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5 results on '"Rauld, Celine"'

1. Innate acting memory Th1 cells modulate heterologous diseases

Author

Rakebrandt, Nikolas, primary, Yassini, Nima, additional, Kolz, Anna, additional, Schorer, Michelle, additional, Lambert, Katharina, additional, Goljat, Eva, additional, Estrada Brull, Anna, additional, Rauld, Celine, additional, Balazs, Zsolt, additional, Krauthammer, Michael, additional, Carballido, José M., additional, Peters, Anneli, additional, and Joller, Nicole, additional

Published
2024
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3. Imaging Mass Cytometry and Single-Cell Genomics Reveal Differential Depletion and Repletion of B-Cell Populations Following Ofatumumab Treatment in Cynomolgus Monkeys

Author

Theil, Diethilde, primary, Smith, Paul, additional, Huck, Catherine, additional, Gilbart, Yoann, additional, Kakarieka, Algirdas, additional, Leppert, David, additional, Rauld, Celine, additional, Schmid, Cindy, additional, Baumgartner, Reto, additional, Stuber, Nathalie, additional, Cordoba, Francisco, additional, Dubost, Valerie, additional, Darribat, Katy, additional, Jivkov, Magali, additional, Frieauff, Wilfried, additional, Kneuer, Rainer, additional, Stoeckli, Markus, additional, Reinker, Stefan, additional, Mansfield, Keith, additional, Carballido, José M., additional, Couttet, Philippe, additional, and Weckbecker, Gisbert, additional

Published
2019
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5. Fingerprints of CD8+ T cells on human pre-plasma and memory B cells.

Author

Strittmatter-Keller, Ulrike, Walter, Caroline, Rauld, Celine, Egli, Nicole, Regairaz, Camille, Rabe, Sabine, Zenke, Gerhard, Carballido, José, and Schweighoffer, Tamás

Subjects
CD8 antigen, DNA fingerprinting, T cells, PLASMA cells, CELL differentiation, GENE expression profiling, TONSILS
Abstract

Differentiation of B cells is a stringently controlled multi-step process, which is still incompletely understood. Here we identify and characterize a rare population of human B cells, which surprisingly carry CD8AB on their surface. Existence of such cells was demonstrated both in tonsils and in human apheresis material. Gene expression profiling and real time PCR detected however no CD8A or CD8B message in these cells. Instead, we found that surface CD8 was hijacked from activated CD8+ T cells by a transfer process that required direct cell-to-cell contact. A focused transcriptome analysis at single cell level allowed the dissection of the CD8 positive B cell population. We found that the affected cells are characteristically of the CD27+CD200- phenotype, and consist of two discrete late-stage subpopulations that carry signatures of activated memory B like cells, and early plasmablasts. Thus, there is only a restricted time window in the differentiation process during which B cells can intimately interact with CD8+ T cells. The findings point to a novel link between the T and B arms of the adaptive immune system, and suggest that CD8+ T cells have the capability to directly shape the global antibody repertoire. [ABSTRACT FROM AUTHOR]

Published
2018
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