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7. Recording, analysis, and interpretation of spreading depolarizations in neurointensive care: Review and recommendations of the COSBID research group

Author

Dreier, Jens P, Fabricius, Martin, Ayata, Cenk, Sakowitz, Oliver W, William Shuttleworth, C, Dohmen, Christian, Graf, Rudolf, Vajkoczy, Peter, Helbok, Raimund, Suzuki, Michiyasu, Schiefecker, Alois J, Major, Sebastian, Winkler, Maren KL, Kang, Eun-Jeung, Milakara, Denny, Oliveira-Ferreira, Ana I, Reiffurth, Clemens, Revankar, Gajanan S, Sugimoto, Kazutaka, Dengler, Nora F, Hecht, Nils, Foreman, Brandon, Feyen, Bart, Kondziella, Daniel, Friberg, Christian K, Piilgaard, Henning, Rosenthal, Eric S, Westover, M Brandon, Maslarova, Anna, Santos, Edgar, Hertle, Daniel, Sánchez-Porras, Renán, Jewell, Sharon L, Balança, Baptiste, Platz, Johannes, Hinzman, Jason M, Lückl, Janos, Schoknecht, Karl, Schöll, Michael, Drenckhahn, Christoph, Feuerstein, Delphine, Eriksen, Nina, Horst, Viktor, Bretz, Julia S, Jahnke, Paul, Scheel, Michael, Bohner, Georg, Rostrup, Egill, Pakkenberg, Bente, Heinemann, Uwe, Claassen, Jan, Carlson, Andrew P, Kowoll, Christina M, Lublinsky, Svetlana, Chassidim, Yoash, Shelef, Ilan, Friedman, Alon, Brinker, Gerrit, Reiner, Michael, Kirov, Sergei A, Andrew, R David, Farkas, Eszter, Güresir, Erdem, Vatter, Hartmut, Chung, Lee S, Brennan, KC, Lieutaud, Thomas, Marinesco, Stephane, Maas, Andrew IR, Sahuquillo, Juan, Dahlem, Markus A, Richter, Frank, Herreras, Oscar, Boutelle, Martyn G, Okonkwo, David O, Bullock, M Ross, Witte, Otto W, Martus, Peter, van den Maagdenberg, Arn MJM, Ferrari, Michel D, Dijkhuizen, Rick M, Shutter, Lori A, Andaluz, Norberto, Schulte, André P, MacVicar, Brian, Watanabe, Tomas, Woitzik, Johannes, Lauritzen, Martin, Strong, Anthony J, and Hartings, Jed A

Published
2017
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8. Early supplemental parenteral nutrition for the achievement of nutritional goals in subarachnoid hemorrhage patients: An observational cohort study

Author

Kofler, Mario, primary, Beer, Ronny, additional, Marinoni, Stephanie, additional, Schiefecker, Alois J., additional, Gaasch, Maxime, additional, Rass, Verena, additional, Lindner, Anna, additional, Lanosi, Bogdan A., additional, Rhomberg, Paul, additional, Pfausler, Bettina, additional, Thomé, Claudius, additional, Stover, John F., additional, Schmutzhard, Erich, additional, and Helbok, Raimund, additional

Published
2022
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9. Additional file 1 of The effect of the volemic and cardiac status on brain oxygenation in patients with subarachnoid hemorrhage: a bi-center cohort study

Author

Rass, Verena, Bogossian, Elisa Gouvea, Ianosi, Bogdan-Andrei, Peluso, Lorenzo, Kofler, Mario, Lindner, Anna, Schiefecker, Alois J., Putnina, Lauma, Gaasch, Max, Hackl, Werner O., Beer, Ronny, Pfausler, Bettina, Taccone, Fabio Silvio, and Helbok, Raimund

Abstract

Additional file 1: Figure S1. Institutional protocol to treat brain tissue hypoxia in IBK. Figure S2. Institutional protocol to treat brain tissue hypoxia in BRU. Table S1. Baseline characteristics, complications, and outcomes stratified by the two study sites. Table S2. Association between CI and PbtO2 (GEE model). Table S3. Changes of variables pre, during, and post fluid administration in a total of 198 infusions stratified by brain tissue hypoxia vs. normal brain tissue oxygenation at baseline. Table S4. Changes of variables pre, during, and post fluid administration in a total of 198 infusions stratified by CI responders and non-responders. Table S5. Changes of variables pre, during, and post fluid administration in a total of 198 infusions stratified by crystalloids vs colloids.

Published
2021
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10. Brain temperature regulation in poor-grade subarachnoid hemorrhage patients – A multimodal neuromonitoring study

Author

Addis, Alberto, primary, Gaasch, Maxime, additional, Schiefecker, Alois J, additional, Kofler, Mario, additional, Ianosi, Bogdan, additional, Rass, Verena, additional, Lindner, Anna, additional, Broessner, Gregor, additional, Beer, Ronny, additional, Pfausler, Bettina, additional, Thomé, Claudius, additional, Schmutzhard, Erich, additional, and Helbok, Raimund, additional

Published
2020
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11. Early Predictors for Infectious Complications in Patients With Spontaneous Intracerebral Hemorrhage and Their Impact on Outcome

Author

Lindner, Anna, primary, Kofler, Mario, additional, Rass, Verena, additional, Ianosi, Bogdan, additional, Gaasch, Max, additional, Schiefecker, Alois J., additional, Beer, Ronny, additional, Loveys, Sebastian, additional, Rhomberg, Paul, additional, Pfausler, Bettina, additional, Thomé, Claudius, additional, Schmutzhard, Erich, additional, and Helbok, Raimund, additional

Published
2019
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12. Recording, analysis, and interpretation of spreading depolarizations in neurointensive care: Review and recommendations of the COSBID research group

Author

Dreier, Jens P., Fabricius, Martin, Ayata, Cenk, Sakowitz, Oliver W., Shuttleworth, C. William, Dohmen, Christian, Graf, Rudolf, Vajkoczy, Peter, Helbok, Raimund, Suzuki, Michiyasu, Schiefecker, Alois J., Major, Sebastian, Winkler, Maren K. L., Kang, Eun-Jeung, Milakara, Denny, Oliveira-Ferreira, Ana I., Reiffurth, Clemens, Revankar, Gajanan S., Sugimoto, Kazutaka, Dengler, Nora F., Hecht, Nils, Foreman, Brandon, Feyen, Bart, Kondziella, Daniel, Friberg, Christian K., Piilgaard, Henning, Rosenthal, Eric S., Westover, M. Brandon, Maslarova, Anna, Santos, Edgar, Hertle, Daniel, Sanchez-Porras, Renan, Jewell, Sharon L., Balanca, Baptiste, Platz, Johannes, Hinzman, Jason M., Lueckl, Janos, Schoknecht, Karl, Schoell, Michael, Drenckhahn, Christoph, Feuerstein, Delphine, Eriksen, Nina, Horst, Viktor, Bretz, Julia S., Jahnke, Paul, Scheel, Michael, Bohner, Georg, Rostrup, Egill, Pakkenberg, Bente, Heinemann, Uwe, Claassen, Jan, Carlson, Andrew P., Kowoll, Christina M., Lublinsky, Svetlana, Chassidim, Yoash, Shelef, Ilan, Friedman, Alon, Brinker, Gerrit, Reiner, Michael, Kirov, Sergei A., Andrew, R. David, Farkas, Eszter, Gueresir, Erdem, Vatter, Hartmut, Chung, Lee S., Brennan, K. C., Lieutaud, Thomas, Marinesco, Stephane, Maas, Andrew I. R., Sahuquillo, Juan, Dahlem, Markus A., Richter, Frank, Herreras, Oscar, Boutelle, Martyn G., Okonkwo, David O., Bullock, M. Ross, Witte, Otto W., Martus, Peter, van den Maagdenberg, Arn M. J. M., Ferrari, Michel D., Dijkhuizen, Rick M., Shutter, Lori A., Andaluz, Norberto, Schulte, Andre P., MacVicar, Brian, Watanabe, Tomas, Woitzik, Johannes, Lauritzen, Martin, Strong, Anthony J., Hartings, Jed A., Dreier, Jens P., Fabricius, Martin, Ayata, Cenk, Sakowitz, Oliver W., Shuttleworth, C. William, Dohmen, Christian, Graf, Rudolf, Vajkoczy, Peter, Helbok, Raimund, Suzuki, Michiyasu, Schiefecker, Alois J., Major, Sebastian, Winkler, Maren K. L., Kang, Eun-Jeung, Milakara, Denny, Oliveira-Ferreira, Ana I., Reiffurth, Clemens, Revankar, Gajanan S., Sugimoto, Kazutaka, Dengler, Nora F., Hecht, Nils, Foreman, Brandon, Feyen, Bart, Kondziella, Daniel, Friberg, Christian K., Piilgaard, Henning, Rosenthal, Eric S., Westover, M. Brandon, Maslarova, Anna, Santos, Edgar, Hertle, Daniel, Sanchez-Porras, Renan, Jewell, Sharon L., Balanca, Baptiste, Platz, Johannes, Hinzman, Jason M., Lueckl, Janos, Schoknecht, Karl, Schoell, Michael, Drenckhahn, Christoph, Feuerstein, Delphine, Eriksen, Nina, Horst, Viktor, Bretz, Julia S., Jahnke, Paul, Scheel, Michael, Bohner, Georg, Rostrup, Egill, Pakkenberg, Bente, Heinemann, Uwe, Claassen, Jan, Carlson, Andrew P., Kowoll, Christina M., Lublinsky, Svetlana, Chassidim, Yoash, Shelef, Ilan, Friedman, Alon, Brinker, Gerrit, Reiner, Michael, Kirov, Sergei A., Andrew, R. David, Farkas, Eszter, Gueresir, Erdem, Vatter, Hartmut, Chung, Lee S., Brennan, K. C., Lieutaud, Thomas, Marinesco, Stephane, Maas, Andrew I. R., Sahuquillo, Juan, Dahlem, Markus A., Richter, Frank, Herreras, Oscar, Boutelle, Martyn G., Okonkwo, David O., Bullock, M. Ross, Witte, Otto W., Martus, Peter, van den Maagdenberg, Arn M. J. M., Ferrari, Michel D., Dijkhuizen, Rick M., Shutter, Lori A., Andaluz, Norberto, Schulte, Andre P., MacVicar, Brian, Watanabe, Tomas, Woitzik, Johannes, Lauritzen, Martin, Strong, Anthony J., and Hartings, Jed A.

Abstract

Spreading depolarizations (SD) are waves of abrupt, near-complete breakdown of neuronal transmembrane ion gradients, are the largest possible pathophysiologic disruption of viable cerebral gray matter, and are a crucial mechanism of lesion development. Spreading depolarizations are increasingly recorded during multimodal neuromonitoring in neuro-critical care as a causal biomarker providing a diagnostic summary measure of metabolic failure and excitotoxic injury. Focal ischemia causes spreading depolarization within minutes. Further spreading depolarizations arise for hours to days due to energy supply-demand mismatch in viable tissue. Spreading depolarizations exacerbate neuronal injury through prolonged ionic breakdown and spreading depolarization-related hypoperfusion (spreading ischemia). Local duration of the depolarization indicates local tissue energy status and risk of injury. Regional electrocorticographic monitoring affords even remote detection of injury because spreading depolarizations propagate widely from ischemic or metabolically stressed zones; characteristic patterns, including temporal clusters of spreading depolarizations and persistent depression of spontaneous cortical activity, can be recognized and quantified. Here, we describe the experimental basis for interpreting these patterns and illustrate their translation to human disease. We further provide consensus recommendations for electrocorticographic methods to record, classify, and score spreading depolarizations and associated spreading depressions. These methods offer distinct advantages over other neuromonitoring modalities and allow for future refinement through less invasive and more automated approaches.

Published
2017

13. Recording, analysis, and interpretation of spreading depolarizations in neurointensive care: Review and recommendations of the COSBID research group

Author

In Vivo NMR ISI, Circulatory Health, Brain, Dreier, Jens P, Fabricius, Martin, Ayata, Cenk, Sakowitz, Oliver W, William Shuttleworth, C, Dohmen, Christian, Graf, Rudolf, Vajkoczy, Peter, Helbok, Raimund, Suzuki, Michiyasu, Schiefecker, Alois J, Major, Sebastian, Winkler, Maren Kl, Kang, Eun-Jeung, Milakara, Denny, Oliveira-Ferreira, Ana I, Reiffurth, Clemens, Revankar, Gajanan S, Sugimoto, Kazutaka, Dengler, Nora F, Hecht, Nils, Foreman, Brandon, Feyen, Bart, Kondziella, Daniel, Friberg, Christian K, Piilgaard, Henning, Rosenthal, Eric S, Westover, M Brandon, Maslarova, Anna, Santos, Edgar, Hertle, Daniel, Sánchez-Porras, Renán, Jewell, Sharon L, Balança, Baptiste, Platz, Johannes, Hinzman, Jason M, Lückl, Janos, Schoknecht, Karl, Schöll, Michael, Drenckhahn, Christoph, Feuerstein, Delphine, Eriksen, Nina, Horst, Viktor, Bretz, Julia S, Jahnke, Paul, Scheel, Michael, Bohner, Georg, Rostrup, Egill, Pakkenberg, Bente, Heinemann, Uwe, Claassen, Jan, Carlson, Andrew P, Kowoll, Christina M, Lublinsky, Svetlana, Chassidim, Yoash, Shelef, Ilan, Friedman, Alon, Brinker, Gerrit, Reiner, Michael, Kirov, Sergei A, Andrew, R David, Farkas, Eszter, Güresir, Erdem, Vatter, Hartmut, Chung, Lee S, Brennan, K C, Lieutaud, Thomas, Marinesco, Stephane, Maas, Andrew Ir, Sahuquillo, Juan, Dahlem, Markus A, Richter, Frank, Herreras, Oscar, Boutelle, Martyn G, Okonkwo, David O, Bullock, M Ross, Witte, Otto W, Martus, Peter, van den Maagdenberg, Arn Mjm, Ferrari, Michel D, Dijkhuizen, Rick M, Shutter, Lori A, Andaluz, Norberto, Schulte, André P, MacVicar, Brian, Watanabe, Tomas, Woitzik, Johannes, Lauritzen, Martin, Strong, Anthony J, Hartings, Jed A, In Vivo NMR ISI, Circulatory Health, Brain, Dreier, Jens P, Fabricius, Martin, Ayata, Cenk, Sakowitz, Oliver W, William Shuttleworth, C, Dohmen, Christian, Graf, Rudolf, Vajkoczy, Peter, Helbok, Raimund, Suzuki, Michiyasu, Schiefecker, Alois J, Major, Sebastian, Winkler, Maren Kl, Kang, Eun-Jeung, Milakara, Denny, Oliveira-Ferreira, Ana I, Reiffurth, Clemens, Revankar, Gajanan S, Sugimoto, Kazutaka, Dengler, Nora F, Hecht, Nils, Foreman, Brandon, Feyen, Bart, Kondziella, Daniel, Friberg, Christian K, Piilgaard, Henning, Rosenthal, Eric S, Westover, M Brandon, Maslarova, Anna, Santos, Edgar, Hertle, Daniel, Sánchez-Porras, Renán, Jewell, Sharon L, Balança, Baptiste, Platz, Johannes, Hinzman, Jason M, Lückl, Janos, Schoknecht, Karl, Schöll, Michael, Drenckhahn, Christoph, Feuerstein, Delphine, Eriksen, Nina, Horst, Viktor, Bretz, Julia S, Jahnke, Paul, Scheel, Michael, Bohner, Georg, Rostrup, Egill, Pakkenberg, Bente, Heinemann, Uwe, Claassen, Jan, Carlson, Andrew P, Kowoll, Christina M, Lublinsky, Svetlana, Chassidim, Yoash, Shelef, Ilan, Friedman, Alon, Brinker, Gerrit, Reiner, Michael, Kirov, Sergei A, Andrew, R David, Farkas, Eszter, Güresir, Erdem, Vatter, Hartmut, Chung, Lee S, Brennan, K C, Lieutaud, Thomas, Marinesco, Stephane, Maas, Andrew Ir, Sahuquillo, Juan, Dahlem, Markus A, Richter, Frank, Herreras, Oscar, Boutelle, Martyn G, Okonkwo, David O, Bullock, M Ross, Witte, Otto W, Martus, Peter, van den Maagdenberg, Arn Mjm, Ferrari, Michel D, Dijkhuizen, Rick M, Shutter, Lori A, Andaluz, Norberto, Schulte, André P, MacVicar, Brian, Watanabe, Tomas, Woitzik, Johannes, Lauritzen, Martin, Strong, Anthony J, and Hartings, Jed A

Published
2017

14. Recording, analysis, and interpretation of spreading depolarizations in neurointensive care:Review and recommendations of the COSBID research group

Author

Dreier, Jens P, Fabricius, Martin, Ayata, Cenk, Sakowitz, Oliver W, William Shuttleworth, C, Dohmen, Christian, Graf, Rudolf, Vajkoczy, Peter, Helbok, Raimund, Suzuki, Michiyasu, Schiefecker, Alois J, Major, Sebastian, Winkler, Maren Kl, Kang, Eun-Jeung, Milakara, Denny, Oliveira-Ferreira, Ana I, Reiffurth, Clemens, Revankar, Gajanan S, Sugimoto, Kazutaka, Dengler, Nora F, Hecht, Nils, Foreman, Brandon, Feyen, Bart, Kondziella, Daniel, Friberg, Christian K, Piilgaard, Henning, Rosenthal, Eric S, Westover, M Brandon, Maslarova, Anna, Santos, Edgar, Hertle, Daniel, Sánchez-Porras, Renán, Jewell, Sharon L, Balança, Baptiste, Platz, Johannes, Hinzman, Jason M, Lückl, Janos, Schoknecht, Karl, Schöll, Michael, Drenckhahn, Christoph, Feuerstein, Delphine, Eriksen, Nina, Horst, Viktor, Bretz, Julia S, Jahnke, Paul, Scheel, Michael, Bohner, Georg, Rostrup, Egill, Pakkenberg, Bente, Heinemann, Uwe, Claassen, Jan, Carlson, Andrew P, Kowoll, Christina M, Lublinsky, Svetlana, Chassidim, Yoash, Shelef, Ilan, Friedman, Alon, Brinker, Gerrit, Reiner, Michael, Kirov, Sergei A, Andrew, R David, Farkas, Eszter, Güresir, Erdem, Vatter, Hartmut, Chung, Lee S, Brennan, K C, Lieutaud, Thomas, Marinesco, Stephane, Maas, Andrew Ir, Sahuquillo, Juan, Dahlem, Markus A, Richter, Frank, Herreras, Oscar, Boutelle, Martyn G, Okonkwo, David O, Bullock, M Ross, Witte, Otto W, Martus, Peter, van den Maagdenberg, Arn Mjm, Ferrari, Michel D, Dijkhuizen, Rick M, Shutter, Lori A, Andaluz, Norberto, Schulte, André P, MacVicar, Brian, Watanabe, Tomas, Woitzik, Johannes, Lauritzen, Martin, Strong, Anthony J, Hartings, Jed A, Dreier, Jens P, Fabricius, Martin, Ayata, Cenk, Sakowitz, Oliver W, William Shuttleworth, C, Dohmen, Christian, Graf, Rudolf, Vajkoczy, Peter, Helbok, Raimund, Suzuki, Michiyasu, Schiefecker, Alois J, Major, Sebastian, Winkler, Maren Kl, Kang, Eun-Jeung, Milakara, Denny, Oliveira-Ferreira, Ana I, Reiffurth, Clemens, Revankar, Gajanan S, Sugimoto, Kazutaka, Dengler, Nora F, Hecht, Nils, Foreman, Brandon, Feyen, Bart, Kondziella, Daniel, Friberg, Christian K, Piilgaard, Henning, Rosenthal, Eric S, Westover, M Brandon, Maslarova, Anna, Santos, Edgar, Hertle, Daniel, Sánchez-Porras, Renán, Jewell, Sharon L, Balança, Baptiste, Platz, Johannes, Hinzman, Jason M, Lückl, Janos, Schoknecht, Karl, Schöll, Michael, Drenckhahn, Christoph, Feuerstein, Delphine, Eriksen, Nina, Horst, Viktor, Bretz, Julia S, Jahnke, Paul, Scheel, Michael, Bohner, Georg, Rostrup, Egill, Pakkenberg, Bente, Heinemann, Uwe, Claassen, Jan, Carlson, Andrew P, Kowoll, Christina M, Lublinsky, Svetlana, Chassidim, Yoash, Shelef, Ilan, Friedman, Alon, Brinker, Gerrit, Reiner, Michael, Kirov, Sergei A, Andrew, R David, Farkas, Eszter, Güresir, Erdem, Vatter, Hartmut, Chung, Lee S, Brennan, K C, Lieutaud, Thomas, Marinesco, Stephane, Maas, Andrew Ir, Sahuquillo, Juan, Dahlem, Markus A, Richter, Frank, Herreras, Oscar, Boutelle, Martyn G, Okonkwo, David O, Bullock, M Ross, Witte, Otto W, Martus, Peter, van den Maagdenberg, Arn Mjm, Ferrari, Michel D, Dijkhuizen, Rick M, Shutter, Lori A, Andaluz, Norberto, Schulte, André P, MacVicar, Brian, Watanabe, Tomas, Woitzik, Johannes, Lauritzen, Martin, Strong, Anthony J, and Hartings, Jed A

Abstract

Spreading depolarizations (SD) are waves of abrupt, near-complete breakdown of neuronal transmembrane ion gradients, are the largest possible pathophysiologic disruption of viable cerebral gray matter, and are a crucial mechanism of lesion development. Spreading depolarizations are increasingly recorded during multimodal neuromonitoring in neurocritical care as a causal biomarker providing a diagnostic summary measure of metabolic failure and excitotoxic injury. Focal ischemia causes spreading depolarization within minutes. Further spreading depolarizations arise for hours to days due to energy supply-demand mismatch in viable tissue. Spreading depolarizations exacerbate neuronal injury through prolonged ionic breakdown and spreading depolarization-related hypoperfusion (spreading ischemia). Local duration of the depolarization indicates local tissue energy status and risk of injury. Regional electrocorticographic monitoring affords even remote detection of injury because spreading depolarizations propagate widely from ischemic or metabolically stressed zones; characteristic patterns, including temporal clusters of spreading depolarizations and persistent depression of spontaneous cortical activity, can be recognized and quantified. Here, we describe the experimental basis for interpreting these patterns and illustrate their translation to human disease. We further provide consensus recommendations for electrocorticographic methods to record, classify, and score spreading depolarizations and associated spreading depressions. These methods offer distinct advantages over other neuromonitoring modalities and allow for future refinement through less invasive and more automated approaches.

Published
2017

15. Brain temperature but not core temperature increases during spreading depolarizations in patients with spontaneous intracerebral hemorrhage

Author

Schiefecker, Alois J, primary, Kofler, Mario, additional, Gaasch, Max, additional, Beer, Ronny, additional, Unterberger, Iris, additional, Pfausler, Bettina, additional, Broessner, Gregor, additional, Lackner, Peter, additional, Rhomberg, Paul, additional, Gizewski, Elke, additional, Hackl, Werner O, additional, Mulino, Miriam, additional, Ortler, Martin, additional, Thome, Claudius, additional, Schmutzhard, Erich, additional, and Helbok, Raimund, additional

Published
2017
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18. Recording, analysis, and interpretation of spreading depolarizations in neurointensive care: Review and recommendations of the COSBID research group

Author

Dreier, Jens P, primary, Fabricius, Martin, additional, Ayata, Cenk, additional, Sakowitz, Oliver W, additional, William Shuttleworth, C, additional, Dohmen, Christian, additional, Graf, Rudolf, additional, Vajkoczy, Peter, additional, Helbok, Raimund, additional, Suzuki, Michiyasu, additional, Schiefecker, Alois J, additional, Major, Sebastian, additional, Winkler, Maren KL, additional, Kang, Eun-Jeung, additional, Milakara, Denny, additional, Oliveira-Ferreira, Ana I, additional, Reiffurth, Clemens, additional, Revankar, Gajanan S, additional, Sugimoto, Kazutaka, additional, Dengler, Nora F, additional, Hecht, Nils, additional, Foreman, Brandon, additional, Feyen, Bart, additional, Kondziella, Daniel, additional, Friberg, Christian K, additional, Piilgaard, Henning, additional, Rosenthal, Eric S, additional, Westover, M Brandon, additional, Maslarova, Anna, additional, Santos, Edgar, additional, Hertle, Daniel, additional, Sánchez-Porras, Renán, additional, Jewell, Sharon L, additional, Balança, Baptiste, additional, Platz, Johannes, additional, Hinzman, Jason M, additional, Lückl, Janos, additional, Schoknecht, Karl, additional, Schöll, Michael, additional, Drenckhahn, Christoph, additional, Feuerstein, Delphine, additional, Eriksen, Nina, additional, Horst, Viktor, additional, Bretz, Julia S, additional, Jahnke, Paul, additional, Scheel, Michael, additional, Bohner, Georg, additional, Rostrup, Egill, additional, Pakkenberg, Bente, additional, Heinemann, Uwe, additional, Claassen, Jan, additional, Carlson, Andrew P, additional, Kowoll, Christina M, additional, Lublinsky, Svetlana, additional, Chassidim, Yoash, additional, Shelef, Ilan, additional, Friedman, Alon, additional, Brinker, Gerrit, additional, Reiner, Michael, additional, Kirov, Sergei A, additional, Andrew, R David, additional, Farkas, Eszter, additional, Güresir, Erdem, additional, Vatter, Hartmut, additional, Chung, Lee S, additional, Brennan, KC, additional, Lieutaud, Thomas, additional, Marinesco, Stephane, additional, Maas, Andrew IR, additional, Sahuquillo, Juan, additional, Dahlem, Markus A, additional, Richter, Frank, additional, Herreras, Oscar, additional, Boutelle, Martyn G, additional, Okonkwo, David O, additional, Bullock, M Ross, additional, Witte, Otto W, additional, Martus, Peter, additional, van den Maagdenberg, Arn MJM, additional, Ferrari, Michel D, additional, Dijkhuizen, Rick M, additional, Shutter, Lori A, additional, Andaluz, Norberto, additional, Schulte, André P, additional, MacVicar, Brian, additional, Watanabe, Tomas, additional, Woitzik, Johannes, additional, Lauritzen, Martin, additional, Strong, Anthony J, additional, and Hartings, Jed A, additional

Published
2016
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19. Parenteral diclofenac infusion significantly decreases brain-tissue oxygen tension in patients with poor-grade aneurysmal subarachnoid hemorrhage

Author

Schiefecker, Alois J, primary, Pfausler, Bettina, additional, Beer, Ronny, additional, Sohm, Florian, additional, Sabo, Jan, additional, Knauseder, Viktoria, additional, Fischer, Marlene, additional, Dietmann, Anelia, additional, Hackl, Werner O, additional, Thomé, Claudius, additional, Schmutzhard, Erich, additional, and Helbok, Raimund, additional

Published
2013
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20. Cerebrospinal fluid red blood cells and total protein are associated with clinical outcome in spontaneous subarachnoid hemorrhage.

Author

Berek, Klaus, Lindner, Anna, Kindl, Philipp, Di Pauli, Franziska, Schiefecker, Alois J., Pfausler, Bettina, Helbok, Raimund, Deisenhammer, Florian, Beer, Ronny, Rass, Verena, and Hegen, Harald

Subjects
*ERYTHROCYTES, *NEUROLOGICAL intensive care, *SUBARACHNOID hemorrhage, *CEREBROSPINAL fluid, *TREATMENT effectiveness, *CEREBRAL vasospasm
Abstract

Background and Purpose Methods Results Conclusions Prognostication in patients with spontaneous subarachnoid hemorrhage (SAH) can be challenging. The aim of this study was to assess whether cerebrospinal fluid (CSF) red blood cell (RBC) count and total protein (TP) concentration are associated with SAH prognosis.Patients with SAH treated at the neurological intensive care unit (ICU) in Innsbruck were included in this real‐world, observational study. Longitudinal CSF samples were collected as part of routine diagnostics. RBC count and CSF TP at the time of admission (RBCfirst, TPfirst), in Week 1 (RBCDays1–7, TPDays1–7), Week 2 (RBCDays8–14, TPDays8–14), and Week 3 or thereafter (RBCDay>14, TPDay>14), the highest detected value (RBChighest, TPhighest), as well as the RBC count adjusted for disease duration (RBCadjusted) were assessed. Primary outcomes were good functional outcome after 3 months, defined as modified Rankin scale score ≤2 and ICU survival.A total of 183 SAH patients with a female predominance (69%), a median (interquartile range [IQR]) age of 60 (50–70) years and median (IQR) Hunt and Hess score of 4 (3–5) were included. Multivariable analyses revealed that lower values of RBCfirst, RBCadjusted, RBChighest, TPfirst and TPhighest were associated with good functional outcome and hospital survival. Lower TP concentrations in Weeks 1, 2 and 3 were associated with good functional outcome, and in Weeks 1 and 2 with ICU survival. Early RBC measurements (Week 1) were associated with good functional outcome and ICU survival.Low CSF RBC counts and TP concentrations were associated with good functional outcome and ICU survival in a real‐world cohort of SAH patients requiring external ventricular drainage. [ABSTRACT FROM AUTHOR]

Published
2024
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