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BackgroundMicrobiome has been linked to the pathogenesis of coronary artery disease (CAD) but data providing direct evidence for an association of short-chain fatty acids (SCFA) with CAD are lacking. This study aimed to evaluate the role of propionate, the most important SCFA in patients with CAD.MethodsWe performed a cross-sectional study enrolling patients admitted for invasive coronary angiography in two university hospitals in Germany. Patients with known or suspected CAD and risk factors for cardiovascular disease were prospectively recruited. Blood sampling was performed after overnight fasting and before invasive procedures. Measurement of propionate was performed by liquid chromatography.ResultsThe study included 1,253 patients (median [IQR], 67 [58–76] years; 799 men [64%]). A total of 739 had invasively confirmed CAD with at least one coronary artery stenosis ≥50% and 514 had exclusion of CAD. CAD patients had significant lower levels of propionate (median 5.75 μM, IQR, 4.1–7.6) compared to the non-CAD groups 6.53 μM (4.6–8.6, p p = 0.002) for propionate as predictor of CAD. The odds ratio was further decreased to 0.45 (CI 0.31–0.65, p ConclusionThe study provides large-scale in vivo data for the association of propionate to manifest coronary artery disease, independent of other traditional cardiovascular risk factors.

Antarctica’s ice shelves are a highly critical component for the interlinkage between ice sheet and ocean. Their shape and evolution play an important role for the strength of ice mass loss, e.g. by amplification or weakening of the buttressing effect. Ocean tides are the most important direct forces acting on the ice shelves, inducing vertical and horizontal motion and deformation. In our study we investigate the effect of ocean tides on the Ekström Ice Shelf. The northward flow of the ice is mainly modulated by the tidal constituents at the ter-diurnal and quarter-diurnal bands, whereas the dominant vertical tides have a diurnal and semi-diurnal periodicity and amplitudes up to ten times larger than the ter- and quarter-diurnal tides. The causes of the higher frequency tidal modulations are still poorly understood. The area of the largest effect of the higher frequency tides is assumed to be the grounding zone of the ice streams feeding the ice shelf. Here we present first results of geophysical experiments at the grounding zone of the Ekström Ice Shelf conducted in the field seasons 2021/2022 and 2022/2023. In 2021/2022 we setup GNSS and seismic stations to record vertical and horizontal motion of the ice as well as seismic events in order to gain insights into ice dynamics and ground properties. In season 2022/2023 GNSS and seismic station were dismantled, and the experiments were complemented by magnetotelluric measurements to image the sub-ice ocean-land transition and the crustal structure beneath the ice stream., The 28th IUGG General Assembly (IUGG2023) (Berlin 2023)

Additional file 3: Figure S1. The original blot image of P62. Figure S2. The original blot image of Beclin1. Figure S3. The original blot image of LC3B. Figure S4. The original blot image of GAPDH.

The interdisciplinary DeepEarthShape project focusses on the weathering zone with drillings and geophysical, geochemical and geobiological approaches. The weathering zone is the uppermost part of the Earth's crust where rocks and soils experience breakdown through the impact of air/gases, water and/or biological organisms. The full picture of weathering processes and our insight into the critical zone is still limited. Since some of the properties of the weathering zone seem to be linked with climate, a set of sites is studied within the framework of the DFG Special Priority Program 1803 belonging to different climate zones and thus experience different vegetation, precipitation and erosion.We utilised a combination of seismics and Radio-Magnetotelluric (RMT) measurements along ~200m long profiles at three study sites in Chile. For the RMT experiment, we used a horizontal magnetic dipole transmitter together with a nearby MT station. To develop the method into an applicable tool for this kind of inter-disciplinary studies, we show RMT results at different stages: Experimental layout tuned with synthetic simulations, RMT data processing using machine learning approaches. And finally, we will show and discuss 2D and 3D inversion results together with geophysical logging data and lab measurements. First results indicate that we can image precipitation and shallow fluid enhanced zones and provide crucial information for other disciplines. Minor faults and folds can be traced into the active weathering zone and linked with surface and borehole information., The 28th IUGG General Assembly (IUGG2023) (Berlin 2023)

Hintergrund: Ein settingbezogenes Instrument zur Erfassung der Lebensqualität (LQ) im Kontext telemedizinischer Versorgung (TM) existiert bislang nicht. Daher können spezifische Aspekte der LQ im Kontext von TM-Studien nur unzureichend erfasst werden. Ziel des durch den Innovationsfond geförderten [zum vollständigen Text gelangen Sie über die oben angegebene URL]