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1. Immunohistochemical features of the bone tissue of the lower extremities in patients with type 2 diabetes mellitus

Author

A. Yu. Tokmakova, E. A. Kogan, E. L. Zaitseva, S. A. Demura, N. V. Zharkov, M. M. Kalandiya, and G. R. Galstyan

Subjects
type 2 diabetes, diabetic foot, neuroosteoarthropathy, markers, bone metabolism, morphology, immunohistochemistry, age, Nutritional diseases. Deficiency diseases, RC620-627
Abstract

Background: Diabetic neuroosteoarthropathy is a serious disabling complication of diabetes mellitus, which, in the absence of timely correct treatment, can lead to high amputations of the affected limb. At present, the reasons and mechanism of the development of Charcot’s foot are not completely clear. It is extremely important to determine the pathophysiological mechanisms of DNOAP formation and to search for reliable markers-predictors of this pathology.Aim: To study the immunohistochemical characteristics of the bone tissue of the lower extremities in patients with diabetic neuroosteoarthropathy in comparison with patients with diabetes mellitus without this pathology.Materials and methods: During the foot surgery, a bone fragment of the foot was harvested for immunohistochemical study of receptor markers for PINP, PIIINP, and RAGE in the group of patients with DNOAP compared with the control group.Results: The study included 20 patients with type 2 diabetes mellitus and were divided into 2 groups: 10 patients with DNOAP made up group 1, 10 patients without DNOAP — group 2.Patients in both groups were comparable in AGE, experience with type 2 diabetes, and glycemic control.During the immunohistochemical study, a significant increase in the staining intensity of receptor markers for PINP, PIIINP, and AGE was recorded in the group of patients with DNOAP compared with the control group (p

Published
2022
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2. PATHOLOGICAL ANATOMY OF INFECTION CAUSED BY SARS-COV-2

Author

E. A. Kogan, Yu. S. Berezovsky, D. D. Protsenko, T. R. Bagdasaryan, E. M. Gretsov, S. A. Demura, G. A. Demyashkin, D. V. Kalinin, A. D. Kukleva, E. V. Kurilina, T. P. Nekrasova, N. B. Paramonova, A. B. Ponomarev, S. G. Radenska-Lopovok, L. A. Semyonova, and A. S. Tertychny

Subjects
0301 basic medicine, Pathology, medicine.medical_specialty, etiology, Autopsy, Disease, 030204 cardiovascular system & hematology, Pathology and Forensic Medicine, Sepsis, Pathogenesis, Other systems of medicine, 03 medical and health sciences, covid-19 infection, 0302 clinical medicine, medicine, Pathological, business.industry, pathogenesis, medicine.disease, Pathological anatomy, pathological anatomy, 030104 developmental biology, Shock (circulatory), Etiology, Anatomy, medicine.symptom, business, Law, RZ201-999
Abstract

Autopsy data from 80 patients who died of the COVID-19 infection were analysed. Using macro- and microscopic studies, specific features of pathological processes in various organs were identified. The obtained experimental data, along with information from literature sources, allowed conclusions to be drawn about the mechanisms of damaging internal organs and body systems, as well as assumptions to be made about individual links in the pathogenesis of COVID-19. The thanatogenesis of the disease and the main causes of death are discussed, including acute cardiopulmonary failure, acute renal failure, pulmonary thromboembolism, shock involving multiple organ failure and sepsis. The critical importance of autopsy is emphasized, which provides valuable information on the morphological substrate for this infection closely associated with possible clinical manifestations.

Published
2020
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