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3. PANTHER: AZD8931, inhibitor of EGFR, ERBB2 and ERBB3 signalling, combined with FOLFIRI: a Phase I/II study to determine the importance of schedule and activity in colorectal cancer

Author

Propper, David J., Gao, Fangfei, Saunders, Mark P., Sarker, Debashis, Hartley, John A., Spanswick, Victoria J., Lowe, Helen L., Hackett, Louise D., Ng, Tony T., Barber, Paul R., Weitsman, Gregory E., Pearce, Sarah, White, Laura, Lopes, Andre, Forsyth, Sharon, and Hochhauser, Daniel

Published
2023
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4. Simultaneous induction of SSMVEP and SMR Using a Gaiting video stimulus: a novel hybrid brain-computer interface

Author

Zhang, Xin, Xu, Guanghua, Ravi, Aravind, Pearce, Sarah, and Jiang, Ning

Subjects
Electrical Engineering and Systems Science - Signal Processing, Computer Science - Human-Computer Interaction
Abstract

We proposed a novel visual stimulus for brain-computer interface. The stimulus is in the form gaiting sequence of a human. The hypothesis is that observing such a visual stimulus would simultaneously induce 1) steady-state motion visual evoked potential (SSMVEP) in the occipital area, similarly to an SSVEP stimulus; and 2) sensorimotor rhythm (SMR) in the primary sensorimotor area, because such action observation (AO) could activate the mirror neuron system. Canonical correlation analysis (CCA) was used to detect SSMVEP from occipital EEG, and event-related spectral perturbations (ERSP) were used to identify SMR in the EEG from the sensorimotor area. The results showed that the proposed visual gaiting stimulus-induced SSMVEP, with classification accuracies of 88.9 $\pm$ 12.0% in a four-class scenario. More importantly, it induced clear and sustained event-related desynchronization/synchronization (ERD/ERS) in the EEG from the sensorimotor area, while no ERD/ERS in the sensorimotor area could be observed when the other two SSVEP stimuli were used. Further, for participants with sufficiently clear SSMVEP pattern (classification accuracy > 85%), the ERD index values in mu-beta band induced by the proposed gaiting stimulus were statistically different from that of the other two types of stimulus. Therefore, a novel BCI based on the proposed stimulus has potential in neurorehabilitation applications because it simultaneously has the high accuracy of an SSMVEP (~90% accuracy in a four-class setup) and the ability to activate sensorimotor cortex. And such potential will be further explored in future studies., Comment: 22 pages, 7 figures and 2 tables

Published
2019
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6. The role of auxiliary subunits in AMPA receptor function

Author

Pearce, Sarah Elizabeth

Subjects
612.8
Abstract

Glutamate receptors of the AMPA-subtype mediate the majority of fast excitatory neurotransmission in the central nervous system (CNS). These receptors are associated with auxiliary proteins that have been shown to affect AMPA receptor (AMPAR) properties. Transmembrane AMPAR Regulatory Proteins (TARPs) were the first identified AMPAR auxiliary subunits, and since then, further auxiliary subunits continue to be identified. In this thesis, I investigate the effects of a novel auxiliary protein candidate – FRRS1L – on AMPAR function, as well as the involvement of TARPs in mediating AMPAR plasticity in a model of ischaemic stroke. I show that when co-expressed with both homomeric GluA1 and heteromeric GluA1/GluA2 AMPAR subunits in tsA201 cells, FRRS1L slows recovery from receptor desensitization, without significant effect on other AMPAR properties. When the prototypical TARP stargazin is additionally co-expressed, the effect of FRRS1L is lost and the receptor properties appear as if only stargazin were associated. I examine the endogenous expression of FRRS1L in the CNS, and find that it is highly abundant in multiple brain regions including the hippocampus, cortex and cerebellum. In cultured hippocampal neurons, overexpressed FRRS1L does not influence mEPSC amplitude or frequency. In a model of ischaemic stroke, direct ASIC1-a activation through lowering of the pH (acidosis) is sufficient to drive AMPAR plasticity in cultured hippocampal neurons. This manifests as a decrease in the GluA2 subunit, resulting in an increase of CP-AMPARs in the membrane. I show that this change in AMPAR subunit expression following acidosis is likely accompanied by an increase in TARP γ-8 expression. Using various techniques, I explore the change in CPAMPAR expression and cell excitability. I show that following acidosis, there is an increase in Ca2+ entry into the cells, which is likely mediated through CPAMPARs.

Published
2018

7. The detection of an extremely bright fast radio burst in a phased array feed survey

Author

Bannister, Keith, Shannon, Ryan, Macquart, Jean-Pierre, Flynn, Chris, Edwards, Philip, O'Neill, Morgan, Osłowski, Stefan, Bailes, Matthew, Zackay, Barak, Clarke, Nathan, D'Addario, Larry, Dodson, Richard, Hall, Peter, Jameson, Andrew, Jones, Dayton, Navarro, Robert, Trinh, Joseph, Allison, James, Anderson, Craig, Bell, Martin, Chippendale, Aaron, Collier, Jordan, Heald, George, Heywood, Ian, Hotan, Aidan, Lee-Waddell, Karen, Madrid, Juan, Marvil, Joshua, McConnell, David, Popping, Attila, Voronkov, Maxim, Whiting, Matthew, Allen, Graham, Bock, Douglas, Brodrick, David, Cooray, Francis, DeBoer, David, Diamond, Philip, Ekers, Ron, Gough, Russell, Hampson, Grant, Harvey-Smith, Lisa, Hay, Stuart, Hayman, Douglas, Jackson, Carole, Johnston, Simon, Koribalski, Baerbel, McClure-Griffiths, Naomi, Mirtschin, Peter, Ng, Alan, Norris, Ray, Pearce, Sarah, Phillips, Chris, Roxby, Daniel, Troup, Euan Robert, and Westmeier, Tobias

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

We report the detection of an ultra-bright fast radio burst (FRB) from a modest, 3.4-day pilot survey with the Australian Square Kilometre Array Pathfinder. The survey was conducted in a wide-field fly's-eye configuration using the phased-array-feed technology deployed on the array to instantaneously observe an effective area of $160$ deg$^2$, and achieve an exposure totaling $13200$ deg$^2$ hr. We constrain the position of FRB 170107 to a region $8'\times8'$ in size (90% containment) and its fluence to be $58\pm6$ Jy ms. The spectrum of the burst shows a sharp cutoff above $1400$ MHz, which could be either due to scintillation or an intrinsic feature of the burst. This confirms the existence of an ultra-bright ($>20$ Jy ms) population of FRBs., Comment: 8 pages, 4 figures, accepted in ApJ letters. Version 2: Fixed galactic coordinates in Table 2

Published
2017
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17. Sybchrotron calibration of microchannel plate detectors for X-ray astronomy

Author

Pearce, Sarah Elizabeth

Subjects
522
Abstract

This thesis describes the calibration of CsI- and KBr-coated microchannel plate (MCP) detectors using the Daresbury Synchrotron Radiation Source (SRS). This work was carried out as part of the calibration programme for the Advanced X-ray Astrophysics Facility (AXAF). The AXAF High Resolution Camera (HRC) consists of two MCP detectors: HRC-I, optimised as an imaging detector, and HRC-S, optimised as the read-out detector for a dispersive spectrometer. Accurate knowledge of the MCP quantum efficiency (QE) variation with energy is particularly important for HRC-S so that atomic absorption edge-related features in the MCP glass and photocathode are not misinterpreted as emission features in astrophysical spectra. The MCPs were calibrated on three beamlines at the SRS, which covered the energy ranges 50-350eV, 250-1400eV and 2-6keV. Calibration included measurement of QE as X-ray energy and incidence angle were varied. The ratio of the QE of CsI- and KBr-coated MCPs was also determined and gain decay of the MCPs was measured as charge was abstracted from a small area. Several significant features in QE were noted, a number of which exhibited characteristics such as white lines, slow onset and energy shifts. There were however, problems with measurement of the monochromator responses at the SRS, which cast doubt upon the accuracy of the QE-energy curves produced. The variation of QE with energy and angle measured at Daresbury was modelled. An existing model was updated to take account of the channel bias angle and was able to reproduce the general features of the QE-energy curves. An attempt was then made to model linear absorption coefficient and hence reproduce the white lines visible on some of the edge-related QE features. The final part of the thesis considers and models the effect of thermal annealing upon the QE of CsI-coated MCPs.

Published
1998

19. Translation initiation of leaderless and polycistronic transcripts in mammalian mitochondria

Author

Remes, Cristina, primary, Khawaja, Anas, additional, Pearce, Sarah F, additional, Dinan, Adam M, additional, Gopalakrishna, Shreekara, additional, Cipullo, Miriam, additional, Kyriakidis, Vasileios, additional, Zhang, Jingdian, additional, Dopico, Xaquin Castro, additional, Yukhnovets, Olessya, additional, Atanassov, Ilian, additional, Firth, Andrew E, additional, Cooperman, Barry, additional, and Rorbach, Joanna, additional

Published
2023
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22. PANTHER: AZD8931, inhibitor of EGFR, ERBB2 and ERBB3 signalling, combined with FOLFIRI: a Phase I/II study to determine the importance of schedule and activity in colorectal cancer

Author

Propper, David J., primary, Gao, Fangfei, additional, Saunders, Mark P., additional, Sarker, Debashis, additional, Hartley, John A., additional, Spanswick, Victoria J., additional, Lowe, Helen L., additional, Hackett, Louise D., additional, Ng, Tony T., additional, Barber, Paul R., additional, Weitsman, Gregory E., additional, Pearce, Sarah, additional, White, Laura, additional, Lopes, Andre, additional, Forsyth, Sharon, additional, and Hochhauser, Daniel, additional

Published
2022
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23. Evaluation of digestively resistant or soluble fibers, short- and medium-chain fatty acids, trace minerals, and antibiotics in nonchallenged nursery pigs on performance, digestibility, and intestinal integrity

Author

Kerr, Brian J, primary, Trachsel, Julian M, additional, Bearson, Bradley L, additional, Loving, Crystal L, additional, Bearson, Shawn M D, additional, Byrne, Kristen A, additional, Pearce, Sarah C, additional, Ramirez, Shelby M, additional, Gabler, Nicholas K, additional, Schweer, Wesley P, additional, Helm, Emma T, additional, and De Mille, Carson M, additional

Published
2022
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24. Electromyographic Effects Of Superimposed Hip Abduction Elastic Resistance During The Deadlift And Barbell Hip Thrust

Author

McCauley, Meghan, primary, Arreglado, John P., additional, Byrd, Charisma, additional, Ison, Christian V., additional, Lee, Patric, additional, Pearce, Sarah, additional, Quila, Monica A., additional, Rivera, Jennifer, additional, Rosas, Holli M., additional, Silvestri, Emma, additional, Weiss, Timothy J., additional, and Jo, Edward, additional

Published
2022
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28. Anxiety in healthcare actors post difficult topic healthcare simulation based learning activity

Author

Pearce, Sarah Elizabeth and Pearce, Sarah Elizabeth

Subjects
Medicine Case studies. Study and teaching United States, Anxiety., Médecine Études de cas. Étude et enseignement États-Unis, Anxiety, Medicine Study and teaching, United States
Abstract

Difficult topic healthcare simulation-based learning activities help to prepare healthcare profession students in a manner which is consistent with the experiences they will face in their careers. However, while these types of simulation-based learning activities need to be simulated, little to no research has been conducted regarding the topic of the psychological effect on standardized patients (SP) who participate in these activities within simulation-based learning experiences. The purpose of this study was to provide a quantitative examination, of the anxiety related effects of difficult topic simulation-based learning activities on standardized patients. This study utilized an experimental quantitative post-test only control group design where 66 study participants were randomly sorted into groups. The number of participants sampled was consistent at 66. Participants were made up of standardized patients from simulation programs across the United States. The treatment group participated in a difficult topic simulation-based learning activity and the control group participated in a non-difficult topic simulation-based learning activity. Study participants completed the State Trait Anxiety Inventory (STAI) to assess the s-anxiety and t-anxiety scores of participants. Data analysis illustrated no difference in t-anxiety scores of standardized patients who participate in difficult topic simulation-based learning activities and those who participate in non-difficult topic simulation-based learning activities, when controlling for years of experience. The researcher rejected the null hypothesis for state scores of standardized patients illustrating a significant relationship between standardized patients’ level of state anxiety and difficult topic and non-difficult topic simulation-based learning activities. Recommendations for future research are discussed.

Published
2022

29. Evaluation of digestively resistant or soluble fibers, short- and medium-chain fatty acids, trace minerals, and antibiotics in nonchallenged nursery pigs on performance, digestibility, and intestinal integrity

Author

Kerr, Brian J., Trachsel, Julian M., Bearson, Bradley L., Loving, Crystal L., Bearson, Shawn M. D., Byrne, Kristen A., Pearce, Sarah C., Ramirez, Shelby M., Gabler, Nicholas K., Schweer, Wesley P., Helm, Emma T., De Mille, Carson M., Kerr, Brian J., Trachsel, Julian M., Bearson, Bradley L., Loving, Crystal L., Bearson, Shawn M. D., Byrne, Kristen A., Pearce, Sarah C., Ramirez, Shelby M., Gabler, Nicholas K., Schweer, Wesley P., Helm, Emma T., and De Mille, Carson M.

Abstract

Nonantibiotic in-feed additives have limited effects on performance, nutrient digestibility, and intestinal function when supplemented to diets fed to nursery pigs. Lay Summary In-feed antimicrobials have been an important technology in swine production for protecting health and supporting growth. However, with legislative restrictions on the use of most antibiotics for growth promotion, research is needed to evaluate in-feed additives in replacing this growth promoting technology. Thus, strategies to enhance energy and nutrient digestibility, intestinal function and integrity, gastrointestinal volatile fatty acid concentrations, and microbial ecology in nursery pigs are desirable targets. The results of the three experiments conducted herein do not indicate that supplementing diets with digestively resistant but fermentable fibers, short-medium-chain fatty acids, or antibiotics have a consistent positive or negative effect on markers of intestinal integrity or barrier function, VFA patterns (ileal, cecal, or colon), ATTD of energy and nutrients, or pig performance. Three experiments (EXP) were conducted to determine the effect of feed additives on performance, intestinal integrity, gastrointestinal volatile fatty acids (VFA), and energy and nutrient digestion in nonchallenged nursery pigs. In EXP 1, 480 pigs (6.36-kg body weight, BW) were placed into 96 pens with 5 pigs/pen, and allotted to 1 of 10 dietary treatments: 1) negative control containing no feed additive (NC), 2) NC + 44 mg chlortetracycline and 38.5 mg tiamulin/kg diet (CTsb), 3) NC + 5% resistant potato starch (RSpo), 4) NC + 5% soluble corn fiber (SCF), 5) NC + 5% sugar beet pulp (SBP), 6) NC + 0.30% fatty acid mix (FAM), 7) NC + 0.10% phytogenic blend of essential oils and flavoring compounds (PHY), 8) NC + 50 mg Cu and 1,600 mg zinc oxide/kg diet (CuZn), 9) NC + 5% resistant corn starch (RScn), and 10) NC + 0.05% beta-glucan (BG) for 28 d. There was no impact of dietary treatment on BW gain or feed

Published
2022

33. Expression of SARS‐CoV‐2 entry factors, electrolyte, and mineral transporters in different mouse intestinal epithelial cell types

Author

Pearce, Sarah C., primary, Suntornsaratoon, Panan, additional, Kishida, Kunihiro, additional, Al‐Jawadi, Arwa, additional, Guardia, Joshua, additional, Nadler, Ian, additional, Flores, Juan, additional, Shiarella, Reilly, additional, Auvinen, Madelyn, additional, Yu, Shiyan, additional, Gao, Nan, additional, and Ferraris, Ronaldo P., additional

Published
2021
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34. Treating Shackled Patients

Author

Finlay, Ilora G., Sastry, B. S. Dwarak, Thomas, Gareth A. O., Pearce, Sarah J., and Nathanson, Vivienne

Published
1997

36. MPV17L2 is required for ribosome assembly in mitochondria

Author

Rosa, Ilaria Dalla, Durigon, Romina, Pearce, Sarah F., Rorbach, Joanna, Hirst, Elizabeth M.A., Vidoni, Sara, Reyes, Aurelio, Brea-Calvo, Gloria, Minczuk, Michal, Woellhaf, Michael W., Herrmann, Johannes M., Huynen, Martijn A., Holt, Ian J., and Spinazzola, Antonella

Published
2014
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44. Metabolic shift underlies recovery in reversible infantile respiratory chain deficiency

Author

Hathazi, Denisa, primary, Griffin, Helen, additional, Jennings, Matthew J, additional, Giunta, Michele, additional, Powell, Christopher, additional, Pearce, Sarah F, additional, Munro, Benjamin, additional, Wei, Wei, additional, Boczonadi, Veronika, additional, Poulton, Joanna, additional, Pyle, Angela, additional, Calabrese, Claudia, additional, Gomez‐Duran, Aurora, additional, Schara, Ulrike, additional, Pitceathly, Robert D S, additional, Hanna, Michael G, additional, Joost, Kairit, additional, Cotta, Ana, additional, Paim, Julia Filardi, additional, Navarro, Monica Machado, additional, Duff, Jennifer, additional, Mattman, Andre, additional, Chapman, Kristine, additional, Servidei, Serenella, additional, Della Marina, Adela, additional, Uusimaa, Johanna, additional, Roos, Andreas, additional, Mootha, Vamsi, additional, Hirano, Michio, additional, Tulinius, Mar, additional, Giri, Mamta, additional, Hoffmann, Eric P, additional, Lochmüller, Hanns, additional, DiMauro, Salvatore, additional, Minczuk, Michal, additional, Chinnery, Patrick F, additional, Müller, Juliane S, additional, and Horvath, Rita, additional

Published
2020
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46. Cell-Type–Specific, Ketohexokinase-Dependent Induction by Fructose of Lipogenic Gene Expression in Mouse Small Intestine

Author

Al-Jawadi, Arwa, primary, Patel, Chirag R, additional, Shiarella, Reilly J, additional, Romelus, Emmanuellie, additional, Auvinen, Madelyn, additional, Guardia, Joshua, additional, Pearce, Sarah C, additional, Kishida, Kunihiro, additional, Yu, Shiyan, additional, Gao, Nan, additional, and Ferraris, Ronaldo P, additional

Published
2020
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50. MitoRibo-Tag Mice Provide a Tool for In Vivo Studies of Mitoribosome Composition

Author

Busch, Jakob D., Cipullo, Miriam, Atanassov, Ilian, Bratic, Ana, Ramos, Eduardo Silva, Schoendorf, Thomas, Li, Xinping, Pearce, Sarah F., Milenkovic, Dusanka, Rorbach, Joanna, Larsson, Nils-Goeran, Busch, Jakob D., Cipullo, Miriam, Atanassov, Ilian, Bratic, Ana, Ramos, Eduardo Silva, Schoendorf, Thomas, Li, Xinping, Pearce, Sarah F., Milenkovic, Dusanka, Rorbach, Joanna, and Larsson, Nils-Goeran

Abstract

Mitochondria harbor specialized ribosomes (mitoribosomes) necessary for the synthesis of key membrane proteins of the oxidative phosphorylation (OXPHOS) machinery located in the mitochondrial inner membrane. To date, no animal model exists to study mitoribosome composition and mitochondrial translation coordination in mammals in vivo. Here, we create MitoRibo-Tag mice as a tool enabling affinity purification and proteomics analyses of mitoribosomes and their interactome in different tissues. We also define the composition of an assembly intermediate formed in the absence of MTERF4, necessary for a late step in mitoribosomal biogenesis. We identify the orphan protein PUSL1, which interacts with a large subunit assembly intermediate, and demonstrate that it is an inner-membrane-associated mitochondrial matrix protein required for efficient mitochondrial translation. This work establishes MitoRibo-Tag mice as a powerful tool to study mitoribosomes in vivo, enabling future studies on the mitoribosome interactome under different physiological states, as well as in disease and aging.

Published
2019

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