34 results on '"Pijnenborg, Marieke"'
Search Results
2. Cardiovascular risk assessment methods yield unequal risk predictions: a large cross-sectional study in psychiatric secondary care outpatients.
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Quadackers, Davy, Liemburg, Edith, Bos, Fionneke, Doornbos, Bennard, Risselada, Arne, PHAMOUS investigators, Bartels-Velthuis, Agna, Bruggeman, Richard, Castelein, Stynke, Jörg, Frederike, Knegtering, Henderikus, Pijnenborg, Marieke, Berger, Marjolein, Visser, Ellen, and Cath, Danielle more...
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PEOPLE with mental illness ,MEDICAL personnel ,CARDIOVASCULAR diseases risk factors ,SECONDARY care (Medicine) ,OUTPATIENT medical care - Abstract
Background: Patients with a mental illness are more likely to develop, and die from, cardiovascular diseases (CVD), necessitating optimal CVD-risk (CVR)-assessment to enable early detection and treatment. Whereas psychiatrists use the metabolic syndrome (MetS)-concept to estimate CVR, GPs use absolute risk-models. Additionally, two PRIMROSE-models have been specifically designed for patients with severe mental illness. We aimed to assess the agreement in risk-outcomes between these CVR-methods. Methods: To compare risk-outcomes across the various CVR-methods, we used somatic information of psychiatric outpatients from the PHAMOUS-, and MOPHAR-database, aged 40–70 years, free of past or current CVD and diabetes. We investigated: (1) the degree-of-agreement between categorical assessments (i.e. MetS-status vs. binary risk-categories); (2) non-parametric correlations between the number of MetS-criteria and absolute risks; and (3) strength-of-agreement between absolute risks. Results: Seven thousand twenty-nine measurements of 3509 PHAMOUS-patients, and 748 measurements of 748 MOPHAR-patients, were included. There was systematic disagreement between the categorical CVR-assessments (all p < 0.036). Only MetS-status versus binary Framingham-assessment had a fair strength-of-agreement (κ = 0.23–0.28). The number of MetS-criteria and Framingham-scores, as well as MetS-criteria and PRIMROSE lipid-scores, showed a moderate-strong correlation (τ = 0.25–0.34). Finally, only the continuous PRIMROSE desk and lipid-outcomes showed moderate strength-of-agreement (ρ = 0.91). Conclusions: The varying methods for CVR-assessment yield unequal risk predictions, and, consequently, carry the risk of significant disparities regarding treatment initiation in psychiatric patients. Considering the significantly increased health-risks in psychiatric patients, CVR-models should be recalibrated to the psychiatric population from adolescence onwards, and uniformly implemented by health care providers. Trial registration: The MOPHAR research has been prospectively registered with the Netherlands Trial Register on 19th of November 2014 (NL4779). [ABSTRACT FROM AUTHOR] more...
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- 2023
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Catalog
3. Barriers and facilitators to implementation of cognitive adaptation training in long‐term inpatient facilities for people diagnosed with severe mental illness: A nursing perspective
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Van Dam, Michelle, Van Weeghel, Jaap, Stiekema, Annemarie, Castelein, Stynke, Pijnenborg, Marieke, Van Der Meer, Lisette, Van Dam, Michelle, Van Weeghel, Jaap, Stiekema, Annemarie, Castelein, Stynke, Pijnenborg, Marieke, and Van Der Meer, Lisette more...
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Introduction Evidence-based interventions in psychiatry often fail to reach clinical practice. Cognitive Adaptation Training (CAT) is an evidence-based psychosocial intervention that aims to improve daily functioning of people diagnosed with a severe mental illness. Implementation of CAT remains challenging, despite demonstrated effectiveness. Aim Identifying facilitators and barriers of CAT on the intervention, nursing, and organizational levels, and investigating relationships between capability, opportunity, motivation, and appraisal using the COM-B model. Method The Measurement Instrument for Determinants of Innovations and CAT-specific questions were administered to 46 nurses. The relationship among capability, opportunity, motivation and appraisal was calculated using the Pearson's r correlation coefficient. Results Nine barriers (mostly organizational level) and 13 facilitators (mostly intervention and nursing level) were identified. Significant moderate correlations were found between capability and opportunity, capability and motivation, capability and appraisal and a strong correlation between motivation and appraisal. Discussion The results suggest that barriers at the organizational level should be removed and facilitators at intervention and nursing levels may be exploited to improve implementation. Implications for practice Future implementation initiatives require ongoing training and supervision of CAT specialists, appointment of local champions to increase commitment among nursing staff and inclusion and commitment of management to overcome organizational barriers. more...
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- 2022
4. S231. A NETWORK META-ANALYSIS ON SOCIAL COGNITION TRAINING FOR PEOPLE WITH PSYCHOTIC DISORDER: RELATIVE EFFICACY, MODERATORS, AND LONG-TERM EFFECTS
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Nijman, Saskia, primary, Veling, Wim, primary, van der Stouwe, Elisabeth, primary, and Pijnenborg, Marieke (Gerdina), primary
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- 2020
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5. T36. NEURAL CHANGES FOLLOWING A BODY-ORIENTED RESILIENCE THERAPY WITH ELEMENTS OF KICKBOXING FOR INDIVIDUALS WITH A PSYCHOTIC DISORDER: A RANDOMIZED CONTROLLED TRIAL
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van der Stouwe, Elisabeth, primary, Pijnenborg, Marieke (Gerdina), primary, Opmeer, Esther, primary, de Vries, Bertine, primary, Bernard Marsman, Jan, primary, Aleman, Andre, primary, and van Busschbach, Jooske, primary more...
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- 2020
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6. M223. EXPLORING YOUR PERSONAL IDENTITY: USING USER-CENTRED-DESIGN FOR THE DEVELOPMENT OF A NEW INTERVENTION FOR SERVICE USERS WITH COMPLEX MENTAL HEALTH NEEDS
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Van der Meer, Lisette, primary, Jonker, Tessa, primary, Wunderink, Charlotte, primary, van Weeghel, Jaap, primary, Pijnenborg, Marieke (Gerdina), primary, and van Setten, Ellie, primary
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- 2020
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7. M230. VIRTUAL REALITY FOR IMPROVING SOCIAL ACTIVITIES AND PARTICIPATION (VR-SOAP): DEVELOPMENT OF A NEW TREATMENT FOR YOUNG PEOPLE WITH PSYCHOSIS
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Muijsson, Dauw, primary, van der Stouwe, Elise, primary, Greaves-Lord, Kirstin, primary, Nijman, Saskia, primary, Pijnenborg, Marieke, primary, and Veling, Wim, primary
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- 2020
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8. M71. THE INFLUENCE OF METACOGNITIVE CAPACITIES ON SPECIFIC NEGATIVE SYMPTOMS: A SYSTEMATIC REVIEW AND INDIVIDUAL PARTICIPANT META-ANALYSIS OF INTERVIEW-BASED DATA
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McGuire, Nicola, primary, Gumley, Andrew, primary, Hasson-Ohayon, Ilanit, primary, Aunjitsakul, Warut, primary, Aydin, Orkun, primary, Bo, Sune, primary, Bonfils, Kelsey, primary, Bröcker, Anna-Lena, primary, de Jong, Steven, primary, DiMaggio, Giancarlo, primary, Inchausti, Felix, primary, Einar Jansen, Jens, primary, Lecomte, Tania, primary, Luther, Lauren, primary, MacBeth, Angus, primary, Montag, Christiane, primary, Buch Pedersen, Marlene, primary, Pijnenborg, Marieke, primary, Popolo, Raffaele, primary, Trauelsen, Ann-Marie, primary, van Donkersgoed, Rozanne, primary, Wu, Weiming, primary, Lysaker, Paul, primary, and McLeod, Hamish, primary more...
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- 2020
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9. T91. THE POSITIVE AND NEGATIVE SYNDROME SCALE SUPERIOR TO A SELF-REPORT QUESTIONNAIRE IN THE PHARMACOTHERAPY MONITORING AND OUTCOME SURVEY
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Bartels-Velthuis, Annegien, primary, Ties, Koen, primary, Visser, Ellen, primary, Arends, Johan, primary, Pijnenborg, Marieke, primary, Wunderink, Lex, primary, Jörg, Frederike, primary, Veling, Wim, primary, Castelein, Stynke, primary, Knegtering, Henderikus, primary, and Bruggeman, Richard, primary more...
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- 2020
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10. Cognitive-behavioural therapy for refractory psychotic symptoms of schizophrenia resistant to atypical antipsychotic medication: Randomised controlled trial
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VALMAGGIA, LUCIA R., VAN DER GAAG, MARK, TARRIER, NICHOLAS, PIJNENBORG, MARIEKE, and SLOOFF, CEES J.
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- 2005
11. The acceptance, feasibility and preliminary effects of dynamic interactive social cognition training in virtual reality (DISCOVR): A pilot study
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Nijman, Saskia, Veling, Wim, Geraets, Chris, Pijnenborg, Marieke, Clinical Psychology and Experimental Psychopathology, Perceptual and Cognitive Neuroscience (PCN), and Clinical Cognitive Neuropsychiatry Research Program (CCNP) more...
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conference abstract ,paranoia ,social cognition ,perception ,male ,controlled study ,human ,self esteem ,skill ,outcome assessment ,Netherlands ,theory of mind ,clinical article ,software ,adult ,questionnaire ,videorecording ,pilot study ,feasibility study ,interview ,social interaction ,anxiety ,female ,randomized controlled trial ,virtual reality ,mental health ,transfer of learning - Abstract
Background: Many people with psychotic disorder experience problems in social functioning, such as finding and maintaining jobs and relationships, which have been shown to be strongly related to deficits in social cognition. A class of interventions called Social Cognition Training (SCT) aims to improve social cognition through practice and strategy training. SCT has been shown to have positive effects on social cognition. (Social) cognition training, however, is known to optimally translate to functional skills when it is applied to and integrated with different areas of daily life. To promote the transfer of training skills to functional domains, it may therefore be beneficial to provide SCT in virtual reality (VR), since it closely resembles real-life social situations. VR is highly realistic and interactive, allowing for practice of social situations in ecologically valid environments. VR is also controllable, allowing for personalization of situations and difficulty level. In the present study, we tested the acceptance and feasibility of a newly developed VR SCT called 'DiSCoVR' (Dynamic Interactive Social Cognition Training in Virtual Reality). Methods: Twenty-two individuals with a psychotic disorder were recruited from three mental health institutions in the Netherlands. All participants received a VR SCT, which was aimed at three domains: 1) emotion perception (identifying virtual characters' emotions in a virtual street); 2) social perception and theory of mind (understanding social situations and the thoughts, emotions and behavior of virtual characters); and 3) practicing social interactions with a virtual character. The intervention strongly emphasized practice with social situations in VR between, and with, virtual characters. Participants also learned strategies to cope with difficulties they experienced in social situations. Participants were assessed at baseline and post-treatment. Acceptance of the intervention was evaluated at post-treatment using a questionnaire. Social cognition was also assessed (emotion perception, social perception and theory of mind) using video/photo tasks and stories. Finally, psychotic symptoms, social anxiety, paranoia, self-esteem and depression were measured using an interview and questionnaires. Results: The results of this pilot study will be presented, focusing on the findings regarding acceptance and feasibility, but also social cognition and other secondary outcome domains. Discussion: The implications of the findings of the pilot study will be discussed in the context of the preparation of a randomized controlled trial of DiSCoVR (for example, necessary alterations to the protocol and/or VR software). Plans for this randomized controlled trial will be discussed. more...
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- 2018
12. F82. INDIVIDUAL GRAY MATTER NETWORKS AND INSIGHT IN PSYCHOTIC DISORDERS
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Larabi, Daouia, primary, Marsman, Jan-Bernard, additional, Aleman, Andre, additional, Tijms, Betty, additional, Opmeer, Esther, additional, Pijnenborg, Marieke (Gerdina), additional, van der Meer, Lisette, additional, Van Tol, Marie-Jose, additional, and Curcic-Blake, Branislava, additional more...
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- 2019
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13. Victimization in Patients With a Psychotic Disorder: Systematic Review and Meta-Analysis on Prevalence and Risk Factors
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Vries, de, Bertine, Busschbach, van, Jooske T., van der Stouwe, Elisabeth C. D., Aleman, André, Pijnenborg, Marieke, Clinical Psychology and Experimental Psychopathology, Clinical Neuropsychology, Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Perceptual and Cognitive Neuroscience (PCN), and Clinical Cognitive Neuropsychiatry Research Program (CCNP) more...
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- 2017
14. F50. METACOGNITIVE REFLECTION AND INSIGHT THERAPY: A MULTICENTER RANDOMIZED CONTROLLED TRIAL
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de Jong, Steven, primary, Donkersgoed, Rozanne van, additional, Timmerman, Marieke, additional, Rot, Marije aan het, additional, Wunderink, Lex, additional, Arends, Johan, additional, van der Gaag, Mark, additional, Aleman, Andre, additional, Lysaker, Paul, additional, and Pijnenborg, Marieke, additional more...
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- 2018
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15. F105. MEASURING EMPATHY IN SCHIZOPHRENIA: THE EMPATHIC ACCURACY TASK AND ITS CORRELATION WITH OTHER EMPATHY MEASURES
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van Donkersgoed, Rozanne, primary, Sportel, Bouwina, additional, De Jong, Steven, additional, aan het Rot, Marije, additional, Wunderink, Alexander, additional, Lysaker, Paul, additional, Hasson-Ohayon, Ilanit, additional, Aleman, Andre, additional, and Pijnenborg, Marieke (Gerdina), additional more...
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- 2018
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16. S237. THE ACCEPTANCE, FEASIBILITY AND PRELIMINARY EFFECTS OF DYNAMIC INTERACTIVE SOCIAL COGNITION TRAINING IN VIRTUAL REALITY (DISCOVR): A PILOT STUDY
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Nijman, Saskia, primary, Veling, Wim, additional, Geraets, Chris, additional, and Pijnenborg, Marieke, additional
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- 2018
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17. The Effects of Lifestyle Interventions on (Long-Term) Weight Management, Cardiometabolic Risk and Depressive Symptoms in People with Psychotic Disorders: A Meta-Analysis
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Bruins, Jojanneke, primary, Jörg, Frederike, additional, Bruggeman, Richard, additional, Slooff, Cees, additional, Corpeleijn, Eva, additional, and Pijnenborg, Marieke, additional
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- 2014
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18. Psychosis-Proneness and Neural Correlates of Self-Inhibition in Theory of Mind
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van der Meer, Lisette, primary, Groenewold, Nynke A., additional, Pijnenborg, Marieke, additional, and Aleman, André, additional
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- 2013
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19. EXPLORING YOUR PERSONAL IDENTITY: USING USER-CENTRED-DESIGN FOR THE DEVELOPMENT OF AÂ NEW INTERVENTION FOR SERVICE USERS WITH COMPLEX MENTAL HEALTH NEEDS.
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Van der Meer, Lisette, Jonker, Tessa, Wunderink, Charlotte, van Weeghel, Jaap, Pijnenborg, Marieke (Gerdina), and van Setten, Ellie
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MENTAL illness treatment ,ATTITUDE (Psychology) ,CONFERENCES & conventions ,GROUP identity ,PSYCHOTHERAPY patients ,PSYCHOSOCIAL factors ,SOCIAL support ,PATIENT-centered care - Abstract
Background: Introduction: As a human being we give meaning to our stories, in relation to the social and physical context. For people with severe and complex mental health needs, who have been dependent on (intensive) residential psychiatric support for a long time, it is possible that talents and qualities disappear because this part of their identity has been buried under a long psychiatric history. This can result in people’s identity becoming limited to ‘patient’, and the experience of life as meaningless. Objectives: For these service-users, few interventions aimed at personal recovery are available that match their cognitive and communicative skills. In this project, we developed a new psychosocial intervention to stimulate self-reflection and personal recovery. Methods: The development of the intervention took place through a “usercentred-design process” (UCD). UCD is an iterative design process in which the needs and wishes of the user are the starting point, and they remain central in the product design circle. Throughout the whole design process, service users, significant others, mental health professionals, peer support workers, artists, and researchers collaborate in order to design a first testable prototype. For each step of design process, we organized focus group meetings and brainstorm sessions with all stakeholders as well as individual interviews with service users. Based on the input in these meetings and interviews, the design was adapted. This was done for each consecutive step, which made the whole design process iterative by nature. Results: A new psychosocial intervention entitled “This Is Me” was developed as a “journey of discovery” through the lives of service users at both verbal and non-verbal levels. From the UCD process four basic principles underlying the intervention were disentangled that have been incorporated in the intervention: 1) “gaining new experiences”, 2) “attention for (self) stigma”, 3) “equal treatment as a person”, 4) “uniqueness of the individual”. This resulted in an intervention in which service-users, together with a teammate, engage in new experiences. Moreover, they are prompted to reflect on these experiences upon their return. With this process, we aim to support people in (re)discovering roles, talents and characteristics to broaden the identity from ‘patienthood’ to ‘personhood’. Discussion: Conclusions: UCD was a useful method for the development of a new psychosocial intervention targeting identity for people with complex mental health needs. The process resulted into new knowledge about factors that are important in the (re)development of identity. In addition, we will present the first results of a pilot study in which we assessed the feasibility and effectiveness of the intervention. [ABSTRACT FROM AUTHOR] more...
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- 2020
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20. THE INFLUENCE OF METACOGNITIVE CAPACITIES ON SPECIFIC NEGATIVE SYMPTOMS: AÂ SYSTEMATIC REVIEW AND INDIVIDUAL PARTICIPANT META-ANALYSIS OF INTERVIEW-BASED DATA.
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McGuire, Nicola, Gumley, Andrew, Hasson-Ohayon, Ilanit, Aunjitsakul, Warut, Aydin, Orkun, Sune Bo, Bonfils, Kelsey, Bröcker, Anna-Lena, de Jong, Steven, DiMaggio, Giancarlo, Inchausti, Felix, Jansen, Jens Einar, Lecomte, Tania, Luther, Lauren, MacBeth, Angus, Montag, Christiane, Pedersen, Marlene Buch, Pijnenborg, Marieke, Popolo, Raffaele, and Trauelsen, Ann-Marie more...
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MENTAL illness risk factors ,COGNITION disorders ,CONFERENCES & conventions ,META-analysis ,SYSTEMATIC reviews - Abstract
Background: Healthy metacognition involves several capacities, including the ability to integrate information about the self and others in order to formulate ways of coping with social challenges and psychological distress. Multiple studies have demonstrated that reduced general metacognitive capacity is predictive of the development and persistence of overall negative symptom burden. However, there have been no published analyses investigating how specific sub-components of metacognition influence the expression of individual negative symptoms. We aggregated individual participant data from studies reporting measures of subtypes of metacognitive functioning and examined the strength of association with specific negative symptoms. Methods: PsycINFO, EMBASE, MEDLINE, Cochrane Library and grey literature databases were searched for eligible studies. Forwards and backwards citation searching and contacting of study authors revealed additional datasets not identified in the original search. Included studies assessed negative symptoms and metacognition using interview-based measures in participants aged 16 years or older. Selection was restricted to quantitative research, excluding case studies, and only English language publications were screened. Experimental and observational studies were screened sequentially at title, abstract and full-text level to determine whether they met search criteria. A second reviewer independently screened a proportion of records to check the reliability of inclusion/exclusion judgements (Cohen’s Kappa = 0.74). Participant data and metadata of included studies were extracted and compiled combining original author and report information for all pre-specified outcomes where available. The proposed plan for the systematic review and meta-analyses was also preregistered on PROPSERO (CRD42019130678). Results: 97 unique reports were identified, of which 30 included negative symptom specific hypotheses. Samples overlapped substantially across publications with these 97 reports corresponding to 30 unique datasets. The raw individual participant level data for 23 of the 30 unique datasets was obtained. Preliminary analyses investigated the relationship between components of metacognition measured with the MAS-A (Lysaker et al., 2005), and the original negative symptoms subscale score of the PANSS (Kay et al., 1987) to maximise available data. We will discuss the results, which suggest that there are distinct relationships between subscales of metacognition and negative symptoms. We will also discuss the limitations of these results including a limited scope for analysing covariates due to the computational complexity of the models used, and difficulties in handling the diversity of data present in the meta-analysis. We will also discuss why high heterogeneity might be present, and provide further support for analysis investigating the relationship between individual negative symptoms and components of metacognition. Discussion: The data suggest there is complexity in the relationship between components of metacognition and individual negative symptoms. It is for subsequent analyses to determine whether individual negative symptoms have distinct relationships with each metacognitive capacity, and whether the variation in the strength of these associations could explain the high heterogeneity observed. [ABSTRACT FROM AUTHOR] more...
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- 2020
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21. VIRTUAL REALITY FOR IMPROVING SOCIAL ACTIVITIES AND PARTICIPATION (VR-SOAP): DEVELOPMENT OF AÂ NEW TREATMENT FOR YOUNG PEOPLE WITH PSYCHOSIS.
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Muijsson, Dauw, van der Stouwe, Elise, Greaves-Lord, Kirstin, Nijman, Saskia, Pijnenborg, Marieke, and Veling, Wim
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CONFERENCES & conventions ,SIMULATION methods in education ,LEISURE ,PSYCHOSES ,INTERPERSONAL relations ,SOCIAL participation - Abstract
Background: Young people with a psychotic disorder have the same social goals as their healthy peers, but their social networks are smaller, they participate less often in leisure activities and are less successful in work and education. Current treatments have only moderate effects on social functioning. Virtual Reality (VR) has a great potential to improve the social functioning of young people with psychosis. With VR, individuals can practice with simulations of difficult social situations in a safe and personalized way. Therefore, we aimed to develop and investigate feasibility of a novel VR treatment (VR-SOAP) for improving social contacts, leisure activities and social participation of young people with a psychotic disorder. Methods: As a first step, a literature search of causes of impaired social functioning was conducted. Underlying relationships and mechanisms of the causes were identified. The causes of impaired social functioning were translated into concepts for the VR modules. The concepts were translated into requirements for the VR modules. Subsequently, the software and the treatment manual were developed in an iterative process with a team of experiential experts, psychosis therapists, researchers, VR experts and software engineers. The final prototype will be tested in a small pilot study with three therapists and six patients. In order to determine the feasibility and acceptability of the treatment and to evaluate and improve the treatment protocol using input from therapists and patients. Results: Several determinants of impaired social functioning were identified: negative symptoms, impaired social cognition, paranoid ideations, social anxiety, low self-esteem, self-stigma and poor communication skills. These causes are multifaceted, but at the same time interrelated and overlapping. VR-SOAP was designed as five modules that address these causes, four optional modules (1–4) and one fixed module (5). The treatment is personalized and takes the specific individual contributing causes into account. Patient and therapist select two out of four optional modules. In module 1 (Negative symptoms) patients will focus on increasing their motivation and pleasure in dealing with amotivation and anhedonia. In module 2 (Social cognition) patients will practice with recognizing facial emotions and interpreting social situations. Module 3 (Paranoid ideations) consists of exposure exercises and behavioural experiments testing harm expectancies. In module 4 (Self-esteem and self-stigma) patients will focus on positive aspects of the self and challenge self-criticism. All patients will end with module 5 (Communication and Interaction skills), in which experiences, knowledge and skills from other modules are integrated and applied in role-plays. Currently, the pilot feasibility study is ongoing. Preliminary results will be presented. Discussion: VR-SOAP is a promising new intervention for enhancing the social functioning of young adults with psychosis. VR is very useful for practising new social behaviour. It enables patients to practice with realworld social situations in a safe and gradual way. In the coming years, a single-blind randomized controlled trial will be conducted to test the effect of VR-SOAP on social contacts, leisure activities and social participation. [ABSTRACT FROM AUTHOR] more...
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- 2020
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22. THE POSITIVE AND NEGATIVE SYNDROME SCALE SUPERIOR TO A SELF-REPORT QUESTIONNAIRE IN THE PHARMACOTHERAPY MONITORING AND OUTCOME SURVEY.
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Bartels-Velthuis, Annegien, Ties, Koen, Visser, Ellen, Arends, Johan, Pijnenborg, Marieke, Wunderink, Lex, Jörg, Frederike, Wim Veling, Castelein, Stynke, Knegtering, Henderikus, and Bruggeman, Richard more...
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CONFERENCES & conventions ,EXPERIMENTAL design ,RESEARCH methodology ,PSYCHOSES ,QUESTIONNAIRES ,RESEARCH methodology evaluation ,EVALUATION - Abstract
Background: Aiming to improve the quality of care for patients with a psychotic disorder, the ongoing Pharmacotherapy Monitoring Outcome Survey (PHAMOUS) started in 2006 in four large mental health care organizations in the Northern Netherlands, by adding it to the at that time mandatory Routine Outcome Monitoring program. However, since the cuts in the financial budgets for mental health care, research nurses are increasingly experiencing time-pressure in the assessments. The Positive and Negative Syndrome Scale (PANSS), part of the assessment, is a time-consuming interview, taking approximately 30 minutes. Therefore, we developed and validated a short self-report questionnaire assessing positive psychotic symptoms, the Brief Positive Symptoms Questionnaire (BPSQ). Methods: The BPSQ was added to PHAMOUS and filled in once by patients in four mental health care institutions in 2017 and 2018. The BPSQ consists of nine items and takes about 2–3 minutes to complete. It was validated against the PANSS positive scale and two items of the Health of the Nations Outcome Scale (HoNOS), with item 6 assessing the problems that patients experience due to hallucinations and delusions and item 8 assessing further mental and behavioural problems. Results: BPSQ data were obtained from n=287 patients (mean age 47.1 years, 67.6% male). The PANSS was assessed in n=244 and HoNOS data were available for n=156 patients. Scores of one patient were considered unreliable and thus removed from the data set. The BPSQ had a Cronbach’s alpha of .81. Spearman’s correlation coefficient of the BPSQ and the PANSS positive scale was significant (ρ(243) = .63, p < .05). Correlations between the BPSQ and HoNOS items 6 and 8 were significant (ρ(155) = .488, p < .05 and ρ(155) = .251, p < .05 respectively). Post hoc analysis showed that the more severely psychotic the patients were, the less the BPSQ and the PANSS positive scale were corresponding. Discussion: Given the medium correlation of the BPSQ with the PANSS positive scale and the low concurrent validity with the two relevant HoNOS items, we argue that the widely used and validated PANSS is indispensable in the PHAMOUS assessment of positive symptoms in a chronic population with psychotic disorders. Replication of this study in first-episode psychotic patients is recommended. [ABSTRACT FROM AUTHOR] more...
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- 2020
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23. NEURAL CHANGES FOLLOWING A BODY-ORIENTED RESILIENCE THERAPY WITH ELEMENTS OF KICKBOXING FOR INDIVIDUALS WITH A PSYCHOTIC DISORDER: A RANDOMIZED CONTROLLED TRIAL.
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van der Stouwe, Elisabeth, Pijnenborg, Marieke (Gerdina), Opmeer, Esther, de Vries, Bertine, Marsman, Jan Bernard, Aleman, Andre, and van Busschbach, Jooske
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BRAIN physiology ,BOXING ,CONFERENCES & conventions ,PSYCHOSES ,PSYCHOLOGICAL resilience ,PSYCHOLOGY of crime victims ,RANDOMIZED controlled trials - Abstract
Background: Individuals with a psychotic disorder are at an increased risk of becoming the victim of a crime. A body-oriented resilience therapy with elements of kickboxing (‘BEATVIC’) aimed at preventing victimization by addressing putatively underlying factors was developed. One of these factors is social cognition, particularly facial affect processing. The current study investigated neural effects of BEATVIC using two face processing tasks. Methods: Participants were randomized to either BEATVIC or a ‘Befriending’ control group consisting of social group meetings. Twentyseven patients (BEATVIC n=14; Befriending n=13) completed an Emotional Faces task and the Wall of Faces task during fMRI, pre and post intervention. General linear model (GLM) analyses and Independent component analyses (ICA) were performed to define networks and investigate group*time effects. Results: Voxelwise GLM analyses yielded no differences between groups over time. On a network level (ICA) we found overall increased activation of the salience network to angry and fearful faces in BEATVIC compared to Befriending. A trend towards significance (p=0.05) for increased activation of the (medial) visual network to (a group of predominantly) angry faces, and decreased deactivation (p=0.08) in the sensorimotor network in response to fearful faces in BEATVIC was observed. Discussion: Increased activation of the salience network may suggest an increased alertness for potentially dangerous faces. Trend findings of the visual network and the sensorimotor network which are formally statistically insignificant may be regarded as tentative and strongly warrant further investigation to allow for more definite conclusions. Increased activation of the visual network might suggest more elaborate processing of visual information. Decreased deactivation in the sensorimotor network might indicate a reduced tendency for “freezing” and enhanced action readiness in response to indirect threat. [ABSTRACT FROM AUTHOR] more...
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- 2020
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24. AÂ NETWORK META-ANALYSIS ON SOCIAL COGNITION TRAINING FOR PEOPLE WITH PSYCHOTIC DISORDER: RELATIVE EFFICACY, MODERATORS, AND LONG-TERM EFFECTS.
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Nijman, Saskia, Veling, Wim, van der Stouwe, Elisabeth, and Pijnenborg, Marieke (Gerdina)
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COGNITION ,CONFERENCES & conventions ,META-analysis ,PSYCHOSES ,SOCIAL skills ,SYSTEMATIC reviews - Abstract
Background: Social cognitive deficits are common in people with a psychotic disorder, and may play an important role in social dysfunction. Social cognition training (SCT) has emerged in the past two decades as a way to improve social cognition through strategy training and repeated practice. Several reviews and meta-analyses have indicated that SCT improves social cognition, but several important questions remain. This meta-analysis addresses three of these questions: Methods: Search results from clinical databases were systematically reviewed by two independent raters. SCTs from included publications were categorized according to their focus (targeted or broad-based) and their inclusion of CRT (with or without). Network meta-analysis was used, since it allows for comparison of more than two treatments, and comparison of any chosen pair of interventions - even those not directly investigated in the literature. It estimates the treatment effect by inference from a network of evidence (i.e., effectAB = effectAC – effectBC), and combines this indirect evidence with original comparisons to estimate treatment effects. For each treatment arm, a pre-post effect size was determined and pairwise comparisons for each combination of study arms were calculated. With network meta-analysis, all SCTs were compared to treatment as usual (the chosen reference group). Meta-regression was used to evaluate the moderating effects of study (methodological quality, total intervention time, use of groups, static/dynamic measures, inclusion of CRT) and participant (age, illness duration, medication dose, gender) characteristics. Follow-up efficacy was investigated using multivariate meta-analysis. Results: Compared to TAU, emotion perception was improved most by targeted SCT without CRT (Cohen’s d=.68) and broad-based SCT without CRT (d=.46). All treatments improved social perception (active control, d=.98, targeted SCT with and without CRT, d=1.36 and d=1.38, broad-based SCT with and without CRT, d=1.35 and d=1.45). Only broad-based SCT without CRT improved ToM (d=.42) more than TAU. Social functioning was significantly improved only by broad-based SCT (without CRT, d=.82, with CRT, d=.41). None of the SCTs significantly improved attribution, general social cognition and psychotic symptoms, compared to TAU. Individual SCT worked better for emotion perception, but SCT in a group was more effective for social functioning. A higher percentage of male participants in a study predicted worse outcomes on functioning and psychotic symptoms. At follow-up, a moderate effect on social functioning (d=.66) was found, but not on psychotic symptoms. Social cognition could not be investigated quantitatively at follow-up due to insufficient data, but qualitative analysis suggested persisting effects. Discussion: While targeted SCT is the most effective for emotion perception and social perception, broad-based SCT produced the best overall outcomes. Using CRT did not enhance SCT effects. Our results suggest that (particularly broad-based approaches to) SCT produce generalized, enduring effects, but more methodologically sound research is necessary to investigate key questions that remain, especially regarding mechanisms of treatment. [ABSTRACT FROM AUTHOR] more...
- Published
- 2020
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25. The positive and negative syndrome scale superior to a self-report questionnaire in the pharmacotherapy monitoring and outcome survey
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Bartels-Velthuis, Annegien, Ties, Koen, Visser, Ellen, Arends, Johan, Pijnenborg, Marieke, Wunderink, Lex, Jorg, Frederike, Veling, Wim, Castelein, Stynke, Knegtering, Henderikus, Bruggeman, Richard, Clinical Cognitive Neuropsychiatry Research Program (CCNP), and Clinical Psychology and Experimental Psychopathology more...
26. Virtually social: research on social cognition and virtual reality in people with a psychotic disorder
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Saskia Nijman, Pijnenborg, Marieke, Veling, Wim, and Clinical Psychology and Experimental Psychopathology
- Abstract
Many people who are susceptible to psychosis have problems understanding what is going on in other people’s minds. Problems in these mental skills called ‘social cognition’ have been linked to difficulties in social functioning, such as finding paid work and making new friends. In a network meta-analysis, we found that problems in social cognition can be treated with ‘Social Cognition Training’ (SCT). SCT targeting multiple domains of social cognition was particularly effective. Therefore, we have developed a virtual reality (VR) SCT, ‘DiSCoVR’, because VR makes it possible to practice accessibly in a realistic, interactive environment. DiSCoVR consisted of sixteen sessions, in which participants practiced with emotion recognition, understanding others, and social interaction in VR. These sessions were guided by a psychologist, who helped participants set social goals and determine an appropriate approach for social situations. DiSCoVR was evaluated by comparing it to a VR-relaxation training (‘VRelax’). In VRelax, participants explored relaxing virtual environments. We found no effect of DiSCoVR social cognition or social functioning, neither directly after training, nor three months later. To understand why, we examined data that were logged as participants practiced emotion recognition in VR. This showed that participants did improve their accuracy and speed of emotion recognition in VR, but this did not translate to improvement outside of VR. DiSCoVR might therefore be too abstract, not realistic enough, or too different from real, daily social situations. A solution could be to use more technologically advanced VR programs that are more focused on concrete social problems. more...
- Published
- 2023
27. Social predictors of psychotic experiences in adolescence: the role of social cognition, social functioning, parenting and religiosity in the emergence and course of adolescent psychotic experiences
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Laura Alida Steenhuis, Pijnenborg, Marieke, Nauta, Maaike, Aleman, Andre, Bartels-Velthuis, Agna, and Clinical Psychology and Experimental Psychopathology
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Psychosis ,Coping (psychology) ,education.field_of_study ,Population ,medicine.disease ,Religiosity ,Social cognition ,Theory of mind ,medicine ,javascript:void(0) ,Paranoia ,medicine.symptom ,Young adult ,Psychology ,education ,Clinical psychology - Abstract
Psychotic experiences are common in the general population, not only in adulthood but also in childhood and adolescence. It is possible that the presence of psychotic experiences in childhood can predict psychotic disorders in young adulthood. This renders it essential to gain more insight into the presence and course of psychotic experiences in childhood and adolescence. In this thesis, social predictors such as social cognition, social functioning and religiosity were examined in relation to psychotic experiences in adolescence. In the first study, a self-report questionnaire for auditory vocal hallucinations was validated. In two following studies, the association between social cognition (theory of mind and emotion identification), social functioning (general and within the family context), and psychotic experiences was examined in two samples of adolescents over a period of five and six years respectively. Subsequently, the association between social functioning and paranoia was examined using daily assessments, in a sample of young persons at ultra-high risk for psychosis. In the last study, the association between religiosity and auditory vocal hallucinations in adolescence was examined. There was no evidence for a trait vulnerability in social cognition in relation to the development of psychotic experiences in adolescence. Lowered social functioning was associated with increased psychotic experiences. Besides this, religious activity and seeking out social contact and support, could signify ways of coping with psychotic experiences. It was also demonstrated that a self-report questionnaire of auditory vocal hallucinations can be reliably and validly used in treatment and research settings. more...
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- 2019
28. Victimization in psychosis
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Elise van der Stouwe, Pijnenborg, Marieke, Aleman, Andre, van Busschbach, Jooske, and Veling, Wim
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media_common.quotation_subject ,Art ,Theology ,media_common - Abstract
In films, in de krant en in andere media wordt vaak een link gelegd tussen psychose en agressie of geweld. Maar in tegenstelling tot wat films en nieuwsberichten doen vermoeden, zijn mensen met een diagnose in het psychose spectrum veel vaker slachtoffer dan dader van een misdrijf. Hoewel dit een grote impact kan hebben op het leven van patiënten, is er op dit moment geen bewezen effectieve interventie voorhanden om slachtofferschap te voorkomen. Daarom heeft de onderzoeksgroep waar promovenda Elise van der Stouwe deel van uit maakt een psychomotorische weerbaarheidstherapie (BEATVIC) ontwikkeld, gestoeld op in de literatuur beschreven mogelijke risicofactoren voor slachtofferschap. Ten eerste heeft van der Stouwe gekeken naar het effect van deze therapie op gedragsniveau. In de voorbereidende pilot studie om de interventie te testen rapporteerden patiënten dat zij het idee hadden dat BEATVIC een positief effect had gehad op verschillende risicofactoren van slachtofferschap en de kans op slachtofferschap zelf. In een grootschalig gerandomiseerd vervolgonderzoek vonden van der Stouwe en haar collega’s geen verschillen tussen de BEATVIC groep en de sociaal contact groep (controle) direct na de interventie op basis van gevalideerde vragenlijsten over slachtofferschap, agressieregulatie, sociale cognitie, interpersoonlijk gedrag, ziekte-inzicht, zelfvertrouwen, zelf-stigma. In het tweede deel van haar proefschrift focust van der Stouwe op beeldvormend hersenonderzoek. Uit haar fMRI sub studie bleek dat slachtofferschap gepaard gaat met meer deactivatie van het sensorimotor netwerk in reactie op dreigende gezichten wat kan wijzen op een bevries (‘freeze’) respons. Na de therapie werden veranderingen gevonden in activatie patronen in specifieke netwerken in het brein; bevindingen die mogelijk duiden op meer alertheid bij dreigende gezichten en meer geneigdheid tot actie als reactie op dreiging. Door eerdere onderzoeken naar het effect van bewegingsinterventies op het brein samen te voegen is overzichtelijk gemaakt dat deze interventies een positief effect hebben op verschillende hersengebieden en verbindingen. more...
- Published
- 2019
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29. Social cognition and treatment in psychosis
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van Donkersgoed, Rozanne Janna Margaretha, Pijnenborg, Marieke, Aleman, Andre, Wunderink, Alexander, and Clinical Psychology and Experimental Psychopathology
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In dit proefschrift wordt onderzoek gedaan naar sociale cognitie en de behandeling van metacognitie bij mensen met een psychotische kwetsbaarheid. Met sociale cognitie wordt bedoeld: de mentale operaties die ten grondslag liggen aan sociale interacties. Met metacognitie wordt verwezen naar het proces van reflecteren op de eigen gedachten en gevoelens en die van anderen. Uit ons onderzoek komt naar voren dat sociale cognitie al verminderd is vóór het ontstaan van een eerste psychose. Aangezien sociale cognitie invloed heeft op sociaal functioneren en daarmee op de mentale gezondheid, is het van groot belang om sociale cognitie te verbeteren bij mensen die het risico lopen op een psychose. Empathie, een onderdeel van sociale cognitie, blijkt verminderd bij mensen die een psychose hebben gehad. Ze hebben meer moeite met het lezen van expressieve gezichten in vergelijking met gezonde personen. Uit eerder onderzoek komt naar voren dat metacognitie verminderd is bij mensen met een psychotische kwetsbaarheid. We onderzochten een nieuwe therapie die metacognitie wil verbeteren (MERIT therapie) op effectiviteit in een ‘randomized controlled trial’. De mensen in de behandelingsgroep lieten een verbetering in metacognitie zien, een half jaar na de therapie, in vergelijking met de mensen die reguliere behandeling kregen. MERIT is een intensieve therapie en is daarom niet de eerste keus voor behandeling voor elke patiënt, maar het is mogelijk wel nuttig voor specifieke groepen patiënten die niet reageren op standaard, korte therapieën. more...
- Published
- 2018
30. Metacognition in psychotic disorders
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de Jong, Steven, Pijnenborg, Marieke, Aleman, Andre, and Clinical Psychology and Experimental Psychopathology
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Being able to think about one’s own thoughts and feelings (metacognition) is often difficult for persons with a psychotic disorder. These difficulties have a negative influence on the (interpersonal) functioning. In the first part of this dissertation, we discuss different definitions of metacognitions which are used and the associated treatments, the link between metacognitive abilities and work experience, and risk of violence. In the second part of this dissertation we discuss our research into the effectiveness of a new psychotherapy aimed at metacognitive capacity in psychosis. First, we report our findings in the treatment of a single patient (case study), then a group of patients with whom we found encouraging results (pilot study), and finally a large study into the effectiveness of 40 sessions of this treatment in 35 patients compared to 35 patients who did not receive any treatment. Our results are modestly encouraging: immediately after treatment we find no differences between the groups; both groups had improved. In the control group, however, this effect disappears after 6 months, while the group which had received therapy continued to improve on metacognitive capacity. more...
- Published
- 2018
31. Schizophrenia spectrum disorders and dissociative disorders: The blurry boundaries between categorical diagnoses
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Renard, Selwyn Benjamin, Pijnenborg, Marieke, Aleman, Andre, Huntjens, Rafaele, and Clinical Psychology and Experimental Psychopathology
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In lijn met de onderzoektrend die afstand neemt van categorische modellen van psychopathologie, wordt in dit proefschrift onderzocht in hoeverre schizofrenie spectrum stoornissen en dissociatieve stoornissen categorisch verschillende aandoeningen zijn. Het proefschrift begint met een overzicht van de literatuur gevolgd door nieuw onderzoek dat de uniekheid en de overlap van deze twee diagnostische clusters toetst. Verschillende benaderingen worden hierbij gebruikt, zo wordt er bijvoorbeeld door middel van netwerk analyse specifiek gekeken naar dissociatieve symptomen, die bij beide diagnoses voorkomen. Een andere studie is gericht op het experimenteel induceren van derealisatie, onafhankelijk van schizotypische ervaringen. Hoewel er verschillen zijn tussen schizofrenie spectrum stoornissen en dissociatieve stoornissen, blijkt uit dit proefschrift dat de grenzen tussen deze diagnoses niet zo duidelijk zijn als categorische modellen van psychopathologie, zoals het DSM-5, impliceren. De bevindingen van het proefschrift worden besproken in relatie tot veelbelovende projecten zoals RDoC, HiTOP en het netwerkmodel van psychopathologie. more...
- Published
- 2017
32. Insight in psychosis: Metacognitive processes and treatment
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de Vos, Annerieke, Aleman, Andre, Pijnenborg, Marieke, and van der Meer, Lisette
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Insight is impaired in 50- 80% of the patients with schizophrenia. Annerieke de Vos working at GGZ Drenthe and the University Medical Hospital Groningen, aimed to elucidate which processes underlie impaired insight and tried to improve insight in patients by targeting these processes. On September 21st she will defend her thesis entitled: "Insight in psychosis. Metacognitive processes and treatment.". Patients with impaired insight may fail to recognize that things in life are not going well and that this may have to do with their psychological functioning, deny that they need help and attribute symptoms to external sources. Impaired insight has been related to a worse wellbeing in patients and to problems with family and clinicians. One of the findings of the thesis was that patients with impaired were less able to use feedback to adjust their performance on a cognitive task. The ability to use feedback falls under the umbrella of metacognition, which can be described as “thinking about thinking”. Another metacognitive process, self-reflection (the ability to evaluate yourself) was also related to impaired insight. People with impaired insight showed lower activation in brain areas involved in self-reflection, which suggests that they might have trouble to critically look at themselves. Also, de Vos and colleagues found that insight improved after targeting these metacognitive processes, however they also improved with a simple cognitive training. In conclusion, according to de Vos and colleagues, having good insight does not necessarily entail accepting a diagnosis (e.g. “I have schizophrenia”). Rather it involves a complex process of integrating information from self and others into a rich and complex self-representation, which includes illness related experiences. Improving insight this way may facilitate recovery in people with schizophrenia. more...
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- 2016
33. Metabolic risk in people with psychotic disorders: No mental health without physical health
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Bruins, Jojanneke, Pijnenborg, Marieke, Jörg, Frederike, and Bruggeman, Richard
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Mensen met psychotische aandoeningen hebben een groter risico op metabole afwijkingen en een lagere gemiddelde levensverwachting dan de algemene bevolking. Routinematig monitoren van metabole risico factoren bij deze patiënten wordt daarom aanbevolen en is al enkele jaren in de Noord-Nederlandse GGZ geïmplementeerd. Dit proefschrift laat zien dat ondanks regelmatig monitoren slechts 43-50% van de patiënten wordt behandeld voor metabole risicofactoren wanneer dit door richtlijnen wordt aanbevolen. Eén van de factoren gerelateerd aan een verhoogd metabool risico, besproken in dit proefschrift, is vitamine D insufficiëntie. Deze relatie kan worden uitgelegd door een complex model waarin negatieve symptomen, antipsychotica en een ongezonde leefstijl een rol spelen. Daarnaast toont dit proefschrift aan dat cannabisgebruikers een lagere BMI, geringere buikomvang en lagere diastolische bloeddruk hebben, maar ook ernstigere psychotische klachten dan niet-gebruikers. Na een jaar waren bij patiënten die gestopt waren met cannabis de BMI, buikomvang, diastolische bloeddruk en triglyceride waarden meer toegenomen, en de psychotische klachten meer afgenomen dan bij andere patiënten. Patiënten met een specifiek AKT1 gen gebruikten vaker cannabis, maar dit speelt geen rol in de relatie tussen cannabisgebruik en BMI. Tevens laat dit proefschrift zien dat de tot nu toe onderzochte leefstijlinterventies het metabole risico bij deze patiëntengroep doen verminderen (afname van lichaamsgewicht, buikomvang, triglyceridewaarden en nuchtere glucose), maar niet doen verdwijnen (geen verbeteringen in bloeddruk en cholesterolwaarden). Dit proefschrift benadrukt dat monitoren niet automatisch leidt tot betere zorg. Dit suggereert dat het huidige proces van monitoren, verwijzen en behandelen van metabole risicofactoren dringend onder de loep moet worden genomen. more...
- Published
- 2016
34. Development and validation of a fidelity instrument for Cognitive Adaptation Training.
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van Dam M, van Weeghel J, Castelein S, Stiekema A, Quee P, Kidd S, Allott K, Maples N, Velligan D, Pijnenborg M, and van der Meer L
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Purpose: Cognitive Adaptation Training (CAT) is a psychosocial intervention with demonstrated effectiveness. However, no validated fidelity instrument is available. In this study, a CAT Fidelity Scale was developed and its psychometric properties, including interrater reliability and internal consistency, were evaluated., Methods: The fidelity scale was developed in a multidisciplinary collaboration between international research groups using the Delphi method. Four Delphi rounds were organized to reach consensus for the items included in the scale. To examine the psychometric properties of the scale, data from a large cluster randomized controlled trial evaluating the implementation of CAT in clinical practice was used. Fidelity assessors conducted 73 fidelity reviews at four mental health institutions in the Netherlands., Results: After three Delphi rounds, consensus was reached on a 44-item CAT Fidelity Scale. After administration of the scale, 24 items were removed in round four resulting in a 20-item fidelity scale. Psychometric properties of the 20-item CAT Fidelity Scale shows a fair interrater reliability and an excellent internal consistency., Conclusions: The CAT fidelity scale in its current form is useful for both research purposes as well as for individual health professionals to monitor their own adherence to the protocol. Future research needs to focus on improvement of items and formulating qualitative anchor point to the items to increase generalizability and psychometric properties of the scale. The described suggestions for improvement provide a good starting point for further development., Competing Interests: None., (© 2022 The Authors.) more...
- Published
- 2022
- Full Text
- View/download PDF
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