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1. LE SUTURATRICI A COMPRESSIONE

Author

Rebuffat C, Fumagalli U, Montorsi M, Roviaro GC, Salvaneschi S, Pezzuoli G., ROSATI , RICCARDO, Rebuffat, C, Rosati, Riccardo, Fumagalli, U, Montorsi, M, Roviaro, Gc, Salvaneschi, S, and Pezzuoli, G.

Published
1990

2. NON CONTINENT COLOSTOMIES

Author

Rebuffat C, Olivari N, Montorsi M, Fumagalli U, Roviaro GC, ROSATI , RICCARDO, Rebuffat, C, Rosati, Riccardo, Olivari, N, Montorsi, M, Fumagalli, U, and Roviaro, Gc

Published
1990

5. LA RESEZIONE ANTERIORE NEL TRATTAMENTO DEL CANCRO DEL RETTO

Author

Montorsi M, Rebuffat C, Poccobelli M, Fumagalli U, Zago M, Torzilli G, Roviaro GC, ROSATI , RICCARDO, Montorsi, M, Rebuffat, C, Rosati, Riccardo, Poccobelli, M, Fumagalli, U, Zago, M, Torzilli, G, and Roviaro, Gc

Published
1990

6. COMPLICANZE E RISULTATI DOPO DUODENOCEFALO-PANCREASECTOMIA

Author

Montorsi M, Zago M, Spina GP, Roviaro GC, Maruotti RA, Fumagalli U, Pezzuoli G., ROSATI , RICCARDO, Montorsi, M, Zago, M, Spina, Gp, Roviaro, Gc, Maruotti, Ra, Fumagalli, U, Rosati, Riccardo, and Pezzuoli, G.

Published
1990

8. PATHOPHYSIOLOGY OF INTESTINAL ANASTOMOSES

Author

ROSATI , RICCARDO, Rebuffat C, Colombi R, Fumagalli U, Settembrini PG, Roviaro GC, Montorsi M., Rosati, Riccardo, Rebuffat, C, Colombi, R, Fumagalli, U, Settembrini, Pg, Roviaro, Gc, and Montorsi, M.

Published
1988

11. IL CARCINOIDE TIMICO: OSSERVAZIONE DI UN CASO OPERATO

Author

Mariani C, Varoli F, Grignani F, Fumagalli U, Colombi R, Fascianella A, Roviaro GC, ROSATI , RICCARDO, Mariani, C, Varoli, F, Grignani, F, Rosati, Riccardo, Fumagalli, U, Colombi, R, Fascianella, A, and Roviaro, Gc

Published
1987

14. ANASTOMOSES CIRCULAIRES PAR COMPRESSION: UNE NOUVELLE PINCE MECHANIQUE

Author

Pezzuoli G, Rebuffat C, Settembrini PG, Roviaro GC, Montorsi M, Bona S, Fumagalli U, Maciocco M, Poccobelli M, Zago M., ROSATI , RICCARDO, Pezzuoli, G, Rebuffat, C, Rosati, Riccardo, Settembrini, Pg, Roviaro, Gc, Montorsi, M, Bona, S, Fumagalli, U, Maciocco, M, Poccobelli, M, and Zago, M.

Published
1988

21. FATTORI PROGNOSTICI NEL CANCRO GASTRICO

Author

Roviaro GC, Montorsi M, Fumagalli U, Varoli F, Olivari N, Bona S., ROSATI , RICCARDO, Roviaro, Gc, Montorsi, M, Fumagalli, U, Rosati, Riccardo, Varoli, F, Olivari, N, and Bona, S.

Published
1986

26. COMPLICANZE DELLA MEDIASTINOSCOPIA

Author

Roviaro GC, Varoli F, Fascianella A, Cosentino F, Mariani C, Settembrini PG, ROSATI , RICCARDO, Roviaro, Gc, Varoli, F, Fascianella, A, Cosentino, F, Mariani, C, Rosati, Riccardo, and Settembrini, Pg

Published
1982

29. COMPRESSION ANASTOMOSES IN SURGERY OF THE RECTUM

Author

Rebuffat C, Montorsi M, Fumagalli U, Maciocco M, Bona S, Roviaro GC, ROSATI , RICCARDO, Rebuffat, C, Rosati, Riccardo, Montorsi, M, Fumagalli, U, Maciocco, M, Bona, S, and Roviaro, Gc

Published
1988

30. LA RIABILITAZIONE DEL COLOSTOMIZZATO

Author

Rebuffat C, Annibali R, Poccobelli M, Varoli F, Roviaro GC, ROSATI , RICCARDO, Rebuffat, C, Annibali, R, Poccobelli, M, Rosati, Riccardo, Varoli, F, and Roviaro, Gc

Published
1986

34. Clinical and immunological study of 150 cases of adenocarcinoma of the lung

Author

Pezzuoli G, Roviaro GC, Varoli F, Maruotti RA, Sartori F, Calabrò F., ZANNINI , PIERO, Pezzuoli, G, Roviaro, Gc, Varoli, F, Maruotti, Ra, Zannini, Piero, Sartori, F, and Calabrò, F.

Subjects
Adult, Male, Immunity, Cellular, Lung Neoplasms, Humans, Female, Adenocarcinoma, Middle Aged, Aged, Retrospective Studies
Abstract

An in-depth retrospective statistical analysis was performed on 150 consecutive cases of adenocarcinoma of the lung. One-hundred and twenty-eight patients (85%) underwent pulmonary resection; 15 (10%) had an explorative thoracotomy and 7 (5%) were considered inoperable. At the time of operation, 72 patients were classified as Stage I, 18 as Stage II and 50 as Stage III. Factors analyzed included age, sex, surgical treatment, staging, immunologic monitoring and survival. When compared with other histotypes of our series a statistically significant difference was found in the male: female ratio (p less than 0.05), surgical resectability (p less than 0.05), frequency of Stage I, and immunologic status evaluated by studies of delayed hypersensitivity skin tests, lymphocyte blastogenesis, antibody dependent cellular cytotoxicity (ADCC), blocking serum factors and intrastromal peritumoral lymphocyte infiltration. There were no significant differences due to age, cigarette smoking, mediastinal lymph node involvement, except for small oat-cell carcinoma or previous pulmonary diseases. In all stages, the five-year survival rate was lower for patients affected with adenocarcinoma than for those affected with other histological types, except small oat-cell carcinoma.

Published
1981

36. Does lobectomy for lung cancer in patients with chronic obstructive pulmonary disease affect lung function? A multicenter national study

Author

Federico Rea, Mario Nosotti, Sergio Harari, N. Bellaviti, Piero Zannini, G.C. Roviaro, Federico Venuta, Angelo Carretta, Maurizio Pavanello, Claudio Schiraldi, Daniele Diso, Alberto Durigato, Sergio Baldi, Enrico Ruffini, Baldi, S, Ruffini, E, Harari, S, Roviaro, Gc, Nosotti, M, Bellaviti, N, Venuta, F, Diso, D, Rea, F, Schiraldi, C, Durigato, A, Pavanello, M, Carretta, A, and Zannini, P

Subjects
Male, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Vital capacity, Lung Neoplasms, medicine.medical_treatment, Vital Capacity, Pulmonary function testing, FEV1/FVC ratio, Pneumonectomy, Pulmonary Disease, Chronic Obstructive, Functional residual capacity, Internal medicine, Forced Expiratory Volume, medicine, Humans, lobectomy, pulmonary function, chronic obstructive pulmonary disease, Aged, Retrospective Studies, COPD, Lung, business.industry, Respiratory disease, respiratory system, medicine.disease, respiratory tract diseases, Surgery, medicine.anatomical_structure, Cardiology, Female, business, Cardiology and Cardiovascular Medicine, circulatory and respiratory physiology
Abstract

Objective: The purpose of this study was to evaluate the effect of lobectomy on pulmonary function in patients with chronic obstructive pulmonary disease. Methods: One hundred thirty-seven patients were analyzed; 49 had normal pulmonary function tests, and 88 had chronic obstructive pulmonary disease. Different functional parameter groups were identified: obstructive (forced expiratory volume in 1 second [FEV1], forced expiratory volume in 1 second/forced vital capacity [FEV1/FVC), and chronic obstructive pulmonary disease index), hyperinflation (residual volume and functional residual capacity), and diffusion (transfer factor of the lung for carbon monoxide). Also, the ratio between observed and predicted postoperative FEV, was calculated. Results: In patients with preoperative FEV, greater than 80% of predicted, postoperative FEV1/FVC slightly but not significantly decreased, and postoperative FEV, significantly decreased. In patients with preoperative FEV1 less than 65%, postoperative FEV, and FEV1/FVC significantly increased. In patients with preoperative FEV1/FVC greater than 70%, postoperative FEV, and FEV1/FVC significantly decreased. In patients with preoperative FEV1/FVC less than 70%, postoperative FEV1/FVC increased, and FEV1 remained unchanged. In patients with a chronic obstructive pulmonary disease index greater than 1.5, postoperative FEV1 and FEV1/FVC significantly decreased, whereas in patients with a chronic obstructive pulmonary disease index less than 1.5, postoperative FEV1/FVC significantly increased and FEV1 remained unchanged. In patients with residual volume and functional residual capacity greater than 115% and transfer factor of the lung for carbon monoxide less than 80% of predicted, postoperative FEV1 diminished less (not significant) compared with patients who had residual volume and functional residual capacity less than 115% (P = .0001). Observed postoperative/predicted postoperative FEV1 was higher if FEV1/FVC was less than 55% (1.46), if FEV1 was less than 80% of predicted (1.21), or if the chronic obstructive pulmonary disease index was less than 1.5 (1.17). Conclusions: Patients with mild to severe chronic obstructive pulmonary disease could have a better late preservation of pulmonary function after lobectomy than healthy patients. Objective: The purpose of this study was to evaluate the effect of lobectomy onpulmonary function in patients with chronic obstructive pulmonary disease.Methods: One hundred thirty-seven patients were analyzed; 49 had normal pulmonaryfunction tests, and 88 had chronic obstructive pulmonary disease. Differentfunctional parameter groups were identified: obstructive (forced expiratory volumein 1 second [FEV1], forced expiratory volume in 1 second/forced vital capacity[FEV1/FVC], and chronic obstructive pulmonary disease index), hyperinflation(residual volume and functional residual capacity), and diffusion (transfer factor ofthe lung for carbon monoxide). Also, the ratio between observed and predictedpostoperative FEV1 was calculated.Results: In patients with preoperative FEV1 greater than 80% of predicted, postoperativeFEV1/FVC slightly but not significantly decreased, and postoperative FEV1significantly decreased. In patients with preoperative FEV1 less than 65%, postoperativeFEV1 and FEV1/FVC significantly increased. In patients with preoperativeFEV1/FVC greater than 70%, postoperative FEV1 and FEV1/FVC significantlydecreased. In patients with preoperative FEV1/FVC less than 70%, postoperativeFEV1/FVC increased, and FEV1 remained unchanged. In patients with a chronicobstructive pulmonary disease index greater than 1.5, postoperative FEV1 andFEV1/FVC significantly decreased, whereas in patients with a chronic obstructivepulmonary disease index less than 1.5, postoperative FEV1/FVC significantly increasedand FEV1 remained unchanged. In patients with residual volume andfunctional residual capacity greater than 115% and transfer factor of the lung forcarbon monoxide less than 80% of predicted, postoperative FEV1 diminished less(not significant) compared with patients who had residual volume and functionalresidual capacity less than 115% (P .0001). Observed postoperative/predictedpostoperative FEV1 was higher if FEV1/FVC was less than 55% (1.46), if FEV1 wasless than 80% of predicted (1.21), or if the chronic obstructive pulmonary diseaseindex was less than 1.5 (1.17).Conclusions: Patients with mild to severe chronic obstructive pulmonary diseasecould have a better late preservation of pulmonary function after lobectomy thanhealthy patients.

Published
2005
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37. Lung cancer in the young

Author

G.C. Roviaro, Giuseppe Pezzuoli, Piero Zannini, Federico Varoli, A. Fascianella, Roviaro, Gc, Varoli, F, Zannini, Piero, Fascianella, A, and Pezzuoli, G.

Subjects
Pulmonary and Respiratory Medicine, Adult, Male, medicine.medical_specialty, Lung Neoplasms, Disease, Adenocarcinoma, Critical Care and Intensive Care Medicine, Survival data, Older patients, Internal medicine, medicine, Humans, Carcinoma, Small Cell, Lung cancer, Retrospective Studies, business.industry, Significant difference, Age Factors, Retrospective cohort study, Middle Aged, medicine.disease, Surgery, Carcinoma, Squamous Cell, Female, Young group, Cardiology and Cardiovascular Medicine, business
Abstract

A long-term retrospective study was carried out on 1,514 cases of lung cancer to assess whether the disease presents substantial differences in young as compared to older patients. Clinical, epidemiologic, surgical, and survival data were evaluated in all cases. A young group under 45 years of age was studied separately and compared with the remaining older patients. In contrast with the literature, our results showed no percentage increase or variation in the male/female ratio of lung cancer in the young group. No significant difference was found regarding clinical picture, operability, histotype, and prognosis.

Published
1985

38. Gene expression analysis of early and advanced gastric cancers.

Author

Vecchi M, Nuciforo P, Romagnoli S, Confalonieri S, Pellegrini C, Serio G, Quarto M, Capra M, Roviaro GC, Contessini Avesani E, Corsi C, Coggi G, Di Fiore PP, and Bosari S

Subjects
Cell Differentiation genetics, Cell Proliferation, Disease Progression, Follow-Up Studies, Humans, Oligonucleotide Array Sequence Analysis, Severity of Illness Index, Stomach Neoplasms classification, Stomach Neoplasms metabolism, Biomarkers, Tumor biosynthesis, Biomarkers, Tumor genetics, Gene Expression Profiling, Stomach Neoplasms genetics, Stomach Neoplasms pathology
Abstract

Gastric carcinoma is one of the major causes of cancer mortality worldwide. Early detection results in excellent prognosis for patients with early cancer (EGC), whereas the prognosis of advanced cancer (AGC) patients remains poor. It is not clear whether EGC and AGC are molecularly distinct, and whether they represent progressive stages of the same tumor or different entities ab initio. Gene expression profiles of EGC and AGC were determined by Affymetrix technology and quantitative polymerase chain reaction. Representative regulated genes were further analysed by in situ hybridization (ISH) on tissue microarrays. Expression analysis allowed the identification of a signature that differentiates AGC from EGC. In addition, comparison with normal gastric mucosa indicated that the majority of alterations associated with EGC are retained in AGC, and that further expression changes mark the transition from EGC to AGC. Finally, ISH analysis showed that representative genes, differentially expressed in the invasive areas of EGC and AGC, are not differentially expressed in the non-invasive areas of the same tumors. Our data are more directly compatible with a progression model of gastric carcinogenesis, whereby EGC and AGC may represent different molecular stages of the same tumor. Finally, the identification of an AGC-specific signature might help devising novel therapeutic strategies for advanced gastric cancer.

Published
2007
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39. Can routine laparoscopy help to reduce the rate of explorative laparotomies for gastric cancer? Laparoscopy in gastric cancer.

Author

Roviaro GC, Varoli F, Sonnino D, Nucca O, Rabughino G, and Scarduelli A

Abstract

1. Background We developed this surgical protocol about performing intraoperative laparoscopy for staging in every patient affected by stomach cancer. Sensitivity and specificity of intraoperative laparoscopy are compared with conventional preoperative staging techniques.2. Methods From January 1994 to June 1999, 83 patients affected by stomach cancer were accepted in our department: 12 patients (14.5%) were excluded from our study after the preoperative staging; in 71 patients (85.5%) an explorative laparoscopy as the first step of the operation was performed.3. Results Laparoscopy confirmed preoperative staging in 53 cases (74.6%), in 12 patients demonstrated an overstaging. Laparoscopy demonstrated in 6 patients unsuspected causes of unresectability.4. Conclusions When performed in patients affected by malignant neoplasm and declared resectable, intraoperative laparoscopy can demonstrate conditions not detectable by traditional preoperative investigations, consequently reducing to zero explorative laparotomies.

Published
2000
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40. Videothoracoscopic treatment of oesophageal leiomyoma.

Author

Roviaro GC, Maciocco M, Varoli F, Rebuffat C, Vergani C, and Scarduelli A

Subjects
Adolescent, Adult, Aged, Female, Humans, Male, Middle Aged, Video Recording, Endoscopy, Esophageal Neoplasms surgery, Leiomyoma surgery, Thoracoscopy
Abstract

Background: Oesophageal leiomyomas are usually so easily removed that thoracotomy seems out of proportion and thoracoscopic removal is therefore highly desirable., Methods: Out of a total of 1003 thoracoscopic operations undertaken between July 1991 and December 1996, seven patients underwent thoracoscopic removal of oesophageal leiomyoma. All of them had been preoperatively studied by oesophagogastroscopy and computed tomographic scanning of the chest which had confirmed the presence of a lesion with benign features. The surgical technique required intubation with a double lumen tube. Operative access was gained through the right chest via three ports and a small utility thoracotomy in the inframammary sulcus. The mean operating time was 120 minutes., Results: Conversion to open thoracotomy was necessary in one case with a very large horseshoe-shaped leiomyoma which was firmly adherent. The mean postoperative hospital stay was seven days. No intraoperative deaths or postoperative complications occurred., Conclusions: The simplicity and safety of the thoracoscopic approach, combined with reduced surgical trauma and postoperative pain and functional and cosmetic advantages, make this technique the approach of choice for the removal of oesophageal leiomyomas.

Published
1998
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41. Tracheal sleeve pneumonectomy for bronchogenic carcinoma.

Author

Roviaro GC, Varoli F, Rebuffat C, Scalambra SM, Vergani C, Sibilla E, Palmarini L, and Pezzuoli G

Subjects
Adult, Aged, Carcinoma, Bronchogenic mortality, Carcinoma, Bronchogenic secondary, Humans, Lung Neoplasms mortality, Middle Aged, Neoplasm Recurrence, Local, Postoperative Complications, Survival Rate, Carcinoma, Bronchogenic surgery, Lung Neoplasms surgery, Pneumonectomy methods
Abstract

For a long time, primary tumors arising less than 2 cm distal to the carina have presented a contraindication to surgical excision. Tracheal sleeve pneumonectomy technique allows carinal resection and reconstruction but still carries considerable postoperative complications. From 1983 to 1992 we performed 27 right tracheal sleeve pneumonectomies and one left. Fourteen patients had N0 nodes, nine had N1, and five had N2. No anastomotic complications, either fistula or stenosis, were observed. Successful outcome depends on meticulous attention to surgical details and careful anaesthetic management with a new ventilation tube. One patient died on the twenty-second postoperative day from myocardial infarction. Complications included pneumonia (one), vocal cord paresis (two), and pleural empyema without bronchial fistula (one). Conservative treatment allowed complete recovery from all complications. There are seven patients alive at 4 years after operation and one at 5 years. Six patients have been disease-free for between 1 and 32 months. Two patients died free of disease at 13 and 42 months. Two patients died of mediastinal recurrence and 10 of distant metastases within 6 and 54 months.

Published
1994

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