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2. Exposure to Secondhand Smoke Extract Increases Cisplatin Resistance in Head and Neck Cancer Cells

Author

Sadhasivam, Balaji, primary, Manyanga, Jimmy, additional, Ganapathy, Vengatesh, additional, Acharya, Pawan, additional, Bouharati, Célia, additional, Chinnaiyan, Mayilvanan, additional, Mehta, Toral, additional, Mathews, Basil, additional, Castles, Samuel, additional, Rubenstein, David A., additional, Tackett, Alayna P., additional, Zhao, Yan D., additional, Ramachandran, Ilangovan, additional, and Queimado, Lurdes, additional

Published
2024
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5. Tamoxifen induces stem-like phenotypes and multidrug resistance by altering epigenetic regulators in ERα+ breast cancer cells

Author

Kalyanaraman, Aparna, primary, Gnanasampanthapandian, Dhanavathy, additional, Shanmughan, Prasad, additional, Kishore, Puneet, additional, Ramalingam, Satish, additional, Arunachalam, Rathnaswami, additional, Jayaraman, Selvaraj, additional, Kaliappan, Ilango, additional, Munuswamy-Ramanujam, Ganesh, additional, Ramachandran, Ilangovan, additional, Sambandam, Yuvaraj, additional, Anbalagan, Muralidharan, additional, Chandrakesan, Parthasarathy, additional, and Palaniyandi, Kanagaraj, additional

Published
2020
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10. Evaluation of potential anti‐cancer activity of cationic liposomal nanoformulated Lycopodium clavatum in colon cancer cells

Author

Paramita, Pragyan, primary, Subramaniam, Vimala Devi, additional, Murugesan, Ramachandran, additional, Gopinath, Madhumala, additional, Ramachandran, Ilangovan, additional, Ramalingam, Satish, additional, Sun, Xiao Feng, additional, Banerjee, Antara, additional, Marotta, Francesco, additional, and Pathak, Surajit, additional

Published
2018
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33. CUGBP2 downregulation by prostaglandin E2 protects colon cancer cells from radiation-induced mitotic catastrophe.

Author

Natarajan G, Ramalingam S, Ramachandran I, May R, Queimado L, Houchen CW, and Anant S

Subjects
Apoptosis drug effects, Apoptosis radiation effects, CELF Proteins, Caspase 7 metabolism, Caspase 9 metabolism, Cell Cycle drug effects, Cell Cycle radiation effects, Cell Proliferation drug effects, Cell Proliferation radiation effects, Checkpoint Kinase 1, Checkpoint Kinase 2, Cyclin B metabolism, Down-Regulation, Gamma Rays, HCT116 Cells, Histones metabolism, Humans, Nerve Tissue Proteins genetics, Phosphorylation drug effects, Phosphorylation radiation effects, Protein Kinases metabolism, Protein Serine-Threonine Kinases metabolism, Proto-Oncogene Proteins c-bcl-2 metabolism, RNA, Small Interfering genetics, RNA-Binding Proteins genetics, bcl-2-Associated X Protein metabolism, bcl-X Protein metabolism, cdc25 Phosphatases metabolism, Dinoprostone pharmacology, Mitosis drug effects, Mitosis radiation effects, Nerve Tissue Proteins metabolism, RNA-Binding Proteins metabolism, Radiation-Protective Agents pharmacology
Abstract

Prostaglandin E(2) (PGE(2)) is a potent inhibitor of ionizing radiation (IR)-induced cell death. Exposure of colon cancer cells to IR leads to increased CUGBP2 expression. Therefore, we tested the hypothesis that PGE(2) radioprotects colon cancer cells by inhibiting CUGBP2 expression. Exposure of HCT-116 cells to gamma-IR (0-12 Gy) resulted in a dose-dependent reduction in cell growth and an increase in the G(2)-M phase of the cell cycle. Western blot analyses demonstrated increased levels of activated caspase 9 and caspase 3. In addition, whereas Bax expression is increased, that of Bcl-2 and Bcl-x(L) was reduced. Further analyses demonstrated increased activation of Chk1 and Chk2 kinases, coupled with higher levels of nuclear cyclin B1 and Cdc2. Pretreatment with PGE(2) suppressed the activation of caspase 3 and caspase 7 and inhibited Bax expression. In addition, PGE(2) treatment restored growth and colony formation to control levels. IR significantly upregulated the expression of CUGBP2 in the cells, which was suppressed when cells were pretreated with PGE(2). Ectopic overexpression of CUGBP2 also induced apoptosis. Furthermore, it reversed the PGE(2)-mediated protection from IR-induced mitotic catastrophe. Furthermore, there was an increase in nuclear localization of cyclin B1 and Cdc2 coupled with increased phosphorylation of p53, Chk1, Chk2, and Cdc25c proteins. Cell cycle analysis also demonstrated increased G(2)-M transition. In contrast, siRNA-mediated suppression of CUGBP2 expression restored normal cell cycle progression and decreased IR-induced apoptosis. Taken together, these data demonstrate that PGE(2) protects colon cancer cells from IR-induced mitotic catastrophe in part through suppression of CUGBP2 expression.

Published
2008
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