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In the United States, the South has a disproportionate burden of cervical cancer, yet research reporting regional prevalence of human papillomavirus (HPV) infection is scarce. Since 2008, Virginia has passed a HPV vaccine mandate and Louisiana a HPV education bill. This dissertation estimated the prevalence of HPV infection among females and assessed the impact of Virginia’s and Louisiana’s HPV vaccination policy on vaccination among adolescent females. The first manuscript estimated the prevalence of HPV infection using data from 4,250 females collected during the 2007–2010 National Health and Nutrition Examination Survey. Among 14–26 year-olds, the prevalence of high-risk oncogenic HPV was 25.6% (95% CI: 22.4 – 33.3) in the South and 29.1% (95% CI: 24.8 – 33.8) in the rest of the country (p= 0.15). Among 27–59 year-olds, infection rates were 20.9% (95% CI: 17.4 – 24.9) for the South and 14.5% (95% CI: 12.9 – 16.3) for the rest of the country (p=0.0001). The second manuscript assessed the impact of Virginia’s HPV vaccine mandate on vaccination using National Immunization Survey-Teen 2008-2012 data (n=3,203). A difference-in-differences estimation and logistic regression analysis were performed with South Carolina and Tennessee serving as comparison states. Virginia’s mandate was not associated with an increase in vaccination rates. Physician recommendation was strongly associated with vaccination in the Virginia-South Carolina (aOR=10.3; p=0.0001) and Virginia-Tennessee analyses (aOR=9.33; 95%CI: 6.11 – 14.3). The third manuscript assessed the impact of Louisiana’s HPV education policy on vaccination using difference-in-differences estimation and logistic regression analysis, with Alabama and Mississippi as comparison states (n=2,327). There was no evidence that the policy increased vaccination rates. Physician recommendation was associated with vaccination in the Louisiana-Alabama (aOR=7.74; 95% CI: 5.22 – 11.5) and Louisiana-Mississippi comparison (aOR=7.05; 95%