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La investigación planteó como objetivo general determinar la relación entre el clima laboral y el rendimiento de los trabajadores de la Municipalidad Provincial Mariscal Ramón Castilla, Loreto - 2021. El enfoque de la investigación fue cuantitativo de tipo básico y diseño no experimental de corte transversal de nivel descriptivo – correlacional; la población y muestra estuvo constituida por 44 trabajadores, se ha empleado como técnica la encuesta y como instrumento el cuestionario. Los resultados demostraron que el nivel de clima organizacional y rendimiento de los trabajadores es medio en un 82% y 95% respectivamente, además, que las dimensiones comportamiento organizacional, estructura organizacional y estilo de dirección están asociadas al rendimiento laboral, dado que el nivel de significancia es menor al 0.05, lo cual demuestra una correlación estadísticamente significativa. Conclusión: Existe relación significativa entre el clima laboral y el rendimiento de los trabajadores de la Municipalidad Provincial Mariscal Ramón Castilla, Loreto – 2021, en vista que, se obtuvo una correlación positiva débil (r=0.491). Asimismo, se obtuvo un nivel de significancia igual a 0.001 que es menor a 0.05 demostrando que, si existe significancia. Lima Norte Escuela de Posgrado Reforma y Modernización del Estado Biodiversidad, cambio climático y calidad ambiental Desarrollo económico, empleo y emprendimiento Alianza para lograr los objetivos

Hydranencephaly is a severe congenital condition where most of the cerebral hemispheres are replaced by a membranous sac. Despite the growing amount of case reports, most pathogenic, phenotypic, and prognostic aspects of hydranencephaly remain controversial. By matching the recent literature data with the findings of our own series (four cases: two fetuses at the twelfth gestational week, a 32-year-old man, and a 14-year-old female), we attempted to date back the insult leading to hydranencephaly to understand its pathogenesis and to explain the basis of its protean phenotype. The variable detection of cerebral remnants seems to mirror the developmental pathway of cerebral arteries. Moreover, fetal and postnatal neuroimaging data and histopathologic findings point toward an early bilateral internal carotid artery occlusion, mostly occurring between the eighth and twelfth gestational weeks, as the main pathogenic mechanism of hydranencephaly.

Objective To report an ataxic variant of Alzheimer disease expressing a novel molecular phenotype. Design Description of a novel phenotype associated with a presenilin 1 mutation. Setting The subject was an outpatient who was diagnosed at the local referral center. Patient A 28-year-old man presented with psychiatric symptoms and cerebellar signs, followed by cognitive dysfunction. Severe β-amyloid (Aβ) deposition was accompanied by neurofibrillary tangles and cell loss in the cerebral cortex and by Purkinje cell dendrite loss in the cerebellum. A presenilin 1 gene (PSEN1 ) S170F mutation was detected. Main Outcome Measures We analyzed the processing of Aβ precursor protein in vitro as well as the Aβ species in brain tissue. Results The PSEN1 S170F mutation induced a 3-fold increase of both secreted Aβ 42 and Aβ 40 species and a 60% increase of secreted Aβ precursor protein in transfected cells. Soluble and insoluble fractions isolated from brain tissue showed a prevalence of N–terminally truncated Aβ species ending at both residues 40 and 42. Conclusion These findings define a new Alzheimer disease molecular phenotype and support the concept that the phenotypic variability associated with PSEN1 mutations may be dictated by the Aβ aggregates' composition.

Aluminum lactate [Al(lact)3] (hydrophilic, hydrolytically unstable) and aluminum acetylacetonate [Al(acae)3] (lipophilic, hydrolytically stable) were tested as potential toxicants to rabbits upon IV administration both as aqueous solutions and as liposome suspensions. Both chemicals behaved as cardiotoxic agents when administered as aqueous solutions, but Al(acae)3 was at least two orders of magnitude more active than Al(lact)3. Al(acae)3, but not Al(lact)3, caused myocardial infarcts resembling those in humans (with contraction bands) at doses as low as 0.24 mg/kg body weight, as well as a prominent acanthocytosis. Al(lact)3, when administered as a liposome suspension, was about 300 times more toxic than in aqueous solution, although cardiac damage was not infarctual in character. Both chemical and physical speciation of aluminum(III) thus play an essential role in determining the toxicity of the metal. Images FIGURE 2. FIGURE 3.

✓ A tuberculoma, encasing the anterior optic pathways in a neoplastiform growth, was found in a 25-year-old man complaining of severe visual loss, diabetes insipidus, and sexual impotence following tuberculous meningitis. Following biopsy and anti-tuberculosis treatment, a satisfactory restoration of sight in one eye allowed the patient to resume an almost normal life.

An aneurysmal bone cyst of the orbital roof, causing a monolateral exophthalmos in a 15-month-old child with no previous history of head injury, was operated upon and histologically misdiagnosed as a giant cell tumor. Radiation treatment in a dosage (3,740 rad) appropriate for the latter diagnosis apparently caused a massive calcification of the residual mass with persisting exophthalmos. At a second operation the lesion was removed completely and a radical change in the histopathological features was found. 12 years after surgery, there is no evidence of residuals upon roentgenographic and CT scan examinations and the exophthalmos has practically disappeared, while there is a normal visual function in the affected eye. Some points of histopathological and gross pathological differential diagnosis between aneurysmal bone cysts and giant cell (‘myeloplaxis’) tumors are discussed.

Sixteen patients (one with tuberculoma of the anterior optic pathways, the other 15 with opto-chiasmatic arachnoiditis) are presented. They are divided into three categories (definite, likely, possible) from the point of view of the pathogenetic link of their optic pathology with a primary tuberculous infection. Neurosurgical treatment had a positive effect upon the visual symptoms in five patients (31.25%), no effect in three cases (18.75%); in the other eight patients (50%) it could not prevent progression of visual impairment.

14 young patients, operated upon for opto-chiasmatic arachnoiditis by craniotomy are presented. 2 main etiopathogenetic forms (and their respective clinical equivalents) of the disease could be recognized. Only 1 postoperative death occurred, in a patient with a dominant clinical picture of intracranial hypertension. Results of surgery (craniotomy and lysis of adhesions) could be distinguished as positive (functional improvement) in 5 cases, indifferent or negative in the others, with a follow-up duration of up to 23 years. The role of the diagnostic value of the pneumoencephalogram as a basis for surgical indication is discussed: it is felt that this examination, when reported as negative, is not of sufficient value to rule out the diagnosis, which must essentially rely upon clinical data.

To ascertain the presence of free aldehyde radicals in elastic fibers, a histochemical method using the Sawicki reagent (N-methyl-benzothiazolone hydrazone) was employed. Three separate studies were conducted on the elastic tissue of bovine ligamentum nuchae. The elastic fibers were tested (a) in native state, (b) after extraction using an autoclave method and (c) after hot NaOH treatment. Free aldehyde radicals were detected histochemically in native and treated fibers, indicating a close attachment of the carbonyl groups to the fibrous-protein component of the elastic material. Pretreatment of the sections with NaBH4 or with NaHSO3 abolished the staining, indicating that the aldehydes in elastin can be reduced or blocked by the addition of bisulfite compounds. The presence of free carbonyl compounds in elastin was confirmed by chemical data with a new chromatographic technique. Using QAE Sephadex column pretreated with sodium bisulfite, aldehyde-bearing peptide fractions could be isolated from the elastin fibers.