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2. 349 INTRAVENOUS CANGRELOR INFUSION IN PATIENTS UNDERGOING COMPLEX VERSUS NON-COMPLEX PERCUTANEOUS CORONARY INTERVENTION: A SUBANALYSIS OF THE ICARUS REGISTRY

Author

Gragnano, Felice, primary, Benenati, Stefano, additional, Scalamera, Riccardo, additional, Bertero, Edoardo, additional, Capolongo, Antonio, additional, De Sio, Vincenzo, additional, Musumeci, Giuseppe, additional, Annibali, Gianmarco, additional, Campagnuolo, Salvatore, additional, Galasso, Gennaro, additional, Silverio, Angelo, additional, Bellino, Michele, additional, Centore, Mario, additional, Menozzi, Alberto, additional, Caretta, Giorgio, additional, Rezzaghi, Marco, additional, De Luca, Leonardo, additional, Veneziano, Francesco Antonio, additional, Cirillo, Plinio, additional, De Rosa, Gennaro, additional, Porto, Italo, additional, and Calabrò, Paolo, additional

Published
2022
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3. 330 INTRAVENOUS CANGRELOR INFUSION IN HIGH BLEEDING RISK PATIENTS UNDERGOING PERCUTANEOUS CORONARY INTERVENTION: PRELIMINARY RESULTS OF THE ICARUS REGISTRY

Author

Benenati, Stefano, primary, Gragnano, Felice, additional, Scalamera, Riccardo, additional, Bertero, Edoardo, additional, Capolongo, Antonio, additional, Sio, Vincenzo De, additional, Musumeci, Giuseppe, additional, Annibali, Gianmarco, additional, Campagnuolo, Salvatore, additional, Galasso, Gennaro, additional, Silverio, Angelo, additional, Bellino, Michele, additional, Centore, Mario, additional, Menozzi, Alberto, additional, Caretta, Giorgio, additional, Rezzaghi, Marco, additional, Luca, Leonardo De, additional, Veneziano, Francesco Antonio, additional, Cirillo, Plinio, additional, Rosa, Gennaro De, additional, Calabrò, Paolo, additional, and Porto, Italo, additional

Published
2022
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4. 910 PREVALENCE AND PROGNOSTIC IMPACT OF ANAEMIA IN PATIENTS UNDERGOING PERCUTANEOUS CORONARY INTERVENTION AND RECEIVING CANGRELOR: A SUBANALYSIS OF THE ICARUS REGISTRY

Author

Capolongo, Antonio, primary, Gragnano, Feliceg, additional, Benenati, Stefano, additional, De Sio, Vincenzo, additional, Scalamera, Riccardo, additional, Bertero, Edoardo, additional, Musumeci, Giuseppe, additional, Annibali, Gianmarco, additional, Campagnuolo, Salvatore, additional, Galasso, Gennaro, additional, Silverio, Angelo, additional, Belllino, Michele, additional, Centore, Mario, additional, Menozzi, Alberto, additional, Caretta, Giorgio, additional, Rezzaghi, Marco, additional, De Luca, Leonardo, additional, Antonio Veneziano, Francesco, additional, Cirillo, Plinio, additional, De Rosa, Gennaro, additional, Porto, Italo, additional, and Calabrò, Paolo, additional

Published
2022
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5. 345 INTRAVENOUS CANGRELOR INFUSION IN ELDERLY PATIENTS UNDERGOING PERCUTANEOUS CORONARY INTERVENTION: A SUBANALYSIS OF THE ICARUS REGISTRY

Author

Benenati, Stefano, primary, Gragnano, Felice, additional, Capolongo, Antonio, additional, De Sio, Vincenzo, additional, Scalamera, Riccardo, additional, Bertero, Edoardo, additional, Musumeci, Giuseppe, additional, Annibali, Gianmarco, additional, Campagnuolo, Salvatore, additional, Galasso, Gennaro, additional, Silverio, Angelo, additional, Bellino, Michele, additional, Centore, Mario, additional, Menozzi, Alberto, additional, Caretta, Giorgio, additional, Rezzaghi, Marco, additional, De Luca, Leonardo, additional, Antonio Veneziano, Francesco, additional, Cirillo, Plinio, additional, De Rosa, Gennaro, additional, Calabrò, Paolo, additional, and Porto, Italo, additional

Published
2022
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6. 902 INCIDENCE, CHARACTERISTICS AND CLINICAL OUTCOMES OF PATIENTS PRESENTING WITH VERSUS WITHOUT CARDIOGENIC SHOCK AND RECEIVING CANGRELOR: AN EXPLORATORY SUBANALYSIS OF THE ICARUS REGISTRY

Author

Scalamera, Riccardo, primary, Benenati, Stefano, additional, Gragnano, Felice, additional, Bertero, Edoardo, additional, Capolongo, Antonio, additional, De Sio, Vincenzo, additional, Musumeci, Giuseppe, additional, Annibali, Gianmarco, additional, Campagnuolo, Salvatore, additional, Galasso, Gennaro, additional, Silverio, Angelo, additional, Belllino, Michele, additional, Centore, Mario, additional, Menozzi, Alberto, additional, Caretta, Giorgio, additional, Rezzaghi, Marco, additional, De Luca, Leonardo, additional, Antonio Veneziano, Francesco, additional, Cirillo, Plinio, additional, De Rosa, Gennaro, additional, Calabrò, Paolo, additional, and Porto, Italo, additional

Published
2022
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11. Allogeneic compared with autologous stem cell transplantation in the treatment of patients younger than 46 years with acute myeloid leukemia (AML) in first complete remission (CR1): an intention-to-treat analysis of the EORTC/GIMEMAAML-10 trial

Author

Suciu, Stefan, Mandelli, Franco, de Witte, Theo, Zittoun, Robert, Gallo, Eugenio, Labar, Boris, De Rosa, Gennaro, Belhabri, Amine, Giustolisi, Rosario, Delarue, Richard, Liso, Vincenzo, Mirto, Salvatore, Leone, Giuseppe, Bourhis, Jean-Henri, Fioritoni, Giuseppe, Jehn, Ulrich, Amadori, Sergio, Fazi, Paola, Hagemeijer, Anne, and Willemze, Roel

Published
2003
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12. Thiotepa-based versus total body irradiation-based myeloablative conditioning prior to allogeneic stem cell transplantation for acute myeloid leukaemia in first complete remission : a retrospective analysis from the Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation

Author

Eder, Sandra, Labopin, Myriam, Arcese, William, Or, Reuven, Majolino, Ignazio, Bacigalupo, Andrea, de Rosa, Gennaro, Volin, Liisa, Beelen, Dietrich, Veelken, Hendrik, Schaap, Nicolaas P M, Kuball, Jurgen, Cornelissen, Jan, Nagler, Arnon, Mohty, Mohamad, Acute Leukemia Working Party, Eder, Sandra, Labopin, Myriam, Arcese, William, Or, Reuven, Majolino, Ignazio, Bacigalupo, Andrea, de Rosa, Gennaro, Volin, Liisa, Beelen, Dietrich, Veelken, Hendrik, Schaap, Nicolaas P M, Kuball, Jurgen, Cornelissen, Jan, Nagler, Arnon, Mohty, Mohamad, and Acute Leukemia Working Party

Published
2016

13. Thiotepa-based versus total body irradiation-based myeloablative conditioning prior to allogeneic stem cell transplantation for acute myeloid leukaemia in first complete remission: a retrospective analysis from the Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation

Author

CTI Kuball, MS Hematologie, Infection & Immunity, Regenerative Medicine and Stem Cells, Cancer, Eder, Sandra, Labopin, Myriam, Arcese, William, Or, Reuven, Majolino, Ignazio, Bacigalupo, Andrea, de Rosa, Gennaro, Volin, Liisa, Beelen, Dietrich, Veelken, Hendrik, Schaap, Nicolaas P M, Kuball, Jurgen, Cornelissen, Jan, Nagler, Arnon, Mohty, Mohamad, Acute Leukemia Working Party, CTI Kuball, MS Hematologie, Infection & Immunity, Regenerative Medicine and Stem Cells, Cancer, Eder, Sandra, Labopin, Myriam, Arcese, William, Or, Reuven, Majolino, Ignazio, Bacigalupo, Andrea, de Rosa, Gennaro, Volin, Liisa, Beelen, Dietrich, Veelken, Hendrik, Schaap, Nicolaas P M, Kuball, Jurgen, Cornelissen, Jan, Nagler, Arnon, Mohty, Mohamad, and Acute Leukemia Working Party

Published
2016

14. Accelerated bone mass senescence after hematopoietic stem cell transplantation

Author

Serio, Bianca, Pezzullo, Luca, Fontana, Raffaele, Annunziata, Silvana, Rosamilio, Rosa, Sessa, M., Giudice, Valentina, Ferrara, Ida Lucia, Rocco, Monia, De Rosa, Gennaro, Ricci, P., Tauchmanovà, Libuse, Montuori, Nunzia, and Selleri, Carmine

Subjects
Hemopoietic stem cell transplantation, surgical procedures, operative, Osteoporosis, Bisphosphonates
Abstract

Osteoporosis and avascular necrosis (AVN) are long-lasting and debilitating complications of hematopoietic stem cell transplantation (HSCT). We describe the magnitude of bone loss, AVN and impairment in osteogenic cell compartment following autologous (auto) and allogeneic (allo) HSCT, through the retrospective bone damage revaluation of 100 (50 auto- and 50 allo-HSCT) longterm survivors up to 15 years after transplant. Current treatment options for the management of these complications are also outlined. We found that auto- and allo-HSCT recipients show accelerated bone mineral loss and microarchitectural deterioration during the first years after transplant. Bone mass density (BMD) at the lumbar spine, but not at the femur neck, may improve in some patients after HSCT, suggesting more prolonged bone damage in cortical bone. Phalangeal BMD values remained low for even more years, suggesting persistent bone micro-architectural alterations after transplant. The incidence of AVN was higher in allo-HSCT recipients compared to autoHSCT recipients. Steroid treatment length, but not its cumulative dose was associated with a higher incidence of bone loss. Allo-HSCT recipients affected by chronic graft versus host disease seem to be at greater risk of continuous bone loss and AVN development. Reduced BMD and higher incidence of AVN was partly related to a reduced regenerating capacity of the normal marrow osteogenic cell compartment. Our results suggest that all patients after autoHSCT and allo-HSCT should be evaluated for their bone status and treated with anti-resorptive therapy as soonas abnormalities are detected.

Published
2013

15. Avid (67)Ga uptake in multiple myeloma relapsing after bone marrow transplant

Author

DE ROSA, GENNARO, PEZZULLO L., DEL VECCHIO S., De Rosa, G, Pezzullo, L, DEL VECCHIO, Silvana, DE ROSA, Gennaro, Pezzullo, L., and DEL VECCHIO, S.

Subjects
Adult, Male, Technetium Tc 99m Sestamibi, Fatal Outcome, Recurrence, Humans, Gallium Radioisotopes, Multiple Myeloma, Radionuclide Imaging, Bone and Bones, Bone Marrow Transplantation
Abstract

Technetium-99m-sestaMIBI is a reliable positive tracer of skeletal lesions in multiple myeloma (MM), while bone scintigraphy by 99mTc-MDP and 67Ga scanning are considered of negligible value. We report the case of a young patient with a 5-year history of light chain MM, which was not eradicated by chemotherapy, radiotherapy, allogeneic bone marrow transplantation, α-interferon and donor lymphocyte infusion. In the final phase of the disease a CT scan showed a 14 cm mediastinal mass (Figure 1A). The neoplastic tissue took up 67Ga more avidly than 99mTc-sesta MIBI (Figures 1B-C), and focal bone lesions showed 67Ga uptake even in areas negative by MIBI scan. The patient died of disease progression in a few months. It seems that a 67Ga scan can identify patients with very aggressive MM.

Published
2000

16. Thiotepa-Based Vs TBI-Based Myeloablative Conditioning Prior To Allogeneic Stem Cell Transplantation (HSCT) For Acute Myeloid Leukemia (AML) In First Complete Remission (CR1): A Retrospective Analysis From The ALWP Of The EBMT

Author

Eder, Sandra, primary, Labopin, Myriam, additional, Arcese, William, additional, Or, Reuven, additional, Majolino, Ignazio, additional, Bacigalupo, Andrea, additional, de Rosa, Gennaro, additional, Volin, Liisa, additional, Beelen, Dietrich, additional, Veelken, Hendrik, additional, Schaap, Nicolaas PM, additional, Kuball, Jurgen H, additional, Cornelissen, Jan, additional, Nagler, Arnon, additional, and Mohty, Mohamad, additional

Published
2013
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19. Circulating Megakaryocyte-Derived Cells Detected by Flow Cytometry As Marker of Aggressive Neoplasms of Megakaryocytic Lineage in Acute Megakaryoblastic Leukemia and Allied Malignancies Presenting As Primary Myelofibrosis

Author

Marotta, Serena, primary, Giagnuolo, Giovanna, additional, Scalia, Giulia, additional, Raia, Maddalena, additional, Basile, Santina, additional, Ciancia, Giuseppe, additional, Pettinato, Guido, additional, Pane, Fabrizio, additional, de Rosa, Gennaro, additional, Del Vecchio, Luigi, additional, and Risitano, Antonio M., additional

Published
2012
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20. Long-Lasting Bone Damage Detected by Dual-Energy X-Ray Absorptiometry, Phalangeal Osteosonogrammetry, andin VitroGrowth of Marrow Stromal Cells after Allogeneic Stem Cell Transplantation

Author

Tauchmanovà, Libuse, primary, Serio, Bianca, additional, Del Puente, Antonio, additional, Risitano, Antonio Maria, additional, Esposito, Antonella, additional, De Rosa, Gennaro, additional, Lombardi, Gaetano, additional, Colao, Annamaria, additional, Rotoli, Bruno, additional, and Selleri, Carmine, additional

Published
2002
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48. Colchicine in Athero-Thrombosis: Molecular Mechanisms and Clinical Evidence

Author

Giovanni Cimmino, Francesco S. Loffredo, Gennaro De Rosa, Plinio Cirillo, Cimmino, G., Loffredo, F. S., De Rosa, G., Cirillo, P., Cimmino, Giovanni, Loffredo, Francesco S, De Rosa, Gennaro, and Cirillo, Plinio

Subjects
Inorganic Chemistry, cardiovascular disease, inflammation, Organic Chemistry, General Medicine, Physical and Theoretical Chemistry, Molecular Biology, Spectroscopy, Catalysis, colchicine, Computer Science Applications
Abstract

Several lines of evidence have clearly indicated that inflammation plays a pivotal role in the development of atherosclerosis and of its thrombotic complications such as acute coronary syndromes or ischemic stroke. Thus, it has been postulated that the use of anti-inflammatory agents might be extremely useful to improve cardiovascular outcome. Recently, increasing attention has been reserved to one of the oldest plant-derived drugs still in use in clinical practice, colchicine that has been used as drug to treat inflammatory diseases such gout or Mediterranean fever. To date, current guidelines of the European Society of Cardiology have included colchicine as first line choice for treatment of acute and recurrent pericarditis. Moreover, several studies have investigated its role in the clinical scenarios of cardiovascular disease including chronic and acute coronary syndromes with promising results. In this review, starting from a description of the mechanism(s) involved behind its anti-inflammatory effects, we give an overview on its potential effects in atherothrombosis and finally present an updated overview of clinical evidence on the role of this drug in cardiovascular disease.

Published
2023

49. Tc99m-sestaMIBI uptake in nonsecretory multiple myeloma

Author

Lucio Catalano, Barbara Salvatore, Silvana Del Vecchio, Maria Teresa Buonanno, Gennaro De Rosa, Bruno Rotoli, Claudia Andretta, Leonardo Pace, Gaetano Paone, Catalano, L, Andretta, C, Pace, L, DEL VECCHIO, Silvana, Salvatore, B, De Rosa, G, Buonanno, Mt, Paone, G, Rotoli, B., Del Vecchio, S, and DE ROSA, Gennaro

Subjects
Male, Technetium Tc 99m Sestamibi, medicine.diagnostic_test, business.industry, conventional imaging, Hematology, Middle Aged, Scintigraphy, medicine.disease, Tc99m Sestamibi, Tc99m-sestaMIBI scintigraphy, Monoclonal component, Radiography, medicine, Humans, Female, Radiopharmaceuticals, Multiple Myeloma, Radionuclide Imaging, Nonsecretory multiple myeloma, Nuclear medicine, business, Multiple myeloma, Aged, Monitoring, Physiologic
Abstract

Staging and monitoring of multiple myeloma (MM) is mainly based on monoclonal component quantification; the absence of such a parameter renders difficult follow up of patients with nonsecretory MM (nsMM). In this study our aims were to determine the specificity and sensitivity of Tc99m-sestaMIBI scintigraphy at diagnosis and during follow up of nsMM patients. Nine nsMM patients were prospectively studied at diagnosis and during treatment for a mean time of 33 months (range: 12 - 65 þ ). Tc99m-sestaMIBI (MIBI) scintigraphy was compared to conventional imaging (CI: X ray with CAT or NMR details) at diagnosis and during follow up. At diagnosis, CI and MIBI were concordant in three patients; CI showed more focal lesions than MIBI in four patients, while MIBI revealed more focal lesions than CI in two patients. During the follow up, MIBI uptake was normal in the four patients who achieved remission. Five patients did not achieve remission: CI and MIBI were concordant in three, while MIBI was falsely negative in two patients. In conclusion, Tc99m-sestaMIBI scintigraphy has high sensitivity (no false positive cases) and 78% specificity (2/9 false negative cases) in tracing active nsMM lesions; it should be considered complementary to CI for monitoring this rare disease.

Published
2005

50. Clinical relevance of intrahepatic hepatitis B virus DNA in HBsAg-negative HBcAb-positive patients undergoing hematopoietic stem cell transplantation for hematological malignancies

Author

Bruno Rotoli, Gennaro De Rosa, Pietro Muretto, Marco Picardi, Fabrizio Pane, Carmine Selleri, Picardi, Marco, DE ROSA, Gennaro, Selleri, Carmine, Pane, Fabrizio, Rotoli, Bruno, and P. M. u. r. e. t. t., O.

Subjects
Male, Transplantation, Hepatitis B virus, Hepatitis B Surface Antigens, business.industry, medicine.medical_treatment, Hematopoietic Stem Cell Transplantation, Hepatitis B virus DNA, Hematopoietic stem cell transplantation, Hepatitis B, Hbsag negative, Liver, Hematologic Neoplasms, Immunology, DNA, Viral, Hepatocytes, Medicine, Humans, Clinical significance, Female, Hepatitis B Antibodies, business
Abstract

Hepatitis flare-up due to hepatitis B virus (HBV) is a well-recognized complication associated with chemotherapy. Data on the clinical impact of HBV DNA in liver tissue of HB-surface antigen (sAg)-negative patients undergoing immunosuppression are scanty.

Published
2006

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