFA score helps physicians in the definition of septic patients, even if the optimal score has still to come. Point-of-care ultrasonography, lactates, procalcitonin and beta-d-glucan are of help for treatment optimization. The purpose of this narrative review is to focus on the management of sepsis in Internal Medicine departments, particularly on crucial concepts regarding diagnosis, risk assessment and treatment. Key Messages Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. The prevalence of sepsis is constantly increasing, affecting more hospital patients than any other disease. At least half of patients affected by sepsis are admitted to Internal Medicine wards. Adherence to guidelines, routine use of clinical and lab scores and point-of-care ultrasonography are of help for early recognition of septic patients and treatment optimization.

Published
2017

15. A GEANT4 web-based application to support intra-operative electron radio-therapy using the European grid infrastructure

Author

Casarino, C, Russo, G, Candiano, G C, La Rocca, G, Barbera, R, Borasi, G, Guatelli, S, Messa, C, Passaro, G, Gilardi, M C, Casarino, C, Russo, G, Candiano, G C, La Rocca, G, Barbera, R, Borasi, G, Guatelli, S, Messa, C, Passaro, G, and Gilardi, M C

Abstract

Radiotherapy techniques deliver ionizing radiations (X-rays, photons, electrons, protons, etc.) inside cancerous tissues to kill the abnormal cells. Radiotherapy-related activities such as the optimization of the therapeutic radiation dose to patients, workers' radioprotection, linear accelerator commissioning, quality assurance processes and technical innovations of linear accelerators are strongly based on the ability to predict the dose distribution. Monte Carlo based simulations are so far the most accurate tool for the calculation of dosimetric parameters, with the drawback of requiring extensive computing resources to achieve statistically meaningful results in a reasonable time frame. In the last years, advanced cancer treatment clinical and research communities have used e-Infrastructures to support their activities. The present paper reports on the development of a computing facility for helping clinical researchers in using modern R&E networking and distributed computing and storage resources for a new radiotherapy technique: the Intra-Operative Electron Radiotherapy. The web application developed addresses some technical and clinical needs as the design of linear accelerators' collimation systems and the optimization of the patient therapeutic dose distribution.

Published
2015

16. A GEANT4 web-based application to support Intra-Operative Electron Radiotherapy using the European grid infrastructure

Author

Casarino, C, Russo, G, Candiano, G, La Rocca, G, Barbera, R, Borasi, G, Guatelli, S, Messa, C, Passaro, G, Gilardi, M, Candiano, GC, Gilardi, MC, Casarino, C, Russo, G, Candiano, G, La Rocca, G, Barbera, R, Borasi, G, Guatelli, S, Messa, C, Passaro, G, Gilardi, M, Candiano, GC, and Gilardi, MC

Abstract

Summary Radiotherapy techniques deliver ionizing radiations (X-rays, photons, electrons, protons, etc.) inside cancerous tissues to kill the abnormal cells. Radiotherapy-related activities such as the optimization of the therapeutic radiation dose to patients, workers' radioprotection, linear accelerator commissioning, quality assurance processes and technical innovations of linear accelerators are strongly based on the ability to predict the dose distribution. Monte Carlo based simulations are so far the most accurate tool for the calculation of dosimetric parameters, with the drawback of requiring extensive computing resources to achieve statistically meaningful results in a reasonable time frame. In the last years, advanced cancer treatment clinical and research communities have used e-Infrastructures to support their activities. The present paper reports on the development of a computing facility for helping clinical researchers in using modern R&E networking and distributed computing and storage resources for a new radiotherapy technique: the Intra-Operative Electron Radiotherapy. The web application developed addresses some technical and clinical needs as the design of linear accelerators' collimation systems and the optimization of the patient therapeutic dose distribution.

Published
2015

19. THE POSITION START DETECTOR FOR THE MAGNEX SPECTROMETER

Author

Orrigo, Sea, Cappuzzello, Francesco, Cunsolo, A, Cavallaro, M, Foti, Antonino, Rodrigues, M. R. D., Calì, C., Litrico, P., Marino, S., Passaro, G., Costa, E., Marchetta, C., Trovato, B., and Petrascu, H.

Published
2006

20. Isospin Against Size Effects In Projectile Dynamical Fission For112,124Sn+58,64Niand124Xe+64ZnReactions At 35 A.MeV

Author

Russotto, P, primary, Filippo, E De, additional, Pagano, A, additional, Piasecki, E, additional, Acosta, L, additional, Amorini, F, additional, Anzalone, A, additional, Auditore, L, additional, Baran, V, additional, Berceanu, I, additional, Boiano, C, additional, Borderie, B, additional, Bruno, M, additional, Cap, T, additional, Cardella, G, additional, Castoldi, A, additional, Cavallaro, S, additional, Chatterjee, M B, additional, Chbihi, A, additional, Colonna, M, additional, D'Agostino, M, additional, D'Andrea, M, additional, Toro, M Di, additional, Fichera, F, additional, Francalanza, L, additional, Geraci, E, additional, Gianì, R, additional, Gnoffo, B, additional, Grimaldi, A, additional, Grzeszczuk, A, additional, Guazzoni, C, additional, Guazzoni, P, additional, Giudice, N, additional, Kowalski, S, additional, Guidara, E La, additional, Lanzalone, G, additional, Lanzanò, G, additional, Lombardo, I, additional, Maiolino, C, additional, Marquínez-Durán, G, additional, Minniti, T, additional, Papa, M, additional, Pagano, E V, additional, Passaro, G, additional, Pirrone, S, additional, Płaneta, R, additional, Politi, G, additional, Porto, F, additional, Quattrocchi, L, additional, Rivet, M F, additional, Rosato, E, additional, Riccio, F, additional, Rizzo, F, additional, Saccà, G, additional, Schmidt, K, additional, Siwek-Wilczyńska, K, additional, Skwira-Chalot, I, additional, Trifirò, A, additional, Trimarchi, M, additional, Verde, G, additional, Vigilante, M, additional, Wieleczko, J P, additional, Wilczyński, J, additional, Zambon, P, additional, Zetta, L, additional, and Zipper, W, additional

Published
2014
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22. Codice di diritto tributario

Author

Tesauro, F, Passaro, G, TESAURO, FRANCESCO, Passaro, G., Tesauro, F, Passaro, G, TESAURO, FRANCESCO, and Passaro, G.

Abstract

Raccolta delle principali leggi tributarie, con annotazioni

Published
1989

23. The gamma and neutron monitor counters for the MICADO project

Author

Finocchiaro Paolo, Cosentino Luigi, Ducasse Quentin, Lo Meo Sergio, Longhitano Fabio, Marchetta Carmelo, Massara Antonio, Pappalardo Alfio, Passaro Giuseppe, and Russo Salvatore

Subjects
gamma-ray counters, neutron counters, radwaste management, radwaste monitoring, Physics, QC1-999
Abstract

In the framework of the MICADO (Measurement and Instrumentation for Cleaning And Decommissioning Operations) European Union (EU) project, aimed at the full digitization of low and intermediate-level radioactive waste (radwaste) management, a set of 32 solid state thermal neutron detectors, named SiLiF, and 36 gamma-ray counters based on a scintillating fiber readout at each end by a silicon photomultiplier, named SciFi, have been built and characterized. MICADO project encompasses a complete active and passive characterization of the radwaste drums with neutrons and gamma rays, followed by a longer-term monitoring phase. The detectors described are suitable for the monitoring of nuclear materials and can be used around radioactive waste drums possibly containing small quantities of actinides, as well as around spent fuel casks in interim storage or during transportation. Suitable polyethylene moderators, for the SiLiF detectors, can be exploited to better shape the detector response to the expected neutron spectrum, according to Monte Carlo simulations that were performed. The SciFi detectors were thoroughly tested with a 22Na and a 137Cs gamma-ray sources. Both detectors described were tested with an intense AmBe source of neutron and gamma ray. The results are satisfactory and show a quite uniform and reproducible behavior. The next step will be the test in a real environment.

Published
2021
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24. The FARCOS project — Status and perspective

Author

S. Pirrone, Lucrezia Auditore, G. Cardella, E. V. Pagano, P. Russotto, Triestino Minniti, F. Rizzo, N. Giudice, G. Politi, E. Morgana, E. De Filippo, M. Trimarchi, G. Passaro, M. D'Andrea, Andrea Castoldi, F. Porto, G. Sacca, R. Bassini, G. Lanzalone, B. Gnoffo, L. Acosta, Michele Papa, Chiara Guazzoni, Elio Rosato, A. Grimaldi, Mariano Vigilante, L. Francalanza, C. Boiano, Antonio Trifiro, L. Quattrocchi, Ivano Lombardo, A. Pagano, F. Fichera, Giuseppe Verde, Borderie, B., Pagano, E. V., Acosta, L., Auditore, L., Bassini, R., Boiano, C., Cardella, G., Castoldi, A., D'Andrea, M., De Filippo, E., Fichera, F., Francalanza, L., Giudice, N., Gnoffo, B., Grimaldi, A., Guazzoni, C., Lanzalone, G., Lombardo, I., Minniti, T., Morgana, E., Pagano, A., Papa, M., Passaro, G., Pirrone, S., Politi, G., Porto, F., Quattrocchi, L., Rizzo, F., Rosato, E., Russotto, P., Sacca, G., Trifiro, A., Trimarchi, M., Verde, G., and Vigilante, M.

Subjects
Physics, sezele, QC1-999, Nuclear equation of state, Nuclear matter, Nuclear physics, Supernova, Neutron star, Physics and Astronomy (all), Perspective (geometry), Incident energy, Rapidity, Statistical physics, Impact parameter
Abstract

Nuclear matter under extreme conditions can be studied in the laboratory with heavy-ion collisions. In this case one can indeed vary the incident energy and explore different impact parameter and rapidity regions to access densities that extend above and below saturation. This opportunity allows one to learn about the nuclear equation of state and its implications in astrophysics phenomena such as supernovae explosions and neutron stars properties. All these phenomena involve time scales that need to be accessed with two- and multi-particle correlation measurements. In this contribution a brief report of the FARCOS array will be presented. In particular, tests with alpha sources and beams and preliminary results from a recent experiment INKIISSY performed using a FARCOS prototype made of four telescopes will be presented.

Published
2015

25. Neutropenic Enterocolitis and Sepsis: Towards the Definition of a Pathologic Profile.

Author

Bertozzi G, Maiese A, Passaro G, Tosoni A, Mirijello A, Simone S, Baldari B, Cipolloni L, and La Russa R

Subjects
Adult, Child, Humans, Prognosis, Enterocolitis, Neutropenic diagnosis, Lymphoma, Neoplasms, Sepsis diagnosis
Abstract

Background: Neutropenic enterocolitis (NE), which in the past was also known as typhlitis or ileocecal syndrome for the segment of the gastrointestinal tract most affected, is a nosological entity that is difficult to diagnose and whose pathogenesis is not fully known to date. Initially described in pediatric patients with leukemic diseases, it has been gradually reported in adults with hematological malignancies and non-hematological conditions, such as leukemia, lymphoma, multiple myeloma, aplastic anemia, and also myelodysplastic syndromes, as well as being associated with other immunosuppressive causes such as AIDS treatment, therapy for solid tumors, and organ transplantation. Therefore, it is associated with high mortality due to the rapid evolution in worse clinical pictures: rapid progression to ischemia, necrosis, hemorrhage, perforation, multisystem organ failure, and sepsis. Case report : A case report is included to exemplify the clinical profile of patients with NE who develop sepsis. Literature Review : To identify a specific profile of subjects affected by neutropenic enterocolitis and the entity of the clinical condition most frequently associated with septic evolution, a systematic review of the literature was conducted. The inclusion criteria were as follows: English language, full-text availability, human subjects, and adult subjects. Finally, the papers were selected after the evaluation of the title and abstract to evaluate their congruity with the subject of this manuscript. Following these procedures, 19 eligible empirical studies were included in the present review. Conclusions : Despite the recent interest and the growing number of publications targeting sepsis and intending to identify biomarkers useful for its diagnosis, prognosis, and for the understanding of its pathogenesis, and especially for multi-organ dysfunction, and despite the extensive research period of the literature review, the number of publications on the topic "neutropenic enterocolitis and sepsis" appears to be very small. In any case, the extrapolated data allowed us to conclude that the integration of medical history, clinical and laboratory data, radiological imaging, and macroscopic and histological investigations can allow us to identify a specific pathological profile.

Published
2021
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26. SiLiF Neutron Counters to Monitor Nuclear Materials in the MICADO Project.

Author

Cosentino L, Ducasse Q, Giuffrida M, Lo Meo S, Longhitano F, Marchetta C, Massara A, Pappalardo A, Passaro G, Russo S, and Finocchiaro P

Abstract

In the framework of the MICADO (Measurement and Instrumentation for Cleaning And Decommissioning Operations) European Union (EU) project, aimed at the full digitization of low- and intermediate-level radioactive waste management, a set of 32 solid state thermal neutron detectors named SiLiF has been built and characterized. MICADO encompasses a complete active and passive characterization of the radwaste drums with neutrons and gamma rays, followed by a longer-term monitoring phase. The SiLiF detectors are suitable for the monitoring of nuclear materials and can be used around radioactive waste drums possibly containing small quantities of actinides, as well as around spent fuel casks in interim storage or during transportation. Suitable polyethylene moderators can be exploited to better shape the detector response to the expected neutron spectrum, according to Monte Carlo simulations that were performed. These detectors were extensively tested with an AmBe neutron source, and the results show a quite uniform and reproducible behavior.

Published
2021
Full Text
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27. Delta-Procalcitonin and Vitamin D Can Predict Mortality of Internal Medicine Patients with Microbiological Identified Sepsis.

Author

Tosoni A, Cossari A, Paratore M, Impagnatiello M, Passaro G, Vallone CV, Zaccone V, Gasbarrini A, Addolorato G, De Cosmo S, Mirijello A, and On Behalf Of The Internal Medicine Sepsis Study Group

Subjects
Biomarkers, Humans, Prognosis, Prospective Studies, ROC Curve, Vitamin D, Procalcitonin, Sepsis diagnosis
Abstract

Background : The management of septic patients hospitalized in Internal Medicine wards represents a challenge due to their complexity and heterogeneity, and a high mortality rate. Among the available prognostic tools, procalcitonin (PCT) is considered a marker of bacterial infection. Furthermore, an association between vitamin D deficiency and poor sepsis-related outcomes has been described. Objectives: To evaluate the prognostic accuracy of two consecutive PCT determinations (Delta-PCT) and of vitamin D levels in predicting mortality in a population of patients with microbiological identified sepsis admitted to Internal Medicine wards. Methods : This is a sub-analysis of a previous prospective study. A total of 80 patients had at least two available consecutive PCT determinations, while 63 had also vitamin D. Delta-PCT was defined as a reduction of PCT > 50% after 48 h, >75% after 72 h, and >85% after 96 h. Mortality rate at 28- and 90-days were considered as main outcome. Results: Mortality rate was 18.7% at 28-days and 30.0% at 90-days. Baseline PCT levels did not differ between survived and deceased patients (28-days: p = 0.525; 90-days: p = 0.088). A significantly higher proportion of survived patients showed Delta-PCT (28-days: p = 0.002; 90-days: p < 0.001). Delta-PCT was associated with a lower 28-days ( p = 0.007; OR = 0.12, 95%CI 0.02-0.46) and 90-days mortality ( p = 0.001; OR = 0.17, 95%CI 0.06-0.48). A significantly higher proportion of deceased patients showed severe vitamin D deficiency (28-days: p = 0.047; 90-days: p = 0.049). Severe vitamin D deficiency was associated with a higher 28-days ( p = 0.058; OR = 3.95, 95%CI 1.04-19.43) and 90-days mortality ( p = 0.054; OR = 2.94, 95%CI 1.00-9.23). Conclusions : Delta-PCT and vitamin D represent two useful tests for predicting prognosis of septic patients admitted to Internal Medicine wards.

Published
2021
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28. Risk Management and Treatment of Coagulation Disorders Related to COVID-19 Infection.

Author

Zanza C, Racca F, Longhitano Y, Piccioni A, Franceschi F, Artico M, Abenavoli L, Maiese A, Passaro G, Volonnino G, and La Russa R

Subjects
Anticoagulants therapeutic use, Humans, Blood Coagulation Disorders complications, Blood Coagulation Disorders drug therapy, COVID-19 complications, Risk Management, Venous Thromboembolism complications, Venous Thromboembolism drug therapy
Abstract

Coronavirus disease 2019 (COVID-19) is an emerging infectious disease. Bilateral pneumonia, acute respiratory failure, systemic inflammation, endothelial dysfunction and coagulation activation are key features of severe COVID-19. Fibrinogen and D-dimer levels are typically increased. The risk for venous thromboembolism is markedly increased, especially in patients in the intensive care unit despite prophylactic dose anticoagulation. Pulmonary microvascular thrombosis has also been described and the risk for arterial thrombotic diseases also appears to be increased while bleeding is less common than thrombosis, but it can occur. Evaluation for venous thromboembolism may be challenging because symptoms of pulmonary embolism overlap with COVID-19, and imaging studies may not be feasible in all cases. The threshold for evaluation or diagnosis of thromboembolism should be low given the high frequency of these events. Management and treatment are new challenges due to the paucity of high-quality evidence regarding efficacy and safety of different approaches to prevent or treat thromboembolic complications of the disease. All inpatients should receive thromboprophylaxis unless contraindicated. Some institutional protocols provide more aggressive anticoagulation with intermediate or even therapeutic dose anticoagulation for COVID-19 patients admitted to ICU. Therapeutic dose anticoagulation is always appropriate to treat deep venous thrombosis or pulmonary embolism, unless contraindicated. This article reviews evaluation and management of coagulation abnormalities in individuals with COVID-19.

Published
2021
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29. Modulation of microbiota as treatment for intestinal inflammatory disorders: An uptodate.

Author

Gallo A, Passaro G, Gasbarrini A, Landolfi R, and Montalto M

Subjects
Anti-Bacterial Agents adverse effects, Anti-Bacterial Agents therapeutic use, Diarrhea etiology, Diarrhea therapy, Fecal Microbiota Transplantation, Humans, Irritable Bowel Syndrome microbiology, Irritable Bowel Syndrome therapy, Prebiotics administration & dosage, Probiotics therapeutic use, Rotavirus Infections therapy, Gastrointestinal Microbiome, Inflammatory Bowel Diseases microbiology, Inflammatory Bowel Diseases therapy
Abstract

Alterations of intestinal microflora may significantly contribute to the pathogenesis of different inflammatory and autoimmune disorders. There is emerging interest on the role of selective modulation of microflora in inducing benefits in inflammatory intestinal disorders, by as probiotics, prebiotics, synbiotics, antibiotics, and fecal microbiota transplantation (FMT). To summarize recent evidences on microflora modulation in main intestinal inflammatory disorders, PubMed was searched using terms microbiota, intestinal flora, probiotics, prebiotics, fecal transplantation. More than three hundred articles published up to 2015 were selected and reviewed. Randomized placebo-controlled trials and meta-analysis were firstly included, mainly for probiotics. A meta-analysis was not performed because of the heterogeneity of these studies. Most of relevant data derived from studies on probiotics, reporting some efficacy in ulcerative colitis and in pouchitis, while disappointing results are available for Crohn's disease. Probiotic supplementation may significantly reduce rates of rotavirus diarrhea. Efficacy of probiotics in NSAID enteropathy and irritable bowel syndrome is still controversial. Finally, FMT has been recently recognized as an efficacious treatment for recurrent Clostridium difficile infection. Modulation of intestinal flora represents a very interesting therapeutic target, although it still deserves some doubts and limitations. Future studies should be encouraged to provide new understanding about its therapeutical role.

Published
2016
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