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2. Tranexamic Acid After Aneurysmal Subarachnoid Hemorrhage Post Hoc Analysis of the ULTRA Trial

Author

Tjerkstra, M., Post, R., Germans, Menno R., Vergouwen, M.D., Jellema, K., Koot, Radboud W., Beer, Frits C. de, Pol, Bram van der, Boogaarts, H.D., Klijn, C.J.M., Peter Vandertop, W., Verbaan, D., Tjerkstra, M., Post, R., Germans, Menno R., Vergouwen, M.D., Jellema, K., Koot, Radboud W., Beer, Frits C. de, Pol, Bram van der, Boogaarts, H.D., Klijn, C.J.M., Peter Vandertop, W., and Verbaan, D.

Abstract

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Published
2022

3. In Silico Analysis of Kinase Expression Identifies WEE1 as a Gatekeeper against Mitotic Catastrophe in Glioblastoma

Author

Mir, Shahryar E., De Witt Hamer, Philip C., Krawczyk, Przemek M., Balaj, Leonora, Claes, An, Niers, Johanna M., Van Tilborg, Angela A.G., Zwinderman, Aeilko H., Geerts, Dirk, Kaspers, Gertjan J.L., Peter Vandertop, W., Cloos, Jacqueline, Tannous, Bakhos A., Wesseling, Pieter, Aten, Jacob A., Noske, David P., Van Noorden, Cornelis J.F., and Würdinger, Thomas

Published
2010
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4. Variation in medical management and neurosurgical treatment of patients with supratentorial spontaneous intracerebral haemorrhage

Author

Sondag, Lotte, Jacobs, Floor A.E., Schreuder, Floris H.B.M., Boogaarts, Jeroen D., Peter Vandertop, W., Dammers, Ruben, Klijn, Catharina J.M., Sondag, Lotte, Jacobs, Floor A.E., Schreuder, Floris H.B.M., Boogaarts, Jeroen D., Peter Vandertop, W., Dammers, Ruben, and Klijn, Catharina J.M.

Abstract

Introduction: The role of surgery in spontaneous intracerebral haemorrhage (sICH) remains controversial. This leads to variation in the percentage of patients who are treated with surgery between countries. Patients and methods: We sent an online survey to all neurosurgeons (n = 140) and to a sample of neurologists (n = 378) in Dutch hospitals, with questions on management in supratentorial sICH in general, and on treatment in six patients, to explore current variation in medical and neurosurgical management. We assessed patient and haemorrhage characteristics influencing treatment decisions. Results: Twenty-nine (21%) neurosurgeons and 92 (24%) neurologists responded. Prior to surgery, neurosurgeons would more frequently administer platelet-transfusion in patients on clopidogrel (64% versus 13%; p = 0.000) or acetylsalicylic acid (61% versus 11%; p = 0.000) than neurologists. In the cases, neurosurgeons and neurologists were similar in their choice for surgery as initial treatment (24% and 31%; p = 0.12), however variation existed amongst physicians in specific cases. Neurosurgeons preferred craniotomy with haematoma evacuation (74%) above minimally-invasive techniques (5%). Age, Glasgow Coma Scale score and ICH location were important factors influencing decisions on treatment for neurosurgeons and neurologists. 69% of neurosurgeons and 80% of neurologists would randomise patients in a trial evaluating the effect of minimally-invasive surgery on functional outcome. Discussion: Our results reflect the lack of evidence about the right treatment strategy in patients with sICH. Conclusion: New high quality evidence is needed to guide treatment decisions for patients with ICH. The willingness to randomise patients into a clinical trial on minimally-invasive surgery, contributes to the feasibility of such studies in the future.

Published
2021

5. Quantifying eloquent locations for glioblastoma surgery using resection probability maps

Author

Neurochirurgie, Brain, Cancer, Müller, Domenique M.J., Robe, Pierre A., Ardon, Hilko, Barkhof, Frederik, Bello, Lorenzo, Berger, Mitchel S., Bouwknegt, Wim, Van den Brink, Wimar A., Nibali, Marco Conti, Eijgelaar, Roelant S., Furtner, Julia, Han, Seunggu J., Hervey-Jumper, Shawn L., Idema, Albert J.S., Kiesel, Barbara, Kloet, Alfred, De Munck, Jan C., Rossi, Marco, Sciortino, Tommaso, Peter Vandertop, W., Visser, Martin, Wagemakers, Michiel, Widhalm, Georg, Witte, Marnix G., Zwinderman, Aeilko H., De Witt Hamer, Philip C., Neurochirurgie, Brain, Cancer, Müller, Domenique M.J., Robe, Pierre A., Ardon, Hilko, Barkhof, Frederik, Bello, Lorenzo, Berger, Mitchel S., Bouwknegt, Wim, Van den Brink, Wimar A., Nibali, Marco Conti, Eijgelaar, Roelant S., Furtner, Julia, Han, Seunggu J., Hervey-Jumper, Shawn L., Idema, Albert J.S., Kiesel, Barbara, Kloet, Alfred, De Munck, Jan C., Rossi, Marco, Sciortino, Tommaso, Peter Vandertop, W., Visser, Martin, Wagemakers, Michiel, Widhalm, Georg, Witte, Marnix G., Zwinderman, Aeilko H., and De Witt Hamer, Philip C.

Published
2021

7. Preclinical evaluation of convection-enhanced delivery of liposomal doxorubicin to treat pediatric diffuse intrinsic pontine glioma and thalamic high-grade glioma

Author

Sewing AC, Lagerweij T, van Vuurden DG, Meel MH, Veringa SJ, Carcaboso AM, Gaillard PJ, Peter Vandertop W, Wesseling P, Noske D, Kaspers GJ, and Hulleman E

Subjects
MTD = maximum tolerated dose, anthracyclines, convection-enhanced delivery, VUMC = VU University Medical Center, pHGG = pediatric high-grade glioma, pHGG, diffuse intrinsic pontine glioma, CED = convection-enhanced delivery, doxorubicin, IC50 = half maximal inhibitory concentration, DIPG = diffuse intrinsic pontine glioma, LG-BSG = low-grade brainstem glioma, BBB = blood-brain barrier, thalamus, oncology, DIPG, pediatric high-grade glioma, BLI = bioluminescent imaging, TOPIIA = topoisomerase Type IIA, GBM = glioblastoma multiforme, CED, PLD = pegylated liposomal doxorubicin, PBS = phosphate-buffered saline
Abstract

OBJECTIVE Pediatric high-grade gliomas (pHGGs) including diffuse intrinsic pontine gliomas (DIPGs) are primary brain tumors with high mortality and morbidity. Because of their poor brain penetrance, systemic chemotherapy regimens have failed to deliver satisfactory results; however, convection-enhanced delivery (CED) may be an alternative mode of drug delivery. Anthracyclines are potent chemotherapeutics that have been successfully delivered via CED in preclinical supratentorial glioma models. This study aims to assess the potency of anthracyclines against DIPG and pHGG cell lines in vitro and to evaluate the efficacy of CED with anthracyclines in orthotopic pontine and thalamic tumor models. METHODS The sensitivity of primary pHGG cell lines to a range of anthracyclines was tested in vitro. Preclinical CED of free doxorubicin and pegylated liposomal doxorubicin (PLD) to the brainstem and thalamus of naïve nude mice was performed. The maximum tolerated dose (MTD) was determined based on the observation of clinical symptoms, and brains were analyzed after H & E staining. Efficacy of the MTD was tested in adult glioma E98-FM-DIPG and E98-FM-thalamus models and in the HSJD-DIPG-007-Fluc primary DIPG model. RESULTS Both pHGG and DIPG cells were sensitive to anthracyclines in vitro. Doxorubicin was selected for further preclinical evaluation. Convection-enhanced delivery of the MTD of free doxorubicin and PLD in the pons was 0.02 mg/ml, and the dose tolerated in the thalamus was 10 times higher (0.2 mg/ml). Free doxorubicin or PLD via CED was ineffective against E98-FM-DIPG or HSJD-DIPG-007-Fluc in the brainstem; however, when applied in the thalamus, 0.2 mg/ml of PLD slowed down tumor growth and increased survival in a subset of animals with small tumors. CONCLUSIONS Local delivery of doxorubicin to the brainstem causes severe toxicity, even at doxorubicin concentrations that are safe in the thalamus. As a consequence, the authors could not establish a therapeutic window for treating orthotopic brainstem tumors in mice. For tumors in the thalamus, therapeutic concentrations to slow down tumor growth could be reached. These data suggest that anatomical location determines the severity of toxicity after local delivery of therapeutic agents and that caution should be used when translating data from supratentorial CED studies to treat infratentorial tumors.

Published
2017

8. Preclinical evaluation of convection-enhanced delivery of liposomal doxorubicin to treat pediatric diffuse intrinsic pontine glioma and thalamic high-grade glioma

Author

Sewing, A. Charlotte P, Lagerweij, Tonny, van Vuurden, Dannis G, Meel, Michaël H., Veringa, Susanna J E, Carcaboso, Angel M., Gaillard, Pieter J., Peter Vandertop, W., Wesseling, Pieter, Noske, David P., Kaspers, Gertjan J.L., Hulleman, Esther, Sewing, A. Charlotte P, Lagerweij, Tonny, van Vuurden, Dannis G, Meel, Michaël H., Veringa, Susanna J E, Carcaboso, Angel M., Gaillard, Pieter J., Peter Vandertop, W., Wesseling, Pieter, Noske, David P., Kaspers, Gertjan J.L., and Hulleman, Esther

Published
2017

9. Preclinical evaluation of convection-enhanced delivery of liposomal doxorubicin to treat pediatric diffuse intrinsic pontine glioma and thalamic high-grade glioma

Author

Pathologie Pathologen staf, PMC Medisch specialisten, Sewing, A. Charlotte P, Lagerweij, Tonny, van Vuurden, Dannis G, Meel, Michaël H., Veringa, Susanna J E, Carcaboso, Angel M., Gaillard, Pieter J., Peter Vandertop, W., Wesseling, Pieter, Noske, David P., Kaspers, Gertjan J.L., Hulleman, Esther, Pathologie Pathologen staf, PMC Medisch specialisten, Sewing, A. Charlotte P, Lagerweij, Tonny, van Vuurden, Dannis G, Meel, Michaël H., Veringa, Susanna J E, Carcaboso, Angel M., Gaillard, Pieter J., Peter Vandertop, W., Wesseling, Pieter, Noske, David P., Kaspers, Gertjan J.L., and Hulleman, Esther

Published
2017

10. Neurosurgical interventions during pregnancy and the puerperium

Author

Vougioukas, V. I., Kyroussis, G., Gläsker, S., Tatagiba, M., Scheufler, K. M., Peter Vandertop, W., Rappaport, Z. H., and Neurosurgery

Subjects
Adult, medicine.medical_specialty, Neurology, Psychological intervention, Neurosurgical Procedures, Pregnancy, medicine, Humans, Intensive care medicine, Neuroradiology, Retrospective Studies, Brain Diseases, Lumbar Vertebrae, medicine.diagnostic_test, business.industry, Obstetrics, Pregnancy Outcome, Interventional radiology, Puerperal Disorders, medicine.disease, Pregnancy Complications, Treatment Outcome, Treatment strategy, Surgery, Female, Neurology (clinical), Neurosurgery, business, Intervertebral Disc Displacement
Abstract

Neurosurgical interventions during pregnancy represent a special clinical challenge and require a meticulously selected treatment strategy. A thorough understanding of the underlying pathophysiological mechanisms involving mother and fetus is mandatory. We report our experience with neurosurgical procedures during pregnancy and the puerperium and summarize the difficulties encountered. The emerging diagnostic as well as therapeutic implications in these complex cases are also discussed.

Published
2004
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11. Time course and risk factors for myocardial dysfunction after aneurysmal subarachnoid hemorrhage

Author

Van Der Bilt, Ivo A., Hasan, Djo, Van Den Brink, Renee B., Cramer, MJ, Van Der Jagt, Mathieu, Van Kooten, Fop, Regtien, Joost G., Van Den Berg, Maarten P., Groen, Rob J., Cate, Folkert J Ten, Kamp, Otto, Götte, Marco J., Horn, Janneke, Girbes, Armand R., Peter Vandertop, W., Algra, Ale, Rinkel, Gabriel J., Wilde, Arthur A., Van Der Bilt, Ivo A., Hasan, Djo, Van Den Brink, Renee B., Cramer, MJ, Van Der Jagt, Mathieu, Van Kooten, Fop, Regtien, Joost G., Van Den Berg, Maarten P., Groen, Rob J., Cate, Folkert J Ten, Kamp, Otto, Götte, Marco J., Horn, Janneke, Girbes, Armand R., Peter Vandertop, W., Algra, Ale, Rinkel, Gabriel J., and Wilde, Arthur A.

Published
2015

12. Time course and risk factors for myocardial dysfunction after aneurysmal subarachnoid hemorrhage

Author

Cardiologie, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Brain, Cardiovasculaire Epi Team 6, Neurologie, Van Der Bilt, Ivo A., Hasan, Djo, Van Den Brink, Renee B., Cramer, MJ, Van Der Jagt, Mathieu, Van Kooten, Fop, Regtien, Joost G., Van Den Berg, Maarten P., Groen, Rob J., Cate, Folkert J Ten, Kamp, Otto, Götte, Marco J., Horn, Janneke, Girbes, Armand R., Peter Vandertop, W., Algra, Ale, Rinkel, Gabriel J., Wilde, Arthur A., Cardiologie, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Brain, Cardiovasculaire Epi Team 6, Neurologie, Van Der Bilt, Ivo A., Hasan, Djo, Van Den Brink, Renee B., Cramer, MJ, Van Der Jagt, Mathieu, Van Kooten, Fop, Regtien, Joost G., Van Den Berg, Maarten P., Groen, Rob J., Cate, Folkert J Ten, Kamp, Otto, Götte, Marco J., Horn, Janneke, Girbes, Armand R., Peter Vandertop, W., Algra, Ale, Rinkel, Gabriel J., and Wilde, Arthur A.

Published
2015

14. Functional multiplex reporter assay using tagged Gaussia luciferase

Author

Van Rijn, S., Nilsson, Jonas, Noske, D. P., Peter Vandertop, W., Tannous, B. A., Würdinger, T., Van Rijn, S., Nilsson, Jonas, Noske, D. P., Peter Vandertop, W., Tannous, B. A., and Würdinger, T.

Abstract

We have developed a multiplex reporter system to monitor multiple biological variables in real-time. The secreted Gaussia luciferase was fused to ten different epitope tags (Gluc tag), each expressed in different tumor cells. By immunobinding of the tags followed by Gluc tag detection, this system allowed the independent and real-time monitoring of mixed cell cultures in vitro and of mixed subcutaneous and intracranial tumor subpopulations in vivo.

Published
2013
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15. Anatomical Differences Determine Distribution of Adenovirus after Convection-Enhanced Delivery to the Rat Brain.

Author

Idema, Sander, Caretti, Viola, Lamfers, Martine L. M., van Beusechem, Victor W., Noske, David P., Peter Vandertop, W., and Dirven, Clemens M. F.

Subjects
ADENOVIRUSES, DNA viruses, LABORATORY rats, GREEN fluorescent protein, BRAIN tumors, IRON oxides, NANOPARTICLES
Abstract

Background: Convection-enhanced delivery (CED) of adenoviruses offers the potential of widespread virus distribution in the brain. In CED, the volume of distribution (Vd) should be related to the volume of infusion (Vi) and not to dose, but when using adenoviruses contrasting results have been reported. As the characteristics of the infused tissue can affect convective delivery, this study was performed to determine the effects of the gray and white matter on CED of adenoviruses and similar sized super paramagnetic iron oxide nanoparticles (SPIO). Methodology/Principal Findings: We convected AdGFP, an adenovirus vector expressing Green Fluorescent Protein, a virus sized SPIO or trypan blue in the gray and white matter of the striatum and external capsule of Wistar rats and towards orthotopic infiltrative brain tumors. The resulting Vds were compared to Vi and transgene expression to SPIO distribution. Results show that in the striatum Vd is not determined by the Vi but by the infused virus dose, suggesting diffusion, active transport or receptor saturation rather than convection. Distribution of virus and SPIO in the white matter is partly volume dependent, which is probably caused by preferential fluid pathways from the external capsule to the surrounding gray matter, as demonstrated by co-infusing trypan blue. Distant tumors were reached using the white matter tracts but tumor penetration was limited. Conclusions/Significance: CED of adenoviruses in the rat brain and towards infiltrative tumors is feasible when regional anatomical differences are taken into account while SPIO infusion could be considered to validate proper catheter positioning and predict adenoviral distribution. [ABSTRACT FROM AUTHOR]

Published
2011
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