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O objeto deste trabalho são os estudos sobre matemática não-arquimediana feitos pelo matemático, engenheiro e astrônomo brasileiro Manuel Amoroso Costa, que, em 1928, realizou uma série de conferências sobre essa matéria na Faculté des Sciences de Paris. Sem poder contar com os manuscritos dessas conferências, que desapareceram, para esta pesquisa foram considerados outros documentos de trabalho do arquivo pessoal do autor, publicações suas, obras de outros autores e estudos históricos sobre o tema por ele estudado, bem como artigos e notas de jornais da época. Como resultado das análises dessas fontes, este trabalho expõe um panorama dos estudos não-arquimedianos de Amoroso Costa, buscando situá-los em seu próprio tempo, e apresenta questões sobre as quais, possivelmente, ele se debruçou.

We start with two main hypotheses: a) the tendency to overproduction and expanded reproduction is inevitable in a context of production based on competition and the search for profit; b) conflicts for resources and the tendential degradation of the quality of life are also inevitable and are only going to worsen as the expanded reproduction takes its toll on the environment and on the material conditions for the reproduction of capital. This paper explores some underlying phenomena to support these claims, such as the Jevons Paradox, the Tendency of the Rate of Profit to Fall, and the Energy Return on Investment. Finally, it discusses the failure of some of the alternatives to the Growth Paradigm: Sustainable Development, Green Growth, Circular Economy and Degrowth.

This research aimed to analyze the relationship between deforestation (DFT) and climatic variables during the rainy (CHU+) and less-rainy (CHU−) seasons in the Tapajós River basin. Data were sourced from multiple institutions, including the Climatic Research Unit (CRU), Center for Weather Forecasts and Climate Studies (CPTEC), PRODES Program (Monitoring of Brazilian Amazon Deforestation Project), National Water Agency (ANA) and National Centers for Environmental Prediction/National Oceanic and Atmospheric Administration (NCEP/NOAA). The study assessed anomalies (ANOM) in maximum temperature (TMAX), minimum temperature (TMIN) and precipitation (PREC) over three years without the occurrence of the El Niño–Southern Oscillation (ENSO) atmospheric–oceanic phenomenon. It also examined areas with higher DFT density using the Kernel methodology and analyzed the correlation between DFT and climatic variables. Additionally, it assessed trends using the Mann–Kendall technique for both climatic and environmental data. The results revealed significant ANOM in TEMP and PREC. In PREC, the highest values of ANOM were negative in CHU+. Regarding temperature, the most significant values were positive ANOM in the south, southwest and northwestern regions of the basin. Concerning DFT density, data showed that the highest concentration was of medium density, primarily along the highways. The most significant correlations were found between DFT and TEMP during the CHU− season in the Middle and Lower Tapajós sub-basins, regions where the forest still exhibits more preserved characteristics. Furthermore, the study identified a positive trend in TEMP and a negative trend in PREC.

Sweet sorghum (Sorghum bicolor [L.] Moench) is a plant that can be an alternative for the production of bioethanol in semi-arid regions. The objective of this work was to evaluate sweet sorghum 'BRS 506' under salt and water stress. The experimental design was in randomized blocks, in a factorial scheme (4x4), with the first factor referring to the electrical conductivities of the irrigation water (1.5; 3.0; 4.5; and 6.0 dS m-1) and the second refers to irrigation depths (53, 67, 85 and 95% of crop evapotranspiration). Gas exchange, leaf water status, leaf sugars and plant growth were evaluated. Salt and water stress cause negative effects on the growth of sweet sorghum 'BRS 506'. Salt stress causes disturbances in gas exchange and sugar levels. Sweet sorghum 'BRS 506' is tolerant to combined salt and water stress.

ABSTRACT The objective of this study was to evaluate the development of pitaya cuttings in different substrates under different frequencies of irrigation. The experiment was conducted from January to May 2017 in a greenhouse at Universidade Federal Rural da Amazônia, Capitao Poço, Pará, Brazil. A completely randomized 3 × 7 factorial design with four replicates was used. Pitaya plants were grown from cuttings in three types of substrates (S1: potting soil; S2: potting soil + cattle manure + wood shavings; and S3: washed sand) under seven irrigation frequencies (24, 48, 72, 96, 120, 144, and 168 h). There was interaction between treatments for root dry matter production, root length variables, the other variables showed no interaction between treatments. The greater development of new and vigorous tissues of the aerial part, the substrates with composition black earth and black earth + manure + sawdust are indicated, and the adoption of the irrigation frequency of 72 h or 96 h. The use of substrate based on black earth + manure + sawdust, allows savings in the rational use of water and energy with the application of the 96 h irrigation frequencies, maintaining satisfactory levels of development to the plant. The washed sand substrate can be used for propagation when this material is abundant, however, greater attention should be paid to the supply of water and nutrients to the plant.

Este trabalho traz algumas considerações relacionadas a produção do múltiplo “Ebó contra o carrego colonial”, um objeto de arte afro-brasileira contemporânea e os desafios de sua inserção e comunicação no cenário artístico – e universitário – da produção visual brasileira, uma vez que seu processo de criação evocou diferentes formas de conhecimento que, historicamente, foram exotizados, demonizados e marginalizados na produção de arte no Brasil.

The increase in water demand in regions with limited good-quality water resources makes it necessary to study the effect of low-quality water on plant metabolism. Therefore, the objective of this study was to evaluate the effect of water and salt stress on the levels of mineral elements and accumulation of toxic elements Na+ and Cl− in the leaves and their consequences on the production variables of the sorghum cultivar IPA SF-15. The design adopted was randomized blocks in a factorial scheme (4 × 4), with four salt concentrations (1.5; 3.0; 4.5, and 6.0 dS m−1) and four irrigation depths (51.3; 70.6; 90.0, and 118.4% of crop evapotranspiration ETc) in three repetitions. To obtain nutrient, sodium, and chlorine contents in the leaf, we collected the diagnosis leaf from six plants per plot. For production data, we performed two harvests at 76 and 95 days after planting (silage point and for sucrose extraction). We evaluated the dry mass, fresh mass yield, and total dry mass for the two cutting periods and applied the F-test at the 5% significance level. There was an effect of water stress but not saline, making it possible to use saline water for sorghum irrigation. As for the toxicity of ions, the plant showed tolerance behavior to Na+ and Cl− ions. The grain filling phase was more sensitive than the final phase of the crop cycle.

Agriculture in semiarid regions commonly face problems because of salt and availability of irrigation water. Considering this, studies on cultures resistant to salt and water stresses involving sweet sorghum are required. Therefore, the aim was to evaluate the growth and other mechanisms of tolerance to salinity and water deficit in BRS 506 sweet sorghum. The experimental design was conducted in Upanema-RN, Brazil, in randomized blocks, where the isolated and interactive effect of 3 salinity levels, expressed as the electrical conductivity of irrigation water (1.5, 3.8, and 6.0 dS m−1), and 3 irrigation depths (55, 83, and 110% of crop evapotranspiration) were evaluated. During the cycle, sorghum adapted to the salinity and deficit irrigation depth, since stem height reduced only −5.5% with increasing salinity and −11.95% with decreasing irrigation depth, and aerial dry mass was affected by interaction only at the end of the cycle. Proline, total amino acids, and total soluble sugars were not differenced by stresses. Additionally, around 68.71% of total Na+ was at roots at the end of the cycle. In summary, sorghum BRS 506 was more tolerant to salt than water stress and used Na+ compartmentalization in root cells as the main tolerance mechanism.

This research aimed to analyze the relationship between deforestation (DFT) and climatic variables during the rainy (CHU+) and less-rainy (CHU−) seasons in the Tapajós River basin. Data were sourced from multiple institutions, including the Climatic Research Unit (CRU), Center for Weather Forecasts and Climate Studies (CPTEC), PRODES Program (Monitoring of Brazilian Amazon Deforestation Project), National Water Agency (ANA) and National Centers for Environmental Prediction/National Oceanic and Atmospheric Administration (NCEP/NOAA). The study assessed anomalies (ANOM) in maximum temperature (TMAX), minimum temperature (TMIN) and precipitation (PREC) over three years without the occurrence of the El Niño–Southern Oscillation (ENSO) atmospheric–oceanic phenomenon. It also examined areas with higher DFT density using the Kernel methodology and analyzed the correlation between DFT and climatic variables. Additionally, it assessed trends using the Mann–Kendall technique for both climatic and environmental data. The results revealed significant ANOM in TEMP and PREC. In PREC, the highest values of ANOM were negative in CHU+. Regarding temperature, the most significant values were positive ANOM in the south, southwest and northwestern regions of the basin. Concerning DFT density, data showed that the highest concentration was of medium density, primarily along the highways. The most significant correlations were found between DFT and TEMP during the CHU− season in the Middle and Lower Tapajós sub-basins, regions where the forest still exhibits more preserved characteristics. Furthermore, the study identified a positive trend in TEMP and a negative trend in PREC. [ABSTRACT FROM AUTHOR]

O presente artigo, motivado pela dificuldade dos alunos de Ensino Médio em compreender os conteúdos da Geometria Descritiva, busca responder à seguinte pergunta: um jogo digital para smartphones poderia auxiliar na compreensão do estudo do ponto? Por tratar-se de conteúdo que serve de base para conceitos mais abstratos da Geometria Descritiva, a dificuldade nesse conteúdo pode gerar lacunas que impactarão nas teorias mais complexas seguintes. Este trabalho versa sobre os resultados parciais de uma pesquisa de mestrado, em andamento, que visa analisar como professores do Ensino Médio percebem a relevância de um jogo digital para o estudo do ponto. Desse modo, apresentam-se aqui as teorias norteadoras do projeto de jogo adotando-se os conceitos de ludicidade, aprendizagem baseada em jogos e as aprendizagens significativa e distraída. Os conceitos do estudo do ponto serão sucintamente expostos para que o leitor possa, a seguir, compreender a contextualização e a dinâmica do jogo. Nesse estudo de caso, sete recém-egressos do ensino médio da instituição que sediou a pesquisa foram convidados a avaliar “Frogo, o Jogo do Estudo do Ponto”. Assim, após usufruírem do game, os participantes responderam anonimamente a um formulário eletrônico com perguntas avaliativas abertas e fechadas. Os resultados obtidos nessa consulta inicial indicam que Frogo pode ser um recurso pedagógico digital motivador para os estudantes nativos digitais com potencial para contribuir com um aprendizado divertido e servir de incentivo para o surgimento de projetos como esse que aspirem por um paradigma educacional menos tradicional.

PURPOSEThe LUME-Lung 1 study has brought consistent evidence of the effective use of nintedanib in lung adenocarcinoma as a second line of treatment; however, differences among ethnicities have been found in some studies.METHODSThis was a retrospective review among 21 medical centers of 150 patients with a confirmed diagnosis of lung adenocarcinoma, included in a compassionate use program of nintedanib from March 2014 to September 2015. The current study aimed to analyze the effectiveness of nintedanib in combination with docetaxel in the Mexican population, using progression-free survival rate and the best objective response to treatment by RECIST 1.1 as a surrogate of effectiveness. In addition, we examined the toxicity profile of our study population as a secondary end point.RESULTSAfter exclusion criteria, only 99 patients met the criteria for enrollment in the current study. From the total study population, 53 patients (53.5%) were male and 46 (46.5%) were female, with an average age of 60 years and stage IV as the most prevalent clinical stage at the beginning of the compassionate use program. A total of 48 patients (48.5%) had partial response; 26 (26.3%), stable disease; 4 (4%), complete response; and 16 (16.2%), progression; and 5 (5%) were nonevaluable. We found a median progression-free survival of 5 months (95% CI, 4.3 to 5.7 months). The most common grade 3 or 4 adverse reactions were fatigue (14%) and diarrhea (13%).CONCLUSIONNintedanib, as part of a chemotherapy regimen, is an effective option with an acceptable toxicity profile for advanced lung adenocarcinoma after first-line treatment progression.

Background A relationship between the EGFR signaling pathway expression in skin and the use of targeted cancer therapies has been previously demonstrated. Consistent evidence to support the use of skin biopsies as a surrogate for therapeutic evaluation is needed. The purpose of this study was to establish the relationship between the expression of EGFR signaling pathway markers in skin samples from EGFR‐mutated metastatic lung adenocarcinoma patients and their response to tyrosine kinase inhibitors. Methods This was a prospective single blind analysis of 35 skin biopsies from 31 patients with confirmed advanced EGFR‐mutated lung adenocarcinoma. Immunohistochemistry was performed: EGFR, p27, Ki67, STAT3 and MAPK, as well as H&E histopathological analysis, in order to determine their treatment response to tyrosine kinase inhibitors. Results EGFR, Ki67, STAT3, stratum corneum thickness (number of layers and millimeters) from skin samples had a statistical correlation with an adequate treatment response (P = 0.025, 0.015, 0.017, 0.041, 0.039 respectively). EGFR, p27 and number of layers of the stratum corneum were related to a better median progression‐free survival (P = 0.025 and P = 0.030). Conclusions The relationship between EGFR pathway inhibition in the skin and oncological outcomes obtained explains the parallel biological effects of tyrosine kinase inhibitors. We hope that our work incites future research to help validate and assess the use of these markers as potential prognostic and predictive factors.

Solid solutions ZnxCd1−xS were compared by coprecipitation and sonochemistry methods, where x=0.2. This rate is the one that presents the best photocatalytic activity and the best performance for the production of hydrogen from a water source, according to our previous results. The influence of the synthesis method on the morphology and its electronic properties of the CdS and Zn0.2Cd0.8S systems was investigated, as well as the effect of the incorporation of Zn in the crystal lattice and its effect on the production of hydrogen from the division of water. X-ray diffraction characterization confirmed the formation of a solid solution corresponding to a face-centered cubic crystalline phase with preferential growth of (111), (220), and (311) planes and hierarchical morphology according to SEM and TEM microscopy, formed by aggregated nanoparticles of ZnxCd1−xS compound. The crystallite size decreased with the Zn incorporation in the crystal lattice from 8.61 nm by a coprecipitation method to 4.37 nm when the synthesis was assisted with sonochemistry, and the crystallite sizes range from 7.92 nm to 3.80 nm for the case of CdS pure. Other characterization techniques were also used, such as photoluminescence (PL), Raman microscopy, and N2 adsorption and desorption. The PL results show tunability of band edge emission as a function of zinc concentration in the Zn0.2Cd0.8S nanoparticles. For the water splitting to hydrogen production, the separation of the charge carriers promoted by the incorporation of Zn in addition to the shallow trap emissions generated defects in the catalyst structure; such processes are important factors found which increased with the sonochemical method, as well as the potential matched positions.

Titanium dioxide (TiO2) is widely used, studied, and synthesized using different methodologies. By a modification of the material, it can be applied to wastewater treatment. A combined sputtering-laser ablation setup was used to deposit TiO2 thin films modified, individually and simultaneously, with gold (Au) and silver (Ag). To investigate the effect of the metal incorporation in titanium and its impact on the photocatalytic activity, with dye discoloration as a pollutant compound model, the deposited films were characterized by UV–Vis, photoluminescence, and Raman spectroscopies, as well as by parallel beam X-ray diffraction. The results showed that films with different Au and Ag loads, and an 18 nm average crystallite size, were obtained. These metals have an essential effect on the deposited film’s compositional, structural, and optical properties, directly reflected in its photocatalytic activity. The photocatalytic test results using UV-Vis showed that, after 1 h of applying a 4.8 V electric voltage, a discoloration of up to 80% of malachite green (MG) was achieved, using ultraviolet (UV) light.

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Emergence of bacterial infections, including those associated with Staphylococcus aureus, brings up a need for searching new and more effective strategies for clinical treatment. The use of medicinal plants associated with conventional antibiotics may represent a therapeutic option. Currently, studies evidence the synergistic effect achieved by combining plant extracts with antibiotics. Our objective was evaluate the in vitro antimicrobial activity and bactericidal kinetics of Matricaria recutita extract (chamomile) and its association with cephalexin and norfloxacin on clinical isolates of S. aureus from bovine origin, characterized as resistant. The tests were performed by method of dilution in solid medium to determine the Minimum Inhibitory Concentration (MIC). In both combinations of M. recutita extract with antibiotics norfloxacin and cephalexin, we observed MIC in dilution 1:64, corresponding to 8μg/mL of the antibiotic and 13.43 μg/mL of extract. Cephalexin associated with chamomile extract produced a effect of the combination in 75% of samples in their MIC. The combination of natural products frequently used by the population with the antibiotics tested in this study, could represent a therapeutic option for treatment of infections caused by S. aureus, as well as the prevention of the increasing development of resistance.

Objetivou-se estudar o desempenho agronômico do pimentão cv. Ikeda, irrigado com diferentes qualidades de água, sob dois métodos de manejos de irrigação: reflectometria no domínio da frequência e tensiometria, sob ambiente protegido. O delineamento estatístico utilizado foi o inteiramente casualizado, em esquema de parcelas subdivididas, constituído de três qualidades de água nas parcelas, e dois manejos de irrigação nas subparcelas. Foram avaliadas a produtividade total; produtividade comercial; eficiência do uso da água; massa média dos frutos; comprimento; diâmetro; relação comprimento/diâmetro; teor de sólidos solúveis; acidez titulável e pH. Os resultados obtidos permitem concluir que a produtividade e qualidade físicas dos frutos de pimentão não foram afetadas pela qualidade da água de irrigação, enquanto a menor demanda hídrica quantificada pela tensiometria influenciou significativamente apenas nos pH dos frutos.

Este texto faz uma abordagem dos princípios da formação profissional dos Institutos federais (IFs) e sua correlação com a abordagem Ciência Tecnologia e Sociedade (CTS). Seu objetivo foi mostrar como os IFS contribuem para pensar a formação profissional na perspectiva CTS, isto é, de forma socialmente engajada. A partir de uma apresentação crítica do campo CTS e do tipo de formação profissional a ele associado, foram indicadas as bases ético-políticas da educação no IFs retomando o documento relativo a suas concepções e diretrizes e a lei de sua criação, a Lei nº 11.892. Mostra-se que os Ifs se apresentam como um espaço privilegiado para a formação CTS, podendo ser ocasião para a associação dessa com uma concepção de formação profissional de trabalhadores, pesquisadores e cidadãos capazes de intervir nos processos de decisão pública envolvendo ciência tecnologia.

The energy sector is one of the fields of interest for different nations around the world. Due to the current fossil fuel crisis, the scientific community develops new energy-saving experiences to address this concern. Buildings are one of the elements of higher energy consumption, so the generation of knowledge and technological development may offer solutions to this energy demand, which are more than welcome. Phase change materials (PCMs) included in building elements such as wall panels, blocks, panels or coatings, for heating and cooling applications have been shown, when heating, to increase the heat storage capacity by absorbing heat as latent heat. Therefore, the use of latent heat storage systems using phase change materials (PCMs) has been investigated within the last two decades. In the present review, the macro and micro encapsulation methods for construction materials are reviewed, the former being the most viable method of inclusion of PCMs in construction elements. In addition, based on the analysis of the existing papers on the encapsulation process of PCMs, the importance to pay more attention to the bio-based PCMs is shown, since more research is needed to process such PCMs. To determine its thermophysical and mechanical behavior at the micro and macro levels, in order to see the feasibility of substituting petroleum-based PCMs with a more environmentally friendly bio-based one, a section devoted to the excellent PCM with lightweight aggregate (PCM-LWA concrete) is presented due to the lack of description given in other reviews.

Este artigo tem como objetivo apresentar o mapeamento automatizado de Tipologias de Paisagem - TP, através de mineração de dados e métricas de Ecologia de Paisagem, utilizando os dados do projeto TerraClass Amazônia para os anos de 2008 e 2010. Assim, constitui uma proposta inovadora de automatização do processo de identificação e delimitação de TP. Posto que, utiliza a composição de uso e cobertura da terra como uma das variáveis de entrada para o sistema de modelagem, ou seja, dados qualitativos do desmatamento. Como recorte de análise foram selecionadas as Regiões de Integração do Araguaia e Tapajós. A combinação de técnicas de estatística envolvendo dados e análises espaciais e não-espaciais, proporcionam aos usuários mecanismos importantes para garimpar padrões e relações em seus dados. Neste sentido, a Mineração de Dados foi proposta, se constituindo atualmente como uma das tecnologias mais promissoras na identificação e análise de dados. De acordo com as análises realizadas, foram identificadas sete tipologias de paisagem. A RI do Tapajós apresentou mais áreas classificadas como "Paisagens Florestais", tanto para o ano de 2008 quanto para o ano de 2010. Já a RI do Araguaia, ao contrário do que foi verificado para a RI do Tapajós, apresenta maior predomínio de Tipologias de Paisagem consolidadas, mais especificamente a TP com Pecuária Consolidada. Portanto, o processo de mapeamento automatizado de Tipologias de Paisagem utilizando o Plugin GeoDMA do Terra View demonstrou-se eficaz e preciso, visto que os resultados alcançados apresentam coerência com a realidade de cada Região de Integração.

Agriculture in semiarid regions commonly face problems because of salt and availability of irrigation water. Considering this, studies on cultures resistant to salt and water stresses involving sweet sorghum are required. Therefore, the aim was to evaluate the growth and other mechanisms of tolerance to salinity and water deficit in BRS 506 sweet sorghum. The experimental design was conducted in Upanema-RN, Brazil, in randomized blocks, where the isolated and interactive effect of 3 salinity levels, expressed as the electrical conductivity of irrigation water (1.5, 3.8, and 6.0 dS m−1), and 3 irrigation depths (55, 83, and 110% of crop evapotranspiration) were evaluated. During the cycle, sorghum adapted to the salinity and deficit irrigation depth, since stem height reduced only −5.5% with increasing salinity and −11.95% with decreasing irrigation depth, and aerial dry mass was affected by interaction only at the end of the cycle. Proline, total amino acids, and total soluble sugars were not differenced by stresses. Additionally, around 68.71% of total Na+ was at roots at the end of the cycle. In summary, sorghum BRS 506 was more tolerant to salt than water stress and used Na+ compartmentalization in root cells as the main tolerance mechanism. [ABSTRACT FROM AUTHOR]