9 results on '"Ploubidis, G. B."'
Search Results
2. Novel DNA methylation signatures of tobacco smoking with trans-ethnic effects
- Author
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Christiansen, C., Castillo-Fernandez, J. E., Domingo-Relloso, A., Zhao, W., El-Sayed Moustafa, J. S., Tsai, P.-C., Maddock, J., Haack, K., Cole, S. A., Kardia, S. L. R., Molokhia, M., Suderman, M., Power, C., Relton, C., Wong, A., Kuh, D., Goodman, A., Small, K. S., Smith, J. A., Tellez-Plaza, M., Navas-Acien, A., Ploubidis, G. B., Hardy, R., and Bell, J. T.
- Published
- 2021
- Full Text
- View/download PDF
3. Measuring behaviours for escaping from house fires: use of latent variable models to summarise multiple behaviours.
- Author
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Ploubidis, G. B., Edwards, P., Kendrick, D., Ablewhite, Joanne, Benford, Penny, Bryan, Clare, Clacy, Rose, Coupland, Carol, Cooper, Nicola, Deave, Toity, Goodenough, Trudy, Hawkins, Adrian, Hayes, Mike, Hindmarch, Paul, Kay, Bryony, Laird-Hopkins, Benita, Majsak-Newman, Gosia, McColl, Elaine, McDaid, Lisa, and Reading, Richard
- Subjects
- *
HOME fires & fire prevention , *LATENT variables , *LOGISTIC regression analysis , *RANDOMIZED controlled trials , *MULTIVARIATE analysis - Abstract
Background: This paper reports the development and testing of a construct measuring parental fire safety behaviours for planning escape from a house fire. Methods: Latent variable modelling of data on parental-reported fire safety behaviours and plans for escaping from a house fire and multivariable logistic regression to quantify the association between groups defined by the latent variable modelling and parental-report of having a plan for escaping from a house fire. Data comes from 1112 participants in a cluster randomised controlled trial set in children's centres in 4 study centres in the UK. Results: A two class model provided the best fit to the data, combining responses to five fire safety planning behaviours. The first group ('more behaviours for escaping from a house fire') comprised 86 % of participants who were most likely to have a torch, be aware of how their smoke alarm sounds, to have external door and window keys accessible, and exits clear. The second group ('fewer behaviours for escaping from a house fire') comprised 14 % of participants who were less likely to report these five behaviours. After adjusting for potential confounders, participants allocated to the 'more behaviours for escaping from a house fire group were 2.5 times more likely to report having an escape plan (OR 2.48; 95 % CI 1.59-3.86) than those in the "fewer behaviours for escaping from a house fire" group. Conclusions: Multiple fire safety behaviour questions can be combined into a single binary summary measure of fire safety behaviours for escaping from a house fire. Our findings will be useful to future studies wishing to use a single measure of fire safety planning behaviour as measures of outcome or exposure. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
4. Diet, physical activity, and sleep in relation to furlough during the COVID-19 pandemic in the UK: evidence from eight longitudinal studies.
- Author
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Maddock, J., Wielgoszewska, B., Green, M. J., Di Gessa, G., Parsons, S., Griffith, G. J., Croft, J., Stevenson, A. J., Booth, C., and Ploubidis, G. B.
- Subjects
CONFERENCES & conventions ,LONGITUDINAL method ,SLEEP ,DIET ,PHYSICAL activity ,COVID-19 pandemic - Published
- 2021
5. Substance use behaviours and the UK furlough scheme: evidence from eight longitudinal population surveys.
- Author
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Green, M., Di Gessa, G., Maddock, J., Parsons, S., Wielgoszewska, B., Stevenson, A. J., Griffith, G. J., Booth, C., Croft, J., and Ploubidis, G. B.
- Subjects
SUBSTANCE abuse ,ELECTRONIC cigarettes ,CONFERENCES & conventions ,HEALTH behavior ,EMPLOYMENT ,ALCOHOL drinking ,SMOKING ,COVID-19 pandemic - Published
- 2021
6. Novel DNA methylation signatures of tobacco smoking with trans-ethnic effects
- Author
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Christiansen, C., Castillo-Fernandez, J. E., Domingo-Relloso, A., Zhao, W., El-Sayed Moustafa, J. S., Tsai, P.-C., Maddock, J., Haack, K., Cole, S. A., Kardia, S. L. R., Molokhia, M., Suderman, M., Power, C., Relton, C., Wong, A., Kuh, D., Goodman, A., Small, K. S., Smith, J. A., Tellez-Plaza, M., Navas-Acien, A., Ploubidis, G. B., Hardy, R., Bell, J. T., Christiansen, C., Castillo-Fernandez, J. E., Domingo-Relloso, A., Zhao, W., El-Sayed Moustafa, J. S., Tsai, P.-C., Maddock, J., Haack, K., Cole, S. A., Kardia, S. L. R., Molokhia, M., Suderman, M., Power, C., Relton, C., Wong, A., Kuh, D., Goodman, A., Small, K. S., Smith, J. A., Tellez-Plaza, M., Navas-Acien, A., Ploubidis, G. B., Hardy, R., and Bell, J. T.
- Abstract
Background Smoking remains one of the leading preventable causes of death. Smoking leaves a strong signature on the blood methylome as shown in multiple studies using the Infinium HumanMethylation450 BeadChip. Here, we explore novel blood methylation smoking signals on the Illumina MethylationEPIC BeadChip (EPIC) array, which also targets novel CpG-sites in enhancers. Method A smoking-methylation meta-analysis was carried out using EPIC DNA methylation profiles in 1407 blood samples from four UK population-based cohorts, including the MRC National Survey for Health and Development (NSHD) or 1946 British birth cohort, the National Child Development Study (NCDS) or 1958 birth cohort, the 1970 British Cohort Study (BCS70), and the TwinsUK cohort (TwinsUK). The overall discovery sample included 269 current, 497 former, and 643 never smokers. Replication was pursued in 3425 trans-ethnic samples, including 2325 American Indian individuals participating in the Strong Heart Study (SHS) in 1989–1991 and 1100 African-American participants in the Genetic Epidemiology Network of Arteriopathy Study (GENOA). Results Altogether 952 CpG-sites in 500 genes were differentially methylated between smokers and never smokers after Bonferroni correction. There were 526 novel smoking-associated CpG-sites only profiled by the EPIC array, of which 486 (92%) replicated in a meta-analysis of the American Indian and African-American samples. Novel CpG sites mapped both to genes containing previously identified smoking-methylation signals and to 80 novel genes not previously linked to smoking, with the strongest novel signal in SLAMF7. Comparison of former versus never smokers identified that 37 of these sites were persistently differentially methylated after cessation, where 16 represented novel signals only profiled by the EPIC array. We observed a depletion of smoking-associated signals in CpG islands and an e
7. Novel DNA methylation signatures of tobacco smoking with trans-ethnic effects
- Author
-
Christiansen, C., Castillo-Fernandez, J. E., Domingo-Relloso, A., Zhao, W., El-Sayed Moustafa, J. S., Tsai, P.-C., Maddock, J., Haack, K., Cole, S. A., Kardia, S. L. R., Molokhia, M., Suderman, M., Power, C., Relton, C., Wong, A., Kuh, D., Goodman, A., Small, K. S., Smith, J. A., Tellez-Plaza, M., Navas-Acien, A., Ploubidis, G. B., Hardy, R., Bell, J. T., Christiansen, C., Castillo-Fernandez, J. E., Domingo-Relloso, A., Zhao, W., El-Sayed Moustafa, J. S., Tsai, P.-C., Maddock, J., Haack, K., Cole, S. A., Kardia, S. L. R., Molokhia, M., Suderman, M., Power, C., Relton, C., Wong, A., Kuh, D., Goodman, A., Small, K. S., Smith, J. A., Tellez-Plaza, M., Navas-Acien, A., Ploubidis, G. B., Hardy, R., and Bell, J. T.
- Abstract
Background Smoking remains one of the leading preventable causes of death. Smoking leaves a strong signature on the blood methylome as shown in multiple studies using the Infinium HumanMethylation450 BeadChip. Here, we explore novel blood methylation smoking signals on the Illumina MethylationEPIC BeadChip (EPIC) array, which also targets novel CpG-sites in enhancers. Method A smoking-methylation meta-analysis was carried out using EPIC DNA methylation profiles in 1407 blood samples from four UK population-based cohorts, including the MRC National Survey for Health and Development (NSHD) or 1946 British birth cohort, the National Child Development Study (NCDS) or 1958 birth cohort, the 1970 British Cohort Study (BCS70), and the TwinsUK cohort (TwinsUK). The overall discovery sample included 269 current, 497 former, and 643 never smokers. Replication was pursued in 3425 trans-ethnic samples, including 2325 American Indian individuals participating in the Strong Heart Study (SHS) in 1989–1991 and 1100 African-American participants in the Genetic Epidemiology Network of Arteriopathy Study (GENOA). Results Altogether 952 CpG-sites in 500 genes were differentially methylated between smokers and never smokers after Bonferroni correction. There were 526 novel smoking-associated CpG-sites only profiled by the EPIC array, of which 486 (92%) replicated in a meta-analysis of the American Indian and African-American samples. Novel CpG sites mapped both to genes containing previously identified smoking-methylation signals and to 80 novel genes not previously linked to smoking, with the strongest novel signal in SLAMF7. Comparison of former versus never smokers identified that 37 of these sites were persistently differentially methylated after cessation, where 16 represented novel signals only profiled by the EPIC array. We observed a depletion of smoking-associated signals in CpG islands and an e
8. Gender inequality in healthy ageing : a study of the English older population over a decade
- Author
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Pongiglione, B., De Stavola, B. L., and Ploubidis, G. B.
- Subjects
305.26 - Abstract
This thesis investigates gender inequalities in healthy ageing among the older English population, using data from the English Longitudinal Study of Ageing. The research aims were achieved by completing the following steps: (i) healthy ageing was intended as advancing to the later stages of the life course without disability; where disability was first theoretically conceptualized and then measured using severity levels that were identified empirically; (ii) gender inequalities in healthy ageing were assessed by studying whether the association between disability and mortality observed over the course of a decade differed between men and women; and (iii) disability and mortality were combined into a summary measure of population health -disability-free life expectancy- in order to estimate how expectancies of healthy life have changed over a decade across the two genders. The work is structured in four papers, denoted Research Paper I-IV. Research Paper I, a systematic literature review of studies analysing inequalities in health expectancy among the older population, inspired the direction taken by this thesis, as it identified gaps and open questions to be addressed to aid the understanding of the dynamics of healthy ageing. Research Paper II attempted to develop an approach to answer some of these questions. First, a solid and theoretically grounded definition of disability was proposed, based on the WHO's International Classification of Functioning Disability and Health (ICF), and in contrast to the data-dependent (and therefore heterogeneous) measures used in the literature. Then, using this definition, explanations of the gender paradox in health and mortality were attempted by analysing whether the association of disability with mortality differed between women and men over the period for which data were available (2002-2012). In Research Paper III the definition of disability elaborated in Research Paper II was used to foster and advance the debate on the usefulness and relevance of adopting a finer categorization of disability, and discuss why it is important to go beyond a binary classification, and to identify the appropriate number of disability levels that is most useful for research purposes. Based on these conclusions, the final aim of this thesis was accomplished in Research Paper IV, which studied the trends in disability-free life expectancy in England over the last decade, comparing the changes experienced by men and women at each severity level of disability. The collective findings of this thesis highlight the importance of defining disability in a consistent and comprehensive way as well as considering different severity levels. This work provides robust empirical evidence for theories of population health change over a decade in the English setting, with gender differences in healthy ageing, and directions of population health changes, found to vary across disability levels.
- Published
- 2017
- Full Text
- View/download PDF
9. Socioeconomic inequality in healthcare utilization and expenditure in the older population of India
- Author
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Pandey, A., Clarke, L., Ploubidis, G. B., and Dandona, L.
- Subjects
362.1 - Abstract
Background: Equity in access and financing healthcare is a key determinant of population health. This study examined the socioeconomic inequality in healthcare utilization and expenditure contrasting older (60 years or more) with younger (under 60 years) population in India over two decades. Methods: National Sample Survey data from all states of India on healthcare utilization (NSS-HUS 1995–96, NSS-HUS 2004 and NSS-HUS 2014) and consumer expenditure (NSS-CES 1993–94, NSS-CES 1999–2000, NSS-CES 2004–05 and NSS-CES 2011–12) were used. Logistic, generalized linear and fractional response models were used to analyze the determinants of healthcare utilization and burden of out-of-pocket (OOP) payments. Deviations in the degree to which healthcare was utilized according to need was measured by a horizontal inequity index with 95% confidence interval (HI, 95% CI). Findings: When compared with younger population, the older population had higher self-reported morbidity rate (4.1 times), outpatient care rate (4.3 times), hospitalization rate (3.6 times), and proportion of hospitalization for non-communicable diseases (80.5% vs 56.7%) in 2014. Amongst the older population, the hospitalization rates were comparatively lower for female, poor and rural residents. Untreated morbidity was disproportionately higher for the poor, more so for the older (HI: -0.320; 95% CI: -0.391, -0.249) than the younger (-0.176; -0.211, -0.141) population in 2014. Outpatient care in public facilities increased for the poor over time, more so for the older than the younger population. Households with older persons only had higher median per capita OOP payments (2.47-4.00 times across NSS-CES and 3.10-5.09 times across NSS-HUS) and catastrophic health expenditure (CHE) (1.01-2.99 times across NSS-CES and 1.10-1.89 times across NSS-HUS) than the other households. The odds of CHE were significantly higher in households with older persons, households headed by females and rural households. Both the vertical and horizontal inequities in OOP payments for hospitalization by the older population increased between 1995 and 2014. Conclusion: These findings can be used for developing an equitable health policy that can more effectively provide healthcare protection to the increasing older population in India.
- Published
- 2017
- Full Text
- View/download PDF
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