6 results on '"Rehmus W"'
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2. The 2020 International Alliance for the Control of Scabies Consensus Criteria for the Diagnosis of Scabies
- Author
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Engelman, D, Yoshizumi, J, Hay, RJ, Osti, M, Micali, G, Norton, S, Walton, S, Boralevi, F, Bernigaud, C, Bowen, AC, Chang, AY, Chosidow, O, Estrada-Chavez, G, Feldmeier, H, Ishii, N, Lacarrubba, F, Mahe, A, Maurer, T, Mahdi, MMA, Murdoch, ME, Pariser, D, Nair, PA, Rehmus, W, Romani, L, Tilakaratne, D, Tuicakau, M, Walker, SL, Wanat, KA, Whitfeld, MJ, Yotsu, RR, Steer, AC, Fuller, LC, Engelman, D, Yoshizumi, J, Hay, RJ, Osti, M, Micali, G, Norton, S, Walton, S, Boralevi, F, Bernigaud, C, Bowen, AC, Chang, AY, Chosidow, O, Estrada-Chavez, G, Feldmeier, H, Ishii, N, Lacarrubba, F, Mahe, A, Maurer, T, Mahdi, MMA, Murdoch, ME, Pariser, D, Nair, PA, Rehmus, W, Romani, L, Tilakaratne, D, Tuicakau, M, Walker, SL, Wanat, KA, Whitfeld, MJ, Yotsu, RR, Steer, AC, and Fuller, LC
- Abstract
BACKGROUND: Scabies is a common parasitic skin condition that causes considerable morbidity globally. Clinical and epidemiological research for scabies has been limited by a lack of standardization of diagnostic methods. OBJECTIVES: To develop consensus criteria for the diagnosis of common scabies that could be implemented in a variety of settings. METHODS: Consensus diagnostic criteria were developed through a Delphi study with international experts. Detailed recommendations were collected from the expert panel to define the criteria features and guide their implementation. These comments were then combined with a comprehensive review of the available literature and the opinion of an expanded group of international experts to develop detailed, evidence-based definitions and diagnostic methods. RESULTS: The 2020 International Alliance for the Control of Scabies (IACS) Consensus Criteria for the Diagnosis of Scabies include three levels of diagnostic certainty and eight subcategories. Confirmed scabies (level A) requires direct visualization of the mite or its products. Clinical scabies (level B) and suspected scabies (level C) rely on clinical assessment of signs and symptoms. Evidence-based, consensus methods for microscopy, visualization and clinical symptoms and signs were developed, along with a media library. CONCLUSIONS: The 2020 IACS Criteria represent a pragmatic yet robust set of diagnostic features and methods. The criteria may be implemented in a range of research, public health and clinical settings by selecting the appropriate diagnostic levels and subcategories. These criteria may provide greater consistency and standardization for scabies diagnosis. Validation studies, development of training materials and development of survey methods are now required. What is already known about this topic? The diagnosis of scabies is limited by the lack of accurate, objective tests. Microscopy of skin scrapings can confirm the diagnosis, but it is insensitive, inva
- Published
- 2020
3. A Novel Germline Heterozygous BCL11B Variant Causing Severe Atopic Disease and Immune Dysregulation.
- Author
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Lu HY, Sertori R, Contreras AV, Hamer M, Messing M, Del Bel KL, Lopez-Rangel E, Chan ES, Rehmus W, Milner JD, McNagny KM, Lehman A, Wiest DL, and Turvey SE
- Subjects
- Adolescent, Animals, DNA Mutational Analysis, Female, Genetic Predisposition to Disease, Heterozygote, Humans, Hypersensitivity diagnosis, Hypersensitivity immunology, Phenotype, Primary Immunodeficiency Diseases diagnosis, Primary Immunodeficiency Diseases immunology, Primary Immunodeficiency Diseases metabolism, Repressor Proteins metabolism, Severity of Illness Index, T-Lymphocytes metabolism, Tumor Suppressor Proteins metabolism, Zebrafish genetics, Zebrafish metabolism, Zebrafish Proteins genetics, Zebrafish Proteins metabolism, Germ-Line Mutation, Hypersensitivity genetics, Primary Immunodeficiency Diseases genetics, Repressor Proteins genetics, T-Lymphocytes immunology, Tumor Suppressor Proteins genetics
- Abstract
B-cell lymphoma/leukemia 11B (BCL11B) is a C
2 H2 zinc finger transcription factor that is critically important for regulating the development and function of a variety of systems including the central nervous system, the skin, and the immune system. Germline heterozygous variants are associated with a spectrum of clinical disorders, including severe combined immunodeficiency as well as neurological, craniofacial, and dermal defects. Of these individuals, ~50% present with severe allergic disease. Here, we report the detailed clinical and laboratory workup of one of the most severe BCL11B-dependent atopic cases to date. Leveraging a zebrafish model, we were able to confirm a strong T-cell defect in the patient. Based on these data, we classify germline BCL11B-dependent atopic disease as a novel primary atopic disorder., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 Lu, Sertori, Contreras, Hamer, Messing, Del Bel, Lopez-Rangel, Chan, Rehmus, Milner, McNagny, Lehman, Wiest and Turvey.)- Published
- 2021
- Full Text
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4. Trametinib therapy for children with neurofibromatosis type 1 and life-threatening plexiform neurofibroma or treatment-refractory low-grade glioma.
- Author
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Ronsley R, Hounjet CD, Cheng S, Rassekh SR, Duncan WJ, Dunham C, Gardiner J, Ghag A, Ludemann JP, Wensley D, Rehmus W, Sargent MA, and Hukin J
- Subjects
- Adolescent, Antineoplastic Agents adverse effects, Brain Neoplasms diagnostic imaging, British Columbia, Child, Child, Preschool, Compassionate Use Trials, Dermatitis, Atopic chemically induced, Drug Resistance, Neoplasm, Female, Glioma diagnostic imaging, Humans, Infant, Male, Neurofibroma, Plexiform diagnostic imaging, Neurofibromatosis 1 diagnostic imaging, Paronychia chemically induced, Pyridones adverse effects, Pyrimidinones adverse effects, Retrospective Studies, Treatment Outcome, Antineoplastic Agents administration & dosage, Brain Neoplasms drug therapy, Glioma drug therapy, Neurofibroma, Plexiform drug therapy, Neurofibromatosis 1 drug therapy, Pyridones administration & dosage, Pyrimidinones administration & dosage
- Abstract
Purpose: To describe a series of children with extensive PNF or treatment refractory PLGG treated on a compassionate basis with trametinib., Methods: We report on six patients with NF-1 treated with trametinib on a compassionate basis at British Columbia Children's Hospital since 2017. Data were collected retrospectively from the patient record. RAPNO and volumetric criteria were used to evaluate the response of intracranial and extracranial lesions, respectively., Results: Subjects were 21 months to 14 years old at the time of initiation of trametinib therapy and 3/6 subjects are male. Duration of therapy was 4-28 months at the time of this report. All patients had partial response or were stable on analysis. Two patients with life-threatening PNF had a partial radiographic response in tandem with significant clinical improvement and developmental catch up. One subject discontinued therapy after 6 months due to paronychia and inadequate response. The most common adverse effect (AE) was grade 1-2 paronychia or dermatitis in 5/6 patients. There were no grade 3 or 4 AEs. At the time of this report, five patients remain on therapy., Conclusion: Trametinib is an effective therapy for advanced PNF and refractory PLGG in patients with NF-1 and is well tolerated in children. Further data and clinical trials are required to assess tolerance, efficacy and durability of response, and length of treatment required in such patients., (© 2021 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.)
- Published
- 2021
- Full Text
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5. Lice infestation causing severe anemia in a 4-year-old child.
- Author
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Ronsley R, Ling F, Rehmus W, and Dmytryshyn A
- Subjects
- Animals, Cardiomegaly diagnostic imaging, Child, Preschool, Female, Humans, Radiography, Thoracic, Anemia, Iron-Deficiency parasitology, Cardiomegaly parasitology, Heart Failure etiology, Lice Infestations complications
- Published
- 2019
6. An assessment of the cost-utility of therapy for psoriasis.
- Author
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Weiss SC, Rehmus W, and Kimball AB
- Abstract
Objective: Recently a number of new therapies have been introduced to treat psoriasis, but concerns have been expressed about their high cost. The purpose of this study was to determine whether most psoriasis treatments lie within the accepted range of cost-utility., Methodology: 32 patients with moderate to severe psoriasis were administered the Euro-Qol 5 Dimension (EQ-5D) survey to calculate their health state utility. Economic modeling was performed with a range of therapeutic costs applying the calculated utility score. Paired t-tests were used to calculate significance., Results: At the conclusion of 2 weeks of therapy, the mean psoriasis area and severity index (PASI) improved 35% to 7.2 (p<0.001). The mean health state utility score on the EQ-5D improved 11.5% from 77.7 units before therapy to 86.7 units after therapy (p=0.007)., Conclusion: A therapy that achieves at least a PASI 35 would be considered cost-effective by conventional standards if it does not exceed $33 600 in cost.
- Published
- 2006
- Full Text
- View/download PDF
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