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1. T cell repertoire analysis suggests a prominent bystander response in human cardiac allograft vasculopathy

Author

Habal, Marlena V., Miller, April M.I., Rao, Samhita, Lin, Sijie, Obradovic, Aleksandar, Khosravi-Maharlooei, Mohsen, See, Sarah B., Roy, Poulomi, Shihab, Ronzon, Ho, Siu-Hong, Marboe, Charles C., Naka, Yoshifumi, Takeda, Koji, Restaino, Susan, Han, Arnold, Mancini, Donna, Givertz, Michael, Madsen, Joren C., Sykes, Megan, Addonizio, Linda J., Farr, Maryjane A., and Zorn, Emmanuel

Published
2021
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3. Clonal hematopoiesis of indeterminate potential and outcomes after heart transplantation: A multicenter study

Author

Amancherla, Kaushik, primary, Schlendorf, Kelly H., additional, Vlasschaert, Caitlyn, additional, Lowery, Brandon D., additional, Wells, Quinn S., additional, See, Sarah B., additional, Zorn, Emmanuel, additional, Colombo, Paolo C., additional, Reilly, Muredach P., additional, Lindenfeld, JoAnn, additional, Uriel, Nir, additional, Freedman, Jane E., additional, Shah, Ravi V., additional, Moslehi, Javid, additional, Bick, Alexander G., additional, and Clerkin, Kevin, additional

Published
2023
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5. Natural Antibodies Are Associated With Rejection and Long-term Renal Allograft Loss in a Multicenter International Cohort

Author

See, Sarah B., Yang, Xue, Burger, Carole, Lamarthée, Baptiste, Snanoudj, Renaud, Shihab, Ronzon, Tsapepas, Demetra S., Roy, Poulomi, Larivière-Beaudoin, Stéphanie, Hamelin, Katia, Mendoza Rojas, Aleixandra, Van Besouw, Nicole M., Bartosic, Amanda, Daniel, Nikita, Rodica, Vasilescu E., Mohan, Sumit, Cohen, David, Ratner, Lloyd, Baan, Carla C., Bromberg, Jonathan S., Cardinal, Héloïse, Anglicheau, Dany, Sun, Yifei, Zorn, Emmanuel, See, Sarah B., Yang, Xue, Burger, Carole, Lamarthée, Baptiste, Snanoudj, Renaud, Shihab, Ronzon, Tsapepas, Demetra S., Roy, Poulomi, Larivière-Beaudoin, Stéphanie, Hamelin, Katia, Mendoza Rojas, Aleixandra, Van Besouw, Nicole M., Bartosic, Amanda, Daniel, Nikita, Rodica, Vasilescu E., Mohan, Sumit, Cohen, David, Ratner, Lloyd, Baan, Carla C., Bromberg, Jonathan S., Cardinal, Héloïse, Anglicheau, Dany, Sun, Yifei, and Zorn, Emmanuel

Abstract

Background. Potentially harmful nonhuman leukocyte antigen antibodies have been identified in renal transplantation, including natural immunoglobulin G antibodies (Nabs) reactive to varied antigenic structures, including apoptotic cells. Methods. In this retrospective, multicenter study, we assessed Nabs by reactivity to apoptotic cells in sera collected from 980 kidney transplant recipients across 4 centers to determine their association with graft outcomes. Results. Elevated pretransplant Nabs were associated with graft loss (hazard ratio [HR] 2.71; 95% confidence interval [CI], 1.15-6.39; P = 0.0232), the composite endpoint of graft loss or severe graft dysfunction (HR 2.40; 95% CI, 1.13-5.10; P = 0.0232), and T cell-mediated rejection (odds ratio [OR] 1.77; 95% CI, 1.07-3.02; P = 0.0310). High pretransplant Nabs together with donor-specific antibodies (DSAs) were associated with increased risk of composite outcomes (HR 6.31; 95% CI, 1.81-22.0; P = 0.0039). In patients with high pretransplant Nabs, the subsequent development of posttransplant Nabs was associated with both T cell-mediated rejection (OR 3.64; 95% CI, 1.61-8.36; P = 0.0021) and mixed rejection (OR 3.10; 95% CI, 1.02-9.75; P = 0.0473). Finally, elevated pre- and posttransplant Nabs combined with DSAs were associated with increased risk of composite outcomes (HR 3.97; 95% CI, 1.51-10.43; P = 0.0052) and T cell-mediated rejection (OR 7.28; 95% CI, 2.16-25.96; P = 0.0016). Conclusions. The presence of pre- and posttransplant Nabs, together with DSAs, was associated with increased risk of poor graft outcomes and rejection after renal transplantation.

Published
2023

10. Early Acute Microvascular Kidney Transplant Rejection in the Absence of Anti-HLA Antibodies Is Associated with Preformed IgG Antibodies against Diverse Glomerular Endothelial Cell Antigens

Author

Delville, Marianne, primary, Lamarthée, Baptiste, additional, Pagie, Sylvain, additional, See, Sarah B., additional, Rabant, Marion, additional, Burger, Carole, additional, Gatault, Philippe, additional, Giral, Magali, additional, Thaunat, Olivier, additional, Arzouk, Nadia, additional, Hertig, Alexandre, additional, Hazzan, Marc, additional, Matignon, Marie, additional, Mariat, Christophe, additional, Caillard, Sophie, additional, Kamar, Nassim, additional, Sayegh, Johnny, additional, Westeel, Pierre-François, additional, Garrouste, Cyril, additional, Ladrière, Marc, additional, Vuiblet, Vincent, additional, Rivalan, Joseph, additional, Merville, Pierre, additional, Bertrand, Dominique, additional, Le Moine, Alain, additional, Van Huyen, Jean Paul Duong, additional, Cesbron, Anne, additional, Cagnard, Nicolas, additional, Alibeu, Olivier, additional, Satchell, Simon C., additional, Legendre, Christophe, additional, Zorn, Emmanuel, additional, Taupin, Jean-Luc, additional, Charreau, Béatrice, additional, and Anglicheau, Dany, additional

Published
2019
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12. Clonal hematopoiesis of indeterminate potential and outcomes after heart transplantation: A multi-center study

Author

Amancherla, Kaushik, Schlendorf, Kelly H., Vlasschaert, Caitlyn, Lowery, Brandon D., Wells, Quinn S., See, Sarah B., Zorn, Emmanuel, Colombo, Paolo C., Reilly, Muredach P., Lindenfeld, JoAnn, Uriel, Nir, Freedman, Jane E., Shah, Ravi V., Moslehi, Javid, Bick, Alexander G., and Clerkin, Kevin

Abstract

Cardiac allograft vasculopathy (CAV) is a leading cause of late graft failure and mortality after heart transplantation (HT). Sharing some features with atherosclerosis, CAV results in diffuse narrowing of the epicardial coronaries and microvasculature with consequent graft ischemia. Recently, clonal hematopoiesis of indeterminate potential (CHIP) has emerged as a risk factor for cardiovascular disease and mortality. We aimed to investigate the relationship between CHIP and post-transplant outcomes, including CAV. We analyzed 479 HT recipients with stored DNA samples at two high-volume transplant centers, Vanderbilt University Medical Center and Columbia University Irving Medical Center. We explored the association between the presence of CHIP mutations with CAV and mortality after HT. In this case-control analysis, carriers of CHIP mutations were not at increased risk of CAV or mortality after HT. In a large multicenter genomics study of the heart transplant population, the presence of CHIP mutations was not associated with increased risk of CAV or post-transplant mortality.

Published
2023
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