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Background and objectivesNonalcoholic fatty liver disease (NAFLD) disproportionately affects Hispanic boys. Further, obesity and insulin resistance are major risk factors for NAFLD. No gene localization studies had been performed on children with biopsy-proven NAFLD. This study aims to identify genomic variants associated with increased adiposity and insulin resistance in a population of children with varying histologic severity of NAFLD.MethodsWe conducted a genome-wide association scan (GWAS) including 624,297 single-nucleotide polymorphisms (SNPs) distributed among all 22 autosomal chromosomes in 234 Hispanic boys (up to 18 years of age) who were consecutively recruited in a prospective cohort study in the Nonalcoholic Steatohepatitis Clinical Research Network Studies. Traits were examined quantitatively using linear regression. SNPs with P value 5% were considered potentially significant.ResultsEvaluated subjects had a median age of 12.0 years, body mass index (BMI) of 31.4, and hemoglobin A1C (Hgb A1C) of 5.3. The prevalence of NAFL, borderline NASH, and definite NASH were 23%, 53%, and 22%, respectively. The GWAS identified 10 SNPs that were associated with BMI z score, 6 within chromosome 2, and 1 within CAMK1D, which has a potential role in liver gluconeogenesis. In addition, the GWAS identified 9 novel variants associated with insulin resistance: HOMA-IR (6) and HbA1c (3).ConclusionsThis study of Hispanic boys with biopsy-proven NAFLD with increased risk for the metabolic syndrome revealed novel genetic variants that are associated with obesity and insulin resistance.

The goal of this study was to utilize a phenomenological case study design to investigate the individual and social identity development of an adolescent male who had been placed in a high-security group home setting. The participant had been identified with emotional disturbance (ED), and 48, XYYY karyotype. The participant described his social and emotional development as being impacted by his environment, his level of personal control, and his view of the future. (Contains 1 table.)

This grounded theory study was designed to investigate the factors that influenced 20 "traditional" university freshmen to withdraw prior to the end of their first year at two Midwestern universities. A two-hour audio-taped interview was conducted with each of the participants, and the grounded theory method was utilized to analyze the interview data. Eighteen of the twenty participants had strong high school GPAs and ACT scores, and would not have been identified as being at-risk for attrition. The grounded theory that emerged from the participants' data indicated that an absence of clear educational goals, as well as individual and institutional distractions, interacted to contribute to the participants' withdrawal from their universities. (Contains 2 tables.)

Legislative term limitations have emerged as the political phenomenon of the 1990s. In 1990, voters in three states, Oklahoma, Colorado and California, approved citizen initiatives to limit state legislative terms. [...]

Differences in cloud effective radius and cloud droplet number concentration (CDNC) estimates inferred from the Aqua MODIS Collections 5.1 and 6 cloud products (MYD06) are examined for warm clouds over global oceans for the year 2008. Individual pixel level retrievals for both collections are aggregated to 1°×1° and compared globally and regionally for the three main spectral channel pairs used for MODIS cloud optical property retrievals. Comparisons between both collections are performed for cases in which all channel pairs are successfully retrieved for each pixel and for cases where one or more channel pairs are successful. The contribution to the observed differences of several key MYD06 Collection 6 algorithm updates are also explored. Global results show a neutral to positive (>50cm-3) change for C6-derived CDNC relative to C5.1 for the 1.6 and 2.1μm channel retrievals corresponding to a neutral to -2μm difference in droplet effective radius. For 3.7μm retrievals, CDNC results show a negative change in the tropics, with differences transitioning towards positive values with increasing latitude spanning (-25 to +50cm-3) related to a (+2.5 to -1μm) transition in effective radius. Regionally, the magnitude and behavior of the annual CDNC cycle are compared for each retrieval channel pair. Results from this study indicate significant intercollection differences in aggregated values of microphysical parameters which may have implications for existing MODIS derived climatologies and validation studies. [ABSTRACT FROM AUTHOR]

Earth system models have been used for climate predictions in recent years due to their capabilities to include biogeochemical cycles, human impacts, as well as coupled and interactive representations of Earth system components (e.g., atmosphere, ocean, land, and sea ice). In this work, the Community Earth System Model (CESM) with advanced chemistry and aerosol treatments, referred to as CESM-NCSU, is applied for decadal (2001-2010) global climate predictions. A comprehensive evaluation is performed focusing on the atmospheric component-the Community Atmosphere Model version 5.1 (CAM5.1) by comparing simulation results with observations/reanalysis data and CESM ensemble simulations from the Coupled Model Intercomparison Project phase 5 (CMIP5). The improved model can predict most meteorological and radiative variables relatively well with normalized mean biases (NMBs) of −14.1 to −9.7% and 0.7-10.8%, respectively, although temperature at 2 m (T2) is slightly underpredicted. Cloud variables such as cloud fraction (CF) and precipitating water vapor (PWV) are well predicted, with NMBs of −10.5 to 0.4%, whereas cloud condensation nuclei (CCN), cloud liquid water path (LWP), and cloud optical thickness (COT) are moderately-to-largely underpredicted, with NMBs of −82.2 to −31.2%, and cloud droplet number concentration (CDNC) is overpredictd by 26.7%. These biases indicate the limitations and uncertainties associated with cloud microphysics (e.g., resolved clouds and subgrid-scale cumulus clouds). Chemical concentrations over the continental U.S. (CONUS) (e.g. [ABSTRACT FROM AUTHOR]

This grounded theory study was designed to investigate the factors that influenced 20 "traditional" university freshmen to withdraw prior to the end of their first year at two Midwestern universities. A two-hour audio-taped interview was conducted with each of the participants, and the grounded theory method was utilized to analyze the interview data. Eighteen of the twenty participants had strong high school GPAs and ACT scores, and would not have been identified as being at-risk for attrition. The grounded theory that emerged from the participants' data indicated that an absence of clear educational goals, as well as individual and institutional distractions, interacted to contribute to the participants' withdrawal from their universities. [ABSTRACT FROM AUTHOR]