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32 results on '"Rijntjes, Jos"'

1. A significant proportion of classic Hodgkin lymphoma recurrences represents clonally unrelated second primary lymphoma

Author

van Bladel, Diede A. G., Stevens, Wendy B. C., Kroeze, Leonie I., de Groen, Ruben A. L., de Groot, Fleur A., van der Last-Kempkes, Jessica L. M., Berendsen, Madeleine R., Rijntjes, Jos, Luijks, Jeroen A. C. W., Bonzheim, Irina, van der Spek, Ellen, Plattel, Wouter J., Pruijt, Johannes F. M., de Jonge-Peeters, Susan D. P. W. M., Velders, Gerjo A., Lensen, Chantal, van Bladel, Esther R., Federmann, Birgit, Hoevenaars, Brigiet M., Pastorczak, Agata, van der Werff ten Bosch, Jutte, Vermaat, Joost S. P., Nooijen, Peet T. G. A., Hebeda, Konnie M., Fend, Falko, Diepstra, Arjan, van Krieken, J Han J. M., Groenen, Patricia J. T. A., van den Brand, Michiel, and Scheijen, Blanca

Published
2023
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2. Detection of Second Primary Lymphoma in Late Diffuse Large B-cell Lymphoma Recurrences

Author

Berendsen, Madeleine R., Bladel, Diede A.G. van, Hesius, Eva, de Groot, Fleur A., Kroeze, Leonie I., Rijntjes, Jos, Luijks, Jeroen A.C.W., Hoevenaars, Brigiet, Halilovic, Altuna, Nooijen, Peet, Bladel, Esther van, Jonge-Peeters, Susan de, Lensen, Chantal, Pruijt, Hans, van der Spek, Ellen, Vermaat, Joost S.P., Hess, Corine, Hebeda, Konnie M., Stevens, Wendy B.C., van Krieken, J. Han J.M., van den Brand, Michiel, Groenen, Patricia J.T.A., and Scheijen, Blanca

Published
2023
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5. Clonal Relationship and Mutation Analysis in Lymphoplasmacytic Lymphoma/Waldenström Macroglobulinemia Associated With Diffuse Large B-cell Lymphoma

Author

Berendsen, Madeleine R., primary, van Bladel, Diede A.G., additional, Hesius, Eva, additional, Berganza Irusquieta, Cristina, additional, Rijntjes, Jos, additional, van Spriel, Annemiek B., additional, van der Spek, Ellen, additional, Pruijt, Johannes F.M., additional, Kroeze, Leonie I., additional, Hebeda, Konnie M., additional, Croockewit, Sandra, additional, Stevens, Wendy B.C., additional, van Krieken, J Han J.M., additional, Groenen, Patricia J.T.A., additional, van den Brand, Michiel, additional, and Scheijen, Blanca, additional

Published
2023
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6. Next-generation sequencing of immunoglobulin gene rearrangements for clonality assessment: a technical feasibility study by EuroClonality-NGS

Author

Scheijen, Blanca, Meijers, Ruud W. J., Rijntjes, Jos, van der Klift, Michèle Y., Möbs, Markus, Steinhilber, Julia, Reigl, Tomas, van den Brand, Michiel, Kotrová, Michaela, Ritter, Julia-Marie, Catherwood, Mark A., Stamatopoulos, Kostas, Brüggemann, Monika, Davi, Frédéric, Darzentas, Nikos, Pott, Christiane, Fend, Falko, Hummel, Michael, Langerak, Anton W., Groenen, Patricia J. T. A., and on behalf of the EuroClonality-NGS Working Group

Published
2019
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7. Quality control and quantification in IG/TR next-generation sequencing marker identification: protocols and bioinformatic functionalities by EuroClonality-NGS

Author

Knecht, Henrik, Reigl, Tomas, Kotrová, Michaela, Appelt, Franziska, Stewart, Peter, Bystry, Vojtech, Krejci, Adam, Grioni, Andrea, Pal, Karol, Stranska, Kamila, Plevova, Karla, Rijntjes, Jos, Songia, Simona, Svatoň, Michael, Froňková, Eva, Bartram, Jack, Scheijen, Blanca, Herrmann, Dietrich, García-Sanz, Ramón, Hancock, Jeremy, Moppett, John, van Dongen, Jacques J. M., Cazzaniga, Giovanni, Davi, Frédéric, Groenen, Patricia J. T. A., Hummel, Michael, Macintyre, Elizabeth A., Stamatopoulos, Kostas, Trka, Jan, Langerak, Anton W., Gonzalez, David, Pott, Christiane, Brüggemann, Monika, Darzentas, Nikos, and on behalf of the EuroClonality-NGS Working Group

Published
2019
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8. Extranodal marginal zone lymphoma clonotypes are detectable prior to eMZL diagnosis in tissue biopsies and peripheral blood of Sjögren’s syndrome patients through immunogenetics

Author

Kolijn, P. Martijn, primary, Huijser, Erika, additional, Wahadat, M. Javad, additional, van Helden-Meeuwsen, Cornelia G., additional, van Daele, Paul L. A., additional, Brkic, Zana, additional, Rijntjes, Jos, additional, Hebeda, Konnie M., additional, Groenen, Patricia J. T. A., additional, Versnel, Marjan A., additional, Thurlings, Rogier M., additional, and Langerak, Anton W., additional

Published
2023
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9. Extranodal marginal zone lymphoma clonotypes are detectable prior to eMZL diagnosis in tissue biopsies and peripheral blood of Sjögren's syndrome patients through immunogenetics

Author

Kolijn, P Martijn, Huijser, Erika, Wahadat, M Javad, van Helden-Meeuwsen, Cornelia G, van Daele, Paul L A, Brkic, Zana, Rijntjes, Jos, Hebeda, Konnie M, Groenen, Patricia J T A, Versnel, Marjan A, Thurlings, Rogier M, Langerak, Anton W, Kolijn, P Martijn, Huijser, Erika, Wahadat, M Javad, van Helden-Meeuwsen, Cornelia G, van Daele, Paul L A, Brkic, Zana, Rijntjes, Jos, Hebeda, Konnie M, Groenen, Patricia J T A, Versnel, Marjan A, Thurlings, Rogier M, and Langerak, Anton W

Abstract

INTRODUCTION: Activated B cells play a key role in the pathogenesis of primary Sjögren's syndrome (pSS) through the production of autoantibodies and the development of ectopic germinal centers in the salivary glands and other affected sites. Around 5-10% of pSS patients develop B-cell lymphoma, usually extranodal marginal zone lymphomas (eMZL) of the mucosa-associated lymphoid tissue (MALT). The aim of the current study is to investigate if the eMZL clonotype is detectable in prediagnostic blood and tissue biopsies of pSS patients.METHODS/RESULTS: We studied prediagnostic tissue biopsies of three pSS patients diagnosed with eMZL and four pSS controls through immunoglobulin (IG) gene repertoire sequencing. In all three cases, we observed the eMZL clonotype in prediagnostic tissue biopsies. Among controls, we observed transient elevation of clonotypes in two pSS patients. To evaluate if eMZL clonotypes may also be detected in the circulation, we sequenced a peripheral blood mononuclear cell (PBMC) sample drawn at eMZL diagnosis and two years prior to eMZL relapse in two pSS patients. The eMZL clonotype was detected in the peripheral blood prior to diagnosis in both cases. Next, we selected three pSS patients who developed eMZL lymphoma and five additional pSS patients who remained lymphoma-free. We sequenced the IG heavy chain (IGH) gene repertoire in PBMC samples taken a median of three years before eMZL diagnosis. In two out of three eMZL patients, the dominant clonotype in the prediagnostic PBMC samples matched the eMZL clonotype in the diagnostic biopsy. The eMZL clonotypes observed consisted of stereotypic IGHV gene combinations (IGHV1-69/IGHJ4 and IGHV4-59/IGHJ5) associated with rheumatoid factor activity, a previously reported feature of eMZL in pSS.DISCUSSION: In conclusion, our results indicate that eMZL clonotypes in pSS patients are detectable prior to overt eMZL diagnosis in both tissue biopsies and peripheral blood through immunogenetic s

Published
2023

12. Next-Generation Sequencing–Based Clonality Assessment of Ig Gene Rearrangements

Author

van den Brand, Michiel, primary, Rijntjes, Jos, additional, Möbs, Markus, additional, Steinhilber, Julia, additional, van der Klift, Michèle Y., additional, Heezen, Kim C., additional, Kroeze, Leonie I., additional, Reigl, Tomas, additional, Porc, Jakub, additional, Darzentas, Nikos, additional, Luijks, Jeroen A.C.W., additional, Scheijen, Blanca, additional, Davi, Frédéric, additional, ElDaly, Hesham, additional, Liu, Hongxiang, additional, Anagnostopoulos, Ioannis, additional, Hummel, Michael, additional, Fend, Falko, additional, Langerak, Anton W., additional, and Groenen, Patricia J.T.A., additional

Published
2021
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16. Quality control and quantification in IG/TR next-generation sequencing marker identification: protocols and bioinformatic functionalities by EuroClonality-NGS

Author

Ministry of Health of the Czech Republic, Associazione Italiana per la Ricerca sul Cancro, Knecht, Henrik, Reigl, Tomas, Kotrová, M., Appelt, Franziska, Stewart, Peter, Bystry, Vojtech, Krejci, Adam, Grioni, Andrea, Pal, Karol, Stranska, Kamila, Plevova, Karla, Rijntjes, Jos, Songia, Simona, Svatoň, Michael, Froňková, Eva, Bartram, Jack, Scheijen, Blanca, Herrmann, Dietrich, García-Sanz, Ramón, Hancock, Jeremy, Moppett, John, Dongen, J. J. M. van, Cazzaniga, Giovanni, Davi, Frédéric, Groenen, Patricia J. T. A., Hummel, Michael, Macintyre, Elizabeth A., Stamatopoulos, Kostas, Trka, Jan, Langerak, Anton W., González, David, Pott, Christiane, Brüggemann, Monika, Darzentas, Nikos, Ministry of Health of the Czech Republic, Associazione Italiana per la Ricerca sul Cancro, Knecht, Henrik, Reigl, Tomas, Kotrová, M., Appelt, Franziska, Stewart, Peter, Bystry, Vojtech, Krejci, Adam, Grioni, Andrea, Pal, Karol, Stranska, Kamila, Plevova, Karla, Rijntjes, Jos, Songia, Simona, Svatoň, Michael, Froňková, Eva, Bartram, Jack, Scheijen, Blanca, Herrmann, Dietrich, García-Sanz, Ramón, Hancock, Jeremy, Moppett, John, Dongen, J. J. M. van, Cazzaniga, Giovanni, Davi, Frédéric, Groenen, Patricia J. T. A., Hummel, Michael, Macintyre, Elizabeth A., Stamatopoulos, Kostas, Trka, Jan, Langerak, Anton W., González, David, Pott, Christiane, Brüggemann, Monika, and Darzentas, Nikos

Abstract

Assessment of clonality, marker identification and measurement of minimal residual disease (MRD) of immunoglobulin (IG) and T cell receptor (TR) gene rearrangements in lymphoid neoplasms using next-generation sequencing (NGS) is currently under intensive development for use in clinical diagnostics. So far, however, there is a lack of suitable quality control (QC) options with regard to standardisation and quality metrics to ensure robust clinical application of such approaches. The EuroClonality-NGS Working Group has therefore established two types of QCs to accompany the NGS-based IG/TR assays. First, a central polytarget QC (cPT-QC) is used to monitor the primer performance of each of the EuroClonality multiplex NGS assays; second, a standardised human cell line-based DNA control is spiked into each patient DNA sample to work as a central in-tube QC and calibrator for MRD quantification (cIT-QC). Having integrated those two reference standards in the ARResT/Interrogate bioinformatic platform, EuroClonality-NGS provides a complete protocol for standardised IG/TR gene rearrangement analysis by NGS with high reproducibility, accuracy and precision for valid marker identification and quantification in diagnostics of lymphoid malignancies.

Published
2019

18. Copy number variations as potential diagnostic and prognostic markers for CNS melanocytic neoplasms in neurocutaneous melanosis

Author

van Engen-van Grunsven, Adriana C H, Rabold, Katrin, Küsters-Vandevelde, Heidi V N, Rijntjes, Jos, Djafarihamedani, Melika, Hehir-Kwa, Jayne Y., Küsters, Benno, Willemsen, Michel A A P, van der Burgt, Ineke, Wesseling, Pieter, Blokx, Willeke A M, Groenen, Patricia J T A, van Engen-van Grunsven, Adriana C H, Rabold, Katrin, Küsters-Vandevelde, Heidi V N, Rijntjes, Jos, Djafarihamedani, Melika, Hehir-Kwa, Jayne Y., Küsters, Benno, Willemsen, Michel A A P, van der Burgt, Ineke, Wesseling, Pieter, Blokx, Willeke A M, and Groenen, Patricia J T A

Published
2017

19. Copy number variations as potential diagnostic and prognostic markers for CNS melanocytic neoplasms in neurocutaneous melanosis

Author

Pathologie patiënten zorg, van Engen-van Grunsven, Adriana C H, Rabold, Katrin, Küsters-Vandevelde, Heidi V N, Rijntjes, Jos, Djafarihamedani, Melika, Hehir-Kwa, Jayne Y., Küsters, Benno, Willemsen, Michel A A P, van der Burgt, Ineke, Wesseling, Pieter, Blokx, Willeke A M, Groenen, Patricia J T A, Pathologie patiënten zorg, van Engen-van Grunsven, Adriana C H, Rabold, Katrin, Küsters-Vandevelde, Heidi V N, Rijntjes, Jos, Djafarihamedani, Melika, Hehir-Kwa, Jayne Y., Küsters, Benno, Willemsen, Michel A A P, van der Burgt, Ineke, Wesseling, Pieter, Blokx, Willeke A M, and Groenen, Patricia J T A

Published
2017

20. Mutations in G Protein Encoding Genes and Chromosomal Alterations in Primary Leptomeningeal Melanocytic Neoplasms

Author

Küsters-Vandevelde, Heidi V N, van Engen- van Grunsven, Ilse A C H, Coupland, Sarah E., Lake, Sarah L., Rijntjes, Jos, Pfundt, Rolph, Küsters, Benno, Wesseling, Pieter, Blokx, Willeke A M, Groenen, Patricia J T A, Küsters-Vandevelde, Heidi V N, van Engen- van Grunsven, Ilse A C H, Coupland, Sarah E., Lake, Sarah L., Rijntjes, Jos, Pfundt, Rolph, Küsters, Benno, Wesseling, Pieter, Blokx, Willeke A M, and Groenen, Patricia J T A

Published
2015

21. Immunoglobulin rearrangement analysis from multiple lesions in the same patient using next-generation sequencing

Author

Sub Bioinformatics, Theoretical Biology and Bioinformatics, Appenzeller, Silke, Gilissen, Christian, Rijntjes, Jos, Tops, Bastiaan B J, Kastner-van Raaij, Annemiek, Hebeda, Konnie M, Nissen, Loes, Dutilh, Bas E, van Krieken, J Han J M, Groenen, Patricia J T A, Sub Bioinformatics, Theoretical Biology and Bioinformatics, Appenzeller, Silke, Gilissen, Christian, Rijntjes, Jos, Tops, Bastiaan B J, Kastner-van Raaij, Annemiek, Hebeda, Konnie M, Nissen, Loes, Dutilh, Bas E, van Krieken, J Han J M, and Groenen, Patricia J T A

Published
2015

22. Mutations in G Protein Encoding Genes and Chromosomal Alterations in Primary Leptomeningeal Melanocytic Neoplasms

Author

Pathologie patiënten zorg, Küsters-Vandevelde, Heidi V N, van Engen- van Grunsven, Ilse A C H, Coupland, Sarah E., Lake, Sarah L., Rijntjes, Jos, Pfundt, Rolph, Küsters, Benno, Wesseling, Pieter, Blokx, Willeke A M, Groenen, Patricia J T A, Pathologie patiënten zorg, Küsters-Vandevelde, Heidi V N, van Engen- van Grunsven, Ilse A C H, Coupland, Sarah E., Lake, Sarah L., Rijntjes, Jos, Pfundt, Rolph, Küsters, Benno, Wesseling, Pieter, Blokx, Willeke A M, and Groenen, Patricia J T A

Published
2015

23. Immunoglobulin rearrangement analysis from multiple lesions in the same patient using next-generation sequencing

Author

Appenzeller, Silke, Gilissen, Christian, Rijntjes, Jos, Tops, Bastiaan B J, Kastner-van Raaij, Annemiek, Hebeda, Konnie M, Nissen, Loes, Dutilh, Bas E, van Krieken, J Han J M, Groenen, Patricia J T A, Sub Bioinformatics, and Theoretical Biology and Bioinformatics

Subjects
Pathology, medicine.medical_specialty, Histology, Lymphoma, Cancer development and immune defence Radboud Institute for Molecular Life Sciences [Radboudumc 2], Biology, Rare cancers Radboud Institute for Molecular Life Sciences [Radboudumc 9], medicine.disease_cause, Immunoglobulin light chain, DNA sequencing, Pathology and Forensic Medicine, Young Adult, medicine, Tumours of the digestive tract Radboud Institute for Molecular Life Sciences [Radboudumc 14], Humans, Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7], Molecular pathology, High-Throughput Nucleotide Sequencing, General Medicine, Ion semiconductor sequencing, Middle Aged, medicine.disease, Ulcerative colitis, Epstein–Barr virus, Lymphoproliferative Disorders, Immunology, biology.protein, Colitis, Ulcerative, Female, Antibody, Immunoglobulin Heavy Chains, Inflammatory diseases Radboud Institute for Molecular Life Sciences [Radboudumc 5]
Abstract

Contains fulltext : 152334.pdf (Publisher’s version ) (Closed access) AIMS: For patients who have multiple lymphomas with discordant pathology, it is relevant to determine whether there is one disseminated lymphoma or two unrelated lymphomas. Patients with disseminated, clonally related lymphomas are usually treated with the most powerful drugs available, while patients with unrelated (primary) lymphomas receive mainly standard first-line therapies. METHODS AND RESULTS: We used next-generation sequencing on the Ion Torrent Personal Genome Machine to characterize the immunoglobulin heavy gene V-D-J rearrangements in two diagnostic tissue samples, including formalin-fixed and paraffin-embedded tissue, of two patients with iatrogenic immunodeficiency-associated Epstein-Barr virus lymphoproliferative disorder, with ulcerative colitis as underlying disease. The immunoglobulin rearrangement sequences obtained by next-generation sequencing revealed undoubtedly clonally related lesions in two tissue biopsies that were taken over time in the first patient, which is concordant with disseminated lymphoma. The other patient showed two clonally unrelated lesions, which is incompatible with clonal dissemination. This information was not inferred from evaluation of the heavy and light chain rearrangements by fragment analysis, which is currently the gold standard. CONCLUSION: Our study demonstrates the diagnostic application of next-generation sequencing of immunoglobulin rearrangement assessment in pathology for clinical decision-making in patients with several simultaneous or subsequent lymphoproliferations.

Published
2015

24. Mutations in G Protein Encoding Genes and Chromosomal Alterations in Primary Leptomeningeal Melanocytic Neoplasms

Author

Küsters-Vandevelde, Heidi V. N., primary, van Engen- van Grunsven, Ilse A. C. H., additional, Coupland, Sarah E., additional, Lake, Sarah L., additional, Rijntjes, Jos, additional, Pfundt, Rolph, additional, Küsters, Benno, additional, Wesseling, Pieter, additional, Blokx, Willeke A. M., additional, and Groenen, Patricia J. T. A., additional

Published
2014
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25. Experimental treatment of NRAS-mutated neurocutaneous melanocytosis with MEK162, a MEK-inhibitor

Author

Küsters-Vandevelde, Heidi VN, primary, Willemsen, Annelieke ECAB, additional, Groenen, Patricia JTA, additional, Küsters, Benno, additional, Lammens, Martin, additional, Wesseling, Pieter, additional, Djafarihamedani, Melika, additional, Rijntjes, Jos, additional, Delye, Hans, additional, Willemsen, Michel A, additional, van Herpen, Carla ML, additional, and Blokx, Willeke AM, additional

Published
2014
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28. ARResT/Interrogate: an interactive immunoprofiler for IG/TR NGS data.

Author

Bystry, Vojtech, Reigl, Tomas, Krejci, Adam, Demko, Martin, Hanakova, Barbora, Grioni, Andrea, Knecht, Henrik, Schlitt, Max, Dreger, Peter, Sellner, Leopold, Herrmann, Dietrich, Pingeon, Marine, Boudjoghra, Myriam, Rijntjes, Jos, Pott, Christiane, Langerak, Anton W., Groenen, Patricia J. T. A., Davi, Frederic, Brüggemann, Monika, and Darzentas, Nikos

Subjects
IMMUNOGLOBULINS, T cell receptors, NUCLEOTIDE sequencing, WEB-based user interfaces, IMMUNOGENETICS, STOCHASTIC processes
Abstract

Motivation: The study of immunoglobulins and T cell receptors using next-generation sequencing has finally allowed exploring immune repertoires and responses in their immense variability and complexity. Unsurprisingly, their analysis and interpretation is a highly convoluted task. Results: We thus implemented ARResT/Interrogate, a web-based, interactive application. It can organize and filter large amounts of immunogenetic data by numerous criteria, calculate several relevant statistics, and present results in the form of multiple interconnected visualizations. [ABSTRACT FROM AUTHOR]

Published
2017
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30. Significance of complete 1p/19q co-deletion, IDH1mutation and MGMTpromoter methylation in gliomas: use with caution

Author

Boots-Sprenger, Sandra H E, Sijben, Angelique, Rijntjes, Jos, Tops, Bastiaan B J, Idema, Albert J, Rivera, Andreana L, Bleeker, Fonnet E, Gijtenbeek, Anja M, Diefes, Kristin, Heathcock, Lindsey, Aldape, Kenneth D, Jeuken, Judith W M, and Wesseling, Pieter

Abstract

The histopathological diagnosis of diffuse gliomas often lacks the precision that is needed for tailored treatment of individual patients. Assessment of the molecular aberrations will probably allow more robust and prognostically relevant classification of these tumors. Markers that have gained a lot of interest in this respect are co-deletion of complete chromosome arms 1p and 19q, (hyper)methylation of the MGMTpromoter and IDH1mutations. The aim of this study was to assess the prognostic significance of complete 1p/19q co-deletion, MGMTpromoter methylation and IDH1mutations in patients suffering from diffuse gliomas. The presence of these molecular aberrations was investigated in a series of 561 diffuse astrocytic and oligodendroglial tumors (low grade n=110, anaplastic n=118 and glioblastoma n=333) and correlated with age at diagnosis and overall survival. Complete 1p/19q co-deletion, MGMTpromoter methylation and/or IDH1mutation generally signified a better prognosis for patients with a diffuse glioma including glioblastoma. However, in all 10 patients with a histopathological diagnosis of glioblastoma included in this study complete 1p/19q co-deletion was not associated with improved survival. Furthermore, in glioblastoma patients >50 years of age the favorable prognostic significance of IDH1mutation and MGMTpromoter methylation was absent. In conclusion, molecular diagnostics is a powerful tool to obtain prognostically relevant information for glioma patients. However, for individual patients the molecular information should be interpreted with caution and weighed in the context of parameters such as age and histopathological diagnosis.

Published
2013
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31. Vegetation succession on the dunes near Oostvoorne, The Netherlands; a comparison of the vegetation in 1959 and 1980

Author

Maarel, Eddy, Boot, René, Dorp, Dick, and Rijntjes, Jos

Abstract

The vegetation of a 150 ha coastal dune area in the SW Netherlands was carefully analyzed and mapped at a scale of 1:2500 in 1959 and 1980. About 600 relevés were treated numerically. 127 vegetation types were distinguished, the overlap in community composition between the two years was very small. An intermediate level between this community level and the level of the structural-physiognomic formation was adopted. 56 so-called subformations, in which floristic and structural characters are combined, have been recognized and the overlap was then considerably larger, at least in number of types. Ordination results suggest that in each subset: grasslands, dune slacks, woodlands + scrubs, the first axis reflects floristic differentiation along with progression. The ordination of the entire material shows moisture as the main factor underlying the first axis, zonation as the second and nutrient status as the third factor.

Published
1985
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32. Identification of IG-clonality status as a pre-treatment predictor for mortality in patients with immunodeficiency-associated Epstein-Barr virus-related lymphoproliferative disorders.

Author

van der Velden WJ, Nissen L, van Rijn M, Rijntjes J, de Haan A, Venkatraman L, Catherwood M, Liu H, El-Daly H, van de Laar L, Craenmehr MH, van Krieken JH, Stevens WB, and Groenen PJ

Subjects
B-Lymphocytes pathology, B-Lymphocytes virology, Humans, Immunoglobulins immunology, Lymphoproliferative Disorders diagnosis, Neoplasm Staging, Patient Outcome Assessment, B-Lymphocytes metabolism, Clonal Evolution genetics, Epstein-Barr Virus Infections complications, Herpesvirus 4, Human, Immunoglobulins genetics, Lymphoproliferative Disorders etiology
Published
2015
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