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7 results on '"Puzone, Roberto"'

1. Narrowed TCR repertoire and viral escape as a consequence of heterologous immunity

Author

Cornberg, Markus, Chen, Alex T., Wilkinson, Lee A., Brehm, Michael A., Kim, Sung-Kwon, Calcagno, Claudia, Ghersi, Dario, Puzone, Roberto, Celada, Franco, Welsh, Raymond M., and Selin, Liisa K.

Subjects
Immunity -- Health aspects, Antigen receptors, T cell -- Properties, Antigen receptors, T cell -- Health aspects, T cells -- Receptors, T cells -- Properties, T cells -- Health aspects
Abstract

Why some virus-specific CD8 TCR repertoires are diverse and others restricted or "oligoclonal" has been unknown. We show here that oligoclonality and extreme clonal dominance can be a consequence of [...]

Published
2006

2. Secondary Somatic Mutations in G-Protein-Related Pathways and Mutation Signatures in Uveal Melanoma

Author

Piaggio, Francesca, primary, Tozzo, Veronica, additional, Bernardi, Cinzia, additional, Croce, Michela, additional, Puzone, Roberto, additional, Viaggi, Silvia, additional, Patrone, Serena, additional, Barla, Annalisa, additional, Coviello, Domenico, additional, J. Jager, Martine, additional, van der Velden, Pieter A., additional, Zeschnigk, Michael, additional, Cangelosi, Davide, additional, Eva, Alessandra, additional, Pfeffer, Ulrich, additional, and Amaro, Adriana, additional

Published
2019
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4. Expression of Ribonucleotide Reductase Subunit-2 and Thymidylate Synthase Correlates with Poor Prognosis in Patients with Resected Stages I–III Non-Small Cell Lung Cancer

Author

Grossi, Francesco, primary, Dal Bello, Maria Giovanna, additional, Salvi, Sandra, additional, Puzone, Roberto, additional, Pfeffer, Ulrich, additional, Fontana, Vincenzo, additional, Alama, Angela, additional, Rijavec, Erika, additional, Barletta, Giulia, additional, Genova, Carlo, additional, Sini, Claudio, additional, Ratto, Giovanni Battista, additional, Taviani, Mario, additional, Truini, Mauro, additional, and Merlo, Domenico Franco, additional

Published
2015
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5. Glyceraldehyde-3-phosphate dehydrogenase gene over expression correlates with poor prognosis in non small cell lung cancer patients

Author

Puzone, Roberto, primary, Savarino, Graziana, additional, Salvi, Sandra, additional, Dal Bello, Maria, additional, Barletta, Giulia, additional, Genova, Carlo, additional, Rijavec, Erika, additional, Sini, Claudio, additional, Esposito, Alessia, additional, Ratto, Giovanni, additional, Truini, Mauro, additional, Grossi, Francesco, additional, and Pfeffer, Ulrich, additional

Published
2013
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6. SNP variants at the MAP3K1/SETD9 locus 5q11.2 associate with somatic PIK3CA variants in breast cancers

Author

Puzone, Roberto and Pfeffer, Ulrich

Abstract

Genome-wide association studies have revealed many breast cancer (BC) risk-associated genetic variants that might functionally interact with other molecular determinants of BC. We analysed the association of 21 known risk-associated single-nucleotide variants (SNVs) with recurrent somatic variants in two cohorts of 77 and 754 oestrogen receptor α-positive BCs. Four SNVs located at 5q11.2 were found to be associated with the somatic PIK3CA variant status in the pilot cohort of 77 cases with odds ratio (OR) up to 6.5 indicating strong effects, and were selected for the validation phase. Two of these SNVs, rs252913 and rs331499, located in the MAP3K1/SETD9 gene boundary, were confirmed to be associated with somatic PIK3CA variants in the large cohort with OR 2.97 (1.17–7.75) and 1.76 (1.11–2.77), respectively, notably higher than their BC risk-associated values, both around 1.1. In the presence of the SNV or of somatic PIK3CA variants, cancers express significantly elevated levels of MAP3K1 and SETD9, with synergy of SNV and PIK3CA variants in MAP3K1 gene overexpression, consistent with a preferential PIK3CA-dependent regulation of the variant alleles.

Published
2017
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