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180 results on '"Pelayo, M."'

5. Characterization of the transcriptional regulator Rv3124 of Mycobacterium tuberculosis identifies it as a positive regulator of molybdopterin biosynthesis and defines the functional consequences of a non-synonymous SNP in the Mycobacterium bovis BCG orthologue

Author

Lopez, Pablo Mendoza, Golby, Paul, Wooff, Esen, Garcia, Javier Nunez, Pelayo, M. Carmen Garcia, Conlon, Kevin, Camacho, Ana Gema, Hewinson, R. Glyn, Polaina, Julio, Garcia, Antonio Suarez, and Gordon, Stephen V.

Subjects
Genetic regulation -- Research, Mycobacterium bovis -- Health aspects, Mycobacterium bovis -- Genetic aspects, Mycobacterium bovis -- Research, Protein-protein interactions -- Genetic aspects, Protein-protein interactions -- Research, Single nucleotide polymorphisms -- Research, Biological sciences
Abstract

A number of single-nucleotide polymorphisms (SNPs) have been identified in the genome of Mycobacterium bovis BCG Pasteur compared with the sequenced strain M. boris 2122/97. The functional consequences of many of these mutations remain to be described; however, mutations in genes encoding regulators may be particularly relevant to global phenotypic changes such as loss of virulence, since alteration of a regulator's function will affect the expression of a wide range of genes. One such SNP falls in bcg3145, encoding a member of the AfsR/Dnrl/SARP class of global transcriptional regulators, that replaces a highly conserved glutamic acid residue at position 159 (E159G) with glycine in a tetratricopeptide repeat (TPR) located in the bacterial transcriptional activation (BTA) domain of BCG3145. TPR domains are associated with protein--protein interactions, and a conserved core (helices T1-T7) of the BTA domain seems to be required for proper function of SARP-family proteins. Structural modelling predicted that the E159G mutation perturbs the third [alpha]-helix of the BTA domain and could therefore have functional consequences. The E159G SNP was found to be present in all BCG strains, but absent from virulent M. bovis and Mycobacterium tuberculosis strains. By overexpressing BCG3145 and Rv3124 in BCG and H37Rv and monitoring transcriptome changes using microarrays, we determined that BCG3145/Rv3124 acts as a positive transcriptional regulator of the molybdopterin biosynthesis moa1 locus, and we suggest that rv3124 be renamed moaR1. The SNP in bcg3145 was found to have a subtle effect on the activity of MoaR1, suggesting that this mutation is not a key event in the attenuation of BCG. DOI: 10.1099/mic.0.037200-0

Published
2010

10. A novel deletion involving the connexin-30 gene, del(GJB6-d13s1854), found in trans with mutations in the GJB2 gene (connexin-26) in subjects with DFNB1 non-syndromic hearing impairment

Author

del Castillo, F J, Rodríguez-Ballesteros, M, Álvarez, A, Hutchin, T, Leonardi, E, de Oliveira, C A, Azaiez, H, Brownstein, Z, Avenarius, M R, Marlin, S, Pandya, A, Shahin, H, Siemering, K R, Weil, D, Wuyts, W, Aguirre, L A, Martín, Y, Moreno-Pelayo, M A, Villamar, M, Avraham, K B, Dahl, H-H M, Kanaan, M, Nance, W E, Petit, C, Smith, R J H, Van Camp, G, Sartorato, E L, Murgia, A, Moreno, F, and del Castillo, I

Published
2005

17. Enhanced protection conferred by mucosal BCG vaccination associates with presence of antigen-specific lung tissue-resident PD-1+ KLRG1− CD4+ T cells

Author

Bull, N, Stylianou, E, Kaveh, D, Pinpathomrat, N, Pasricha, J, Harrington-Kandt, R, Garcia-Pelayo, M, Hogarth, P, and McShane, H

Abstract

BCG, the only vaccine licensed against tuberculosis, demonstrates variable efficacy in humans. Recent preclinical studies highlight the potential for mucosal BCG vaccination to improve protection. Lung tissue-resident memory T cells reside within the parenchyma, potentially playing an important role in protective immunity to tuberculosis. We hypothesised that mucosal BCG vaccination may enhance generation of lung tissue-resident T cells, affording improved protection against Mycobacterium tuberculosis. In a mouse model, mucosal intranasal (IN) BCG vaccination conferred superior protection in the lungs compared to the systemic intradermal (ID) route. Intravascular staining allowed discrimination of lung tissue-resident CD4+ T cells from those in the lung vasculature, revealing that mucosal vaccination resulted in an increased frequency of antigen-specific tissue-resident CD4+ T cells compared to systemic vaccination. Tissue-resident CD4+ T cells induced by mucosal BCG displayed enhanced proliferative capacity compared to lung vascular and splenic CD4+ T cells. Only mucosal BCG induced antigen-specific tissue-resident T cells expressing a PD-1+ KLRG1− cell-surface phenotype. These cells constitute a BCG-induced population which may be responsible for the enhanced protection observed with IN vaccination. We demonstrate that mucosal BCG vaccination significantly improves protection over systemic BCG and this correlates with a novel population of BCG-induced lung tissue-resident CD4+ T cells.

Published
2018
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18. Association Between Vitamin D and Adrenal Parameters with Metabolic and Inflammatory Markers in Polycystic Ovary Syndrome

Author

Maidana, P., primary, Fritzler, A., additional, Mocarbel, Y., additional, Perez Lana, M. B., additional, González, D., additional, Rosales, M., additional, González de Chazal, F., additional, Sternberg, K., additional, Lamas Majek, E., additional, Mallea-Gil, S., additional, Genovesi, E., additional, Pelayo, M., additional, Fabre, B., additional, and Mesch, V., additional

Published
2019
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21. Cause of death and predictors of all-cause mortality in anticoagulated patients with nonvalvular atrial fibrillation: Data from ROCKET AF

Author

Pokorney, Sean D, Piccini, Jonathan P., Stevens, Susanna R., Patel, Manesh R., Pieper, Karen S., Halperin, Jonathan L., Breithardt, Günter, Singer, Daniel E., Hankey, Graeme J., Hacke, Werner, Becker, Richard C., Berkowitz, Scott D., Nessel, Christopher C., Mahaffey, Kenneth W., Fox, Keith A. A., Califf, Robert M., Anderson, J., Bedwell, N., Bilsker, M., Bruce, G., Agah, R., Desantis, M., Eisenberg, S., Flores, A., Herzog, W., Klein, S., Snyder, H., Krueger, S., Almaguer, E., Lavie, E., Lee, C., Mallis, G., Modi, M., Woodworth, G., Niazi, I., Peart, B., Sundaram, S., Snoddy, B., Sotolongo, R., Moloney, J., Vijayaraghavan, K., Whittier, F., Yellen, L., Banerjee, S., Lustgarten, D., Suresh, D., Gelernt, M., Levinson, L., Ghanekar, R., Kneller, G., Hall, C., Fadl, Y., Pirwitz, M., French, W., Mayer, N., Pugeda, J., Steel, K., Mody, F., Malik, A., Chandna, H., Go, A., Emlein, G., Bowden, W., Moscoso, R., Hodson, R., Berk, M., Pan, D., Pappas, J., Orchard, R., Lynchard, G., Vijay, N., Khan, W., El Khadra, M., Antonishen, M., Cucher, F., Staab, M., Zebrack, J., Borromeo, S., Heilman, J., Chaturvedi, S., Makam, S., Turk, S., Hyers, T., Williams, G., Labroo, A., Gill, S., Myears, D., Weinstein, J., Shanes, J., Chandrashekhar, Y., Shah, S., Reiter, W., Logemann, T., Almquist, A., Bhagwat, R., Tak, T., Shen Ling, J., Patel, P., Artis, A., Arouni, A., Lauer, M., Kinney, K., Elsen, J., Roan, P., Villafria, R., Sumpter, M., Ip, J., Welka, S., Schifferdecker, B., Sandoval, R., Speirs, S., Jones, A., Haldis, T., Kazmierski, J., Sutherland, J., Dietrich, D., Telfer, E., Berry, J., Mcelveen, A., Russell, J., Sackett, M., Antonios, N., Smith, D., Vora, K., Kirby, A., Lui, H., Mego, D., Ziada, K., Navas, J., Taussig, A., Koren, M., Vogel, C., Saba, F., Parrott, C., Schneider, R., Shirwany, A., Rubin, M., Treasure, C., Bertolet, B., Chang, M., Langberg, J., Becker, R., Cohen, Y., Mcgrew, F., White, J., Arzola, F., Zelenka, J., Tannenbaum, A., Fernandes, V., Jamnadas, P., Agamasu, J., Collins, B., Jauch, W., Sasseen, B., Hotchkiss, D., Abadier, R., Osunkoya, A., Schlau, A., Chappel, C., Foster, M., Braun, E., Mostel, E., Capo, J., Ashchi, M., Howard, V., Albirini, A., Burger, A., Rolston, D., Staniloae, C., Bacon, J., Wiseman, A., Mcgarvey, J., Sonel, A., Hamroff, G., Chang, D., Daboul, N., Broderick, G., Meholick, A., Corbelli, J., Silverman, R., Raffetto, J., Fishberg, R., Georgeson, S., Held, J., Seidner, M., Saint Jacques, H., Heitner, J., Kutalek, S., Friedlander, I., Hutchinson, B., Walia, J., Kondo, N., Smiley, N., Blitz, L., Dale, H., Sulman, S., Szulawski, I., Modares, F., Martin, R., Nahhas, A., Renzi, M., Akyea Djamson, A., Alfieri, A., Sandhu, J., Voyce, S., Amaram, S., Meyerrose, G., Shoukfeh, M., Lee, F., Villegas, B., Idowu, O., Khera, A., Sam, C., Vo, A., Lieber, I., Smith, T., Awan, N., Tsai, C., Ganim, R., Alzaghrini, G., Pitt, W., Shepherd, A., Tang, S., Stoltz, S., Nelson, W., Cox, S., Meymandi, S., Melucci, M., Thomas, G., Gogia, H., Machell, C., Chandrasekaran, S., Brown, C., Jetty, P., Miller, G., Dykstra, G., Jaffrani, N., Zakhary, B., Caruso, A., Zolty, R., Fox, D., Jacobs, G., Lebenthal, M., Mukherjee, S., Zimetbaum, P., Kingsley, J., Jones, R., Robinson, V., Kenton, D., Usedom, J., Williams, S., Snipes, C., Wilson, V., Hasty, R., Shoemaker, J., Donahue, M., Al Saghir, Y., Thomsen, E., Yarows, S., Chastain, S., Mclaughlin, P., Wakham, M., Shrestha, D., Simmons, J., Fisher, D., Seymour, Z., Frandsen, B., First, B., Sharpe, C., Popeil, L., Guthrie, R., Hunter, J., Alvarado, O., Sandberg, J., Gutman, N., Belber, A., Arkhipov, M., Ballyzek, M., Baranov, A., Barbarash, O., Barbarich, V., Belenky, D., Berkovich, O., Bokarev, I., Boyarkin, M., Vaniev, S., Volkova, E., Gratsiansky, N., Demin, A., Zadionchenko, V., Zateyshchikov, D., Zrazhevsky, K., Mazaev, V., Martynov, A., Mikhailov, S., Mkrtchian, V., Novozhenov, V., Raskina, T., Rebrov, A., Sanina, N., Simanekov, V., Sitnikova, M., Smolenskaya, O., Stryuk, R., Storozhakov, G., Tankhilevich, B., Tereschenko, S., Khokhlov, A., Khrustalev, O., Chernov, S., Shvarts, Y., Shubik, Y., Shulman, V., Yakushin, S., Bugrova, O., Ivleva, A., Libis, R., Khozyainova, N., Maslov, S., Baranova, E., Sherenkov, A., Libov, I., Lusov, V., Chumakova, G., Kuznetsov, V., Ryamzina, I., Reshetko, O., Boldueva, S., Alekseeva, N., Novikova, T., Dvornikov, V., Idrisova, E., Shostak, N., Yarokhno, N., Tebloev, K., Treshkur, T., Mazurov, V., Loktin, E., Sedavnyh, I., Alexeeva, O., Yakhontova, P., Repin, A., Izmozherova, N., Kostenko, V., Fokin, A., Ketova, G., Kouz, S., Leader, R., Ayala Paredes, F., Luton, R., Ma, P., Pandey, S., Pesant, Y., Senior, R., Vertes, G., Bell, A., Crowley, D., Vizel, S., Lasko, B., Landry, D., Berger, L., Heath, J., Bessoudo, R., Ling, M., Tellier, G., Berlingieri, J., Kafka, H., Hill, L., Mazza, G., O'Mahony, W., Chilvers, M., O'Mahony, M., Newman, D., Silagy, S., Heffernan, M., Bennett, M., Bhesania, T., Rockman, G., Ng, K., Kalra, B., Meneses, G., Liang, W., Cheung, M., Kozak, J., Pugen, G., Vavougios, J., Kates, M., Nunes Vaz, C., Jaffer, S., Orfi, J., Faiers, A., Chung, C., Felsen, S., Bergman, S., Bernstein, I., Brownscombe, L., Stockdill, J., Silver, E., Ezekiel, D., Jagan, N., Khurana, M., Reisler, H., Goldman, H., Maung, T., Wong, F., Gillis, G., Vexler, R., Goldberg, B., Luterman, M., Gould, D., Coutu, B., Ouellet, A., Macdonald, P., Jones, M., Collette, R., Chong, P., Fargher, T., St Maurice, F., Fortin, C., Chehayeb, R., Proulx, G., Roy, R., Liutkus, J., Syan, G., Rupka, D., Lichtenstein, T., Kooy, J., Papastergiou, D., Lubelsky, B., Doyle, W., Rajakumar, A., Cha, J., Choudhry, A., Bhamjee, H., Mawji, A., Durfresne, M., Constance, C., Mutrie, J., Najarali, A., Warren, R., Mucha, M., Borts, D., Nord, P., Carrier, S., Dawood, M., Sabe Affaki, G., Archibald, J., Abram, N., Teitelbaum, E., Ebrahim, I., Siebert, R., van Zyl, L., Theron, H., Lloyd, E., Sommers, R., Podgorski, G., Steingo, L., Dalby, A., Bayat, J., Herbst, L., Bester, F., Corbett, C., Bennett, J., Roodt, A., Roux, J., Abelson, M., Mohamed, Z., Nortje, H., Da Silva, A., Nikolaides, K., Liagkas, K., Papasteriadis, E., Achimastos, A., Koliopoulos, N., Trikas, A., Manolis, A., Ruiter, J., Basart, D., Crijns, H., Withagen, A., Janssen, M., Van Langeveld, R., van Gelder, I., Hamer, B., Van Der Heijden, R., Hertzeberger, D., Van Hessen, M., Pieterse, M., Groutars, R., Kuijper, A., De Ruiter, G., van Boven, A., Hoogslag, P., Kragten, H., Thijssen, H., Veldkamp, R., Scavee, C., Heidbuchel, H., Debruyne, P., Deruyter, B., El Ali, H., Goethals, M., Cytryn, R., Striekwold, H., De Wolf, L., Goethals, P., Provenier, F., Hellemans, S., Galinier, M., Coisne, D., Koenig, A., Galley, D., Destrac, S., Leduc, J., Rifai, A., Citron, B., Ellie, E., Fournier, P., Steg, G., Landel, R., Robinson, A., Ziegler, F., Boulliat, J., Zuber, M., Vida, M., Galve Basilio, E., Lopez, M., Íñiguez, C., Iglesias Alonso, L., Cavero Gibanel, M., Olivan Martinez, J., Calvo Iglesias, F., Marco Vera, P., Bruguera Cortada, J., Jaber Houbani, A., Merino, J., Olaz Preciado, F., Balaguer, J., de la Hera Galarza, J., Martinez Rubio, A., Fontcuberta, J., Sotillo Marti, J., Gonzalez Juanatey, J., Del Campo, R., Vivanco, G., Alvarez Garcia, P., Pelayo, M., Lippai, J., Zamolyi, K., Károly, T., Vertes, A., Nagy, A., Kosa, I., Janosi, A., Lupkovics, G., Kalo, E., Forster, T., Kis, E., Tenczer, J., Bereczki, D., Komoly, S., Csanyi, A., Kiss, R., Valikovics, A., Dioszeghy, P., Masini, F., Terrosu, P., Cirrincione, V., Marabotti, C., Cosmi, F., Salvioni, A., Binetti, G., Piovaccari, G., Nassiacos, D., Boriani, Giuseppe, Calvi, V., De Caterina, R., Pengo, V., Parati, G., Carolei, A., D'Angelo, A., Di Biase, M., Fattore, L., Agnelli, G., Merlini, P., Furlan, M., Rasura, M., Gandolfo, C., Ageno, W., Piovella, F., Micieli, G., Cinteza, M., Fierbinteanu, C., Natase Melicovici, D., Ionescu, D., Macarie, C., Nanea, I., Radoi, M., Tatu Chitoiu, G., Dragulescu, S., Tudose, A., Militaru, C., Bengus, C., Ungureanu, G., Tau, A., Popa, V., Pirvu, O., Bojinca, M., Sipciu, D., Popescu, M., Chiru, M., Vinereanu, D., Tudoran, M., Cojocaru, T., Vintila, M., Aron, G., Petrascu, O., Bolohan, F., Baumgartner, R., Sekoranja, L., Vojacek, J., Lacnak, B., Kellnerova, I., Dunaj, M., Cihalik, C., Janota, T., Janousek, J., Bouchal, P., Spacek, R., Choi Siruckova, J., Heinc, P., Vojtisek, P., Pirchala, M., Malecha, J., Padour, F., Linhart, A., Mandysova, E., Jandik, J., Zidkova, E., Sipula, D., Ostadal, P., Polasek, R., Stransky, V., Marcinek, G., Rysava, D., Osmancik, P., Huber, K., Drexel, H., Brainin, M., Eichinger Hasenauer, S., Lang, W., Pilger, E., Moriarty, A., Hudson, I., Tang, K., Cleland, J., Macwalter, R., Cooke, J., Mcinnes, G., Durairaj, R., Macleod, M., Murdoch, D., Kadr, H., Lip, G., Andrews, R., Hunt, B., Jackson, P., Roffe, C., Syed, H., Bath, P., Coyle, J., Kelly, D., Stender, S., Torppedersen, C., Tuxen, C., Jensen, G., Melchior, T., Klarlund, K., Dahlstrom, C., Nielsen, T., Nielsen, E., Bronnum Schou, J., Sykulski, R., Blomstrom, P., Lindholm, C., Wallen, T., Nilsson, C., Bertholds, E., Carlsater, J., Sirnes, P., Elle, S., Risberg, K., Furuseth, K., Skag, A., Hoivik, H., Landmark, N., Kjaernli, T., Berg Johansen, J., Gradek, G., Drzewiecki, A., Pluta, W., Szwed, H., Trusz Gluza, M., Ogorek, M., Loboz Grudzien, K., Ruszkowski, P., Sciborski, R., Kopaczewski, J., Jaworska, K., Kubica, J., Opolski, G., Hoffman, A., Krzciuk, M., Sinkiewicz, W., Piotrowski, W., Kolodziej, P., Goszczynska, M., Rynkiewicz, A., Chojnowska, L., Lewczuk, J., Biedrzycka, M., Piepiorka, M., Kowal, J., Karczmarczyk, A., Pruszczyk, P., Tendera, M., Gaciong, Z., Krzeminska Pakula, M., Kornacewicz Jach, Z., Kania, G., Brachmann, J., Lawall, H., Guelker, H., Spitzer, S., Moebiuswinkler, S., Dempfle, C., Bode, C., Darius, H., Genth Zotz, S., Sommer, S., Roehnisch, J., Strasser, R., Daenschel, W., Schwencke, C., vom Dahl, J., Meuser, M., Behrens Spandau, S., Behrens Humbold, S., Muegge, A., Schoen, N., Grooterhorst, P., Ebert, H., Kraemer, A., Kohler, B., Taggeselle, J., Claus, G., Sarnighausen, H., Al Zoebi, A., Schroeder, T., Weissbrodt, M., Lange, R., Gabelmann, M., Kaeaeb, S., Doerr, M., Boscher, D., Bosch, R., Sonntag, F., Bauknecht, C., Omran, H., Leicht, M., Veltkamp, R., Hohensee, H., Dieckmann, H., Winkelmann, B., Bernhardt, P., Schnabel, A., Kadel, C., Proskynitopoulos, N., Seidl, K., Schellong, S., Rios, C., Guevara, C., Coloma, R., Torrejon, H., Parra Galvan, J., Drago Silva, J., Gallegos, J., Mendoza, A., Negron, S., Watanabe, L., Medina, F., Virgen Carrilo, L., Alvarez Lopez, H., Rodriguez, I., Leiva Pons, J., Baños Velasco, A., Villarreal Careaga, J., De los Rios, M., Alcocer Gamba, M., Llamas Esperon, G., Villeda, E., Ahuad Guerrero, A., Alvariqueta, A., Amuchastegui, M., Bluguermann, J., Caime, G., Cuneo, C., Gabito, A., Garcia Brasca, D., Hominal, M., Jure, H., Luquez, H., Montana, O., Piskorz, D., Listorti, S., Serra, J., Sessa, H., Varini, S., Vita, N., Aiub, J., Mackinnon, I., Chekherdemian, S., Castagnino, J., Cimbaro Canella, J., Sgammini, H., Escudero, A., Albina, G., Rapallo, C., Balparda, C., Chahin, M., Fuentealba, V., Riccitelli, M., Casabe, J., Lobo Marquez, L., Kevorkian, R., Cuadrado, J., Dran, R., Muntaner, J., Gonzalez, M., Cartasegna, L., Hasbani, E., Hrabar, A., Sanchez, A., Vogel, D., Hershson, A., Avezum, A., Jaber, J., Ernesto Leaes, P., Bozza, A., Lorga Filho, A., Pimentel Filho, P., Moura Jorge, J., Maia, L., Manenti, E., D'Aurea Mora, R., de Souza Neto, J., Precoma, D., Rabelo, A., Rocha, J., Rossi, P., Kerr Saraiva, J., Zimerman, L., Bodanese, L., Figueiredo, E., de Souza, W. Sebba Barroso, Braga, J., Alessi, S., Gomes, M., Silva, R., Teixeira, M., Costa, F., Motta, M., Sobral Filho, D., Reis, G., Garbelini, B., Zimmermann, S., Pereira Barretto, A., Dohmann, H., Barreto Filho, J., Ghorayeb, N., Borelli, F., Rossi dos Santos, F., Lopes Prudente, M., Vejar, M., Lanas, F., Del Pino, R., Potthoff, S., Charme, G., Aguirre, A., Saldana, A., Garces, E., Bunster, L., Figueroa, H., Olivares, C., Raffo, C., Vergara, E., Sepulveda, P., Jano, G., Morales Alvarado, J., Suarez, R., Urina, M., Perez, G., Quintero, A., Pava, L., Botero Lopez, R., Luengas, C., Hernandez, E., Sanchez, D., Poveda, C., Coronel, J., Beltran, R., Jaramillo, C., Pardo, J., Ponte Negretti, C., Isea, J., Vergara, G., Morr, I., Sim, K., Wan Ahmad, W., Yusof, Z., Rosman, A., Basri, H., Thompson, P., Jeffery, P., Purnell, I., Roberts Thomson, P., Heddle, W., Waites, J., Walters, D., Amerena, J., Challa, P., Karrasch, J., Lowy, A., Fitzpatrick, D., Parsons, M., Phan, T., Bladin, C., Donnan, G., Aroney, G., Gerraty, R., Anderson, C., Blombery, P., Martin, P., Tissa Wijeratne, K., Cross, D., Crimmins, D., Packham, D., Jackson, D., Chua, W., Merino, R., Magno, M., Tirador, L., Batalla, E., Manalo, C., Uy, N., Ebo, G., Reyes, E., Bernan, A., Richards, M., Hart, H., Mann, S., Fisher, R., Stewart, R., Wilkins, G., Barber, A., Tan, R., Ong, H., Singh, R., Sukonthasarn, A., Tanomsup, S., Krittayaphong, R., Piamsomboon, C., Piyayotai, D., Sunsaneewitayakul, B., Baek, S., Seo, H., Rim, S., Kim, C., Kim, K., Ryu, K., Jo, S., Tahk, S., Lee, H., Kim, Y., Shin, D., Choi, Y., Chung, N., Namgung, J., Hong, T., Shin, W., Jin, S., Yan, X., Fu, G., Lu, G., Yang, K., Xu, D., Chen, J., Liu, J., Wu, S., Song, J., Liao, Y., Xu, B., Li, Z., Ma, S., Yin, Y., Zhao, Y., Hu, D., Ma, C., Ma, J., Sun, J., Li, H., Hong, X., Yu, B., Lu, Q., Yang, J., Wu, Z., Li, Y., Huang, Y., Wang, Y., Liu, M., Cheng, Y., Yang, T., Chen, K., Wang, H., Yuan, Z., Wang, J., Zeng, Z., Chen, Y., Yavuzgil, O., Kozan, O., Etemoglu, M., Diker, E., Belgi, A., Ceyhan, C., Cin, V., Yilmaz, O., Ata, N., Altunkeser, B., Agacdiken Agir, A., Karadede, A., Topsakal, R., Gulati, R., Madhavan, A., Jain, S., Oomman, A., Janorkar, S., Kumar, P., Madhukar Naik, A., Thacker, H., Rajasekhar, V., Reddy, R., Keshavamurthy, C., Jain, P., Gowdappa, B., Gadkari, M., Abhyankar, A., Ramesh Babu, B., Vydianathan, P., Sinha, S., Garg, N., Rao, S., Gautam, P., Chockalingam, K., Kumbla, M., Panwar, R., Banker, D., Kaste, M., Jäkälä, P., Roine, R., Mihov, A., Raev, D., Yordanova, V., Dimitrova, S., Benov, H., Tsanova, V., Kyolean, M., Marchev, S., Stoikov, A., Zdravkov, N., Ramshev, K., Krastev, A., Stamenova, P., Angelova, I., Pencheva, G., Grigorova, V., Petrauskiene, B., Skripkauskiene, I., Raugaliene, R., Norkiene, S., Mazutavicius, R., Kavoliuniene, A., Aidietiene, S., Aganauskiene, J., Dailydkiene, A., Marcinkeviciene, J., Grigoniene, L., Anusauskiene, J., Kavaliauskiene, R., Lizogub, V., Rudenko, L., Tseluyko, V., Voronkov, L., Sychov, O., Svyshchenko, Y., Sirenko, Y., Serkova, V., Seredyuk, N., Pertseva, T., Netyazhenko, V., Lishnevska, V., Kupchynska, O., Koval, O., Koshukova, G., Karpenko, O., Grishyna, O., Faynyk, A., Dzyak, G., Dyadyk, O., Yena, L., Volkov, V., Rudyk, I., Kopytsya, M., Kononenko, L., Amosova, K., Zhurba, S., Kazimirko, V., Iuzkiv, I., Shershnyova, O., Khomazyuk, T., Batushkin, V., Vykhovanyuk, I., Popik, G., Skrebkov, V., Skurtov, A., Mishchenko, T., Lytvynenko, N., Sokolova, L., Vatutin, M., Shved, M., Rebrov, B., Kadina, L., Vajda, M., Ursol, G., Zheleznyy, V., Vysochanska, T., Gozhenko, A., Fan, K., Ho, D., Tse, H., Yu, C., Wong, L., Yeh, H., Pai, P., Hsieh, I., Huang, C., Hsieh, Y., Yin, W., Tsai, L., Huang, T., Chen, C., Chiang, F., Ueng, K., Charng, M., Marmor, A., Katz, A., Butnaru, A., Lewis, B., Eldar, M., Rosenhack, S., Elias, N., Koifman, B., Shochat, M., Swissa, M., Zimlichman, R., Bental, T., Weiss, A., Ganam, R., Elias, M., Nseir, W., Oliven, A., Brenner, B., Dayan, M., Pokorney, S, Piccini, J, Stevens, S, Patel, M, Pieper, K, Halperin, J, Breithardt, G, Singer, D, Hankey, G, Hacke, W, Becker, R, Berkowitz, S, Nessel, C, Mahaffey, K, Fox, K, Califf, R, Parati, G, Neurologian yksikkö, and Clinicum

Subjects
Male, Time Factors, medicine.medical_treatment, Administration, Oral, Comorbidity, Kaplan-Meier Estimate, 030204 cardiovascular system & hematology, THERAPY, Sudden Cardiac Death, 3124 Neurology and psychiatry, Sudden cardiac death, 0302 clinical medicine, Rivaroxaban, Risk Factors, Cause of Death, Atrial Fibrillation, 80 and over, Medicine, Arrhythmia and Electrophysiology, atrial fibrillation, 030212 general & internal medicine, Stroke, Cause of death, Original Research, CATHETER ABLATION, Aged, 80 and over, DABIGATRAN, Age Factors, Atrial fibrillation, 3. Good health, Intention to Treat Analysis, Treatment Outcome, Mortality, Warfarin, Aged, Anticoagulants, Double-Blind Method, Drug Administration Schedule, Factor Xa Inhibitors, Female, Humans, Multivariate Analysis, Proportional Hazards Models, Risk Assessment, Sex Factors, Cardiology and Cardiovascular Medicine, Administration, medicine.drug, Oral, medicine.medical_specialty, Catheter ablation, Dabigatran, 03 medical and health sciences, RISK-FACTOR, Intensive care medicine, METAANALYSIS, Ischemic Stroke, Intracranial Hemorrhage, Heart Failure, CONGESTIVE-HEART-FAILURE, business.industry, EFFICACY, medicine.disease, warfarin, Emergency medicine, FOLLOW-UP, business
Abstract

Background Atrial fibrillation is associated with higher mortality. Identification of causes of death and contemporary risk factors for all‐cause mortality may guide interventions. Methods and Results In the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF) study, patients with nonvalvular atrial fibrillation were randomized to rivaroxaban or dose‐adjusted warfarin. Cox proportional hazards regression with backward elimination identified factors at randomization that were independently associated with all‐cause mortality in the 14 171 participants in the intention‐to‐treat population. The median age was 73 years, and the mean CHADS 2 score was 3.5. Over 1.9 years of median follow‐up, 1214 (8.6%) patients died. Kaplan–Meier mortality rates were 4.2% at 1 year and 8.9% at 2 years. The majority of classified deaths (1081) were cardiovascular (72%), whereas only 6% were nonhemorrhagic stroke or systemic embolism. No significant difference in all‐cause mortality was observed between the rivaroxaban and warfarin arms ( P =0.15). Heart failure (hazard ratio 1.51, 95% CI 1.33–1.70, P CI 1.51–1.90, P Conclusions In a large population of patients anticoagulated for nonvalvular atrial fibrillation, ≈7 in 10 deaths were cardiovascular, whereas Clinical Trial Registration URL : https://www.clinicaltrials.gov/ . Unique identifier: NCT 00403767.

Published
2016
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22. Clasificación microscópica de las lesiones cutáneas producidas por Hypoderma lineatum

Author

Cabanelas, E., Panadero, R., Fuertes, M., Fernández Fernández, M., Benavides, Julio, López, C., Pérez Creo, A., Díaz, P., Morrondo-Pelayo, M. Patrocinio, Díez-Baños, Pablo, and Pérez Pérez, Valentín

Abstract

Trabajo presentado a la: XXVII Reunión de la Sociedad Española de Anatomía Patológica Veterinaria. (Barcelona, España, 17 al 19 Junio, 2015).

Published
2015

23. Preliminary results of an inter-laboratory study on quantitative phase analysis

Author

Suárez, M., Aparicio, P., Barrenechea, J. F., Cuevas, J., Delgado, R., Fernández, A. M., Huertas, F. J., García-González, M. T., García-Romero, Emilia, González, I., Fernández, R., León-Reina, Laura, López-Galindo, A., Párraga, J., Pelayo, M., Pozo, E., Pozo, M., Martín-García, J. M., Nieto, F., Sánchez-Bellón, A., Santarén, J., Ruiz, A. I., Terroso, E., and Terroso, D.

Abstract

Trabajo presentado en el Euroclay, celebrado en Edimburgo (Escocia), del 5 al 10 de julio de 2015, Quantitative phase analysis (QPA) of clayey materials using X-Ray diffraction data has always been a challenge. While quantitative methods based on Rietveld analysis offer excellent results for non-clay minerals, they become problematic when high crystallochemical and order degree variations are present in the phases, as is the case of most clay minerals. In the summer of 2014, the Spanish Clay Society (Sociedad Española de Arcillas, SEA) proposed a collective QPA experiment to its members. The aim was to compare the results obtained in different clay laboratories studying the same samples by X-Ray diffraction. This comparative study is a starting point for a long-term work focused on the development of an optimized QPA guide for clay minerals adapted to modern equipment and software. The results presented in this talk are those from the 2014 preliminary study in which the 22 participant laboratories analyzed three samples following their own laboratory routines. The only condition was not to use other complementary techniques for the quantification (e.g. IR spectroscopy, thermal or chemical analysis). The samples were mixtures of nearly pure quartz, feldspar, calcite, alunite, and different clays. Clay minerals included two different smectites (with low and high crystallinity), sepiolite, kaolinite and palygorskite. The set of procedures, technical characteristics of the equipment, and software used in each laboratory was very different and, as a consequence, comparison of the results is not straightforward. The results were classified into "Reflecting Powers Method" (RPM) and “Relative Intensity Ratio (RIR) – Rietveld methods” groups. As it is well known RPM is based on the peaks areas while RIR is based on the peak intensities. As expected, a high dispersion of the results was found both globally and per group. At first glance, RPM returned, on average, better approximations to the true composition of the samples. Interestingly that trend was clearer in samples with clay minerals having higher variability in crystallochemistry and crystalline range order.

Published
2015

25. Evidence of montmorillonite/Fe-rich smectite transformation in the Morrón de Mateo bentonite deposit (Spain): Implications for the clayey barrier behaviour

Author

Pelayo, M., García Romero, Emilia, Labajo, M.A., Pérez del Villar Guillén, L., Pelayo, M., García Romero, Emilia, Labajo, M.A., and Pérez del Villar Guillén, L.

Abstract

The Morrón de Mateo bentonite deposit (Cabo de Gata region, Spain) has been studied as a natural analogue of the thermal and geochemical effects on the clayey barrier in a deep geological repository of high level radioactive wastes. This deposit was intruded by a volcanic dome inducing an increase of temperature and supplying Fe–Mg-rich solutions, which were responsible for the alteration of the previously bentonitised pyroclastic materials (white tuff formation). The textural, mineralogical and crystallochemical features of the smectites located within the vicinity and away from the dome have been studied in order to elucidate the intrusion effects on these smectites. The results obtained show that distal smectites are Al-montmorillonites, similar to those from other bentonite deposits in the Cabo de Gata region; whereas proximal smectites are a mixture of Al-montmorillonites, Fe-rich montmorillonites and beidellites, and intermediate smectites between beidellite and Fe-rich-saponite. The textural relationships between these smectites indicate that smectites with intermediate composition come from the transformation of Al-montmorillonite, through gradual steps, consisting of increasingly Mg and Fe-rich smectites. This transformation process is confirmed when the structural formulae of proximal smectites are plotted on the MgVIvs (Al + Fe3 +)VI diagram. Thus, a gradual transition from dioctahedral smectites to smectites with an intermediate chemical composition is observed, which tend toward trioctahedral smectites. These observations suggest that the transformation of dioctahedral smectites into an intermediate term between di- and trioctahedral Fe-rich smectites could be originated under natural conditions. This transformation can be considered as an analogue process to that expected in the bentonite barrier from a deep geological repository of radioactive wastes whether the two following conditions would occur: i) an increase of temperature due to the radioactive, ENRESA/CIEMAT, Depto. de Mineralogía y Petrología, Fac. de Ciencias Geológicas, FALSE, pub

Published
2016

26. Characterization of soil erosion indicators using hyperspectral data from a Mediterranean rainfed cultivated region

Author

Schmid, T., Rodriguez-Rastrero, M., Escribano, P., Palacios-Orueta, Alicia, Ben-Dor, E., Plaza, A., Milewski, R., Huesca, M., Bracken, A., Cicuendez, V., Pelayo, M., Chabrillat, S., Schmid, T., Rodriguez-Rastrero, M., Escribano, P., Palacios-Orueta, Alicia, Ben-Dor, E., Plaza, A., Milewski, R., Huesca, M., Bracken, A., Cicuendez, V., Pelayo, M., and Chabrillat, S.

Abstract

The determination of surface soil properties is an important application of remotely sensed hyperspectral imagery. Moreover, different soil properties can be associated with erosion processes, with significant implications for land management and agricultural uses. This study integrates hyperspectral data supported by morphological and physico-chemical ground data to identify and map soil properties that can be used to assess soil erosion and accumulation. These properties characterize different soil horizons that emerge at the surface as a consequence of the intensity of the erosion processes, or the result of accumulation conditions. This study includes: 1) field and laboratory characterization of the main soil types in the study area; 2) identification and definition of indicators of soil erosion and accumulation stages (SEAS); 3) compilation of the site-specific MEDiterranean Soil Erosion Stages (MEDSES) spectral library of soil surface characteristics using field spectroscopy; 4) using hyperspectral airborne data to determine a set of endmembers for different SEAS and introducing these into the support vector machine (SVM) classifier to obtain their spatial distribution; and 5) evaluation of the accuracy of the classification applying a field validation protocol. The study region is located within an agricultural region in Central Spain, representative of Mediterranean agricultural uses dominated by a gently sloping relief, and characterized by soils with contrasting horizons. Results show that the proposed method is successful in mapping different SEAS that indicate preservation, partial loss, or complete loss of fertile soils, as well as down-slope accumulation of different soil materials.

Published
2016

27. Evidence of montmorillonite/Fe-rich smectite transformation in the Morrón de Mateo bentonite deposit (Spain): Implications for the clayey barrier behaviour

Author

Empresa Nacional de Residuos Radiactivos (España), Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (España), Pelayo, M., García-Romero, Emilia, Labajo, M. A., Pérez Del Villar, L., Empresa Nacional de Residuos Radiactivos (España), Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (España), Pelayo, M., García-Romero, Emilia, Labajo, M. A., and Pérez Del Villar, L.

Abstract

The Morrón de Mateo bentonite deposit (Cabo de Gata region, Spain) has been studied as a natural analogue of the thermal and geochemical effects on the clayey barrier in a deep geological repository of high level radioactive wastes. This deposit was intruded by a volcanic dome inducing an increase of temperature and supplying Fe–Mg-rich solutions, which were responsible for the alteration of the previously bentonitised pyroclastic materials (white tuff formation). The textural, mineralogical and crystallochemical features of the smectites located within the vicinity and away from the dome have been studied in order to elucidate the intrusion effects on these smectites. The results obtained show that distal smectites are Al-montmorillonites, similar to those from other bentonite deposits in the Cabo de Gata region; whereas proximal smectites are a mixture of Al-montmorillonites, Fe-rich montmorillonites and beidellites, and intermediate smectites between beidellite and Fe-rich-saponite. The textural relationships between these smectites indicate that smectites with intermediate composition come from the transformation of Al-montmorillonite, through gradual steps, consisting of increasingly Mg and Fe-rich smectites. This transformation process is confirmed when the structural formulae of proximal smectites are plotted on the MgVIvs (Al + Fe3 +)VI diagram. Thus, a gradual transition from dioctahedral smectites to smectites with an intermediate chemical composition is observed, which tend toward trioctahedral smectites. These observations suggest that the transformation of dioctahedral smectites into an intermediate term between di- and trioctahedral Fe-rich smectites could be originated under natural conditions. This transformation can be considered as an analogue process to that expected in the bentonite barrier from a deep geological repository of radioactive wastes whether the two following conditions would occur: i) an increase of temperature due to the radioactive

Published
2016

28. La investigación sobre la mujer : informes en sus primeras versiones

Author

Salles, Vania, McPhail, Elsie, Aguilar H., Citlali, Alonso, José Antonio, Avila C., Abelardo, Bedregal S., Ximena, Bialik P., Raquel, Blanco S., Mercedes, Bustos R., Olga, Cano, Gabriela, Carreras, Mercedes, Castañeda, Carmen, De Lima, Dinorah, Döring, María Teresa, Forero P., Alcira, Gamboa C., José, Gargallo, Francesca, de León, Deyanira González, González M., Soledad, Greenwell, Evelyn, Hidalgo, Teresa, Olvera S., Claudia, Pacheco, Lucila, Pelayo M., Alonso, Peña S., Florencia, Pérez G., Sara E., Motta, Eduardo Pérez, Quan R., Stella, Quezada, Gabriela, Radkau, Verena, Rapold, Dora, Ramírez D., Silvia, Ramos, Carmen, Rueda A., Fabiola, Sánchez, Martha Judith, Sánchez M., María Cristina, Sandoval F., Etelvina, Selva, Beatriz, Solís de A., Ana Alicia, Tarrés, María Luisa, Torres M., María Teresa, Zapata, Francisco, Salles, Vania, McPhail, Elsie, Aguilar H., Citlali, Alonso, José Antonio, Avila C., Abelardo, Bedregal S., Ximena, Bialik P., Raquel, Blanco S., Mercedes, Bustos R., Olga, Cano, Gabriela, Carreras, Mercedes, Castañeda, Carmen, De Lima, Dinorah, Döring, María Teresa, Forero P., Alcira, Gamboa C., José, Gargallo, Francesca, de León, Deyanira González, González M., Soledad, Greenwell, Evelyn, Hidalgo, Teresa, Olvera S., Claudia, Pacheco, Lucila, Pelayo M., Alonso, Peña S., Florencia, Pérez G., Sara E., Motta, Eduardo Pérez, Quan R., Stella, Quezada, Gabriela, Radkau, Verena, Rapold, Dora, Ramírez D., Silvia, Ramos, Carmen, Rueda A., Fabiola, Sánchez, Martha Judith, Sánchez M., María Cristina, Sandoval F., Etelvina, Selva, Beatriz, Solís de A., Ana Alicia, Tarrés, María Luisa, Torres M., María Teresa, and Zapata, Francisco

Published
1988
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29. Cause of Death and Predictors of All‐Cause Mortality in Anticoagulated Patients With Nonvalvular Atrial Fibrillation: Data From ROCKET AF

Author

Pokorney, Sean D., primary, Piccini, Jonathan P., additional, Stevens, Susanna R., additional, Patel, Manesh R., additional, Pieper, Karen S., additional, Halperin, Jonathan L., additional, Breithardt, Günter, additional, Singer, Daniel E., additional, Hankey, Graeme J., additional, Hacke, Werner, additional, Becker, Richard C., additional, Berkowitz, Scott D., additional, Nessel, Christopher C., additional, Mahaffey, Kenneth W., additional, Fox, Keith A. A., additional, Califf, Robert M., additional, Anderson, J., additional, Bedwell, N., additional, Bilsker, M., additional, Bruce, G., additional, Agah, R., additional, DeSantis, M., additional, Eisenberg, S., additional, Flores, A., additional, Herzog, W., additional, Klein, S., additional, Snyder, H., additional, Krueger, S., additional, Almaguer, E., additional, Lavie, E., additional, Lee, C., additional, Mallis, G., additional, Modi, M., additional, Woodworth, G., additional, Niazi, I., additional, Peart, B., additional, Sundaram, S., additional, Snoddy, B., additional, Sotolongo, R., additional, Moloney, J., additional, Vijayaraghavan, K., additional, Whittier, F., additional, Yellen, L., additional, Banerjee, S., additional, Lustgarten, D., additional, Suresh, D., additional, Gelernt, M., additional, Levinson, L., additional, Ghanekar, R., additional, Kneller, G., additional, Hall, C., additional, Fadl, Y., additional, Pirwitz, M., additional, French, W., additional, Mayer, N., additional, Pugeda, J., additional, Steel, K., additional, Mody, F., additional, Malik, A., additional, Chandna, H., additional, Go, A., additional, Emlein, G., additional, Bowden, W., additional, Moscoso, R., additional, Hodson, R., additional, Berk, M., additional, Pan, D., additional, Pappas, J., additional, Orchard, R., additional, Lynchard, G., additional, Vijay, N., additional, Khan, W., additional, El Khadra, M, additional, Antonishen, M., additional, Cucher, F., additional, Staab, M., additional, Zebrack, J., additional, Borromeo, S, additional, Heilman, J., additional, Chaturvedi, S., additional, Makam, S., additional, Turk, S., additional, Hyers, T., additional, Williams, G., additional, Labroo, A., additional, Gill, S., additional, Myears, D., additional, Weinstein, J., additional, Shanes, J., additional, Chandrashekhar, Y., additional, Shah, S., additional, Reiter, W., additional, Logemann, T., additional, Almquist, A., additional, Bhagwat, R., additional, Tak, T., additional, Shen‐Ling, J., additional, Patel, P., additional, Artis, A., additional, Arouni, A., additional, Lauer, M., additional, Kinney, K., additional, Elsen, J., additional, Roan, P., additional, Villafria, R., additional, Sumpter, M., additional, Ip, J., additional, Welka, S., additional, Schifferdecker, B., additional, Sandoval, R., additional, Speirs, S., additional, Jones, A., additional, Haldis, T., additional, Kazmierski, J., additional, Sutherland, J., additional, Dietrich, D., additional, Telfer, E., additional, Berry, J., additional, McElveen, A., additional, Russell, J., additional, Sackett, M., additional, Antonios, N., additional, Smith, D., additional, Vora, K., additional, Kirby, A., additional, Lui, H., additional, Mego, D., additional, Ziada, K., additional, Navas, J., additional, Taussig, A., additional, Koren, M., additional, Vogel, C., additional, Saba, F., additional, Parrott, C., additional, Schneider, R., additional, Shirwany, A., additional, Rubin, M., additional, Treasure, C, additional, Bertolet, B., additional, Chang, M., additional, Langberg, J., additional, Becker, R., additional, Cohen, Y., additional, McGrew, F., additional, White, J., additional, Arzola, F., additional, Zelenka, J., additional, Tannenbaum, A., additional, Fernandes, V., additional, Jamnadas, P., additional, Agamasu, J., additional, Collins, B., additional, Jauch, W., additional, Sasseen, B., additional, Hotchkiss, D., additional, Abadier, R., additional, Osunkoya, A., additional, Schlau, A., additional, Chappel, C., additional, Foster, M., additional, Braun, E., additional, Mostel, E., additional, Capo, J., additional, Ashchi, M., additional, Howard, V., additional, Albirini, A., additional, Burger, A., additional, Rolston, D., additional, Staniloae, C., additional, Bacon, J., additional, Wiseman, A., additional, McGarvey, J, additional, Sonel, A., additional, Hamroff, G., additional, Chang, D., additional, Daboul, N., additional, Broderick, G., additional, Meholick, A., additional, Corbelli, J., additional, Silverman, R., additional, Raffetto, J., additional, Fishberg, R., additional, Georgeson, S., additional, Held, J., additional, Seidner, M., additional, Saint‐Jacques, H., additional, Heitner, J., additional, Kutalek, S., additional, Friedlander, I., additional, Hutchinson, B., additional, Walia, J., additional, Kondo, N., additional, Smiley, N., additional, Blitz, L., additional, Dale, H., additional, Sulman, S., additional, Szulawski, I., additional, Modares, F., additional, Martin, R., additional, Nahhas, A., additional, Renzi, M., additional, Akyea‐Djamson, A., additional, Alfieri, A., additional, Sandhu, J., additional, Voyce, S., additional, Amaram, S., additional, Meyerrose, G., additional, Shoukfeh, M., additional, Lee, F., additional, Villegas, B., additional, Idowu, O., additional, Khera, A., additional, Sam, C., additional, Vo, A., additional, Lieber, I., additional, Smith, T., additional, Awan, N., additional, Tsai, C., 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30. Histological and immunohistochemical characterization of Hypoderma lineatum (Diptera: Oestridae) warbles

Author

Xunta de Galicia, Ministerio de Economía y Competitividad (España), Cabanelas, E., Panadero, R., Fuertes Franco, Miguel, Fernández Fernández, Miguel, Benavides, Julio, López, C., Pérez-Creo, A., Díaz, P., Morrondo-Pelayo, M. Patrocinio, Díez-Baños, Pablo, Pérez Pérez, Valentín, Xunta de Galicia, Ministerio de Economía y Competitividad (España), Cabanelas, E., Panadero, R., Fuertes Franco, Miguel, Fernández Fernández, Miguel, Benavides, Julio, López, C., Pérez-Creo, A., Díaz, P., Morrondo-Pelayo, M. Patrocinio, Díez-Baños, Pablo, and Pérez Pérez, Valentín

Abstract

© 2015 Elsevier B.V. Hypoderma larvae are tissue invading parasites which spend several months migrating within the host tissues before completing their development in the sub-dermal tissues of the back. Subcutaneous stages of the parasite produce an inflammatory reaction in the skin called >warbles>, as well as holes through which larvae breathe. In order to elucidate the microscopical structure of the warbles, three hides from warbled cows were collected in a slaughterhouse in Lugo (NW, Spain) between March and May 2012. A total of 60 skin samples, including warbles at different phases of development, were chosen for histopathological and immunohistochemical examination. Microscopic lesions were classified into three groups, according to the predominance and distribution of different cell populations. In warbles containing living or recently dead larvae with apparently well preserved cuticle (type 1), plasma cells were observed in high number. However, macrophages and lymphocytes were the predominant cells in granulomas (type 2) formed in relation to remnants of the dead parasite, containing or not remains of the altered cuticle. Scars (type 3) were characterized by granulation tissue. Immunohistochemistry showed that B lymphocytes and IgG+ cells were predominant in the lesions, as long as the cuticle of the larvae is intact. On the other side, CD3+ lymphocytes increased once cuticle is destroyed and a granuloma is formed. Macrophages, revealed by CD68+, MAC387+ and lysozyme immunolabelling, were detected in all types of lesions, but they were more abundant in type 2 and scarce in scars. These cells appeared isolated around the intact larvae or forming aggregates around its remains in the granuloma. Moreover, a strong immunolabelling against MAC387 antibody was registered in the squamous epithelium covering the breathing pore. This finding may be associated with the expression of calprotectin, a molecule involved on the healing process of the skin after larvae out

Published
2015

31. Enhanced protection conferred by mucosal BCG vaccination associates with presence of antigen-specific lung tissue-resident PD-1+KLRG1−CD4+T cells

Author

Bull, N. C., Stylianou, E., Kaveh, D. A., Pinpathomrat, N., Pasricha, J., Harrington-Kandt, R., Garcia-Pelayo, M. C., Hogarth, P. J., and McShane, H.

Abstract

BCG, the only vaccine licensed against tuberculosis, demonstrates variable efficacy in humans. Recent preclinical studies highlight the potential for mucosal BCG vaccination to improve protection. Lung tissue-resident memory T cells reside within the parenchyma, potentially playing an important role in protective immunity to tuberculosis. We hypothesised that mucosal BCG vaccination may enhance generation of lung tissue-resident T cells, affording improved protection against Mycobacterium tuberculosis. In a mouse model, mucosal intranasal (IN) BCG vaccination conferred superior protection in the lungs compared to the systemic intradermal (ID) route. Intravascular staining allowed discrimination of lung tissue-resident CD4+T cells from those in the lung vasculature, revealing that mucosal vaccination resulted in an increased frequency of antigen-specific tissue-resident CD4+T cells compared to systemic vaccination. Tissue-resident CD4+T cells induced by mucosal BCG displayed enhanced proliferative capacity compared to lung vascular and splenic CD4+T cells. Only mucosal BCG induced antigen-specific tissue-resident T cells expressing a PD-1+KLRG1−cell-surface phenotype. These cells constitute a BCG-induced population which may be responsible for the enhanced protection observed with IN vaccination. We demonstrate that mucosal BCG vaccination significantly improves protection over systemic BCG and this correlates with a novel population of BCG-induced lung tissue-resident CD4+T cells.

Published
2019
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32. El sistema granito-mineralización de uranio de El Berrocal como análogo natural de un almacenamiento de residuos radiactivos

Author

Pérez del Villar, L., de la Cruz, B., Pardillo, J., Pelayo, M., Rivas, P., and Astudillo, J.

Subjects
Granitos, mineralización de uranio, QE1-996.5, natural analogues, granitos, Geology, Granites, uranium ore deposit, Sierra de Gredos, análogos naturales, residuos radiactivos, sierra de gredos, radioactive wastes, el berrocal, El Berrocal
Abstract

This work summarizes the analogical study of the radioactive elements and rare earths are deposits applied to the modelling and validation of the migration/retention processes of the high level radioactive artificial isotopes in a geological environment. The geological, mineralogical and geochemical characteristics of the El Berrocal granite- U mineralization system suggest that this system cannot be considered as a global natural analogue for a radioactive waste repository. However, the low-temperature hydrothermal processes, which affected it, including that one which originated the uraniferous mineralization, as well as the weathering processes, can be considered as geochemical processes analogous to those that could take place in a high level radioactive repository. En este trabajo se resume la aplicación del estudio analógico de los yacimientos de elementos radiactivos a la modelización y validación de los procesos de migración/retención de los radioisótopos artificiales de alta actividad, en un medio geológico. Las características geológicas, mineralógicas y geoquímicas del sistema granito-mineralización de uranio de El Berrocal sugieren que dicho sistema no puede considerarse como un análogo natural global de un almacenamiento de residuos radiactivos. Sin embargo, los procesos hidrotermales de baja temperatura que lo afectaron, incluido el que originó la mineralización uranífera, así como los de alteración supergénica, pueden considerarse como procesos geoquímicos análogos a los que podrían tener lugar en un almacenamiento de residuos radiactivos de alta actividad.

Published
1993
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33. El proyecto de El Berrocal: síntesis preliminar

Author

Pardillo, J., Pelayo, M., García, M., Marín, C., Hernández, A., Tunero, M., Gómez, P., de la Cruz, B., Pérez del Villar, L., and Rivas, P.

Subjects
granito, lcsh:QE1-996.5, fracturation, radionucleidos, Migración, lcsh:Geology, transporte, coloides, colloids, transport, El Berrocal, fracturación, Migration, radionuclides, granite
Abstract

El Berrocal is an international research project on the natural radionuclide migration in a fissured granitic environment. This project is being carried out in the El Berrocal zone, north of the village of Nombela (Toledo). The gelogical formation studied is a granitic pluton with an epithermal vein-type mineralization comprising quartz, sphalerite, pyrite and chalcopyrite; and pitchblende, pyrite, carbonates and barite. The activities of the project are focused on the structural, lithological, geochemical, hydrochemical and hydrogeological aspects of the granite-U mineralization system, in order to establish a migration model of the natural radionuclides of the environment. The concurrence of the tectonic, hydrothermal and supergenic processes has originated several U remobilizations during the deuteric, hydrothermal and supergenic alteration phases, which affected the system. These phases are responsible of the mineralogical species and present distribution of this element within the system. The Th remobilization is much more limited, due to its different geochemical behavior. The present water-rock interaction processes account for the different types of water existing in the system, which are sulphatic, in the shallowest zones, and calcium bicarbonated in the deepest. The U contents in these waters vary from 1 to 100 ppb. The hydrogeology of the zone is controlled, at a local scale, by the topography and the fracture network, and the mineralized quartz dyke plays a major role on the groundwater flow. The isotopic analyses of the U and Th series in the infill materials seem to indicate recent sorption-desorption U processes and coprecipitation with carbonates.«El Berrocal», es un proyecto internacional de investigación sobre la migración de radionucleidos naturales en un medio granítico fisurado. Este proyecto se está desarrollando en la zona de El Berrocal, situada al norte de Nombela (Toledo), en un plutón granítico con una mineralización filoniana epitermal de uranio. El objetivo del proyecto es conocer los aspectos estructurales, litológicos, geoquímicos, hidroquímicos e hidrogeológicos del sistema granito-mineralización de U, a fin de establecer un modelo de migración de los radionucleidos naturales del medio. La convergencia de procesos tectónicos, hidrotermales y supergénicos ha dado lugar a sucesivas removilizaciones del uranio durante las fases deutérica, hidrotermal y supergénica, que afectaron al sistema. Estas fases son las responsables de la mineralogía y distribución actual de dicho elemento en el sistema. La removilización del torio es mucho más restringida debido a su diferente comportamiento geoquímico. Los procesos actuales de interacción agua-roca están condicionando los tipos de aguas existentes en el sistema que son: sulfatadas, en las zonas más superficiales y bicarbonatadas cálcicas, en las más profundas. Los contenidos en uranio en estas aguas están comprendidos entre 1 y 100 ppb. La hidrogeología de la zona está controlada, a nivel local, por la topografía y la red de fracturación, siendo el dique de cuarzo mineralizado un accidente con repercusión importante en la circulación de las aguas subterráneas. El análisis isotópico de las series del uranio y del torio en rellenos fisurales parece indicar procesos recientes de sorción-desorción de uranio y coprecipitación con carbonatos.

Published
1993

34. El sistema granito-mineralización de uranio de El Berrocal como análogo natural de un almacenamiento de residuos radiactivos

Author

Astudillo, J., Rivas, P., Pelayo, M., Pardillo, J., de la Cruz, B., and Pérez del Villar, L.

Subjects
Granitos, lcsh:Geology, natural analogues, radioactive wastes, análogos naturales, lcsh:QE1-996.5, Granites, uranium ore deposit, Sierra de Gredos, El Berrocal, mineralización de uranio, residuos radiactivos
Abstract

This work summarizes the analogical study of the radioactive elements and rare earths are deposits applied to the modelling and validation of the migration/retention processes of the high level radioactive artificial isotopes in a geological environment. The geological, mineralogical and geochemical characteristics of the El Berrocal granite- U mineralization system suggest that this system cannot be considered as a global natural analogue for a radioactive waste repository. However, the low-temperature hydrothermal processes, which affected it, including that one which originated the uraniferous mineralization, as well as the weathering processes, can be considered as geochemical processes analogous to those that could take place in a high level radioactive repository.En este trabajo se resume la aplicación del estudio analógico de los yacimientos de elementos radiactivos a la modelización y validación de los procesos de migración/retención de los radioisótopos artificiales de alta actividad, en un medio geológico. Las características geológicas, mineralógicas y geoquímicas del sistema granito-mineralización de uranio de El Berrocal sugieren que dicho sistema no puede considerarse como un análogo natural global de un almacenamiento de residuos radiactivos. Sin embargo, los procesos hidrotermales de baja temperatura que lo afectaron, incluido el que originó la mineralización uranífera, así como los de alteración supergénica, pueden considerarse como procesos geoquímicos análogos a los que podrían tener lugar en un almacenamiento de residuos radiactivos de alta actividad.

Published
1993

35. El proyecto de El Berrocal: síntesis preliminar

Author

Rivas, P., Pérez del Villar, L., de la Cruz, B., Gómez, P., Tunero, M., Hernández, A., Marín, C., García, M., Pelayo, M., and Pardillo, J.

Subjects
QE1-996.5, fracturación, granito, Migración, fracturation, radionucleidos, Geology, migración, transporte, coloides, colloids, transport, el berrocal, El Berrocal, Migration, radionuclides, granite
Abstract

El Berrocal is an international research project on the natural radionuclide migration in a fissured granitic environment. This project is being carried out in the El Berrocal zone, north of the village of Nombela (Toledo). The gelogical formation studied is a granitic pluton with an epithermal vein-type mineralization comprising quartz, sphalerite, pyrite and chalcopyrite; and pitchblende, pyrite, carbonates and barite. The activities of the project are focused on the structural, lithological, geochemical, hydrochemical and hydrogeological aspects of the granite-U mineralization system, in order to establish a migration model of the natural radionuclides of the environment. The concurrence of the tectonic, hydrothermal and supergenic processes has originated several U remobilizations during the deuteric, hydrothermal and supergenic alteration phases, which affected the system. These phases are responsible of the mineralogical species and present distribution of this element within the system. The Th remobilization is much more limited, due to its different geochemical behavior. The present water-rock interaction processes account for the different types of water existing in the system, which are sulphatic, in the shallowest zones, and calcium bicarbonated in the deepest. The U contents in these waters vary from 1 to 100 ppb. The hydrogeology of the zone is controlled, at a local scale, by the topography and the fracture network, and the mineralized quartz dyke plays a major role on the groundwater flow. The isotopic analyses of the U and Th series in the infill materials seem to indicate recent sorption-desorption U processes and coprecipitation with carbonates. «El Berrocal», es un proyecto internacional de investigación sobre la migración de radionucleidos naturales en un medio granítico fisurado. Este proyecto se está desarrollando en la zona de El Berrocal, situada al norte de Nombela (Toledo), en un plutón granítico con una mineralización filoniana epitermal de uranio. El objetivo del proyecto es conocer los aspectos estructurales, litológicos, geoquímicos, hidroquímicos e hidrogeológicos del sistema granito-mineralización de U, a fin de establecer un modelo de migración de los radionucleidos naturales del medio. La convergencia de procesos tectónicos, hidrotermales y supergénicos ha dado lugar a sucesivas removilizaciones del uranio durante las fases deutérica, hidrotermal y supergénica, que afectaron al sistema. Estas fases son las responsables de la mineralogía y distribución actual de dicho elemento en el sistema. La removilización del torio es mucho más restringida debido a su diferente comportamiento geoquímico. Los procesos actuales de interacción agua-roca están condicionando los tipos de aguas existentes en el sistema que son: sulfatadas, en las zonas más superficiales y bicarbonatadas cálcicas, en las más profundas. Los contenidos en uranio en estas aguas están comprendidos entre 1 y 100 ppb. La hidrogeología de la zona está controlada, a nivel local, por la topografía y la red de fracturación, siendo el dique de cuarzo mineralizado un accidente con repercusión importante en la circulación de las aguas subterráneas. El análisis isotópico de las series del uranio y del torio en rellenos fisurales parece indicar procesos recientes de sorción-desorción de uranio y coprecipitación con carbonatos.

Published
1993
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36. African 1, an epidemiologically important clonal complex of **Mycobacterium bovis** dominant in Mali, Nigeria, Cameroon, and Chad

Author

Müller, B., Hilty, M., Berg, S., Garcia-Pelayo, M. C., Dale, J., Boschiroli, M. L., Cadmus, S., Ngandolo, B. N. R., Godreuil, S., Diguimbaye-Djaibé, C., Kazwala, R., Bonfoh, B., Njanpop-Lafourcade, B. M., Sahraoui, N., Guetarni, D., Aseffa, A., Mekonnen, M. H., Razanamparany, V. R., Ramarokoto, H., Djonne, B., Oloya, J., Machado, A., Mucavele, C., Skjerve, E., Portaels, F., Rigouts, L., Michel, A., Müller, A., Källenius, G., van Helden, P. D., Hewinson, R. G., Zinsstag, J., Gordon, J., Gordon, S. V., and Smith, N. H.

Subjects
Africa, West, Tuberculosis, Chad, Bacterial diseases, Population, Molecular Sequence Data, Prevalence, Strains, Nigeria, Mali, Microbiology, Evolutionary genetics, parasitic diseases, medicine, Animals, Africa, Central, Cameroon, Typing, education, Molecular Biology, Spoligotyping, Genetics, Mycobacterium bovis, education.field_of_study, biology, Molecular epidemiology, business.industry, Spacer DNA, biology.organism_classification, medicine.disease, Biotechnology, Bacterial Typing Techniques, Africa, Cattle, Human medicine, Chromosome Deletion, business, Geographical distribution, BCG vaccine, Tuberculosis, Bovine, Population Genetics and Evolution
Abstract

We have identified a clonal complex of Mycobacterium bovis present at high frequency in cattle in population samples from several sub-Saharan west-central African countries. This closely related group of bacteria is defined by a specific chromosomal deletion (RDAf1) and can be identified by the absence of spacer 30 in the standard spoligotype typing scheme. We have named this group of strains the African 1 (Af1) clonal complex and have defined the spoligotype signature of this clonal complex as being the same as the M. bovis BCG vaccine strain but with the deletion of spacer 30. Strains of the Af1 clonal complex were found at high frequency in population samples of M. bovis from cattle in Mali, Cameroon, Nigeria, and Chad, and using a combination of variable-number tandem repeat typing and spoligotyping, we show that the population of M. bovis in each of these countries is distinct, suggesting that the recent mixing of strains between countries is not common in this area of Africa. Strains with the Af1-specific deletion (RDAf1) were not identified in M. bovis isolates from Algeria, Burundi, Ethiopia, Madagascar, Mozambique, South Africa, Tanzania, and Uganda. Furthermore, the spoligotype signature of the Af1 clonal complex has not been identified in population samples of bovine tuberculosis from Europe, Iran, and South America. These observations suggest that the Af1 clonal complex is geographically localized, albeit to several African countries, and we suggest that the dominance of the clonal complex in this region is the result of an original introduction into cows naïve to bovine tuberculosis.

Published
2009

37. The study of Spanish clays for their use as sealing materials in nuclear waste repositories: 20 years of progress

Author

Villar, M. V., Fernández-Soler, J. M., Delgado Huertas, Antonio, Reyes, Emilio, Linares, J., Jiménez de Cisneros, C., Huertas, F. J., Caballero, E., Leguey, Santiago, Cuevas, Julián, Garralón, A., Fernández, A. M., Pelayo, M., Martín, P. L., Pérez Del Villar, L., and Astudillo, J.

Subjects
Bentonite barrier, Arcillas españolas, Barrera de bentonita, Montmorillonita, Saponita, Radioactive waste disposal, Spanish clays, Natural analogues, Análogos naturales, Almacenamiento de residuos radiactivos, Montmorillonite, Saponite
Abstract

[EN] The paper summarises the studies that have been performed in Spain as regards the selection and characterisation of clays suitable for sealing and backfilling of radioactive waste repositories. This research began in the 80’s under the auspices of ENRESA, the Spanish agency for nuclear waste management, and started by a survey of apt clay deposits and suppliers. The characterisation of the clays and the criteria followed for their further selection were those already accepted by the international community: mineralogical purity, retention properties, plasticity, low permeability, high swelling pressure and thermal conductivity. These initial studies resulted in the selection of deposits from the Cabo de Gata region (Almería) and the Tertiary Basin of Madrid (Toledo), whose detailed characterisation was carried out by several laboratories. The Cortijo de Archidona deposit (Almería) was finally selected and the bentonite taken there has been the object of various research projects that have ended in this bentonite being one of the best characterised from the mineralogical, thermal, hydraulic, mechanical, geochemical and alterability points of view. Besides, and more recently, the behaviour of the bentonite under the conditions of a repository has been studied at laboratory and natural scale, and the long-term evolution of the barrier is being analysed by natural analogues studies in the Cabo de Gata area.S, [ES] El artículo resume los estudios que se han llevado a cabo en España para la selección y caracterización de arcillas aptas como material de sellado y relleno en almacenamientos de residuos radiactivos. La investigación comenzó en los años 80 bajo el patrocinio de ENRESA, la agencia española para la gestión de residuos nucleares, con la búsqueda de yacimientos de arcilla apropiados. El tipo de caracterización realizado y los criterios seguidos para la selección estaban ya aceptados por la comunidad internacional: pureza mineralógica, propiedades de retención, plasticidad, baja permeabilidad, elevada presión de hinchamiento y conductividad térmica. Estos estudios iniciales dieron lugar a la selección de yacimientos de la región de Cabo de Gata (Almería) y de la Cuenca Terciaria de Madrid (Toledo), cuya caracterización detallada fue realizada por varios laboratorios. Finalmente se seleccionó el yacimiento de Cortijo de Archidona (Almería), y la bentonita procedente de él ha sido objeto de varios proyectos de investigación que han hecho que esta bentonita sea una de las más intensamente caracterizadas en sus aspectos mineralógico, térmico, hidráulico, mecánico, geoquímico y de alterabilidad. Además, posteriormente se ha estudiado el comportamiento de esta bentonita en condiciones similares a las de un almacenamiento a escala de laboratorio y natural, y la posible evolución a largo plazo de la barrera se ha analizado mediante estudios de análogos naturales en la región de Cabo de Gata., This paper is dedicated to Pedro Rivas, a pioneer in the study of some of the issues herein presented and the head of many of the research projects compiled. He has participated intensely in all the described investigations. The useful suggestions and comments from the referees A. Meunier and R. Pusch have improved the paper and are gratefully acknowledged.

Published
2006

38. African 2, a clonal complex of Mycobacterium bovis epidemiologically important in East Africa

Author

Berg, Stefan, García Pelayo, M Carmen, Müller, Borna, Hailu, Elena, Asiimwe, Benon, Kremer, Kristin, Dale, James, Boniotti, M Beatrice, Rodriguez, Sabrina, Hilty, Markus, Rigouts, Leen, Firdessa, Rebuma, Machado, Adelina, Mucavele, Custodia, Ngandolo, Bongo Nare Richard, Bruchfeld, Judith, Boschiroli, Laura, Müller, Annélle, Sahraoui, Naima, Pacciarini, Maria, Cadmus, Simeon, Joloba, Moses, van Soolingen, Dick, Michel, Anita L, Djønne, Berit, Aranaz Martín, Alicia, Zinsstag, Jakob, van Helden, Paul, Portaels, Françoise, Kazwala, Rudovick, Källenius, Gunilla, Hewinson, R Glyn, Aseffa, Abraham, Gordon, Stephen V, Smith, Noel H, Berg, Stefan, García Pelayo, M Carmen, Müller, Borna, Hailu, Elena, Asiimwe, Benon, Kremer, Kristin, Dale, James, Boniotti, M Beatrice, Rodriguez, Sabrina, Hilty, Markus, Rigouts, Leen, Firdessa, Rebuma, Machado, Adelina, Mucavele, Custodia, Ngandolo, Bongo Nare Richard, Bruchfeld, Judith, Boschiroli, Laura, Müller, Annélle, Sahraoui, Naima, Pacciarini, Maria, Cadmus, Simeon, Joloba, Moses, van Soolingen, Dick, Michel, Anita L, Djønne, Berit, Aranaz Martín, Alicia, Zinsstag, Jakob, van Helden, Paul, Portaels, Françoise, Kazwala, Rudovick, Källenius, Gunilla, Hewinson, R Glyn, Aseffa, Abraham, Gordon, Stephen V, and Smith, Noel H

Abstract

We have identified a clonal complex of Mycobacterium bovis isolated at high frequency from cattle in Uganda, Burundi, Tanzania, and Ethiopia. We have named this related group of M. bovis strains the African 2 (Af2) clonal complex of M. bovis. Af2 strains are defined by a specific chromosomal deletion (RDAf2) and can be identified by the absence of spacers 3 to 7 in their spoligotype patterns. Deletion analysis of M. bovis isolates from Algeria, Mali, Chad, Nigeria, Cameroon, South Africa, and Mozambique did not identify any strains of the Af2 clonal complex, suggesting that this clonal complex of M. bovis is localized in East Africa. The specific spoligotype pattern of the Af2 clonal complex was rarely identified among isolates from outside Africa, and the few isolates that were found and tested were intact at the RDAf2 locus. We conclude that the Af2 clonal complex is localized to cattle in East Africa. We found that strains of the Af2 clonal complex of M. bovis have, in general, four or more copies of the insertion sequence IS6110, in contrast to the majority of M. bovis strains isolated from cattle, which are thought to carry only one or a few copies., Centro de Vigilancia Sanitaria Veterinaria (VISAVET), TRUE, pub

Published
2011

40. Estudios mineralógicos y litogeoquímicos de El Berrocal

Author

Pérez del Villar, L., Cruz, B. de la, Pardillo Porras, J., Cózar, J. S., Pelayo, M., Marín, C., Rivas, P., Crespo, M. T., Galán, M. P., Reyes, E., Caballero, E., Delgado, A., and Núñez, R.

Subjects
Migration/retention of radionuclides, Natural analogue, Berrocal plutón, Mineralogy, Lithogeochemistry
Abstract

The different materials existing in the El Berrocal pluton are characterized from a mineralogical, chemical and geochemical point of view. The influence of the alteration processes on the migration/ retention of U, Th and other radionuclides is analyzed and the analogies of the hydrothermal alteration processes to those of a high level radioactive waste repository are established

Published
1996

41. The El Berrocal mineralógical and lithogeochemical studies

Author

Pérez del Villar, L., Cruz, B. de la, Pardillo Porras, J., Cózar, J. S., Pelayo, M., Marín, C., Rivas, P., Crespo, M. T., Galán, M. P., Reyes, E., Caballero, E., Delgado, A., and Núñez, R.

Subjects
Migration/retention of radionuclides, Natural analogue, Berrocal plutón, Mineralogy, Lithogeochemistry
Abstract

The different materials existing in the El Berrocal pluton are characterized from a mineralogical, chemical and geochemical point of view. The influence of the alteration processes on the migration/ retention of U, Th and other radionuclides is analyzed and the analogies of the hydrothermal alteration processes to those of a high level radioactive waste repository are established

Published
1996

42. African 2, a Clonal Complex of Mycobacterium bovis Epidemiologically Important in East Africa

Author

Berg, Stefan, primary, Garcia-Pelayo, M. Carmen, additional, Müller, Borna, additional, Hailu, Elena, additional, Asiimwe, Benon, additional, Kremer, Kristin, additional, Dale, James, additional, Boniotti, M. Beatrice, additional, Rodriguez, Sabrina, additional, Hilty, Markus, additional, Rigouts, Leen, additional, Firdessa, Rebuma, additional, Machado, Adelina, additional, Mucavele, Custodia, additional, Ngandolo, Bongo Nare Richard, additional, Bruchfeld, Judith, additional, Boschiroli, Laura, additional, Müller, Annélle, additional, Sahraoui, Naima, additional, Pacciarini, Maria, additional, Cadmus, Simeon, additional, Joloba, Moses, additional, van Soolingen, Dick, additional, Michel, Anita L., additional, Djønne, Berit, additional, Aranaz, Alicia, additional, Zinsstag, Jakob, additional, van Helden, Paul, additional, Portaels, Françoise, additional, Kazwala, Rudovick, additional, Källenius, Gunilla, additional, Hewinson, R. Glyn, additional, Aseffa, Abraham, additional, Gordon, Stephen V., additional, and Smith, Noel H., additional

Published
2012
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43. African 2, a Clonal Complex of Mycobacterium bovis Epidemiologically Important in East Africa

Author

Berg, Stefan, primary, Garcia-Pelayo, M. Carmen, additional, Müller, Borna, additional, Hailu, Elena, additional, Asiimwe, Benon, additional, Kremer, Kristin, additional, Dale, James, additional, Boniotti, M. Beatrice, additional, Rodriguez, Sabrina, additional, Hilty, Markus, additional, Rigouts, Leen, additional, Firdessa, Rebuma, additional, Machado, Adelina, additional, Mucavele, Custodia, additional, Ngandolo, Bongo Nare Richard, additional, Bruchfeld, Judith, additional, Boschiroli, Laura, additional, Müller, Annélle, additional, Sahraoui, Naima, additional, Pacciarini, Maria, additional, Cadmus, Simeon, additional, Joloba, Moses, additional, van Soolingen, Dick, additional, Michel, Anita L., additional, Djønne, Berit, additional, Aranaz, Alicia, additional, Zinsstag, Jakob, additional, van Helden, Paul, additional, Portaels, Françoise, additional, Kazwala, Rudovick, additional, Källenius, Gunilla, additional, Hewinson, R. Glyn, additional, Aseffa, Abraham, additional, Gordon, Stephen V., additional, and Smith, Noel H., additional

Published
2011
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44. Characterization of the transcriptional regulator Rv3124 of Mycobacterium tuberculosis identifies it as a positive regulator of molybdopterin biosynthesis and defines the functional consequences of a non-synonymous SNP in the Mycobacterium bovis BCG orthologue

Author

Mendoza Lopez, Pablo, primary, Golby, Paul, additional, Wooff, Esen, additional, Garcia, Javier Nunez, additional, Garcia Pelayo, M. Carmen, additional, Conlon, Kevin, additional, Gema Camacho, Ana, additional, Hewinson, R. Glyn, additional, Polaina, Julio, additional, Suárez García, Antonio, additional, and Gordon, Stephen V., additional

Published
2010
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45. A Comprehensive Survey of Single Nucleotide Polymorphisms (SNPs) across Mycobacterium bovis Strains and M. bovis BCG Vaccine Strains Refines the Genealogy and Defines a Minimal Set of SNPs That Separate Virulent M. bovis Strains and M. bovis BCG Strains

Author

Garcia Pelayo, M. Carmen, primary, Uplekar, Swapna, additional, Keniry, Andrew, additional, Mendoza Lopez, Pablo, additional, Garnier, Thierry, additional, Nunez Garcia, Javier, additional, Boschiroli, Laura, additional, Zhou, Xiangmei, additional, Parkhill, Julian, additional, Smith, Noel, additional, Hewinson, R. Glyn, additional, Cole, Stewart T., additional, and Gordon, Stephen V., additional

Published
2009
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46. Eliminación de larvas de Protostrongylidae y Dictyocaulidae por ovinos marcados de los montes Cántabro-Leoneses

Author

Morrondo-Pelayo, M. Patrocinio, Manga-González, M. Yolanda, and González Lanza, Camino

Abstract

Trabajo presentado al I Congreso Internacional de las Asociaciones Sudoccidental-Europeas de Parasitología (ICASEP I). VII Congreso Nacional Español de Parasitología. II Congreso Ibérico de Parasitología, El propósito de este estudio fue establecer el modelo epidemiologico de las bronconeumonias verminosas ovinas en la montaña de León. Con este fin, se han realizado investigaciones parasitológicas en los hospedadores definitivos (ovinos) e intermediarios (moluscos) durante 2 años., Estudio financiado por el proyecto CSIC ID-608

Published
1991

47. Cinética de la eliminación larvaria de nematodos broncopulmonares en ovinos de la provincia de León

Author

Morrondo-Pelayo, M. Patrocinio, González Lanza, Camino, Hidalgo-Argüello, Rosario, and Manga-González, M. Yolanda

Abstract

Trabajo presentado al I Congreso Internacional de las Asociaciones Sudoccidentel-Europeas de Parasitología (ICASEP I). VII Congreso Nacional Español de Parasitología. II Congreso Ibérico de Parasitología, Se estudió mensualmente, desde Marzo 1986 a Febrero 1987, la eliminación de larvas I (L-I) de Protostrongylidae y Dictyocaulidae en ovinos explotados en régimen de pastoreo extensivo, procedentes de 4 localidades de la cuenca del Porma..., Estudio financiado por el Proyecto CSIC ID-608

Published
1991

48. Molecular and clinical characterisation of three Spanish families with maternally inherited non-syndromic hearing loss caused by the 1494C->T mutation in the mitochondrial 12S rRNA gene

Author

Rodriguez-Ballesteros, M, primary, Olarte, M, additional, Aguirre, L A, additional, Galan, F, additional, Galan, R, additional, Vallejo, L A, additional, Navas, C, additional, Villamar, M, additional, Moreno-Pelayo, M A, additional, Moreno, F, additional, and del Castillo, I, additional

Published
2006
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49. Joint larval development of Cystocaulus ocreatus/Muellerius capillaris and C. ocreatus/Neostrongylus linearis (Nematoda) in six species of Helicidae (Mollusca) experimentally infected

Author

Manga-González, M. Yolanda and Morrondo-Pelayo, M. Patrocinio

Abstract

http://www.ncbi.nlm.nih.gov/pubmed/2085207 [EN] This is the first study on the experimental susceptibility of the following species of molluscs: Cernuella (X.) cespitum arigonis, Helicella (H.) itala, Helicella ordunensis, Cochlicella barbara, Cepaea nemoralis and Helix (C.) aspersa, as intermediare hosts for the combination of both C. ocreatus and M. capillaris, pulmonary parasites in ruminants. Furthermore, the larval development of C. ocreatus and N. linearis, the two taken together, has been followed in Cernuella (X.) cespitum arigonis, H. ordunensis and C. nemoralis. Approximately 40 specimens of each of the above-mentioned species of molluscs were infected with the parasites listed. Bearing in mind the results obtained, we believe that while Cernuella (X.) cespitum arigonis, H. ordunensis, C. nemoralis, C. barbara and Helicella (H.) itala are suitable intermediate hosts for the larval combination of C. ocreatus and M. capillaris, the same cannot be said of Helix (C.) aspersa. Likewise, the first 3 species of molluscs quoted are ideal for the joint larval development of C. ocreatus and N. linearis. It seems that double infections favour larval development. [GER] Dies ist die erste Studie zur experimentellen Empfänglichkeit folgender Schneckenarten als Zwischenwirte für die Kombination von C. ocreatus/M. capillaris (Lungenparasiten von Wiederkäuem): Cernuella (X.) cespitum arigonis, Helicella (H.) itala, H. ordunensis, Cochlicella barbara, Cepaea nemoralis und Helix (C.) aspersa. Weiter wurde die kombinierte Larvalentwicklung von C. ocreatus und N. linearis in Cernuella (X.) cespitum arigonis, H. ordunensis und C. nemoralis verfolgt. Etwa 40 Exemplare jeder der genannten Schneckenarten wurde mit den erwähnten Parasitenkombinationen infiziert. Auf Grund der Ergebnisse nehmen wir an, daß Cernuella (X.) cespitum arigonis, H. ordunensis, C. nemoralis, C. barbara und Helicella (H.) itala empfängliche Zwischenwirte für die larvale Kombination von C. ocreatus und M. capillaris sind, während dies für Helix (C.) aspersa nicht zutrifft. Die ersten 3 genannten Schneckenarten sind dabei ideal für die kombinierte Larvalentwicklung von C. ocreatus und N. linearis. Es scheint, daß Doppelinfektionen die Larvalentwicklung begünstigen. This work was supported, in part, by both CAICYT (Project number 142/85) and CSIC (ID-211)

Published
1990

50. Receptividad experimental de algunas especies de Helicodontinae y Helicinae (Mollusca, Stylommatophora) a larvas de Neostrongylus linearis (Nematoda, Protostrongylidae)

Author

Manga-González, M. Yolanda and Morrondo-Pelayo, M. Patrocinio

Abstract

Trabajo presentado al VIII Congreso Nacional de Malacología (Valencia, 2 al 5 de octubre de 1990), Se ha estudiado la idoneidad de Oestophora (Oestophora) barbula (R0SSMSSLER, 1838), Oestophorella buvinieri (MICHAUD, 1841), Cepaea nemoralis (LINNAEUS, 1758) y Helix (Cryptompha lus) aspersa MULLER, 1774, como moluscos hospedadores intermediarios (H.I.) experimentales de Neostrongylus linearis (MAROTEL, 1913) GEBAUER, 1932, — parásito broncopulmonar de pequeños rumiantes. Los moluscos de cada especie (adultos) se agruparon, para su infestación por el método KASSAI, en lotes de 40 ejemplares.

Published
1990

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