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2. A Pilot Single-Blinded, Randomized, Controlled Trial Comparing BNT162b2 vs. JNJ-78436735 Vaccine as the Third Dose After Two Doses of BNT162b2 Vaccine in Solid Organ Transplant Recipients

Author

Natori, Yoichiro, primary, Martin, Eric, additional, Mattiazzi, Adela, additional, Arosemena, Leopoldo, additional, Ortigosa-Goggins, Mariella, additional, Shobana, Sivan, additional, Roth, David, additional, Kupin, Warren Lee, additional, Burke, George William, additional, Ciancio, Gaetano, additional, Morsi, Mahmoud, additional, Phancao, Anita, additional, Munagala, Mrudula R., additional, Butrous, Hoda, additional, Manickavel, Suresh, additional, Sinha, Neeraj, additional, Sota, Katherine, additional, Pallikkuth, Suresh, additional, Bini, Julia, additional, Simkins, Jacques, additional, Anjan, Shweta, additional, Vianna, Rodrigo M., additional, and Guerra, Giselle, additional

Published
2023
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4. A Pilot Single-Blinded, Randomized, Controlled Trial Comparing BNT162b2 vs. JNJ-78436735 Vaccine as the Third Dose After Two Doses of BNT162b2 Vaccine in Solid Organ Transplant Recipients.

Author

Yoichiro Natori, Martin, Eric, Mattiazzi, Adela, Arosemena, Leopoldo, Ortigosa-Goggins, Mariella, Shobana, Sivan, Roth, David, Kupin, Warren Lee, Burke, George William, Ciancio, Gaetano, Morsi, Mahmoud, Phancao, Anita, Munagala, Mrudula R., Butrous, Hoda, Manickavel, Suresh, Sinha, Neeraj, Sota, Katherine, Pallikkuth, Suresh, Bini, Julia, and Simkins, Jacques

Subjects
COVID-19 vaccines, TRANSPLANTATION of organs, tissues, etc., KIDNEY transplantation, VACCINES, IMMUNE response, BOOSTER vaccines
Abstract

Solid Organ Transplant (SOT) recipients are at significant higher risk for COVID-19 and due to immunosuppressive medication, the immunogenicity after vaccination is suboptimal. In the previous studies, booster method showed significant benefit in this population. In the current study, we compared using a mix-and-match method vs. same vaccine as a third dose in SOT recipients. This was a patient-blinded, single center, randomized controlled trial comparing BNT162b2 vs. JNJ-78436735 vaccine as the third dose after two doses of BNT162b2 vaccine. We included adult SOT recipients with functional graft who had received two doses of BNT162b2 vaccine. Participants were randomly assigned to receive either BNT162b2 or JNJ-78436735 in one-to-one ratio. Primary outcome was SARSCoV- 2 IgG positivity at 1 month after the third dose. Sixty SOT recipients, including 36 kidney, 12 liver, 2 lung, 3 heart, and 5 combined transplants, were enrolled, and 57 recipients were analyzed per protocol. There were no statistically significant differences between the two vaccine protocols for IgG positivity (83.3% vs. 85.2% for BNT162b2 and JNJ-78436735, respectively, p = 0.85, Odds Ratio 0.95, 95% Confidence Interval 0.23-4.00). Comparison of the geometric mean titer demonstrated a higher trend with BNT162b2 (p = 0.09). In this pilot randomized controlled trial comparing mix and match method vs. uniform vaccination in SOT recipients, both vaccines were safely used. Since this was a small sample sized study, there was no statistically significant difference in immunogenicity; though, the mix and match method showed relatively lower geometric mean titer, as compared to uniform vaccine. Further studies need to be conducted to determine duration of this immunogenicity. [ABSTRACT FROM AUTHOR]

Published
2023
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5. 1347. Comparison Between SARS-Cov-2, non-SARS-Cov-2 Coronavirus, Influenza and RSV Infections Among Solid Organ Transplant Recipients

Author

Mendoza, Maria A, primary, Gabriel, Motoa, additional, Raja, Mohammed, additional, Anjan, Shweta, additional, Fernandez, Anmary A, additional, Courel, Steve, additional, Chandorkar, Aditya, additional, O’Brien, Christopher, additional, Phancao, Anita, additional, Sinha, Neeraj, additional, Vianna, Rodrigo, additional, Gaetano, Ciancio, additional, Loebe, Mathias, additional, Simkins, Jacques, additional, Camargo, Jose F, additional, Morris, Michele I, additional, Abbo, Lilian M, additional, Guerra, Giselle, additional, and Natori, Yoichiro, additional

Published
2021
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6. Cefazolin plus ertapenem and heart transplantation as salvage therapy for refractory LVAD infection due to methicillin‐susceptible Staphylococcus aureus : A case series

Author

Cardenas‐Alvarez, Jorge L., primary, Suarez, Jose, additional, Motoa, Gabriel, additional, Anjan, Shweta, additional, Natori, Yoichiro, additional, Loebe, Matthias, additional, Breda, Joao R., additional, Thakkar‐Rivera, Nina, additional, Phancao, Anita, additional, Ghodsizad, Ali, additional, Bauerlein, Joseph E., additional, Munagala, Mrudula R., additional, and Simkins, Jacques, additional

Published
2021
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8. A Randomized, Controlled Pilot Study of the Effects of Acupuncture on Circulating Endothelial Progenitor Cells in Coronary Heart Disease

Author

Painovich, Jeannette, Phancao, Anita, Mehta, Puja, Chowdhury, Supurna, Dhawan, Shivani, Li, Ning, Taylor, Doris, Qiao, Yi, Brantman, Anna, Ma, Xiuling, and Merz, C. Noel Bairey

Subjects
Original Research
Abstract

Coronary heart disease (CHD) remains the number one killer of men and women in the United States, and despite traditional secondary prevention, individuals with the disease remain at risk. Endothelial progenitor cells (EPCs) may have beneficial effects on atherosclerosis, angiogenesis, and vascular repair and may contribute systemically to ongoing endogenous repair processes. Traditional acupuncture (TA), a modality used in the practice of Chinese medicine, appears to have beneficial effects in many areas associated with CHD.The study examined the effects of TA on circulating EPCs in individuals with CHD.The research team performed a randomized, controlled pilot study.All interventions were performed at the Cedars-Sinai Medical Center in Los Angeles, CA.The study included 13 participants in 3 groups: (1) TA (n = 5), (2) sham acupuncture (SA, n = 5), or (3) waiting control (WC, n = 3).The TA group received acupuncture treatments for 12 wk at CHD-specific sites, while the SA group received no-needle pressure at nonacupuncture sites for the same period, and the WC group received no intervention.The study measured the number of EPCs circulating in peripheral blood to determine cell surface markers for expressions of cluster of differentiation 34, 133 (CD34+/CD133+) and vascular endothelial growth factor receptor 2 (VEGF-R2+).Eight men and 5 women with a mean age of 59 ± 10.9 y were included. Compared with their measurements at baseline, members of the TA group had a significantly greater change in the level of EPCs expressing CD34+/VEGF-R2+ compared with the SA group (P = .04). No group differences were evident in immature EPCs expressing CD34+/CD133+.The study's results suggest that TA can alter the number of EPCs circulating in peripheral blood by increasing the mobilization of the VEGF-R2+ EPC subpopulations. Further studies are warranted to evaluate whether TA can beneficially affect CHD via augmentation of EPC regenerative pathways.

Published
2014

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