1. Ionizing radiation induced cataracts: Recent biological and mechanistic developments and perspectives for future research
- Author
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Miguel Jarrin, Munira Kadhim, Stephen Barnard, Roy A. Quinlan, Claudia Dalke, Scott Bright, Elizabeth A. Ainsbury, Richard Tanner, Sarah Kunze, Jochen Graw, Nobuyuki Hamada, and Joseph R. Dynlacht
- Subjects
0301 basic medicine ,Cataract Mechanisms ,Dosimetric Modeling ,Ir ,Lens Biology ,Radiation Cataract ,Radiation Lens Effects ,Health, Toxicology and Mutagenesis ,Biology ,Bioinformatics ,Cataract ,Ionizing radiation ,Toxicology ,03 medical and health sciences ,Corneal Opacity ,Cataracts ,Radiation, Ionizing ,Lens, Crystalline ,Genetics ,medicine ,media_common.cataloged_instance ,Animals ,Humans ,European union ,media_common ,Human studies ,business.industry ,Low dose ,Tissue level ,medicine.disease ,030104 developmental biology ,Models, Animal ,Radiation protection ,business - Abstract
The lens of the eye has long been considered as a radiosensitive tissue, but recent research has suggested that the radiosensitivity is even greater than previously thought. The 2012 recommendation of the International Commission on Radiological Protection (ICRP) to substantially reduce the annual occupational equivalent dose limit for the ocular lens has now been adopted in the European Union and is under consideration around the rest of the world. However, ICRP clearly states that the recommendations are chiefly based on epidemiological evidence because there are a very small number of studies that provide explicit biological, mechanistic evidence at doses
- Published
- 2016