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1. Event rates and incidence of post-COVID-19 condition in hospitalised SARS-CoV-2 positive children and young people and controls across different pandemic waves: exposure-stratified prospective cohort study in Moscow (StopCOVID)

Author

Pazukhina, Ekaterina, Rumyantsev, Mikhail, Baimukhambetova, Dina, Bondarenko, Elena, Markina, Nadezhda, El-Taravi, Yasmin, Petrova, Polina, Ezhova, Anastasia, Andreeva, Margarita, Iakovleva, Ekaterina, Bobkova, Polina, Pikuza, Maria, Trefilova, Anastasia, Abdeeva, Elina, Galiautdinova, Aysylu, Filippova, Yulia, Bairashevskaia, Anastasiia, Zolotarev, Aleksandr, Bulanov, Nikolay, DunnGalvin, Audrey, Chernyavskaya, Anastasia, Kondrikova, Elena, Kolotilina, Anastasia, Gadetskaya, Svetlana, Ivanova, Yulia V., Turina, Irina, Eremeeva, Alina, Fedorova, Ludmila A., Comberiati, Pasquale, Peroni, Diego G., Nekliudov, Nikita, Genuneit, Jon, Reyes, Luis Felipe, Brackel, Caroline L. H., Mazankova, Lyudmila, Miroshina, Alexandra, Samitova, Elmira, Borzakova, Svetlana, Carson, Gail, Sigfrid, Louise, Scott, Janet T., McFarland, Sammie, Greenhawt, Matthew, Buonsenso, Danilo, Semple, Malcolm G., Warner, John O., Olliaro, Piero, Osmanov, Ismail M., Korsunskiy, Anatoliy A., and Munblit, Daniel

Published
2024
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2. Short-term and medium-term clinical outcomes of multisystem inflammatory syndrome in children: a prospective observational cohort study

Author

Glazyrina, Anastasia, Zholobova, Elena, Iakovleva, Ekaterina, Bobkova, Polina, Krasnaya, Ekaterina, Kovygina, Karina, Romanova, Olga, Blyuss, Oleg, Tutelman, Konstantin, Petrova, Polina, Bairashevskaia, Anastasiia, Rumyantsev, Mikhail, Korsunskiy, Anatoliy A., Kondrikova, Elena, Nargizyan, Anzhelika, Yusupova, Valeriya, Korobyants, Evgeniya, Sologub, Anna, Kurbanova, Seda, Suvorov, Aleksandr, Sigfrid, Louise, Buonsenso, Danilo, Peroni, Diego G., McArdle, Andrew James, Comberiati, Pasquale, and Munblit, Daniel

Published
2024
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6. Prevalence and risk factors of post-COVID-19 condition in adults and children at 6 and 12 months after hospital discharge: a prospective, cohort study in Moscow (StopCOVID)

Author

Pazukhina, Ekaterina, Andreeva, Margarita, Spiridonova, Ekaterina, Bobkova, Polina, Shikhaleva, Anastasia, El-Taravi, Yasmin, Rumyantsev, Mikhail, Gamirova, Aysylu, Bairashevskaia, Anastasiia, Petrova, Polina, Baimukhambetova, Dina, Pikuza, Maria, Abdeeva, Elina, Filippova, Yulia, Deunezhewa, Salima, Nekliudov, Nikita, Bugaeva, Polina, Bulanov, Nikolay, Avdeev, Sergey, Kapustina, Valentina, Guekht, Alla, DunnGalvin, Audrey, Comberiati, Pasquale, Peroni, Diego G., Apfelbacher, Christian, Genuneit, Jon, Reyes, Luis Felipe, Brackel, Caroline L. H., Fomin, Victor, Svistunov, Andrey A., Timashev, Peter, Mazankova, Lyudmila, Miroshina, Alexandra, Samitova, Elmira, Borzakova, Svetlana, Bondarenko, Elena, Korsunskiy, Anatoliy A., Carson, Gail, Sigfrid, Louise, Scott, Janet T., Greenhawt, Matthew, Buonsenso, Danilo, Semple, Malcolm G., Warner, John O., Olliaro, Piero, Needham, Dale M., Glybochko, Petr, Butnaru, Denis, Osmanov, Ismail M., and Munblit, Daniel

Published
2022
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7. Human Milk and Allergic Diseases: An Unsolved Puzzle.

Author

Munblit, Daniel, Peroni, Diego G, Boix-Amorós, Alba, Hsu, Peter S, Van't Land, Belinda, Gay, Melvin CL, Kolotilina, Anastasia, Skevaki, Chrysanthi, Boyle, Robert J, Collado, Maria Carmen, Garssen, Johan, Geddes, Donna T, Nanan, Ralph, Slupsky, Carolyn, Wegienka, Ganesa, Kozyrskyj, Anita L, and Warner, John O

Subjects
Milk, Human, Humans, Hypersensitivity, Oligosaccharides, Micronutrients, Breast Feeding, Meta-Analysis as Topic, Randomized Controlled Trials as Topic, Microbiota, Observational Studies as Topic, allergic diseases, allergy, breastfeeding, cytokines, human milk, microbiome, oligosaccharides, thymus, Milk, Human, Food Sciences, Nutrition and Dietetics
Abstract

There is conflicting evidence on the protective role of breastfeeding in relation to the development of allergic sensitisation and allergic disease. Studies vary in methodology and definition of outcomes, which lead to considerable heterogeneity. Human milk composition varies both within and between individuals, which may partially explain conflicting data. It is known that human milk composition is very complex and contains variable levels of immune active molecules, oligosaccharides, metabolites, vitamins and other nutrients and microbial content. Existing evidence suggests that modulation of human breast milk composition has potential for preventing allergic diseases in early life. In this review, we discuss associations between breastfeeding/human milk composition and allergy development.

Published
2017

15. A specific synbiotic-containing amino acid-based formula restores gut microbiota in non-IgE mediated cow’s milk allergic infants: a randomized controlled trial

Author

Wopereis, Harm, van Ampting, Marleen T. J., Cetinyurek-Yavuz, Aysun, Slump, Rob, Candy, David C. A., Butt, Assad M., Peroni, Diego G., Vandenplas, Yvan, Fox, Adam T., Shah, Neil, Roeselers, Guus, Harthoorn, Lucien F., Michaelis, Louise J., Knol, Jan, West, Christina E., and the ASSIGN study group

Published
2019
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17. Case Report: MIS-C With Prominent Hepatic and Pancreatic Involvement in a Vaccinated Adolescent – A Critical Reasoning

Author

Consolini, Rita, Costagliola, Giorgio, Spada, Erika, Colombatto, Piero, Orsini, Alessandro, Bonuccelli, Alice, Brunetto, Maurizia R., and Peroni, Diego G.

Subjects
Pediatrics, Perinatology and Child Health
Abstract

Multisystem inflammatory syndrome in children (MIS-C) is a pathologic condition that has emerged during the coronavirus disease 2019 (COVID-19) pandemic. Although the epidemiological evidence of association between MIS-C and SARS-CoV-2 infection has been demonstrated, its pathogenic mechanism is still undefined. We describe the case of a 17-year old female, previously vaccinated against SARS-CoV-2, presenting with a history of asthenia, fever, cough, anorexia, abdominal pain, and vomiting. During the hospitalization, the patient developed bilateral conjunctivitis, hand vasculitis, cutaneous rash, and multiple pulmonary nodules, following by hepatitis and pancreatitis. As she reported a high-risk contact with a SARS-CoV-2 positive patient 10 days before admission, the epidemiological link and the clinical picture characterized by multi-system organ disfunction and inflammatory biomarkers increase led us to the diagnosis of MIS-C. Therefore, the patient was treated with intravenous immunoglobulin and corticosteroids, resulting in a rapid resolution of fever, cutaneous, and pulmonary involvement, while the recovery of hepatitis and pancreatitis was observed in the following weeks. This case leads to the discussion on whether SARS-CoV-2 immunized children and adolescents should be considered at risk of developing MIS-C and on their possible presentation with non-classic clinical features. Additionally, due to the increasing number of vaccinated children and adolescents, the issues resulting either from the diagnostic suspect of MIS-C or from the consequent need of an early therapeutic approach are discussed.

Published
2022

18. The Clinical Impact of Methotrexate-Induced Stroke-Like Neurotoxicity in Paediatric Departments: An Italian Multi-Centre Case-Series

Author

Santangelo, Andrea, primary, Bartolini, Emanuele, additional, Nuzzi, Giulia, additional, Foiadelli, Thomas, additional, Michev, Alexandre, additional, Mina, Tommaso, additional, Trambusti, Irene, additional, Fichera, Valeria, additional, Bonuccelli, Alice, additional, Massimetti, Gabriele, additional, Peroni, Diego G., additional, De Marco, Emanuela, additional, Coccoli, Luca, additional, Luti, Laura, additional, Bernasconi, Sayla, additional, Nardi, Margherita, additional, Menconi, Maria Cristina, additional, Casazza, Gabriella, additional, Pruna, Dario, additional, Mura, Rosamaria, additional, Marra, Chiara, additional, Zama, Daniele, additional, Striano, Pasquale, additional, Cordelli, Duccio M., additional, Battini, Roberta, additional, and Orsini, Alessandro, additional

Published
2022
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20. Alpine altitude climate treatment for severe and uncontrolled asthma:An EAACI position paper

Author

Fieten, Karin B., Drijver-Messelink, Marieke T., Cogo, Annalisa, Charpin, Denis, Sokolowska, Milena, Agache, Ioana, Taborda-Barata, Luís Manuel, Eguiluz-Gracia, Ibon, Braunstahl, Gerrit J., Seys, Sven F., van den Berge, Maarten, Bloch, Konrad E., Ulrich, Silvia, Cardoso-Vigueros, Carlos, Kappen, Jasper H., Brinke, Anneke ten, Koch, Markus, Traidl-Hoffmann, Claudia, da Mata, Pedro, Prins, David J., Pasmans, Suzanne G.M.A., Bendien, Sarah, Rukhadze, Maia, Shamji, Mohamed H., Couto, Mariana, Oude Elberink, Hanneke, Peroni, Diego G., Piacentini, Giorgio, Weersink, Els J.M., Bonini, Matteo, Rijssenbeek-Nouwens, Lucia H.M., Akdis, Cezmi A., Fieten, Karin B., Drijver-Messelink, Marieke T., Cogo, Annalisa, Charpin, Denis, Sokolowska, Milena, Agache, Ioana, Taborda-Barata, Luís Manuel, Eguiluz-Gracia, Ibon, Braunstahl, Gerrit J., Seys, Sven F., van den Berge, Maarten, Bloch, Konrad E., Ulrich, Silvia, Cardoso-Vigueros, Carlos, Kappen, Jasper H., Brinke, Anneke ten, Koch, Markus, Traidl-Hoffmann, Claudia, da Mata, Pedro, Prins, David J., Pasmans, Suzanne G.M.A., Bendien, Sarah, Rukhadze, Maia, Shamji, Mohamed H., Couto, Mariana, Oude Elberink, Hanneke, Peroni, Diego G., Piacentini, Giorgio, Weersink, Els J.M., Bonini, Matteo, Rijssenbeek-Nouwens, Lucia H.M., and Akdis, Cezmi A.

Abstract

Currently available European Alpine Altitude Climate Treatment (AACT) programs combine the physical characteristics of altitude with the avoidance of environmental triggers in the alpine climate and a personalized multidisciplinary pulmonary rehabilitation approach. The reduced barometric pressure, oxygen pressure, and air density, the relatively low temperature and humidity, and the increased UV radiation at moderate altitude induce several physiological and immunological adaptation responses. The environmental characteristics of the alpine climate include reduced aeroallergens such as house dust mites (HDM), pollen, fungi, and less air pollution. These combined factors seem to have immunomodulatory effects controlling pathogenic inflammatory responses and favoring less neuro-immune stress in patients with different asthma phenotypes. The extensive multidisciplinary treatment program may further contribute to the observed clinical improvement by AACT in asthma control and quality of life, fewer exacerbations and hospitalizations, reduced need for oral corticosteroids (OCS), improved lung function, decreased airway hyperresponsiveness (AHR), improved exercise tolerance, and improved sinonasal outcomes. Based on observational studies and expert opinion, AACT represents a valuable therapy for those patients irrespective of their asthma phenotype, who cannot achieve optimal control of their complex condition despite all the advances in medical science and treatment according to guidelines, and therefore run the risk of falling into a downward spiral of loss of physical and mental health. In the light of the observed rapid decrease in inflammation and immunomodulatory effects, AACT can be considered as a natural treatment that targets biological pathways.

Published
2022

24. Risk factors for long covid in previously hospitalised children using the ISARIC Global follow-up protocol: A prospective cohort study

Author

Osmanov, Ismail M., Spiridonova, Ekaterina, Bobkova, Polina, Gamirova, Aysylu, Shikhaleva, Anastasia, Andreeva, Margarita, Blyuss, Oleg, El-Taravi, Yasmin, DunnGalvin, Audrey, Comberiati, Pasquale, Peroni, Diego G., Apfelbacher, Christian, Genuneit, Jon, Mazankova, Lyudmila, Miroshina, Alexandra, Chistyakova, Evgeniya, Samitova, Elmira, Borzakova, Svetlana, Bondarenko, Elena, Korsunskiy, Anatoliy A., Konova, Irina, Hanson, Sarah Wulf, Carson, Gail, Sigfrid, Louise, Scott, Janet, Greenhawt, Matthew, Whittaker, Elizabeth A., Garralda, Elena, Swann, Olivia, Buonsenso, Danilo, Nicholls, Dasha E., Simpson, Frances, Jones, Christina, Semple, Malcolm G., Warner, John O., Vos, Theo, Olliaro, Piero, and Munblit, Daniel

Subjects
Adolescent, SARS-CoV-2, COVID-19, Hospitalized, Post-COVID-19 condition, Risk Factors, Aged, Child, Child, Hospitalized, Female, Follow-Up Studies, Humans, Prospective Studies, Previously hospitalised children
Abstract

Background: The long-term sequelae of coronavirus disease 2019 (Covid-19) in children remain poorly characterised. This study aimed to assess long-term outcomes in children previously hospitalised with Covid-19 and associated risk factors.\ud \ud Methods: This is a prospective cohort study of children (≤18 years old) admitted with confirmed Covid-19. Children admitted to the hospital between April 2, 2020 and August 26, 2020, were included. Telephone interview using the International Severe Acute Respiratory and emerging Infection Consortium (ISARIC) Covid-19 Health and Wellbeing paediatric follow-up survey. Persistent symptoms (>5 months) were further categorised by system(s) involved.\ud \ud Findings: 518 of 853 (61%) of eligible children were available for the follow-up assessment and included in the study. Median age was 10.4 years (IQR, 3–15.2) and 270 (52.1%) were girls; median follow-up since hospital discharge was 256 (223–271) days. At the time of the follow-up interview 126 (24.3%) participants reported persistent symptoms among which fatigue (53, 10.7%), sleep disturbance (36, 6.9%,) and sensory problems (29, 5.6%) were the most common. Multiple symptoms were experienced by 44 (8.4%) participants. Risk factors for persistent symptoms were: older age “6–11 years” (odds ratio 2.74 (95% confidence interval 1.37 to 5.75) and “12–18 years” (2.68, 1.41 to 5.4); and a history of allergic diseases (1.67, 1.04 to 2.67).\ud \ud Interpretation: A quarter of children experienced persistent symptoms months after hospitalization with acute covid-19 infection, with almost one in ten experiencing multi-system involvement. Older age and allergic diseases were associated with higher risk of persistent symptoms at follow-up.

Published
2022

25. Additional file 1 of Prevalence and risk factors of post-COVID-19 condition in adults and children at 6 and 12 months after hospital discharge: a prospective, cohort study in Moscow (StopCOVID)

Author

Pazukhina, Ekaterina, Andreeva, Margarita, Spiridonova, Ekaterina, Bobkova, Polina, Shikhaleva, Anastasia, El-Taravi, Yasmin, Rumyantsev, Mikhail, Gamirova, Aysylu, Bairashevskaia, Anastasiia, Petrova, Polina, Baimukhambetova, Dina, Pikuza, Maria, Abdeeva, Elina, Filippova, Yulia, Deunezhewa, Salima, Nekliudov, Nikita, Bugaeva, Polina, Bulanov, Nikolay, Avdeev, Sergey, Kapustina, Valentina, Guekht, Alla, DunnGalvin, Audrey, Comberiati, Pasquale, Peroni, Diego G., Apfelbacher, Christian, Genuneit, Jon, Reyes, Luis Felipe, Brackel, Caroline L. H., Fomin, Victor, Svistunov, Andrey A., Timashev, Peter, Mazankova, Lyudmila, Miroshina, Alexandra, Samitova, Elmira, Borzakova, Svetlana, Bondarenko, Elena, Korsunskiy, Anatoliy A., Carson, Gail, Sigfrid, Louise, Scott, Janet T., Greenhawt, Matthew, Buonsenso, Danilo, Semple, Malcolm G., Warner, John O., Olliaro, Piero, Needham, Dale M., Glybochko, Petr, Butnaru, Denis, Osmanov, Ismail M., and Munblit, Daniel

Abstract

Additional file 1: Table S1. Categorisation of symptoms. Table S2. Prevalence of post-COVID-19 condition manifestations in adults and children at first (6 months) and second (12 months) follow-up. Table S3. P values for prevalence of post-COVID-19 condition manifestations comparison between adults and children at first (6 months) and second (12 months) follow-up. Table S4. Characteristics (comorbidities and COVID-19 severity) among respondents and non-respondents (adults and children) at first (6 months) and second (12 months) follow-up. Figure S1. Post-COVID-19 condition phenotypes in adults at first (6 month) follow-up and subsequent complete resolving by 12 months.

Published
2022
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29. Risk factors for post-COVID-19 condition in previously hospitalised children using the ISARIC Global follow-up protocol: a prospective cohort study

Author

Osmanov, Ismail M., primary, Spiridonova, Ekaterina, additional, Bobkova, Polina, additional, Gamirova, Aysylu, additional, Shikhaleva, Anastasia, additional, Andreeva, Margarita, additional, Blyuss, Oleg, additional, El-Taravi, Yasmin, additional, DunnGalvin, Audrey, additional, Comberiati, Pasquale, additional, Peroni, Diego G., additional, Apfelbacher, Christian, additional, Genuneit, Jon, additional, Mazankova, Lyudmila, additional, Miroshina, Alexandra, additional, Chistyakova, Evgeniya, additional, Samitova, Elmira, additional, Borzakova, Svetlana, additional, Bondarenko, Elena, additional, Korsunskiy, Anatoliy A., additional, Konova, Irina, additional, Hanson, Sarah Wulf, additional, Carson, Gail, additional, Sigfrid, Louise, additional, Scott, Janet T., additional, Greenhawt, Matthew, additional, Whittaker, Elizabeth A., additional, Garralda, Elena, additional, Swann, Olivia V., additional, Buonsenso, Danilo, additional, Nicholls, Dasha E., additional, Simpson, Frances, additional, Jones, Christina, additional, Semple, Malcolm G., additional, Warner, John O., additional, Vos, Theo, additional, Olliaro, Piero, additional, and Munblit, Daniel, additional

Published
2021
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32. Acute cough in children and adolescents: A systematic review and a practical algorithm by the Italian Society of Pediatric Allergy and Immunology

Author

Marseglia, Gian Luigi, primary, Manti, Sara, additional, Chiappini, Elena, additional, Brambilla, Ilaria, additional, Caffarelli, Carlo, additional, Calvani, Mauro, additional, Cardinale, Fabio, additional, Cravidi, Claudio, additional, Duse, Marzia, additional, Martelli, Alberto, additional, Minasi, Domenico, additional, Del Giudice, Michele Miraglia, additional, Pajno, Giovanni, additional, Peroni, Diego G., additional, Tosca, Maria Angela, additional, Licari, Amelia, additional, and Ciprandi, Giorgio, additional

Published
2021
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33. Chronic cough in childhood: A systematic review for practical guidance by the Italian Society of Pediatric Allergy and Immunology

Author

Marseglia, Gian Luigi, primary, Manti, Sara, additional, Chiappini, Elena, additional, Brambilla, Ilaria, additional, Caffarelli, Carlo, additional, Calvani, Mauro, additional, Cardinale, Fabio, additional, Cravidi, Claudio, additional, Duse, Marzia, additional, Martelli, Alberto, additional, Minasi, Domenico, additional, Del Giudice, Michele Miraglia, additional, Pajno, Giovanni, additional, Peroni, Diego G., additional, Tosca, Maria Angela, additional, Licari, Amelia, additional, and Ciprandi, Giorgio, additional

Published
2021
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34. Lactoferrin is an important factor when breastfeeding and COVID‐19 are considered

Author

Peroni, Diego G. and Fanos, Vassilios

Subjects
medicine.medical_specialty, Amniotic fluid, Coronavirus disease 2019 (COVID-19), COVID19, viruses, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Breastfeeding, Virus, 03 medical and health sciences, 0302 clinical medicine, 030225 pediatrics, Pandemic, medicine, Humans, Pediatrics, Perinatology, and Child Health, 030212 general & internal medicine, Lactoferrin, breast milk, child, mother, COVID19, child, Pregnancy, biology, Milk, Human, Lactoferrin, Obstetrics, business.industry, Brief Report, Colostrum, mother, Infant, Newborn, COVID-19, General Medicine, medicine.disease, Breast Feeding, Pediatrics, Perinatology and Child Health, biology.protein, breast milk, Brief Reports, business
Abstract

The COVID-19 pandemic raises issues about breastfeeding when mothers have tested positive for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We don't know whether the virus can be passed to a foetus or baby during pregnancy or delivery and it has not been found in amniotic fluid or breastmilk (1). Separating babies from virus positive mothers make breastfeeding problematic and could prevent possible protection against viruses (2).

Published
2020

35. Asthma in children and adolescents: the ControL'Asma project

Author

Licari, Amelia, Ciprandi, Giorgio, Marseglia, Gian Luigi, Silvestri, Michela, Tosca, Maria Angela, Anastasio, Elisa, Brambilla, Ilaria, Caffarelli, Carlo, Castagnoli, Riccardo, Chini, Loredana, Ciprandi, Riccardo, De Vittori, Valenina, Duse, Marzia, Di Cicco, Maria Elisa, Indinnimeo, Lucian, Kantar, Ahmad, Leone, Maddalena, Marinelli, Guido, Moschese, Viviana, Olcese, Roberta, Peroni, Diego G, Pistorio, Angela, Salmaso, Claudia, and Zicari, Anna Maria

Subjects
Male, Adolescent, respiratory symptoms, lung function, asthma, asthma control, children, adolescents, VAS, Comorbidity, Review, Settore MED/38, respiratory tract diseases, Italy, Adolescents, Asthma, Asthma control, Children, Lung function, Respiratory symptoms, immune system diseases, Hypersensitivity, Humans, Child, Rhinitis
Abstract

The control of asthma is the objective of asthma management. However, it is difficult to obtain in clinical practice. The Italian Society of Allergy and Clinical Immunology promoted the nationwide project “ControL’Asma” to investigate the real situation in a group of children and adolescents with asthma. The preliminary outcomes demonstrated that many asthmatic subjects do not achieve adequate asthma control. Moreover, asthma in Italian children and adolescents was usually more frequent in males, had an early onset and allergic phenotype with very frequent rhinitis comorbidity, uncontrolled and partly controlled asthma affected about the half of subjects. However, this project suggested that the assessment of asthma symptom perception by VAS could be a reliable tool in the asthma management. (www.actabiomedica.it)

Published
2020

36. Use of Soy-Based Formulas and Cow's Milk Allergy: Lights and Shadows

Author

Verduci, Elvira, primary, Di Profio, Elisabetta, additional, Cerrato, Lucia, additional, Nuzzi, Giulia, additional, Riva, Luca, additional, Vizzari, Giulia, additional, D'Auria, Enza, additional, Giannì, Maria Lorella, additional, Zuccotti, Gianvincenzo, additional, and Peroni, Diego G., additional

Published
2020
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43. Reviewing the evidence on breast milk composition and immunological outcomes

Author

Afd Pharmacology, Pharmacology, Boix-Amorós, Alba, Collado, Maria Carmen, Van't Land, Belinda, Calvert, Anna, Le Doare, Kirsty, Garssen, Johan, Hanna, Heather, Khaleva, Ekaterina, Peroni, Diego G, Geddes, Donna T, Kozyrskyj, Anita L, Warner, John O, Munblit, Daniel, Afd Pharmacology, Pharmacology, Boix-Amorós, Alba, Collado, Maria Carmen, Van't Land, Belinda, Calvert, Anna, Le Doare, Kirsty, Garssen, Johan, Hanna, Heather, Khaleva, Ekaterina, Peroni, Diego G, Geddes, Donna T, Kozyrskyj, Anita L, Warner, John O, and Munblit, Daniel

Published
2019

44. A specific synbiotic-containing amino acid-based formula in dietary management of cow's milk allergy: A randomized controlled trial

Author

Afd Pharmacology, Pharmacology, Fox, Adam T., Wopereis, Harm, Van Ampting, Marleen T.J., Oude Nijhuis, Manon M., Butt, Assad M., Peroni, Diego G., Vandenplas, Yvan, Candy, David C.A., Shah, Neil, West, Christina E., Garssen, Johan, Harthoorn, Lucien F., Knol, Jan, Michaelis, Louise J., Afd Pharmacology, Pharmacology, Fox, Adam T., Wopereis, Harm, Van Ampting, Marleen T.J., Oude Nijhuis, Manon M., Butt, Assad M., Peroni, Diego G., Vandenplas, Yvan, Candy, David C.A., Shah, Neil, West, Christina E., Garssen, Johan, Harthoorn, Lucien F., Knol, Jan, and Michaelis, Louise J.

Published
2019

45. Reviewing the evidence on breast milk composition and immunological outcomes

Author

Boix Amorós, Alba, Collado, María Carmen, Van't Land, Belinda, Calvert, Anna, Le Doare, Kirsty, Garssen, Johan, Hanna, Heather, Khaleva, Katerina, Peroni, Diego G., Geddes, Donna T., Kozyrskyj, Anita L., Warner, John O., Munblit, Daniel, Boix Amorós, Alba, Collado, María Carmen, Van't Land, Belinda, Calvert, Anna, Le Doare, Kirsty, Garssen, Johan, Hanna, Heather, Khaleva, Katerina, Peroni, Diego G., Geddes, Donna T., Kozyrskyj, Anita L., Warner, John O., and Munblit, Daniel

Abstract

A large number of biologically active components have been found in human milk (HM), and in both human and animal models, studies have provided some evidence suggesting that HM composition can be altered by maternal exposures, subsequently influencing health outcomes for the breastfed child. Evidence varies from the research studies on whether breastfeeding protects the offspring from noncommunicable diseases, including those associated with immunological dysfunction. It has been hypothesized that the conflicting evidence results from HM composition variations, which contain many immune active molecules, oligosaccharides, lactoferrin, and lysozyme in differing concentrations, along with a diverse microbiome. Determining the components that influence infant health outcomes in terms of both short- and long-term sequelae is complicated by a lack of understanding of the environmental factors that modify HM constituents and thereby offspring outcomes. Variations in HM immune and microbial composition (and the differing infantile responses) may in part explain the controversies that are evidenced in studies that aim to evaluate the prevalence of allergy by prolonged and exclusive breastfeeding. HM is a “mixture” of immune active factors, oligosaccharides, and microbes, which all may influence early immunological outcomes. This comprehensive review provides an in-depth overview of existing evidence on the studied relationships between maternal exposures, HM composition, vaccine responses, and immunological outcomes.

Published
2019

46. How changes in nutrition have influenced the development of allergic diseases in childhood

Author

Peroni Diego G, Bonomo Beatrice, Casarotto Serena, Boner Attilio L, and Piacentini Giorgio L

Subjects
Allergy, Children, Infant feeding, Diet, Nutrients, Anti-oxidants, Vitamin D, Pediatrics, RJ1-570
Abstract

Abstract The increasing prevalence of allergic diseases in childhood in the last decades could be linked to concomitant dietary changes, especially with the modified and lower consumption of fruit, vegetables and minerals. The consumption of these foods by pregnant women and children in the first years of life seems to be associated with a reduced risk of asthma and related symptoms. Foods that can prevent the development of wheezing through their antioxidant effects contain vitamin C and selenium; blood levels of these elements correlate negatively with the risk of wheezing. Intake of vitamin E during pregnancy also appears to be correlated with a reduced risk of wheezing for the unborn child. Similarly, low intake of zinc and carotenoids by pregnant women is associated with an increased risk of wheezing and asthma in childhood. Fiber also has anti-inflammatory properties and protective effects against allergic diseases such as atopic dermatitis and asthma. The consumption of fat influences the development of the airways. Populations in Western countries have increased their consumption of n-6 PUFAs and, in parallel, reduced n-3 PUFAs. This has led to decreased production of PGE2, which is believed to have a protective effect against inflammation of the airways. Conflicting hypotheses also concern vitamin D; both an excess and a deficiency of vitamin D, in fact, have been associated with an increased risk of asthma. Further studies on the role of these substances are necessary before any conclusions can be drawn on a clinical level. Astratto La crescente prevalenza negli ultimi decenni delle malattie allergiche in età pediatrica potrebbe essere legata a concomitanti cambiamenti nella dieta, in particolare alla minore e modificata introduzione di frutta, verdura e minerali. Il consumo di questi alimenti da parte delle donne in gravidanza e dei bambini nei primi anni di vita sembra essere associato ad un ridotto rischio di asma e di sintomi correlati. Gli alimenti che possono prevenire lo sviluppo di respiro sibilante (wheezing) attraverso i loro effetti antiossidanti contengono vitamina C e selenio; i livelli ematici di questi elementi sono correlati negativamente con il rischio di wheezing. Inoltre l'assunzione di vitamina E durante la gravidanza sembra essere correlato con un rischio ridotto di respiro sibilante per il nascituro. Allo stesso modo, basso apporto di zinco e di carotenoidi in donne in gravidanza è associata ad un aumentato rischio di wheezing e asma nell'infanzia. Anche le fibre hanno proprietà anti-infiammatorie ed effetti protettivi contro le malattie allergiche come la dermatite atopica e l’asma. Il consumo di grassi influenza lo sviluppo delle vie aeree. Le popolazioni dei paesi occidentali hanno aumentato il loro consumo di n-6 PUFA e, parallelamente, ridotto n-3 PUFA. Ciò ha portato alla diminuzione della produzione di PGE2, che si ritiene abbia un effetto protettivo contro l'infiammazione delle vie aeree. Ipotesi contrastanti riguardano la vitamina D, sia un eccesso che una carenza di vitamina D, infatti, sono stati associati ad un aumentato rischio di asma. Ulteriori studi sul ruolo di queste sostanze sono necessari prima di trarre conclusioni sul piano clinico.

Published
2012
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47. A synbiotic-containing amino-acid-based formula improves gut microbiota in non-IgE-mediated allergic infants

Author

Candy, David C A, Van Ampting, Marleen T J, Nijhuis, Manon M Oude, Wopereis, Harm, Butt, Assad M, Peroni, Diego G, Vandenplas, Yvan, Fox, Adam T, Shah, Neil, West, Christina E, Garssen, Johan, Harthoorn, Lucien F, Knol, Jan, Michaelis, Louise J, Afd Pharmacology, Pharmacology, Afd Pharmacology, Pharmacology, Growth and Development, Clinical sciences, and Pediatrics

Subjects
0301 basic medicine, Male, Synbiotics, medicine.medical_treatment, ved/biology.organism_classification_rank.species, Milk allergy, Gut flora, Gastroenterology, Pediatrics, law.invention, Probiotic, 0302 clinical medicine, fluids and secretions, law, Microbiologie, Amino Acids, Bifidobacterium breve, biology, Pediatrik, food and beverages, Infant Formula, Milk, Treatment Outcome, Female, medicine.medical_specialty, Microbiology, Article, 03 medical and health sciences, Double-Blind Method, Internal medicine, medicine, Animals, Humans, Life Science, Pediatrics, Perinatology, and Child Health, VLAG, Clostridium, business.industry, ved/biology, Eubacterium, Prebiotic, Infant, Hypoallergenic, Immunoglobulin E, medicine.disease, biology.organism_classification, Gastrointestinal Microbiome, 030104 developmental biology, 030228 respiratory system, Infant formula, Pediatrics, Perinatology and Child Health, Cattle, Milk Hypersensitivity, business
Abstract

BackgroundPrebiotics and probiotics (synbiotics) can modify gut microbiota and have potential in allergy management when combined with amino-acid-based formula (AAF) for infants with cow's milk allergy (CMA).MethodsThis multicenter, double-blind, randomized controlled trial investigated the effects of an AAF-including synbiotic blend on percentages of bifidobacteria and Eubacterium rectale/Clostridium coccoides group (ER/CC) in feces from infants with suspected non-IgE-mediated CMA. Feces from age-matched healthy breastfed infants were used as reference (healthy breastfed reference (HBR)) for primary outcomes. The CMA subjects were randomized and received test or control formula for 8 weeks. Test formula was a hypoallergenic, nutritionally complete AAF including a prebiotic blend of fructo-oligosaccharides and the probiotic strain Bifidobacterium breve M-16V. Control formula was AAF without synbiotics.ResultsA total of 35 (test) and 36 (control) subjects were randomized; HBR included 51 infants. At week 8, the median percentage of bifidobacteria was higher in the test group than in the control group (35.4% vs. 9.7%, respectively; P

Published
2018

48. Statistical Approaches in the Studies Assessing Associations between Human Milk Immune Composition and Allergic Diseases: A Scoping Review

Author

Blyuss, Oleg, primary, Cheung, Ka Yan, additional, Chen, Jessica, additional, Parr, Callum, additional, Petrou, Loukia, additional, Komarova, Alina, additional, Kokina, Maria, additional, Luzan, Polina, additional, Pasko, Egor, additional, Eremeeva, Alina, additional, Peshko, Dmitrii, additional, Eliseev, Vladimir I., additional, Pedersen, Sindre Andre, additional, Azad, Meghan B., additional, Jarvinen, Kirsi M., additional, Peroni, Diego G., additional, Verhasselt, Valerie, additional, Boyle, Robert J., additional, Warner, John O., additional, Simpson, Melanie R., additional, and Munblit, Daniel, additional

Published
2019
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